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Cited by 189Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Low-dose endotoxemia and human neuropsychological functions

Krabbe, Karen Suárez, Reichenberg, Abraham, Yirmiya, Raz, Smed, Annelise, Pedersen, Bente Klarlund, Bruunsgaard, Helle·2005·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2005.04.010
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Abstract

Epidemiological data demonstrate an association between systemic low-grade inflammation defined as 2- to 3-fold increases in circulating inflammatory mediators and age-related decline in cognitive function. However, it is not known whether small elevations of circulating cytokine levels cause direct effects on human neuropsychological functions. We investigated changes in emotional, cognitive, and inflammatory parameters in an experimental in vivo model of low-grade inflammation. In a double-blind crossover study, 12 healthy young males completed neuropsychological tests before as well as 1.5, 6, and 24 h after an intravenous injection of Escherichia coli endotoxin (0.2 ng/kg) or saline in two experimental sessions. Endotoxin administration had no effect on body temperature, cortisol levels, blood pressure or heart rate, but circulating levels of tumor necrosis factor (TNF) and interleukin (IL)-6 increased 2- and 7-fold, respectively, reaching peak values at 3 h, whereas soluble TNF-receptors and IL-1 receptor antagonist peaked at 4.5 h. The neutrophil count increased and the lymphocyte count declined. In this model, low-dose endotoxemia did not affect cognitive performance significantly but declarative memory performance was inversely correlated with cytokine increases. In conclusion, our findings demonstrate a negative association between circulating IL-6 and memory functions during very low-dose endotoxemia independently of physical stress symptoms, and the hypothalamo-pituitary-adrenal axis.

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Crossref · 10.1016/j.bbi.2005.04.010

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  • A preponderance of studies examining inflammation's effects on mood and behavior have used solely male participants.

    “a preponderance of studies examining the effects of inflammation on mood and behavior have been conducted with solely male participants (Brydon et al., 2009, 2008; Harrison et al., 2014, 2009; Krabbe et al., 2005; Reichenberg et al., 2001; Wright et al., 2005).”

    From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Krabbe et al., 2005

  • The parasite trypanosoma can produce prostaglandins, including PGD2 with known somnogenic properties, and triggers the release of pro-inflammatory cytokines.

    “the parasite trypanosoma can produce PGs, including PGD2 with known somnogenic properties, and triggers the release of pro-inflammatory cytokines (298).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [298]

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Authors
Krabbe, K. S., Reichenberg, A., Yirmiya, R., Smed, A., Pedersen, B. K., & Bruunsgaard, H.
Affiliations
  • University of Copenhagen (DK)
  • Icahn School of Medicine at Mount Sinai (US)
  • Hebrew University of Jerusalem (IL)
  • Rigshospitalet (DK)
Corresponding author
Krabbe, Karen Suárez
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2005-09
Volume
19
Issue
5
Pages
453-460
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2005.04.010
OpenAlex
W2151445726
Cited by
189
References
43
Citations by year
2026: 6 · 2025: 6 · 2024: 8 · 2023: 3 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 11 · 2018: 8 · 2017: 17 · 2016: 12 · 2015: 11 · 2014: 11 · 2013: 11 · 2012: 13
FWCI
2.63
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
Funders
Sundhed og Sygdom, Det Frie Forskningsråd
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
endotoxemia, low-grade inflammation, interleukin-6, TNF-α, cytokines, declarative memory, cognitive function, emotional functioning, hypothalamic-pituitary-adrenal axis, cortisol, neutrophil count, lymphocyte count, soluble TNF receptors, interleukin-1 receptor antagonist, Escherichia coli endotoxin
MeSH terms
Adult, Affect, Aging, Blood Cell Count, Cognition, Double-Blind Method, Emotions, Endotoxins, Humans, Learning, Leukocyte Count, Male, Memory, Memory, Short-Term, Neuropsychological Tests, Psychomotor Performance, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Cross-Over Studies, Endotoxemia

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