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Cited by 532Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Dense Inhibitory Connectivity in Neocortex

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Fino, Elodie, Yuste, Rafael·2011·Neuron
DOI 10.1016/j.neuron.2011.02.025PMC PMC3086675
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Abstract

The connectivity diagram of neocortical circuits is still unknown, and there are conflicting data as to whether cortical neurons are wired specifically or not. To investigate the basic structure of cortical microcircuits, we use a two-photon photostimulation technique that enables the systematic mapping of synaptic connections with single-cell resolution. We map the inhibitory connectivity between upper layers somatostatin-positive GABAergic interneurons and pyramidal cells in mouse frontal cortex. Most, and sometimes all, inhibitory neurons are locally connected to every sampled pyramidal cell. This dense inhibitory connectivity is found at both young and mature developmental ages. Inhibitory innervation of neighboring pyramidal cells is similar, regardless of whether they are connected among themselves or not. We conclude that local inhibitory connectivity is promiscuous, does not form subnetworks, and can approach the theoretical limit of a completely connected synaptic matrix.

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Crossref · 10.1016/j.neuron.2011.02.025

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  • Sst interneurons densely connect to other interneuron types and pyramidal cells.

    “while densely connecting to other IN types and pyramidal cells (Fino and Yuste, 2011; Pfeffer et al., 2013).”

    From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Fino and Yuste, 2011

    The Discussion section “Somatostatin interneurons densely innervate local territories” reports dense connections from somatostatin-expressing interneurons to layer 2/3 pyramidal cells. The paper does not establish that they densely connect to other interneuron types; its discussion of coupling among somatostatin-positive cells concerns gap junctions, not dense connections to other types. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Some interneuron subtypes, such as PVBCs and NGFCs, demonstrate very high rates of connectivity to PCs, with connection probabilities in paired recordings in the range of ~50-90%.

    “Some subtypes, such as PVBCs and NGFCs, demonstrate very high rates of connectivity to PCs: connection probabilities in paired recordings are in the range of ~50–90% (204, 331, 876, 880).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [331]

  • Certain forms of inhibition are promiscuous and less selective in downstream targeting than initially thought.

    “However, recent evidence suggests that certain forms of inhibition are promiscuous and less selective in downstream targeting than initially thought (331, 552, 876, 918).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [331]

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Research works printed but not linked: 4

  1. Braitenberg V Schüzt A Anatomy of the cortex 1991 Springer Berlin
  2. Hebb DO The organization of behaviour 1949 The organization of behaviour, Wiley
  3. Hubel DH Wiesel TN Functional architecture of the macaque monkey visual cortex Proc R Soc Lond B 1977 198 1 59 20635
  4. Somogyi P Tamas G Lujan R Buhl E Salient features of synaptic organisation in the cerebral cortex Brain Res Brain Res Rev 1998 26 113 135 9651498

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Authors
Fino, E., & Yuste, R.
Affiliations
Howard Hughes Medical Institute (US)
ORCID
Yuste, Rafael
Venue
Neuron
Publisher
Elsevier BV
Published
2011-03
Volume
69
Issue
6
Pages
1188-1203
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2011.02.025
PMC
PMC3086675
OpenAlex
W1966894829
Cited by
532
References
70
Citations by year
2026: 15 · 2025: 23 · 2024: 22 · 2023: 26 · 2022: 30 · 2021: 34 · 2020: 40 · 2019: 31 · 2018: 37 · 2017: 44 · 2016: 55 · 2015: 38 · 2014: 39 · 2013: 48 · 2012: 35
FWCI
18.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
  • Columbia Academic Commons (Columbia University)
Funders
  • Howard Hughes Medical Institute
  • National Eye Institute (R01EY011787)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
inhibitory connectivity, neocortex, GABAergic interneurons, pyramidal neurons, cortical microcircuits, frontal cortex, mice, developmental maturation, local connectivity
MeSH terms
Action Potentials, Animals, gamma-Aminobutyric Acid, Nerve Net, Neural Inhibition, Neurons, Somatostatin, Synapses, Patch-Clamp Techniques, Neocortex, Excitatory Postsynaptic Potentials, Mice

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