Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission
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Increased relative brain size characterizes the evolution of primates, suggesting that enhanced cognition plays an important part in the behavioral adaptations of this mammalian order. In addition to changes in brain anatomy, cognition can also be regulated by molecular changes that alter synaptic function, but little is known about modifications of synapses in primate brain evolution. The aim of the current study was to investigate the expression patterns and evolution of 20 synaptic genes from the prefrontal cortex of 12 primate species. The genes investigated included glutamate receptors, scaffolding proteins, synaptic vesicle components, as well as factors involved in synaptic vesicle release and structural components of the nervous system. Our analyses revealed that there have been significant changes during primate brain evolution in the components of the glutamatergic signaling pathway in terms of gene expression, protein expression, and promoter sequence changes. These results could entail functional modifications in the regulation of specific genes related to processes underlying learning and memory.
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There are significant differences between humans and chimpanzees in the cortical expression of glutamate receptor genes.
“Despite this high structural conservation, there are significant differences between humans and chimpanzees in the cortical expression of glutamate receptor genes (Liu et al., 2012;Muntané et al., 2015), suggesting that changes to regulatory regions may have had important functional consequences for the emergence of the human cognitive phenotype.”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Muntané et al., 2015
Changes to regulatory regions may have had important functional consequences for the emergence of the human cognitive phenotype.
“suggesting that changes to regulatory regions may have had important functional consequences for the emergence of the human cognitive phenotype.”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Muntané et al., 2015
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R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Guide for the Care and Use of Laboratory Animals: Eighth Edition
(2011) · doi:10.17226/12910 · Cited by 16,199 · see citing works
APE: Analyses of Phylogenetics and Evolution in R language
Paradis, E., Claude, J., & Strimmer, K. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg412 · Cited by 12,037 · see citing works
Inferring the historical patterns of biological evolution
Pagel, M. (1999) · Nature · doi:10.1038/44766 · Cited by 5,200 · see citing works
The 1996 Guide for the Care and Use of Laboratory Animals
Clark, J. D., Gebhart, G. F., Gonder, J. C., Keeling, M. E., & Kohn, D. F. (1997) · ILAR Journal · doi:10.1093/ilar.38.1.41 · Cited by 4,420 · see citing works
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568 · see citing works
HyPhy: hypothesis testing using phylogenies
Pond, S. L. K., Frost, S. D. W., & Muse, S. V. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti079 · Cited by 2,866 · see citing works
King, M.-C., & Wilson, A. C. (1975) · Science · doi:10.1126/science.1090005 · Cited by 2,815 · see citing works
Synaptic density in human frontal cortex —Developmental changes and effects of aging
Peter R., H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90349-4 · Cited by 2,645 · see citing works
Initial sequence of the chimpanzee genome and comparison with the human genome
The Chimpanzee Sequencing and Analysis Consortium (2005) · Nature · doi:10.1038/nature04072 · Cited by 2,459 · see citing works
What is principal component analysis?
Ringnér, M. (2008) · Nature Biotechnology · doi:10.1038/nbt0308-303 · Cited by 2,407 · see citing works
EVOLUTION OF THE BRAIN AND INTELLIGENCE
Radinsky, L., & Jerison, H. J. (1975) · Evolution · doi:10.2307/2407154 · Cited by 1,982 · see citing works
Genetic enhancement of learning and memory in mice
Tang, Y., Shimizu, E., Dubé, G., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999) · Nature · doi:10.1038/43432 · Cited by 1,867 · see citing works
Zhang, J. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi237 · Cited by 1,785 · see citing works
Molecular evolution of FOXP2, a gene involved in speech and language
Enard, W., Przeworski, M., Fisher, S. E., Lai, C. S. L., Wiebe, V., Kitano, T., Monaco, A. P., & Pääbo, S. (2002) · Nature · doi:10.1038/nature01025 · Cited by 1,603 · see citing works
PDZ domain proteins of synapses
Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,565 · see citing works
RNA integrity and the effect on the real-time qRT-PCR performance
Fleige, S., & Pfaffl, M. W. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.12.003 · Cited by 1,488 · see citing works
Dong, X.-X., Wang, Y., & Qin, Z.-H. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.24 · Cited by 1,297 · see citing works
The evolution of gene expression levels in mammalian organs
Brawand, D., Soumillon, M., Necsulea, A., Julien, P., Csárdi, G., Harrigan, P., Weier, M., Liechti, A., Aximu-Petri, A., Kircher, M., et al. (2011) · Nature · doi:10.1038/nature10532 · Cited by 1,248 · see citing works
Linked Regularities in the Development and Evolution of Mammalian Brains
Finlay, B. L., & Darlington, R. B. (1995) · Science · doi:10.1126/science.7777856 · Cited by 1,217 · see citing works
The Evolution of Transcriptional Regulation in Eukaryotes
Wray, G. A. (2003) · Molecular Biology and Evolution · doi:10.1093/molbev/msg140 · Cited by 1,203 · see citing works
Self-citationMechanisms of CaMKII action in long-term potentiation
Lisman, J., Yasuda, R., & Raghavachari, S. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3192 · Cited by 1,134 · see citing works
Phylogenetic Signal, Evolutionary Process, and Rate
Revell, L. J., Harmon, L. J., & Collar, D. C. (2008) · Systematic Biology · doi:10.1080/10635150802302427 · Cited by 879 · see citing works
Intra- and Interspecific Variation in Primate Gene Expression Patterns
Enard, W., Khaitovich, P., Klose, J., Zöllner, S. K., Heißig, F., Giavalisco, P., Nieselt, K., Muchmore, E. A., Varki, A. P., Ravid, R., et al. (2002) · Science · doi:10.1126/science.1068996 · Cited by 845 · see citing works
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene
Alarcón, M., Abrahams, B. S., Stone, J. L., Duvall, J. A., Perederiy, J. V., Bomar, J. M., Sebat, J., Wigler, M., Martin, C. L., Ledbetter, D. H., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.005 · Cited by 818 · see citing works
Vergleichende Lokalisationslehre der Großhirnrinde
Brodmann, K. (1909) · Cited by 705 · see citing works
Temporal dynamics and genetic control of transcription in the human prefrontal cortex
Colantuoni, C., Lipska, B. K., Ye, T., Hyde, T. M., Tao, R., Leek, J. T., Colantuoni, E. A., Elkahloun, A. G., Herman, M. M., Weinberger, D. R., et al. (2011) · Nature · doi:10.1038/nature10524 · Cited by 685 · see citing works
A functional genetic link between distinct developmental language disorders
Vernes, S. C., Newbury, D. F., Abrahams, B. S., Winchester, L., Nicod, J., Groszer, M., Alarcón, M., Oliver, P. L., Davies, K. E., Geschwind, D. H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802828 · Cited by 676 · see citing works
The 10kTrees website: A new online resource for primate phylogeny
Arnold, C., Matthews, L. J., & Nunn, C. L. (2010) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.20251 · Cited by 661 · see citing works
Barrett, L. W., Fletcher, S., & Wilton, S. D. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0990-9 · Cited by 603 · see citing works
Arking, D. E., Cutler, D. J., Brune, C. W., Teslovich, T. M., West, K., Ikeda, M., Rea, A., Guy, M., Lin, S., Cook, E. H., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.015 · Cited by 590 · see citing works
Translational control by the 3′-UTR: the ends specify the means
Mazumder, B., Seshadri, V., & Fox, P. L. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00002-1 · Cited by 506 · see citing works
Elevated gene expression levels distinguish human from non-human primate brains
Cáceres, M., Lachuer, J., Zapala, M. A., Redmond, J. C., Kudo, L., Geschwind, D. H., Lockhart, D. J., Preuss, T. M., & Barlow, C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135499100 · Cited by 491 · see citing works
MEMBRANE-ASSOCIATED GUANYLATE KINASES REGULATE ADHESION AND PLASTICITY AT CELL JUNCTIONS
Funke, L., Dakoji, S., & Bredt, D. S. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133339 · Cited by 469 · see citing works
Regional Dendritic and Spine Variation in Human Cerebral Cortex: a Quantitative Golgi Study
Jacobs, B. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.6.558 · Cited by 423 · see citing works
Transcriptional neoteny in the human brain
Somel, M., Franz, H., Zheng, Y., Lorenc, A., Guo, S., Giger, T., Kelso, J. F., Nickel, B., Dannemann, M., Bahn, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900544106 · Cited by 409 · see citing works
Testing and Quantifying Phylogenetic Signals and Homoplasy in Morphometric Data
Klingenberg, C. P., & Gidaszewski, N. A. (2010) · Systematic Biology · doi:10.1093/sysbio/syp106 · Cited by 404 · see citing works
Jucker, M. (2010) · Nature Medicine · doi:10.1038/nm.2224 · Cited by 401 · see citing works
Preuss, T. M., & Goldman‐Rakic, P. S. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903100402 · Cited by 359 · see citing works
Genomewide Comparison of DNA Sequences between Humans and Chimpanzees
Ebersberger, I., Metzler, D., Schwarz, C., & Pääbo, S. (2002) · The American Journal of Human Genetics · doi:10.1086/340787 · Cited by 343 · see citing works
Genetics and the making of Homo sapiens
Carroll, S. B. (2003) · Nature · doi:10.1038/nature01495 · Cited by 340 · see citing works
Comparing the human and chimpanzee genomes: Searching for needles in a haystackPreprint
Varki, A. P., & Altheide, T. K. (2005) · Genome Research · doi:10.1101/gr.3737405 · Cited by 339 · see citing works
Expression profiling in primates reveals a rapid evolution of human transcription factors
Gilad, Y., Oshlack, A., Smyth, G. K., Speed, T. P., & White, K. P. (2006) · Nature · doi:10.1038/nature04559 · Cited by 323 · see citing works
The pyramidal cell in cognition: a comparative study in human and monkey
Elston, G. N., Benavides-Piccione, R., & DeFelipe, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-17-j0002.2001 · Cited by 317 · see citing works
Regional Patterns of Gene Expression in Human and Chimpanzee BrainsPreprint
Khaitovich, P., Muetzel, B., She, X., Lachmann, M., Hellmann, I., Dietzsch, J., Steigele, S., Do, H.-H., Weiß, G., Enard, W., et al. (2004) · Genome Research · doi:10.1101/gr.2538704 · Cited by 311 · see citing works
Haygood, R., Fedrigo, O. D., Hanson, B., Yokoyama, K.-D., & Wray, G. A. (2007) · Nature Genetics · doi:10.1038/ng2104 · Cited by 309 · see citing works
Self-citationPyramidal Cells of the Frontal Lobe: All the More Spinous to Think With
Elston, G. N. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-j0002.2000 · Cited by 289 · see citing works
Wildman, D. E., Uddin, M., Liu, G., Grossman, L. I., & Goodman, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232172100 · Cited by 289 · see citing works
Lu, J., Helton, T. D., Blanpied, T. A., Rácz, B., Newpher, T. M., Weinberg, R. J., & Ehlers, M. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.041 · Cited by 273 · see citing works
Human-Specific Transcriptional Networks in the Brain
Konopka, G., Friedrich, T., Davis‐Turak, J., Winden, K. D., Oldham, M. C., Gao, F., Chen, L., Wang, G.-Z., Luo, R., Preuss, T. M., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.034 · Cited by 264 · see citing works
Blanchette, M., Bataille, A. R., Chen, X., Poitras, C., Laganière, J., Lefèbvre, C., Deblois, G., Giguère, V., Ferretti, V., Bergeron, D., et al. (2006) · Genome Research · doi:10.1101/gr.4866006 · Cited by 258 · see citing works
Uddin, M., Wildman, D. E., Liu, G., Xu, W., Johnson, R. M., Hof, P. R., Kapatos, G., Grossman, L. I., & Goodman, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308725100 · Cited by 238 · see citing works
Self-citationNatural selection on gene expression
Gilad, Y., Oshlack, A., & Rifkin, S. A. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.06.002 · Cited by 218 · see citing works
Bayés, À., Collins, M. O., Croning, M. D. R., van de Lagemaat, L. N., Choudhary, J. S., & Grant, S. G. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046683 · Cited by 216 · see citing works
Spatial Organization of Neurons in the Frontal Pole Sets Humans Apart from Great Apes
Semendeferi, K., Teffer, K., Buxhoeveden, D. P., Park, M. S., Bludau, S., Amunts, K., Travis, K., & Buckwalter, J. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq191 · Cited by 210 · see citing works
BODDY, A. M., McGOWEN, M. R., SHERWOOD, C. C., GROSSMAN, L. I., GOODMAN, M., & WILDMAN, D. E. (2012) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2012.02491.x · Cited by 207 · see citing works
Self-citationBirth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux
Burki, F., & Kaessmann, H. (2004) · Nature Genetics · doi:10.1038/ng1431 · Cited by 203 · see citing works
Neuroproteomics: understanding the molecular organization and complexity of the brain
Bayés, À., & Grant, S. G. N. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2701 · Cited by 188 · see citing works
MAGUKs, Synaptic Development, and Synaptic Plasticity
Zheng, C.-Y., Seabold, G. K., Hořák, M., & Petralia, R. S. (2011) · The Neuroscientist · doi:10.1177/1073858410386384 · Cited by 188 · see citing works
Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy
Heuer, E., F. Rosen, R., Cintron, A., & C. Walker, L. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315885 · Cited by 169 · see citing works
Nowick, K., Gernat, T., Almaas, E., & Stubbs, L. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911376106 · Cited by 162 · see citing works
Mechanical Concepts in Cardiovascular and Pulmonary Physiology.
Hetenyi, G. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-89-2-295_1 · Cited by 152 · see citing works
Evolution of Synapse Complexity and Diversity
Emes, R. D., & Grant, S. G. N. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150433 · Cited by 151 · see citing works
Interactive Exploration of Microarray Gene Expression Patterns in a Reduced Dimensional SpacePreprint
Misra, J., Schmitt, W., Hwang, D., et al. (2002) · Genome Research · doi:10.1101/gr.225302 · Cited by 151 · see citing works
FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution
Enard, W. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.04.008 · Cited by 149 · see citing works
Comparative RNA sequencing reveals substantial genetic variation in endangered primatesPreprint
Perry, G. H., Melsted, P., Marioni, J. C., Wang, Y., Bainer, R. O., Pickrell, J. K., Michelini, K., Zehr, S. M., Yoder, A. D., Stephens, M., et al. (2011) · Genome Research · doi:10.1101/gr.130468.111 · Cited by 147 · see citing works
Selection on Human Genes as Revealed by Comparisons to Chimpanzee cDNAPreprint
Hellmann, I., Zöllner, S., Enard, W., Ebersberger, I., Nickel, B., & Pääbo, S. (2003) · Genome Research · doi:10.1101/gr.944903 · Cited by 143 · see citing works
Bianchi, S., Stimpson, C. D., Bauernfeind, A. L., Schapiro, S. J., Baze, W. B., McArthur, M. J., Bronson, E., Hopkins, W. D., Semendeferi, K., Jacobs, B., et al. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs239 · Cited by 142 · see citing works
Self-citationCain, C. E., Blekhman, R., Marioni, J. C., & Gilad, Y. (2011) · Genetics · doi:10.1534/genetics.110.126177 · Cited by 138 · see citing works
Interdisciplinary Topics in Gerontology
Gryfe, C. I. (2014) · Interdisciplinary topics in gerontology · doi:10.1159/issn.0074-1132 · Cited by 138 · see citing works
The evolution of gene expression and the transcriptome–phenotype relationship
Harrison, P. W., Wright, A. E., & Mank, J. E. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.12.004 · Cited by 121 · see citing works
Role of the maguk protein family in synapse formation and function
Oliva, C., Escobedo, P., Astorga, C., Molina, C., & Sierralta, J. A. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20949 · Cited by 120 · see citing works
Induced gene expression in human brain after the split from chimpanzee
Gu, J., & Gu, X. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(02)00040-9 · Cited by 119 · see citing works
Increased Cortical Expression of Two Synaptogenic Thrombospondins in Human Brain Evolution
Cáceres, M., Suwyn, C. R., Maddox, M., Thomas, J. W., & Preuss, T. M. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl140 · Cited by 114 · see citing works
Neuropil distribution in the cerebral cortex differs between humans and chimpanzees
Spocter, M. A., Hopkins, W. D., Barks, S. K., Bianchi, S., Hehmeyer, A. E., Anderson, S. M., Stimpson, C. D., Fobbs, A. J., Hof, P. R., & Sherwood, C. C. (2012) · Journal of Comparative Neurology · doi:10.1002/cne.23074 · Cited by 113 · see citing works
Self-citationBurman, K. J., Palmer, S. M., Gamberini, M., & Rosa, M. G. P. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20837 · Cited by 107 · see citing works
Rapid metabolic evolution in human prefrontal cortex
Fu, X., Giavalisco, P., Liu, X., Catchpole, G., Fu, N., Ning, Z., Guo, S., Zheng, Y., Somel, M., Pääbo, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019164108 · Cited by 99 · see citing works
Cell Adhesion, the Backbone of the Synapse: "Vertebrate" and "Invertebrate" Perspectives
Giagtzoglou, N., Ly, C. V., & Bellen, H. J. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003079 · Cited by 97 · cited 1× · see citing works
“Also, cell-adhesion molecules coordinate multiple steps in the synapse with potentially rapid regulation of expression (Giagtzoglou et al. 2009).”
BackgroundSynaptic vesicle protein trafficking at the glutamate synapse
Santos, M., Li, H., & Voglmaier, S. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.029 · Cited by 96 · see citing works
Perez, S. E., Raghanti, M. A., Hof, P. R., Kramer, L., Ikonomovic, M. D., Lacor, P. N., Erwin, J. M., Sherwood, C. C., & Mufson, E. J. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23428 · Cited by 95 · see citing works
Self-citationCharacterization of Phosphorylation Sites on the Glutamate Receptor 4 Subunit of the AMPA Receptors
Carvalho, A. L., Kameyama, K., & Huganir, R. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04748.1999 · Cited by 83 · see citing works
Smaers, J. B., Schleicher, A., Zilles, K., & Vinicius, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009123 · Cited by 81 · see citing works
Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor
Brim, B. C., Haskell, R. E., Awedikian, R., Ellinwood, N. M., Jin, L. E., Kumar, A., Foster, T. C., & Magnusson, K. R. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.026 · Cited by 73 · see citing works
Gardoni, F., Marcello, E. E., & Luca, M. D. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.068 · Cited by 71 · see citing works
AMPA RECEPTOR REGULATION MECHANISMS: FUTURE TARGET FOR SAFER NEUROPROTECTIVE DRUGS
Jayakar, S. S., & Dikshit, M. (2004) · International Journal of Neuroscience · doi:10.1080/00207450490430453 · Cited by 48 · see citing works
The learning skills of great apes
Rumbaugh, D. M., & Gill, T. V. (1973) · Journal of Human Evolution · doi:10.1016/0047-2484(73)90073-0 · Cited by 47 · see citing works
SNARE proteins and schizophrenia: linking synaptic and neurodevelopmental hypotheses.
Johnson, R., Oliver, P. L., & Davies, K. E. (2008) · Acta Biochimica Polonica · doi:10.18388/abp.2008_3022 · Cited by 45 · see citing works
Comparative Neuropathology of Brain Aging in Primates
Hof, P. R., Gilissen, E., Sherwood, C. C., Duan, H., Lee, P. W. H., Delman, B. N., Naidich, T. P., Gannon, P. J., Perl, D. P., & Erwin, J. M. (2002) · KARGER eBooks · doi:10.1159/000061462 · Cited by 44 · see citing works
Self-citationStructural Basis for Spinophilin−Neurabin Receptor Interaction
Kelker, M. S., Dancheck, B., Ju, T., et al. (2007) · Biochemistry · doi:10.1021/bi602341c · Cited by 39 · see citing works
Jiang, H., & Jia, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.10.075 · Cited by 38 · see citing works
A Potential Role for Glucose Transporters in the Evolution of Human Brain Size
Fedrigo, O. D., Pfefferle, A. D., Babbitt, C. C., Haygood, R., Wall, C. E., & Wray, G. A. (2011) · Brain Behavior and Evolution · doi:10.1159/000329852 · Cited by 35 · see citing works
Self-citationFedrigo, O. D., Warner, L., Pfefferle, A. D., Babbitt, C. C., Cruz‐Gordillo, P., & Wray, G. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012545 · Cited by 30 · see citing works
Self-citationCyto-, myelo- and chemoarchitecture of the prefrontal cortex of the Cebus monkey
Cruz-Rizzolo, R. J., Lima, M. A. D., Ervolino, E., de Oliveira, J. A., & Casatti, C. A. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-6 · Cited by 30 · see citing works
Evolution of the Brain and Intelligence Evolution of the Brain and Intelligence . Harry J. Jerison
(1975) · Current Anthropology · doi:10.1086/201571 · Cited by 23 · see citing works
Mima, K., Deguchi, S., & Yamauchi, T. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01941-3 · Cited by 19 · see citing works
Extensive Changes in the Expression of the Opioid Genes between Humans and Chimpanzees
Cruz-Gordillo, P., Fedrigo, O., Wray, G. A., & Babbitt, C. C. (2010) · Brain, Behavior and Evolution · doi:10.1159/000320968 · Cited by 16 · see citing works
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Sorted by citations
Brain Plasticity and Human Evolution
Sherwood, C. C., & Gómez-Robles, A. (2017) · Annual Review of Anthropology · doi:10.1146/annurev-anthro-102215-100009 · Cited by 170 · see citing works
Self-citationGlutamate receptors in domestication and modern human evolution
O’Rourke, T., & Boeckx, C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.004 · Cited by 50 · see citing works
- Authors
- Muntané, G., Horvath, J. E., Hof, P. R., Ely, J. J., Hopkins, W. D., Raghanti, M. A., Lewandowski, A. H., Wray, G. A., & Sherwood, C. C.
- Affiliations
- George Washington University (US)
- North Carolina Central University (US)
- New York Consortium in Evolutionary Primatology (US)
- Holloman Air Force Base (US)
- Georgia State University (US)
- Kent State University (US)
- Cleveland Metroparks Zoo (US)
- Duke University (US)
- Corresponding author
- Muntané, Gerard
- ORCID
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01-09
- Volume
- 25
- Issue
- 6
- Pages
- 1596-1607
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC4428301
- OpenAlex
- W2135534142
- Cited by
- 36
- References
- 98
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 2 · 2021: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0827531, 220020293)
- James S. McDonnell Foundation (220020293, 22002078)
- National Institutes of Health (P51OD011133, P51OD011132)
- National Institute of Neurological Disorders and Stroke (R01NS073134, NS‐042867, R01NS042867)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- primate brain evolution, synaptic gene expression, prefrontal cortex, glutamatergic neurotransmission, glutamate receptors, synaptic scaffolding proteins, synaptic vesicle release, gene expression evolution, learning and memory
- MeSH terms
- Animals, Biological Evolution, Female, Humans, Male, Membrane Proteins, Nerve Tissue Proteins, Synaptic Transmission, Phylogeny, Primates, Promoter Regions, Genetic, RNA, Messenger, Synapses, Signal Transduction, Gene Expression, Databases, Bibliographic, Receptors, Glutamate, Statistics, Nonparametric, Neocortex, Principal Component Analysis
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