Cited by 740Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorGambling Behavior and Treatments

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Dissociable Neural Responses in Human Reward Systems

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Elliott, Rebecca, Friston, Karl J., Dolan, Raymond J.·2000·The Journal of Neuroscience

DOI 10.1523/jneurosci.20-16-06159.2000PMC PMC6772605

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Abstract

Reward is one of the most important influences shaping behavior. Single-unit recording and lesion studies in experimental animals have implicated a number of regions in response to reinforcing stimuli, in particular regions of the extended limbic system and the ventral striatum. In this experiment, functional neuroimaging was used to assess neural response within human reward systems under different psychological contexts. Nine healthy volunteers were scanned using functional magnetic resonance imaging during the performance of a gambling task with financial rewards and penalties. We demonstrated neural sensitivity of midbrain and ventral striatal regions to financial rewards and hippocampal sensitivity to financial penalties. Furthermore, we show that neural responses in globus pallidus, thalamus, and subgenual cingulate were specific to high reward levels occurring in the context of increasing reward. Responses to both reward level in the context of increasing reward and penalty level in the context of increasing penalty were seen in caudate, insula, and ventral prefrontal cortex. These results demonstrate dissociable neural responses to rewards and penalties that are dependent on the psychological context in which they are experienced.

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Authors: Elliott, R., Friston, K. J., & Dolan, R. J.
Affiliations: UCL Queen Square Institute of Neurology (GB)
The Royal Free Hospital (GB)
ORCID: Elliott, Rebecca
Friston, Karl J.
Dolan, Raymond J.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2000-08-15
Volume: 20
Issue: 16
Pages: 6159-6165
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.20-16-06159.2000
PMC: PMC6772605
OpenAlex: W2105389170
Cited by: 740
References: 55
Citations by year: 2026: 2 · 2025: 9 · 2024: 23 · 2023: 16 · 2022: 10 · 2021: 13 · 2020: 18 · 2019: 12 · 2018: 20 · 2017: 21 · 2016: 15 · 2015: 34 · 2014: 36 · 2013: 29 · 2012: 50
FWCI: 13.62
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion, other-oa)
UCL Discovery (University College London) (submittedVersion)
Max Planck Digital Library (submittedVersion, other-oa)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords: reward processing, punishment, monetary rewards, fines, gambling task, ventral striatum, midbrain, hippocampus, globus pallidus, thalamus, subgenual anterior cingulate cortex, caudate nucleus, insula, ventral prefrontal cortex
MeSH terms: Brain, Brain Mapping, Emotions, Humans, Magnetic Resonance Imaging, Motivation, Neuropsychological Tests, Psychomotor Performance, Reward

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Dissociable Neural Responses in Human Reward Systems

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