The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
How to make an oligodendrocyte
Open accessAbstract
Oligodendrocytes produce myelin, an insulating sheath required for the saltatory conduction of electrical impulses along axons. Oligodendrocyte loss results in demyelination, which leads to impaired neurological function in a broad array of diseases ranging from pediatric leukodystrophies and cerebral palsy, to multiple sclerosis and white matter stroke. Accordingly, replacing lost oligodendrocytes, whether by transplanting oligodendrocyte progenitor cells (OPCs) or by mobilizing endogenous progenitors, holds great promise as a therapeutic strategy for the diseases of central white matter. In this Primer, we describe the molecular events regulating oligodendrocyte development and how our understanding of this process has led to the establishment of methods for producing OPCs and oligodendrocytes from embryonic stem cells and induced pluripotent stem cells, as well as directly from somatic cells. In addition, we will discuss the safety of engrafted stem cell-derived OPCs, as well as approaches by which to modulate their differentiation and myelinogenesis in vivo following transplantation.
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Metadata
- Authors
- Goldman, S. A., & Kuypers, N. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2015-12-01
- Volume
- 142
- Issue
- 23
- Pages
- 3983-3995
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2257936017
- Cited by
- 223
- References
- 27
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
