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Cited by 91Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Reward processing in male adults with childhood ADHD—a comparison between drug-naïve and methylphenidate-treated subjects

Stoy, Meline, Schlagenhauf, Florian, Schlochtermeier, Lorna, Wrase, Jana, Knutson, Brian, Lehmkuhl, Ulrike, Huss, Michael, Heinz, Andreas +1 more·2011·Psychopharmacology
DOI 10.1007/s00213-011-2166-y
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Abstract

Rationale Dysfunctional reward processing has been proposed as a main deficit in attention-deficit/hyperactivity disorder (ADHD), which could be modulated by treatment with methylphenidate (MPH).Objectives We examined differences in reward processing in adulthood (independent of actual ADHD) depending on MPH treatment during childhood.Methods Eleven males with childhood ADHD treated with MPH, 12 drug-naïve males with childhood ADHD, and 12 controls matched by age, handedness, and smoking behavior were studied drug-free using functional magnetic resonance imaging. BOLD-responses were compared during a monetary incentive delay task using an ANOVA design focusing on the ventral striatum during anticipation and the orbitofrontal cortex during outcome.Results Controls, drug-naïve, and treated subjects did not differ significantly in their activations in the ventral striatum and orbitofrontal cortex. Explorative analyses revealed decreased insula activation during outcome of loss avoidance in drug-naïve subjects in comparison to both groups, while treated subjects did not differ from controls. Insula activation correlated significantly positive with harm avoidance in the treated group. Furthermore, comparing subjects with actual ADHD symptoms, remitters and controls we observed decreased putamen activition in ADHD persisters.Conclusions Basal ganglia reward processing seemed to be unrelated to MPH pretreatment, but was related to remission. On the other hand, the revealed differences between treated and drug-naïve subjects with childhood ADHD, i.e., in the insula, give evidence for more pronounced abnormal activation in reward-associated brain regions in untreated subjects with childhood ADHD and underpin the need of prospective studies on long-term effects of psychostimulant treatment.

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  • In response to monetary loss, one study found no differences in adults with childhood ADHD, while another found enhanced activation in 28 ADHD adults in temporal pole and limbic regions of amygdala and insula.

    “In response to monetary loss, one study found no differences in adults with childhood ADHD (Stoy et al., 2011), while another found enhanced activation in 28 ADHD adults in temporal pole and limbic regions of amygdala and insula (Wilbertz et al., 2017).”

    From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Stoy et al., 2011

  • Amygdala hyperactivation has also been reported in ADHD during the processing of delayed rewards.

    “Amygdala hyperactivation has also been reported in ADHD during the processing of delayed rewards, perhaps consistent with the delay aversion found in some behavioral studies (38, 99-101).”

    From Emotion Dysregulation in Attention Deficit Hyperactivity Disorder (2014) · cites this paper as [101]

  • Children with ADHD have reduced NAc activity when anticipating monetary rewards, seen particularly in drug-naive children, carriers of the DAT nine-repeat allele, and in response to seeking gains rather than avoiding losses.

    “Children with ADHD have reduced NAc activity when anticipating monetary rewards [18,486,487], which is seen particularly in drug-naive children [490], in carriers of the DAT nine-repeat allele [491], and in response to seeking gains rather than avoiding losses [492].”

    From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [490]

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Authors
Stoy, M., Schlagenhauf, F., Schlochtermeier, L., Wrase, J., Knutson, B., Lehmkuhl, U., Huss, M., Heinz, A., & Ströhle, A.
Affiliations
  • Stiftung Charité (DE)
  • Charité – Universitätsmedizin Berlin (DE)
  • Freie Universität Berlin (DE)
  • Stanford University (US)
  • Johannes Gutenberg University Mainz (DE)
Corresponding author
Ströhle, Andreas
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2011-02-08
Volume
215
Issue
3
Pages
467-481
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-011-2166-y
OpenAlex
W2112761769
Cited by
91
References
66
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 9 · 2018: 8 · 2017: 2 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 12
FWCI
6.13
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
childhood ADHD, reward processing, methylphenidate, psychostimulant treatment, monetary incentive delay task, ventral striatum, orbitofrontal cortex, insula, putamen, harm avoidance, loss avoidance, remission, ADHD persistence, basal ganglia
MeSH terms
Adult, Central Nervous System Stimulants, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Basal Ganglia, Brain, Humans, Magnetic Resonance Imaging, Male, Methylphenidate, Reward, Case-Control Studies, Young Adult

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