Cited by 377Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

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D1/D5 Dopamine Receptor Activation Increases the Magnitude of Early Long-Term Potentiation at CA1 Hippocampal Synapses

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Otmakhova, Nonna A., Lisman, John E.·1996·The Journal of Neuroscience

DOI 10.1523/jneurosci.16-23-07478.1996PMC PMC6579102

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Abstract

The role of the mesolimbic dopaminergic system in the reinforcement of learning suggests that dopamine should be able to modulate activity-dependent synaptic plasticity. We have examined the effect of D1/D5 agonists on early long-term potentiation (LTP) (40 min) in the CA1 region of hippocampal slices. D1/D5 agonists (+)bromo-APB, 6-chloro-PB, and dihydrexidine increased the magnitude of LTP in a synapse-specific manner (by approximately 10, 15, and 20%, respectively). This D1/D5 effect was mimicked by a low dose (10 microM) of the adenylyl cyclase activator forskolin. The D1/D5 antagonist (+)SCH 23390 reduced early LTP. In catecholamine-depleted slices, LTP was smaller by approximately 20-25% and could not be decreased further by D1/D5 antagonist. Under these conditions, D1/D5 agonist 6-chloro-PB and forskolin produced a larger enhancement of LTP (20-25%), restoring it to the control level. At the same dose, dideoxyforskolin did not affect early LTP. The D1/D5 agonist effect was completely blocked by the D1/D5 antagonist (+)SCH 23390. These results indicate that dopamine produces a synapse-specific enhancement of early LTP through D1/D5 receptors and cAMP.

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Authors: Otmakhova, N. A., & Lisman, J. E.
Affiliations: Brandeis University (US)
ORCID: Lisman, John E.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1996-12-01
Volume: 16
Issue: 23
Pages: 7478-7486
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.16-23-07478.1996
PMC: PMC6579102
OpenAlex: W1868297237
Cited by: 377
References: 72
Citations by year: 2026: 4 · 2025: 8 · 2024: 13 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 2 · 2019: 7 · 2018: 15 · 2017: 15 · 2016: 12 · 2015: 18 · 2014: 23 · 2013: 14 · 2012: 27
FWCI: 3.37
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: W. M. Keck Foundation
Abbott Laboratories
National Institutes of Health
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke (R01NS027337, 5 R01 NS27337-7)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dopamine D1/D5 receptors, long-term potentiation, hippocampal CA1, synaptic plasticity, adenylate cyclase, cAMP signaling, forskolin, SCH 23390, catecholamine depletion, learning reinforcement, mesolimbic dopamine system
MeSH terms: Animals, Catecholamines, Colforsin, Hippocampus, Rats, Inbred Strains, Synapses, Receptors, Dopamine D1, Long-Term Potentiation, Dopamine Agonists, Dopamine Antagonists, Receptors, Dopamine D5, Rats

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D1/D5 Dopamine Receptor Activation Increases the Magnitude of Early Long-Term Potentiation at CA1 Hippocampal Synapses

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