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A User's Guide to the Encyclopedia of DNA Elements (ENCODE)

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The ENCODE Project Consortium·2011·PLoS Biology
DOI 10.1371/journal.pbio.1001046
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Abstract

The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.

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Metadata

Authors
The ENCODE Project Consortium
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2011-04-19
Volume
9
Issue
4
Pages
e1001046
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
DOI
10.1371/journal.pbio.1001046
OpenAlex
W1544691147
Cited by
1,506
References
26
FWCI
81.00
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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