Cited by 107Proteoglycans and glycosaminoglycans researchNeuroscience and Neuropharmacology ResearchGlycosylation and Glycoproteins Research

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Neurons Produce a Neuronal Cell Surface-Associated Chondroitin Sulfate Proteoglycan

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Lander, Cynthia, Zhang, Hong, Hockfield, Susan·1998·The Journal of Neuroscience

DOI 10.1523/jneurosci.18-01-00174.1998PMC PMC6793429

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Abstract

Monoclonal antibody Cat-315 recognizes a chondroitin sulfate proteoglycan (CSPG) expressed on the surface of subsets of neurons in many areas of the mammalian CNS (Lander et al., 1997). The cell type-specific expression exhibited by the Cat-315 CSPG and other perineuronal net CSPGs imparts a distinct molecular surface identity to a neuron (Celio and Blumcke, 1994; Lander et al., 1997). The cell type(s) producing these surface-associated proteins and yielding this cellular diversity has remained in question. The expression of the Cat-315 CSPG in primary rat cortical cultures has permitted an examination of the cellular source of the Cat-315 antigen, as well as a determination of its spatial relationship to the neuronal surface. Live-cell labeling of primary neuronal cultures demonstrates that the Cat-315 CSPG is on the extracellular surface of neurons. Furthermore, extraction experiments demonstrate that the Cat-315 CSPG lacks a transmembrane domain and that the entire molecule is extracellular and, therefore, can be considered a constituent of brain extracellular matrix. Several lines of evidence indicate that neurons with cell surface staining produce the Cat-315 CSPG. First, neurons with cell surface staining also show intracellular Cat-315 immunoreactivity. Second, β-xyloside or monensin, reagents that inhibit the synthesis and transport of CSPGs, increase intracellular Cat-315 immunoreactivity within neurons that express cell surface Cat-315 immunoreactivity. Third, double labeling with Cat-315 and a polyclonal antibody for the Golgi complex demonstrates a precise colocalization of the intracellular Cat-315 immunoreactivity with the Golgi. Together, these observations demonstrate that neurons contribute to the extracellular matrix of brain and that the Cat-315 CSPG is produced by the neurons that carry Cat-315 cell surface immunoreactivity.

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Authors: Lander, C., Zhang, H., & Hockfield, S.
Affiliations: Yale University (US)
ORCID: Zhang, Hong
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1998-01-01
Volume: 18
Issue: 1
Pages: 174-183
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.18-01-00174.1998
PMC: PMC6793429
OpenAlex: W2121360720
Cited by: 107
References: 62
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 8 · 2012: 6
FWCI: 1.43
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Eye Institute (EY 06511)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Keywords: chondroitin sulfate proteoglycans, perineuronal nets, extracellular matrix, Golgi apparatus, primary cortical neurons, monensin
MeSH terms: Animals, Antibodies, Monoclonal, Epitopes, Antigens, Surface, Astrocytes, Brain Chemistry, Cells, Cultured, Cerebral Cortex, Extracellular Matrix, Neurons, Chondroitin Sulfate Proteoglycans, Rats, Sprague-Dawley, Rats

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Neurons Produce a Neuronal Cell Surface-Associated Chondroitin Sulfate Proteoglycan

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