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Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma “readthrough” acetylcholinesterase.
Abstract
Endotoxin stimulation of the immune system produces marked alterations in memory functioning. However, molecular links between this cognitive response and infection-responding neurotransmission pathways are still unknown. The cytokine and memory responses of volunteers injected with 0.8 ng/kg Salmonella endotoxin were compared with changes in plasma levels and integrity of the stress-induced acetylcholinesterase variant, AChE-R. Vascular endothelial cells were found to express AChE-R messenger RNA and protein both in healthy and inflamed human tissues. Plasma AChE activity was reduced after endotoxin treatment, but not placebo treatment, parallel to the decline in cortisol after the endotoxin-induced peak and inversely to the accumulation of a C-terminal immunopositive AChE-R peptide of 36 amino acid residues. AChE-R cleavage coincided with significant endotoxin-induced improvement in working memory and impairment in declarative memory. By 3 h posttreatment, working memory improvement was negatively correlated with AChE-R cleavage, which showed association to proinflammatory cytokine levels. By 9 h posttreatment, declarative memory impairment was negatively correlated with AChE-R cleavage and positively correlated with the suppressed AChE activity. Endotoxin-induced peripheral cholinergic stress responses are hence associated with greater impairment in declarative memory and lower improvement in working memory, pointing at AChE-R as a surrogate marker of psychoneuroimmunological stress.
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Human experimental studies employing LPS-induced immune activation reported either increased, no, or decreased cognitive performance after LPS administration.
“Experimental approaches in humans, employing lipopolysaccharide (LPS)-induced immune activation to investigate the effects of a peripheral inflammatory response on learning and memory reported either increased [24], no [25], [26], [27] or decreased [28] cognitive performance after LPS administration.”
From Dose-dependent effects of endotoxin on neurobehavioral functions in humans (2011) · cites this paper as [24]
Data in humans so far reported inconsistent results of experimental endotoxemia with a significant improvement or no effect on working memory.
“However, data in humans so far reported inconsistent results of experimental endotoxemia with a significant improvement [24] or no effect on working memory [25], [27].”
From Dose-dependent effects of endotoxin on neurobehavioral functions in humans (2011) · cites this paper as [24]
Experimental data in humans are controversial, either reporting impaired or unaffected declarative memory performance after LPS administration.
“However, experimental data in humans are controversial, either reporting impaired [24], [28] or unaffected declarative memory performance [25], [26], [27] after LPS administration.”
From Dose-dependent effects of endotoxin on neurobehavioral functions in humans (2011) · cites this paper as [24]
Citations
Cites
Tabachnick, B. G., & Fidell, L. S. (1983) · Cited by 79,882
Statistical principles in experimental design.
Winer, B. J. (1962) · McGraw-Hill Book Company · doi:10.1037/11774-000 · Cited by 27,137
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Baddeley, A. (1992) · Science · doi:10.1126/science.1736359 · Cited by 5,258
Statistical Principles in Experimental Design
Green, P. E., Winer, B. J., Brown, D. R., & Michels, K. M. (1992) · Journal of Marketing Research · doi:10.2307/3172747 · Cited by 4,333
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598
The AIDS dementia complex: I. Clinical features
NAVIA, B. A., Jordan, B. D., & Price, R. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190602 · Cited by 1,667
Stroke-Associated Pneumonia: Major Advances and Obstacles
Hannawi, Y., Hannawi, B., Rao, C. P. V., Suárez, J. I., & Bershad, E. M. (2013) · Cerebrovascular Diseases · doi:10.1159/000350199 · Cited by 1,664
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543
Acetylcholinesterase — new roles for an old actor
Soreq, H., & Seidman, S. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067589 · Cited by 1,397
Self-citationCytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365
Self-citationMCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287
Maier, S. F., & Watkins, L. R. (1998) · Psychological Review · doi:10.1037/0033-295x.105.1.83 · Cited by 1,130
Kirschbaum, C., Wolf, O. T., May, M., Wippich, W., & Hellhammer, D. H. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00118-x · Cited by 815
Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., et al. (1998) · Cytokine · doi:10.1006/cyto.1997.0290 · Cited by 772
Acute cortisone administration impairs retrieval of long-term declarative memory in humans
de Quervain, D. J.-F., Roozendaal, B., Nitsch, R. M., McGaugh, J. L., & Hock, C. (2000) · Nature Neuroscience · doi:10.1038/73873 · Cited by 745
Norušis, M. J. (1994) · Medical Entomology and Zoology · Cited by 710
Nicotinic acetylcholine involvement in cognitive function in animals
Levin, E. D., & Simon, B. B. (1998) · Psychopharmacology · doi:10.1007/s002130050667 · Cited by 675
Acute stress facilitates long-lasting changes in cholinergic gene expression
Kaufer, D., Friedman, A., Seidman, S., & Soreq, H. (1998) · Nature · doi:10.1038/30741 · Cited by 588
Self-citationPharmacological stimulation of the cholinergic antiinflammatory pathway
Bernik, T. R., Friedman, S. G., Ochani, M., DiRaimo, R., Ulloa, L., Yang, H., Sudan, S., Czura, C. J., Ivanova, S. M., & Tracey, K. J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011714 · Cited by 529
Quirarte, G. L., Roozendaal, B., & McGaugh, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14048 · Cited by 386
Jin, C., & Reed, J. C. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm832 · Cited by 340
Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase.
Chen, J.-M., Dando, P. M., Rawlings, N. D., Brown, M. A., Young, N. E., Stevens, R. A., Hewitt, E., Watts, C., & Barrett, A. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.8090 · Cited by 320
A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors
Heeschen, C., Weis, M., Aicher, A., Dimmeler, S., & Cooke, J. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14676 · Cited by 320
The immune system and memory consolidation: a role for the cytokine IL-1β
Pugh, C., Fleshner, M., Watkins, L. R., Maier, S. F., & Rudy, J. W. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00048-8 · Cited by 317
Cholinergic Enhancement and Increased Selectivity of Perceptual Processing During Working Memory
Furey, M. L., Pietrini, P., & Haxby, J. V. (2000) · Science · doi:10.1126/science.290.5500.2315 · Cited by 308
Owen, A. M., Morris, R. G., Sahakian, B. J., Polkey, C. E., & Robbins, T. W. (1996) · Brain · doi:10.1093/brain/119.5.1597 · Cited by 308
Roozendaal, B., Nguyen, B. T., Power, A. E., & McGaugh, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11642 · Cited by 293
Pugh, C. R., Kumagawa, K., Fleshner, M., Watkins, L. R., Maier, S. F., & Rudy, J. W. (1998) · Brain, Behavior, and Immunity · doi:10.1006/brbi.1998.0524 · Cited by 286
Lupien, S. J., Nair, N. P. V., Briére, S., Maheu, F., Tu, M. T., Lemay, Μ., McEwen, B. S., & Meaney, M. J. (1999) · Reviews in the Neurosciences · doi:10.1515/revneuro.1999.10.2.117 · Cited by 283
Neuronal computations underlying the firing of place cells and their role in navigation
Burgess, N., & O'Keefe, J. M. (1996) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:6 · Cited by 244
Shaw, K. N. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00232-7 · Cited by 241
Interleukin-1β, but not interleukin-6, impairs spatial navigation learning
Oitzl, M. S., van Oers, H. J. J., Schöbitz, B., & de Kloet, E. R. (1993) · Brain Research · doi:10.1016/0006-8993(93)90468-3 · Cited by 234
Alternative Splicing and Neuritic mRNA Translocation Under Long-Term Neuronal Hypersensitivity
Meshorer, E., Erb, C., Gazit, R., Pavlovsky, L., Kaufer, D., Friedman, A., Glick, D., Ben‐Arie, N., & Soreq, H. (2002) · Science · doi:10.1126/science.1066752 · Cited by 228
Self-citationDose-dependent effects of endotoxin on human sleep
Mullington, J., Korth, C., Hermann, D. M., Orth, A., Galanos, C., Holsboer, F., & Pollmächer, T. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.4.r947 · Cited by 226
Self-citationElevation of tumor necrosis factor in head injury
Goodman, J. C., Robertson, C. S., Grossman, R. G., & Narayan, R. K. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90105-v · Cited by 224
Helmstaedter, C., Grunwald, T., Lehnertz, K., Gleißner, U., & Elger, C. E. (1997) · Brain and Cognition · doi:10.1006/brcg.1997.0930 · Cited by 220
Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization
Arendt, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00516-9 · Cited by 171
Human responses to bacterial endotoxin.
Burrell, R. E. (1994) · PubMed · Cited by 154
Capuron, L., Ravaud, A., & Dantzer, R. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200105000-00007 · Cited by 148
Beeri, R., Andres, C. R., Lev-Lehman, E., Timberg, R., Huberman, T., Shani, M., & Soreq, H. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00211-9 · Cited by 136
Self-citationZhang, Y.-H., Lu, J., Elmquist, J. K., & Saper, C. B. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06578.2000 · Cited by 135
Sternfeld, M., Shoham, S., Klein, O., Flores‐Flores, C., Evron, T., Idelson, G. H., Kitsberg, D., Patrick, J. W., & Soreq, H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.140004597 · Cited by 130
Self-citationPharmacotherapy for Alzheimer's disease: progress and prospects
Palmer, A. M. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02056-4 · Cited by 118
Muscarinic receptors involved in hippocampal plasticity
Segal, M., & Auerbach, J. M. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00051-9 · Cited by 107
Willard, B. B., Hauss‐Wegrzyniak, B., & Wenk, G. L. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00216-4 · Cited by 107
The Pharmacotherapy of Alzheimer's Disease Based on the Cholinergic Hypothesis: an Update
Weinstock, M. (1995) · Neurodegeneration · doi:10.1006/neur.1995.0042 · Cited by 104
LPS-induced neuroinflammatory effects do not recover with time
Hauss‐Wegrzyniak, B., Vraniak, P., & Wenk, G. L. (2000) · Neuroreport · doi:10.1097/00001756-200006050-00032 · Cited by 99
Beeri, R., Novère, N. G. L., Mervis, R. F., Huberman, T., Grauer, E., Changeux, J., & Soreq, H. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062441.x · Cited by 99
Self-citationMood and cognitive disorders in cancer patients receiving cytokine therapy.
Meyers, C. A. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_5 · Cited by 98 · cited 3×
“Journal of Molecular Neuroscience 199 Volume 21, 2003”
BackgroundLinthorst, A. C. E., Flachskamm, C., Holsboer, F., & Reul, J. M. H. M. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00604-4 · Cited by 94
Memory in multiple sclerosis: Contextual encoding deficits
Thornton, A. E., Raz, N., & Tucker, K. A. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813200 · Cited by 92
Diurnal Variations in the Human Host Response to Endotoxin
Pollmächer, T., Mullington, J. M., Korth, C., Schreiber, W., Hermann, D. M., Orth, A., Galanos, C., & Holsboer, F. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/174.5.1040 · Cited by 90
Self-citationComplex regulation of acetylcholinesterase gene expression in human brain tumors
Perry, C., Sklan, E. H., Birikh, K. R., Shapira, M., Trejo, L., Eldor, A., & Soreq, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205945 · Cited by 89
Self-citationBehavioral and psychological effects of immune activation
Yirmiya, R. (1997) · Current Opinion in Psychiatry · doi:10.1097/00001504-199711000-00011 · Cited by 88
Self-citationShapira, M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1273 · Cited by 87
Grisaru, D., Deutsch, V. R., Shapira, M., Pick, M., Sternfeld, M., Melamed‐Book, N., Kaufer, D., Galyam, N., Gait, M. J., Owen, D. J., et al. (2001) · Molecular Medicine · doi:10.1007/bf03401943 · Cited by 83
Self-citationOgura, H., Kosasa, T., Kuriya, Y., & Yamanishi, Y. (2000) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2000.22.2.796070 · Cited by 81
Tracey, K. J., Czura, C. J., & Ivanova, S. (2001) · The FASEB Journal · doi:10.1096/fj.01-0148hyp · Cited by 79
Erb, C., Troost, J., Kopf, S. R., Schmitt, U., Löffelholz, K., Soreq, H., & Klein, J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00287.x · Cited by 71
Self-citationAntisense prevention of neuronal damages following head injury in mice
Shohami, E., Kaufer, D., Chen, Y., Seidman, S., Cohen, O., Ginzberg, D., Melamed‐Book, N., Yirmiya, R., & Soreq, H. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000104 · Cited by 64
Self-citationAntioxidants Attenuate Acute Toxicity of Tumor Necrosis Factor-alpha Induced by Brain Injury in Rat
Trembovler, V., Beit‐Yannai, E., Younis, F. M., Gallily, R., Horowitz, M., & Shohami, E. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313640 · Cited by 61
Cohen, O., Erb, C., Ginzberg, D., Pollak, Y., Seidman, S., Shoham, S., Yirmiya, R., & Soreq, H. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001103 · Cited by 61
Self-citationANIMAL MODELS OF VASCULAR DEMENTIA WITH EMPHASIS ON STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS
Saito, H., Togashi, H., Yoshioka, M., Nakamura, N., Minami, M., & Parvez, H. S. (1995) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1995.tb02906.x · Cited by 58
Attentional and mnemonic deficits associated with infectious disease in humans
Capuron, L., Lamarque, D., Dantzer, R., & Goodall, G. (1999) · Psychological Medicine · doi:10.1017/s0033291798007740 · Cited by 57
IL1 Beta Impairs Relational but Not Procedural Rodent Learning in a Water Maze Task
Gibertini, M. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0407-4_27 · Cited by 52
Harder, J. A., Baker, H. F., & Ridley, R. M. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00381-x · Cited by 49
Yirmiya, R., Barak, O., Avitsur, R., Gallily, R., & Weidenfeld, J. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01295-4 · Cited by 41
Self-citationA methodological review of ?method skeptic? reports
McCaffrey, R. J., & Lynch, J. K. (1992) · Neuropsychology Review · doi:10.1007/bf01109049 · Cited by 8
Higher Cortisol Values Facilitate Spatial Memory in Toddlers: Brief Report
Stansbury, K. E., Haley, D. W., & KOENEKER, A. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06744.x · Cited by 8
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Roberts, J. C., & Jones, S. B. (1997) · Shock · doi:10.1097/00024382-199703000-00010 · Cited by 3
Fahmi, H., & Chaby, R. (1994) · Immunological Investigations · doi:10.3109/08820139409066821 · Cited by 3
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Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483
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Goshen, I., & Yirmiya, R. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.10.001 · Cited by 399
Self-citationReview: Systemic inflammation andAlzheimer's disease
Holmes, C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01307.x · Cited by 356
Sparkman, N. L., Buchanan, J. B., Heyen, J. R. R., Chen, J., Beverly, J. L., & Johnson, R. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3376-06.2006 · Cited by 307
Teeling, J. L., & Perry, V. H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.031 · Cited by 259
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Grigoleit, J.-S., Kullmann, J. S., Wolf, O. T., Hammes, F., Wegner, A., Jablonowski, S., Engler, H., Gizewski, E., Oberbeck, R., & Schedlowski, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028330 · Cited by 241
Murray, C., Sanderson, D. J., Barkus, C., Deacon, R. M. J., Rawlins, J. N. P., Bannerman, D. M., & Cunningham, C. M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.002 · Cited by 228
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Hash-Converse, J. M. (2008) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3np24sm
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Sternberg, E. M. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1063692.516602
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Verdam, F. J. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20120601fv
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Metadata
- Authors
- Cohen, O., Reichenberg, A., Perry, C., Ginzberg, D., Pollmächer, T., Soreq, H., & Yirmiya, R.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Max Planck Society (DE)
- Corresponding author
- Soreq, Hermona
- Venue
- Journal of Molecular Neuroscience
- Published
- 2003
- Volume
- 21
- Issue
- 3
- Pages
- 199-212
- ISSN
- 0895-8696 (ISSN-L)
- OpenAlex
- W2139402373
- Cited by
- 88
- References
- 73
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- endotoxin, Salmonella endotoxin, working memory, declarative memory, inflammatory cytokines, cortisol, psychoneuroimmunology, vascular endothelial cells, memory impairment
- MeSH terms
- Acetylcholinesterase, Endotoxins, Humans, Hydrocortisone, Male, Memory, Memory Disorders, Peptide Fragments, Reaction Time, RNA, Messenger, Stress, Physiological, Neuroimmunomodulation, Biomarkers, Cytokines
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