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Cited by 70Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorGambling Behavior and Treatments

Context-dependent cortical activation in response to financial reward and penalty: an event-related fMRI study

Akitsuki, Yuko, Sugiura, Motoaki, Watanabe, Jobu, Yamashita, Keiichi, Sassa, Yuko, Awata, Shuichi, Matsuoka, Hiroo, Maeda, Yasuhiro +3 more·2003·NeuroImage
DOI 10.1016/s1053-8119(03)00250-7
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Abstract

An event-related fMRI technique was used to assess neural responses to financial reward and penalty during a simple gambling task. We attempted to determine whether brain activities are dependent on the unique context of an event sequence. Thirty-six healthy volunteers participated in the study. The task was to guess the color of the suit of a card on each trial and to respond by pressing a button. Every correct response ("win") and incorrect response ("loss") was associated with financial reward and penalty, respectively. The magnitude of reward or penalty in each trial did not change; however, the subjects' self-reported emotional arousal was significantly higher for the events of "the fourth win of four wins in a row" and "the fourth loss of four losses in a row." We also found that the bilateral anterior cingulate and medial prefrontal cortices were specifically activated when the subjects experienced "the fourth win of four wins in a row" and "the fourth loss of four losses in a row." When the subjects experienced "a win following four losses in a row" or "a loss following four wins in a row," the right dorsolateral prefrontal cortex was specifically activated. Our data indicate that there exist brain activities associated with the event-sequence context in which abstract reward or penalty is received. These context-dependent activities appear to be crucial for adapting oneself to new circumstances and may account for clinical symptoms of various mental illnesses in which dysfunction of these regions has been reported.

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  • Previous studies have shown that outcome processing is highly sensitive to the range of possible outcomes from which the final outcome is selected.

    “Previous studies have shown that outcome processing is highly sensitive to the range of possible outcomes from which the final outcome is selected (Akitsuki et al., 2003; Nieuwenhuis et al., 2005).”

    From Distinct neural representations of placebo and nocebo effects (2015) · cites this paper as Akitsuki et al., 2003

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Authors
Akitsuki, Y., Sugiura, M., Watanabe, J., Yamashita, K., Sassa, Y., Awata, S., Matsuoka, H., Maeda, Y., Matsue, Y., Fukuda, H., & Kawashima, R.
Affiliations
  • Tohoku University (JP)
  • Tottori University (JP)
  • Tohoku Fukushi University (JP)
Corresponding author
Akitsuki, Yuko
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2003-08
Volume
19
Issue
4
Pages
1674-1685
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/s1053-8119(03)00250-7
OpenAlex
W2036010003
Cited by
70
References
64
Citations by year
2025: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 8 · 2012: 3
FWCI
1.63
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Science and Technology Agency
  • Tohoku University
  • Ministry of Education, Culture, Sports, Science and Technology
  • Research Institute of Science and Technology for Society
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords
monetary rewards, fines, gambling, anterior cingulate cortex, medial prefrontal cortex, dorsolateral prefrontal cortex, emotional arousal, event-related fMRI
MeSH terms
Adolescent, Adult, Arousal, Attention, Brain Mapping, Cerebral Cortex, Dominance, Cerebral, Emotions, Female, Frontal Lobe, Gambling, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Psychomotor Performance, Punishment, Imaging, Three-Dimensional

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