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Cited by 353

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Activation of NK Cells by an Endocytosed Receptor for Soluble HLA-G

Open access
Rajagopalan, Sumati, Bryceson, Yenan T, Kuppusamy, Shanmuga P, Geraghty, Daniel E, Meer, Arnold van der, Joosten, Irma, Long, Eric O·2005·PLoS Biology
DOI 10.1371/journal.pbio.0040009
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Abstract

Signaling from endosomes is emerging as a mechanism by which selected receptors provide sustained signals distinct from those generated at the plasma membrane. The activity of natural killer (NK) cells, which are important effectors of innate immunity and regulators of adaptive immunity, is controlled primarily by receptors that are at the cell surface. Here we show that cytokine secretion by resting human NK cells is induced by soluble, but not solid-phase, antibodies to the killer cell immunoglobulin-like receptor (KIR) 2DL4, a receptor for human leukocyte antigen (HLA)-G. KIR2DL4 was constitutively internalized into Rab5-positive compartments via a dynamin-dependent process. Soluble HLA-G was endocytosed into KIR2DL4-containing compartments in NK cells and in 293T cells transfected with KIR2DL4. Chemokine secretion induced by KIR2DL4 transfection into 293T cells occurred only with recombinant forms of KIR2DL4 that trafficked to endosomes. The profile of genes up-regulated by KIR2DL4 engagement on resting NK cells revealed a proinflammatory/proangiogenic response. Soluble HLA-G induced secretion of a similar set of cytokines and chemokines. This unique stimulation of resting NK cells by soluble HLA-G, which is endocytosed by KIR2DL4, implies that NK cells may provide useful functions at sites of HLA-G expression, such as promotion of vascularization in maternal decidua during early pregnancy.

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Metadata

Authors
Rajagopalan, S., Bryceson, Y. T., Kuppusamy, S. P., Geraghty, D. E., Meer, A. V. D., Joosten, I., & Long, E. O.
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2005-12-27
Volume
4
Issue
1
Pages
e9
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
DOI
10.1371/journal.pbio.0040009
OpenAlex
W2088974691
Cited by
353
References
59
FWCI
8.59
Type
journal article
Language
en
Open access
gold

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