Cited by 444Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

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SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

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Boily, Gino, Seifert, Erin L., Bevilacqua, Lisa, He, Xiao Hong, Sabourin, Guillaume, Estey, Carmen, Moffat, Cynthia, Crawford, Sean, Saliba, Sarah, Jardine, Karen, Xuan, Jian, Evans, Meredith, Harper, Mary-Ellen, McBurney, Michael W.·2008·PLoS ONE

DOI 10.1371/journal.pone.0001759PMC PMC2258149

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Abstract

The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food. These mice are hypermetabolic, contain inefficient liver mitochondria, and have elevated rates of lipid oxidation. When challenged with a 40% reduction in caloric intake, normal mice maintained their metabolic rate and increased their physical activity while the metabolic rate of SirT1-null mice dropped and their activity did not increase. Moreover, CR did not extend lifespan of SirT1-null mice. Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction.

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Background
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
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Authors: Boily, G., Seifert, E. L., Bevilacqua, L., He, X. H., Sabourin, G., Estey, C., Moffat, C., Crawford, S., Saliba, S., Jardine, K., Xuan, J., Evans, M., Harper, M.-E., & McBurney, M. W.
Affiliations: University of Ottawa (CA)
Corresponding author: McBurney, Michael W.
ORCID: Bevilacqua, Lisa
Crawford, Sean
Harper, Mary-Ellen
McBurney, Michael W.
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2008-03-12
Volume: 3
Issue: 3
Pages: e1759
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0001759
PMC: PMC2258149
OpenAlex: W2035543709
Cited by: 444
References: 40
Citations by year: 2026: 4 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 16 · 2020: 17 · 2019: 22 · 2018: 20 · 2017: 23 · 2016: 27 · 2015: 25 · 2014: 34 · 2013: 41 · 2012: 29
FWCI: 20.45
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Canadian Diabetes Association
University of Guelph
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: SIRT1, sirtuins, caloric restriction, energy metabolism, hypermetabolism, mitochondrial efficiency, liver mitochondria, lipid oxidation, metabolic rate, physical activity, lifespan
MeSH terms: Animals, Energy Intake, Calorimetry, Energy Metabolism, Hormones, Mitochondria, Liver, Reactive Oxygen Species, Mice, Knockout, Sirtuins, Mice, Sirtuin 1

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SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

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