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Cited by 364

The DOI matches its Crossref record.

Skeletal muscle weakness in old age: underlying mechanisms

BROOKS, SUSAN V., FAULKNER, JOHN A.·1994·Medicine & Science in Sports & Exercise
DOI 10.1249/00005768-199404000-00006
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Abstract

Maintenance of muscle mass and strength contributes to mobility which impacts on quality of life. Although muscle atrophy, declining strength, and physical frailty are generally accepted as inevitable concomitants of aging, the causes are unknown. Clarification of the mechanisms responsible for these changes would enhance our understanding of the degree to which they are preventable or treatable. The decline in muscle function between maturity and old age is similar for muscles of many different animals including human beings, and is typified by the decreases of ∼35% in maximum force, ∼30% in maximum power, and 20% in normalized force (kN·m−2) and power (W·kg−1) of extensor digitorum longus (EDL) muscles in old compared with adult mice. Much of the age-associated muscle atrophy and declining strength may be explained by motor unit remodeling which appears to occur by selective denervation of muscle fibers with reinnervation by axonal sprouting from an adjacent innervated unit. Muscles in old mice appear more susceptible to injury than muscles in young or adult mice and have a decreased capacity for recovery. The process of age related denervation may be aggravated by an increased susceptibility of muscles in old animals to contraction-induced injury coupled with impaired capacity for regeneration.

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Authors
BROOKS, S. V., & FAULKNER, J. A.
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1994-04
Volume
26
Issue
4
Pages
432???439
ISSN
0195-9131 (ISSN-L)
DOI
10.1249/00005768-199404000-00006
OpenAlex
W4297573836
Cited by
364
References
0
FWCI
1.72
Type
journal article
Language
en
Open access
closed

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