Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex
Open accessAbstract
Neuronal responses during sensory processing are influenced by both the organization of intracortical connections and the statistical features of sensory stimuli. How these intrinsic and extrinsic factors govern the activity of excitatory and inhibitory populations is unclear. Using two-photon calcium imaging in vivo and intracellular recordings in vitro, we investigated the dependencies between synaptic connectivity, feature selectivity and network activity in pyramidal cells and fast-spiking parvalbumin-expressing (PV) interneurons in mouse visual cortex. In pyramidal cell populations, patterns of neuronal correlations were largely stimulus-dependent, indicating that their responses were not strongly dominated by functionally biased recurrent connectivity. By contrast, visual stimulation only weakly modified co-activation patterns of fast-spiking PV cells, consistent with the observation that these broadly tuned interneurons received very dense and strong synaptic input from nearby pyramidal cells with diverse feature selectivities. Therefore, feedforward and recurrent network influences determine the activity of excitatory and inhibitory ensembles in fundamentally different ways.
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Because rodent visual cortex lacks orientation columns, the summed excitatory input from nearby pyramidal neurons to interneurons is broad.
“Rodent visual cortex, however, lacks orientation columns, thus the sum of excitatory inputs from nearby pyramidal neurons to interneurons will be broad (Hofer et al., 2011).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Hofer et al., 2011
The Introduction says that neurons with different orientation preferences are locally intermixed in mouse V1, and the Discussion reports that broadly tuned PV/FS interneurons sample inputs from nearby pyramidal cells with diverse orientation preferences. This supports the proposed relationship, but the paper’s direct findings concern mouse PV/FS interneurons, not interneurons throughout rodent visual cortex. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn mouse visual cortex, fast-spiking neurons are more broadly selective for orientation, direction and spatial frequency than pyramidal cells.
“in mouse visual cortex, selectivity to visual stimuli such as orientation, direction, and spatial frequency are broader for FS neurons than for pyramidal cells”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Hofer et al., 2011
The Results (‘Visual responses of PV interneurons’; page unavailable) report broader orientation tuning in most PV neurons than in pyramidal cells, and the Discussion identifies most PV neurons as fast-spiking. Our copy does not establish the same comparison for direction or spatial-frequency selectivity: its direction measurements are used to calculate orientation tuning, and the searched passages contain no spatial-frequency comparison. (LLM, conf=0.88)
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- Authors
- Hofer, S. B., Ko, H., Pichler, B., Vogelstein, J., Ros, H., Zeng, H., Lein, E., Lesica, N. A., & Mrsic-Flogel, T. D.
- Affiliations
- University College London (GB)
- National Institute for Medical Research (GB)
- Johns Hopkins University (US)
- Allen Institute for Brain Science (US)
- Venue
- Nature Neuroscience
- Published
- 2011-07-17
- Volume
- 14
- Issue
- 8
- Pages
- 1045-1052
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC6370002
- OpenAlex
- W2061681507
- Cited by
- 470
- References
- 50
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 34 · 2023: 19 · 2022: 31 · 2021: 29 · 2020: 38 · 2019: 28 · 2018: 42 · 2017: 30 · 2016: 40 · 2015: 38 · 2014: 32 · 2013: 40 · 2012: 26
- FWCI
- 17.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- Wellcome Trust (095074)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- visual cortex, excitation-inhibition balance, pyramidal neurons, parvalbumin interneurons, fast-spiking interneurons, neural correlations, synaptic connectivity, recurrent connectivity, feature selectivity, stimulus dependence, mouse visual cortex
- MeSH terms
- Analysis of Variance, Animals, Calcium, Evoked Potentials, Visual, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Neurons, Organic Chemicals, Parvalbumins, Photic Stimulation, Reaction Time, Statistics as Topic, Synapses, Visual Cortex, Visual Pathways, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Mice, In Vitro Techniques
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