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A conserved germline multipotency program

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Juliano, Celina E., Swartz, S. Zachary, Wessel, Gary M.·2010·Development

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Abstract

The germline of multicellular animals is segregated from somatic tissues, which is an essential developmental process for the next generation. Although certain ecdysozoans and chordates segregate their germline during embryogenesis, animals from other taxa segregate their germline after embryogenesis from multipotent progenitor cells. An overlapping set of genes, including vasa, nanos and piwi, operate in both multipotent precursors and in the germline. As we propose here, this conservation implies the existence of an underlying germline multipotency program in these cell types that has a previously underappreciated and conserved function in maintaining multipotency.

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Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms
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A chromosome-scale epigenetic map of the Hydra genome reveals conserved regulators of cell state
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Self-citation

See all 268

Authors: Juliano, C. E., Swartz, S. Z., & Wessel, G. M.
Venue: Development
Publisher: The Company of Biologists
Published: 2010-12-15
Volume: 137
Issue: 24
Pages: 4113-4126
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.047969
OpenAlex: W1972475184
Cited by: 268
References: 171
FWCI: 3.78
Type: journal article
Language: en
Open access: green

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A conserved germline multipotency program

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