Cited by 295Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesNeurotransmitter Receptor Influence on Behavior

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Facilitation of Affiliation and Pair-Bond Formation by Vasopressin Receptor Gene Transfer into the Ventral Forebrain of a Monogamous Vole

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Pitkow, Lauren J., Sharer, Catherine A., Ren, Xianglin, Insel, Thomas R., Terwilliger, Ernest F., Young, Larry J.·2001·The Journal of Neuroscience

DOI 10.1523/jneurosci.21-18-07392.2001PMC PMC6762997

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Abstract

Behaviors associated with monogamy, including pair-bond formation, are facilitated by the neuropeptide vasopressin and are prevented by a vasopressin receptor [V1a receptor (V1aR)] antagonist in the male prairie vole. The neuroanatomical distribution of V1aR dramatically differs between monogamous and nonmonogamous species. V1aR binding is denser in the ventral pallidal region of several unrelated monogamous species compared with nonmonogamous species. Because the ventral pallidum is involved in reinforcement and addiction, we hypothesize that V1aR activation in this region promotes pair-bond formation via a mechanism similar to conditioning. Using an adeno-associated viral vector to deliver the V1aR gene, we increased the density of V1aR binding in the ventral pallial region of male prairie voles. These males exhibited increased levels of both anxiety and affiliative behavior compared with control males. In addition, males overexpressing the V1aR in the ventral pallidal region, but not control males, formed strong partner preferences after an overnight cohabitation, without mating, with a female. These data demonstrate a role for ventral pallidal V1aR in affiliation and social attachment and provide a potential molecular mechanism for species differences in social organization.

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Authors: Pitkow, L. J., Sharer, C. A., Ren, X., Insel, T. R., Terwilliger, E. F., & Young, L. J.
Affiliations: Emory University (US)
Beth Israel Deaconess Medical Center (US)
ORCID: Insel, Thomas R.
Young, Larry J.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2001-09-15
Volume: 21
Issue: 18
Pages: 7392-7396
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.21-18-07392.2001
PMC: PMC6762997
OpenAlex: W2127294078
Cited by: 295
References: 37
Citations by year: 2026: 1 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 14 · 2016: 21 · 2015: 10 · 2014: 17 · 2013: 11 · 2012: 18
FWCI: 30.66
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (9876754)
U.S. Public Health Service (58824, 56897)
National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: vasopressin V1a receptor, pair bonding, monogamy, Microtus ochrogaster, ventral pallidum, affiliative behavior, anxiety, mate preferences, social attachment, neuropeptide signaling
MeSH terms: Dependovirus, Animals, Anxiety, Autoradiography, Choice Behavior, Arvicolinae, Genetic Vectors, Globus Pallidus, Male, Pair Bond, Sexual Behavior, Animal, Social Facilitation, Prosencephalon, Receptors, Vasopressin, Maze Learning, Gene Transfer, Horizontal

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Facilitation of Affiliation and Pair-Bond Formation by Vasopressin Receptor Gene Transfer into the Ventral Forebrain of a Monogamous Vole

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