Molecular Variation in AVP and AVPR1a in New World Monkeys (Primates, Platyrrhini): Evolution and Implications for Social Monogamy
Open accessAbstract
The neurohypophysial hormone arginine vasopressin (AVP) plays important roles in fluid regulation and vascular resistance. Differences in AVP receptor expression, particularly mediated through variation in the noncoding promoter region of the primary receptor for AVP (AVPR1a), may play a role in social phenotypes, particularly social monogamy, in rodents and humans. Among primates, social monogamy is rare, but is common among New World monkeys (NWM). AVP is a nonapeptide and generally conserved among eutherian mammals, although a recent paper demonstrated that some NWM species possess a novel form of the related neuropeptide hormone, oxytocin. We therefore characterized variation in the AVP and AVPR1a genes in 22 species representing every genus in the three major platyrrhine families (Cebidae, Atelidae and Pitheciidae). For AVP, a total of 16 synonymous substitutions were detected in 15 NWM species. No non-synonymous substitutions were noted, hence, AVP is conserved in NWM. By contrast, relative to the human AVPR1a, 66 predicted amino acids (AA) substitutions were identified in NWM. The AVPR1a N-terminus (ligand binding domain), third intracellular (G-protein binding domain), and C-terminus were variable among species. Complex evolution of AVPR1a is also apparent in NWM. A molecular phylogenetic tree inferred from AVPR1a coding sequences revealed some consensus taxonomic separation by families, but also a mixed group composed of genera from all three families. The overall dN/dS ratio of AVPR1a was 0.11, but signals of positive selection in distinct AVPR1a regions were observed, including the N-terminus, in which we identified six potential positive selection sites. AA substitutions at positions 241, 319, 399 and 409 occurred uniquely in marmosets and tamarins. Our results enhance the appreciation of genetic diversity in the mammalian AVP/AVPR1a system, and set the stage for molecular modeling of the neurohypophyseal hormones and social behavior in primates.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
New World monkeys have genetic variation in OT and AVP peptide and receptor genes across species.
“Species differences in receptor binding characteristics vary widely, especially in light of recent discoveries in New World monkeys, which show genetic variations in both the OT and AVP peptide and receptor genes across species (105-110).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [106]
Receptor binding characteristics differ widely across species.
“Species differences in receptor binding characteristics vary widely, especially in light of recent discoveries in New World monkeys, which show genetic variations in both the OT and AVP peptide and receptor genes across species (105-110).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [106]
V1aR structure in New World monkeys differs significantly from receptors in other primate genera, especially in the N- and C-termini.
“With regard to the AVP system, while there are no known variants in the AVP ligand in NWM, V1aR structure in NWM differs significantly from receptors in other primate genera especially in the N- and C-termini.”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Ren et al., 2014
Among New World monkeys there have been many physico-chemically radical and conservative amino acid substitutions in the N-terminus, third intracellular loop, and C-terminus when compared to the human V1aR.
“Among NWM there have been many physico-chemically radical and conservative amino acid substitutions in the N-terminus, third intracellular loop, and C-terminus when compared to the human V1aR (Ren et al., 2014).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Ren et al., 2014
A phylogeny generated using AVPR1a nucleotide sequences groups socially monogamous species more closely than grouping from canonical phylogenies.
“Moreover, a phylogeny generated using AVPR1a nucleotide sequences groups socially monogamous species more closely than grouping from canonical phylogenies.”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Ren et al., 2014
Callicebus V1aR is more similar to Pro8-OT Cebidae including socially monogamous callitrichines than to other pithiceds.
“Rather than sharing V1aR similarity with the other members of the pithiceds, Callicebus V1aR is more similar to the Pro8-OT Cebidae including the socially monogamous callitrichines.”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Ren et al., 2014
Four V1aR substitutions (Gly172, Cys241, Asn319, Val399) were significantly associated with New World monkeys classified as socially monogamous.
“four of which (Gly172, Cys241, Asn319, Val399) were significantly associated with NWM classified as socially monogamous (Ren et al., 2014).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Ren et al., 2014
There are several substitutions unique to the callitrichines, a clade characterized by social monogamy.
“There are several substitutions unique to the callitrichines, a clade characterized by social monogamy (Fig. 4b; Ren et al., 2014).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Ren et al., 2014
Socially monogamous Callicebus and callitrichine AVPR1a sequences are more similar than callitrichines and other non-socially monogamous Cebidae V1aR sequences, despite the greatest evolutionary distance between Callicebus and callitrichines among New World monkeys.
“Moreover, while Callicebus and callitrichines are separated by the greatest evolutionary distance among NWM, the socially monogamous Callicebus and callitrichine AVPR1a sequences are more similar than the callitrichines and other non-socially monogamous Cebidae V1aR sequences.”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Ren et al., 2014
V1aR has undergone significant modification among New World monkeys.
“The V1aR has undergone significant modification among NWM (Ren et al., 2014).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Ren et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.
Tamura, K., Stecher, G., Peterson, D., Filipski, A., & Kumar, S. (2013) · Molecular biology and evolution · doi:10.1093/molbev/mst197 · Cited by 41,174 · see citing works
DnaSP v5: a software for comprehensive analysis of DNA polymorphism data
Librado, P., & Rozas, J. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp187 · Cited by 16,045 · see citing works
PAML 4: Phylogenetic Analysis by Maximum Likelihood
Yang, Z. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm088 · Cited by 13,879 · see citing works
Kleiman, D. G. (1977) · The Quarterly Review of Biology · doi:10.1086/409721 · Cited by 1,436 · see citing works
A molecular phylogeny of living primates
Perelman, P., Johnson, W. E., Roos, C., Seuánez, H. N., Horvath, J. E., Moreira, M. A. M., Kessing, B., Pontius, J., Roelke, M., Rumpler, Y., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001342 · Cited by 1,414 · cited 3× · see citing works
“AVPR1a phylogeny and evolution in primates A molecular phylogenetic tree was generated based on AVPR1a coding sequences (Figure 3A) and contrasted with a consensus molecular tree based on 54 nuclear genes ([30]; Figure 3B).”
BackgroundMethodPrimate adaptation and evolution
(1989) · Choice Reviews Online · doi:10.5860/choice.26-3889 · Cited by 1,246 · see citing works
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173 · see citing works
Hearing silence: non-neutral evolution at synonymous sites in mammals
Chamary, J., Parmley, J. L., & Hurst, L. D. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1770 · Cited by 827 · see citing works
The evolution of social monogamy in mammals
Lukas, D., & Clutton-Brock, T. H. (2013) · Science · doi:10.1126/science.1238677 · Cited by 678 · see citing works
Lim, M. M., Wang, Z., Olazábal, D. E., Ren, X., Terwilliger, E. F., & Young, L. J. (2004) · Nature · doi:10.1038/nature02539 · Cited by 628 · see citing works
Kristiansen, K. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.05.002 · Cited by 611 · see citing works
Microsatellite instability generates diversity in brain and sociobehavioral traits
Hammock, E. A. D., & Young, L. J. (2005) · Science · doi:10.1126/science.1111427 · Cited by 545 · see citing works
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504 · see citing works
Young, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R., & Insel, T. R. (1999) · Nature · doi:10.1038/23475 · Cited by 488 · see citing works
Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems
Koshimizu, T., Nakamura, K., Egashira, N., Hiroyama, M., Nonoguchi, H., & Tanoue, A. (2012) · Physiological Reviews · doi:10.1152/physrev.00035.2011 · Cited by 413 · see citing works
Young (1999) · doi:10.1038/23650 · Cited by 389 · see citing works
Rates of conservative and radical nonsynonymous nucleotide substitutions in mammalian nuclear genes
Zhang, J. (2000) · Journal of Molecular Evolution · doi:10.1007/s002399910007 · Cited by 356 · see citing works
Rates of Nucleotide Substitution in Primates and Rodents and the Generation–Time Effect Hypothesis
Li, W.-H., Ellsworth, D. L., Krushkal, J., Chang, B. H.-J., & Hewett-Emmett, D. (1996) · Molecular Phylogenetics and Evolution · doi:10.1006/mpev.1996.0012 · Cited by 335 · cited 1× · see citing works
“in the rodent lineage, relative to the primate lineage [36].”
BackgroundStructural bases of vasopressin/oxytocin receptor function
Barberis, C., Mouillac, B., & Durroux, T. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1560223 · Cited by 311 · see citing works
Site-to-Site Variation of Synonymous Substitution Rates
Pond, S. L. K., & Muse, S. V. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi232 · Cited by 274 · see citing works
Male infanticide leads to social monogamy in primates
Opie, C., Atkinson, Q. D., Dunbar, R., & Shultz, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307903110 · Cited by 273 · see citing works
A Mitogenomic Phylogeny of Living Primates
Finstermeier, K., Zinner, D. P., Brameier, M., Meyer, M., Kreuz, E., Hofreiter, M., & Roos, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069504 · Cited by 266 · see citing works
Nonapeptides and the evolutionary patterning of sociality
GOODSON, J. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00401-9 · Cited by 228 · see citing works
Life in groups: the roles of oxytocin in mammalian sociality
Anacker, A. M. J., & Beery, A. K. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00185 · Cited by 216 · see citing works
Examination of AVPR1a as an autism susceptibility gene
Wassink, T. H., Piven, J., Vieland, V. J., Pietila, J., Goedken, R. J., Folstein, S. E., & Sheffield, V. C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001503 · Cited by 212 · see citing works
Deconstructing sociality, social evolution and relevant nonapeptide functions
Goodson, J. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.005 · Cited by 206 · see citing works
Primate Phylogeny: Morphological vs Molecular Results
Shoshani, J., Groves, C. P., Simons, E. L., & Gunnell, G. F. (1996) · Molecular Phylogenetics and Evolution · doi:10.1006/mpev.1996.0009 · Cited by 202 · see citing works
The neurohypophysial endocrine regulatory cascade: precursors, mediators, receptors, and effectors
Acher, R., & Chauvet, J. (1995) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1995.1009 · Cited by 135 · see citing works
Associations between Dopamine D4 Receptor Gene Variation with Both Infidelity and Sexual Promiscuity
Garcia, J. R., MacKillop, J., Aller, E. L., Merriwether, A. M., Wilson, D. S., & Lum, J. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014162 · Cited by 134 · see citing works
Mammalian monogamy is not controlled by a single gene
Fink, S., Excoffier, L., & Heckel, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602380103 · Cited by 133 · cited 2× · see citing works
“is not predicted by a single polymorphism in the promoter region of the AVPR1a gene [12].”
BackgroundLiu, J., & Wess, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8772 · Cited by 133 · see citing works
Monogamy Evolves through Multiple Mechanisms: Evidence from V1aR in Deer Mice
Turner, L. M., Young, A. R., Römpler, H., Schöneberg, T., Phelps, S. M., & Hoekstra, H. E. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msq013 · Cited by 122 · see citing works
A novel form of oxytocin in New World monkeys
Lee, A. G., Cool, D. R., Grunwald, W. C., Neal, D. E., Buckmaster, C. L., Cheng, M. Y., Hyde, S. A., Lyons, D. M., & Parker, K. J. (2011) · Biology Letters · doi:10.1098/rsbl.2011.0107 · Cited by 91 · see citing works
(1995) · PubMed · Cited by 90 · see citing works
Evidence for purifying selection acting on silent sites in BRCA1
Hurst, L. D., & Pál, C. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(00)02173-9 · Cited by 89 · see citing works
Correlates of genetic monogamy in socially monogamous mammals: insights from Azara's owl monkeys
Huck, M., Fernández‐Duque, E., Babb, P. L., & Schurr, T. G. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.0195 · Cited by 86 · see citing works
Evolutionary genetics and implications of small size and twinning in callitrichine primates
Harris, R. A., Tardif, S. D., Vinař, T., Wildman, D. E., Rutherford, J. N., Rogers, J., Worley, K. C., & Aagaard, K. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316037111 · Cited by 84 · see citing works
Thibonnier, M., Graves, M. K., Wagner, M., Chatelain, N., Soubrier, F., Corvol, P. L., Willard, H. F., & Jeunemaı̂tre, X. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1108 · Cited by 73 · see citing works
Vasopressin and pair-bond formation: genes to brain to behavior.
Nair, H. P., & Young, L. J. (2006) · Physiology · doi:10.1152/physiol.00049.2005 · Cited by 68 · see citing works
Berrada, K., Plesnicher, C. L., Luo, X., & Thibonnier, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002288200 · Cited by 63 · see citing works
Donaldson, Z. R., Kondrashov, F. A., Putnam, A. S., Bai, Y., Stoinski, T., Hammock, E. A. D., & Young, L. J. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-180 · Cited by 61 · see citing works
Wallis, M. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.07.030 · Cited by 48 · see citing works
High variability and non-neutral evolution of the mammalian avpr1a gene
Fink, S., Excoffier, L., & Heckel, G. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-176 · Cited by 46 · see citing works
Mating system and avpr1a promoter variation in primates
Rosso, L., Keller, L., Kaessmann, H., & Hammond, R. L. (2008) · Biology Letters · doi:10.1098/rsbl.2008.0122 · Cited by 36 · see citing works
Hawtin, S. R., Wesley, V. J., Parslow, R. A., Patel, S., & Wheatley, M. (2000) · Biochemistry · doi:10.1021/bi0013400 · Cited by 32 · see citing works
Babb, P. L., Fernández‐Duque, E., & Schurr, T. G. (2010) · Journal of Molecular Evolution · doi:10.1007/s00239-010-9383-6 · Cited by 29 · see citing works
Saito, S., Iida, A., Sekine, A., Kawauchi, S., Higuchi, S., Ogawa, C., & Nakamura, Y. (2003) · Journal of Human Genetics · doi:10.1007/s10038-003-0062-y · Cited by 26 · see citing works
Hawtin, S. R., Wesley, V. J., Parslow, R. A., Simms, J., Miles, A., McEwan, K., & Wheatley, M. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.3.0795 · Cited by 24 · see citing works
Ferguson, D. R. (1969) · General and Comparative Endocrinology · doi:10.1016/0016-6480(69)90181-6 · Cited by 23 · see citing works
Thibonnier, M., Plesnicher, C. L., Berrada, K., & Berti‐Mattera, L. N. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.1.e81 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Freeman, S. M., & Young, L. J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12382 · Cited by 196 · see citing works
“Species differences in receptor binding characteristics vary widely, especially in light of recent discoveries in New World monkeys, which show genetic variations in both the OT and AVP peptide and receptor genes across species (105-110).”
BackgroundPredicting loss of evolutionary history: Where are we?
Véron, S., Davies, T. J., Cadotte, M. W., Clergeau, P., & Pavoine, S. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12228 · Cited by 88 · see citing works
Social Monogamy in Nonhuman Primates: Phylogeny, Phenotype, and Physiology
French, J. A., Cavanaugh, J., Mustoe, A. C., Carp, S. B., & Womack, S. L. (2017) · The Journal of Sex Research · doi:10.1080/00224499.2017.1339774 · Cited by 72 · see citing works
Self-citationOxytocin and vasopressin enhance responsiveness to infant stimuli in adult marmosets
Taylor, J. H., & French, J. A. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.10.002 · Cited by 68 · see citing works
Self-citationNeuropeptide diversity and the regulation of social behavior in New World primates
French, J. A., Taylor, J. H., Mustoe, A. C., & Cavanaugh, J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.004 · Cited by 66 · see citing works
Self-citationVargas-Pinilla, P., Paixão-Côrtes, V. R., Paré, P., Tovo-Rodrigues, L., Vieira, C. M. D. A. G., Xavier, A., Comas, D., Pissinatti, A., Sinigaglia, M., Rigo, M. M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419399112 · Cited by 59 · see citing works
Parreiras‐e‐Silva, L. T., Vargas‐Pinilla, P., Duarte, D. Â., Longo, D., Pardo, G. V. E., Finkler, A. D., Paixão‐Côrtes, V. R., Paré, P., Rovaris, D. L., Oliveira, E. B., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711687114 · Cited by 48 · see citing works
Genetic Diversity in Oxytocin Ligands and Receptors in New World Monkeys
Ren, D., Lu, G., Moriyama, H., Mustoe, A. C., Harrison, E. B., & French, J. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0125775 · Cited by 47 · see citing works
Self-citationDíaz‐Muñoz, S. L., & Bales, K. L. (2015) · American Journal of Primatology · doi:10.1002/ajp.22463 · Cited by 40 · see citing works
Oxytocin structure and function in New World monkeys: from pharmacology to behavior
Mustoe, A. C., Taylor, J. H., & French, J. A. (2018) · Integrative Zoology · doi:10.1111/1749-4877.12318 · Cited by 25 · see citing works
Self-citationModulating vertebrate physiology by genomic fine-tuning of GPCR functions
Schöneberg, T. (2024) · Physiological Reviews · doi:10.1152/physrev.00017.2024 · Cited by 17 · see citing works
Staes, N., Guevara, E. E., Helsen, P., Eens, M., & Stevens, J. M. G. (2021) · Journal of Human Evolution · doi:10.1016/j.jhevol.2021.102949 · Cited by 16 · see citing works
Leu8 and Pro8 oxytocin agonism differs across human, macaque, and marmoset vasopressin 1a receptors
Mustoe, A. C., Schulte, N. A., Taylor, J. H., French, J. A., & Toews, M. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-52024-9 · Cited by 15 · see citing works
Self-citationPierce, M. L., French, J. A., & Murray, T. F. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110060 · Cited by 14 · see citing works
Self-citationWade, M., Hoffmann, T. J., Knafo‐Noam, A., O’Connor, T. G., & Jenkins, J. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.05.002 · Cited by 8 · see citing works
Genes, dopamine pathways, and sociality in primates
French, J. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605972113 · Cited by 6 · see citing works
Self-citationThe Genome of the Common Marmoset
Vallender, E. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811829-0.00019-4 · Cited by 4 · see citing works
AVPR1b variation and the emergence of adaptive phenotypes in Platyrrhini primates
Fam, B. S. D. O., Reales, G., Vargas‐Pinilla, P., Paré, P., Viscardi, L. H., Sortica, V. A., Felkl, A. B., Franco, Á. D. O., Lucion, A. B., Costa-Neto, C. M., et al. (2019) · American Journal of Primatology · doi:10.1002/ajp.23028 · Cited by 4 · see citing works
Evolution of Neuropeptide Signaling: From a Single Cell to Mammals
Krabichler, Q., & Grinevich, V. (2025) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-80209-6_1 · Cited by 3 · see citing works
Pierce, M. L., French, J. A., & Murray, T. F. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109832 · Cited by 3 · see citing works
Self-citationGumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2026) · eLife · doi:10.7554/elife.105355.3 · Cited by 2 · see citing works
Vattem, N., Snyder, M., Leschinsky, A., Aziz, A., Amin, J., Butt, M., Aburas, J., & Pierce, M. L. (2026) · NeuroSci · doi:10.3390/neurosci7050100 · Cited by 1 · see citing works
Oxytocin, Vasopressin, and Development of Social Behavior in Primates
Bales, K. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804042-3.00094-4
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2026) · eLife · doi:10.1101/2024.12.09.627541
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2025) · eLife · doi:10.7554/elife.105355.1
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2025) · eLife · doi:10.7554/elife.105355
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2026) · eLife · doi:10.7554/elife.105355.2
- Authors
- Ren, D., Chin, K. R., & French, J. A.
- Affiliations
- University of Nebraska at Omaha (US)
- Corresponding author
- Ren, Dongren
- ORCID
- French, Jeffrey A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-10-31
- Volume
- 9
- Issue
- 10
- Pages
- e111638
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4216101
- OpenAlex
- W2133194321
- Cited by
- 28
- References
- 50
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 1
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health (P51OD01107, RR013986, HD 042882, P51OD011107, P51OD011133)
- National Center for Research Resources (RR-013986, P51RR013986)
- California National Primate Research Center (HD071998, HD053555)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 042882, HD071998, R01HD042882, R01HD053555, R01HD071998, HD053555, R56HD042882)
- Office of Research Infrastructure Programs, National Institutes of Health (P51 OD011133)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- vasopressin, AVPR1A, arginine vasopressin receptor, New World monkeys, Platyrrhini, social monogamy, molecular evolution, positive selection, synonymous substitutions, nonsynonymous substitutions, oxytocin, marmoset, tamarins, ligand-binding domain, molecular phylogeny, dN/dS ratio, social behavior
- MeSH terms
- Animals, Arginine Vasopressin, Behavior, Animal, Biological Evolution, Humans, Models, Molecular, Molecular Sequence Data, Phylogeny, Social Behavior, Genetic Variation, Open Reading Frames, Receptors, Vasopressin, Platyrrhini
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
