Cited by 300Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorDecision-Making and Behavioral Economics

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Immediate Reward Bias in Humans: Fronto-Parietal Networks and a Role for the Catechol-O-Methyltransferase 158Val/ValGenotype

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Boettiger, Charlotte A., Mitchell, Jennifer M., Tavares, Venessa C., Robertson, Margaret, Joslyn, Geoff, D'Esposito, Mark, Fields, Howard L.·2007·The Journal of Neuroscience

DOI 10.1523/jneurosci.2551-07.2007PMC PMC6673461

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Abstract

The tendency to choose lesser immediate benefits over greater long-term benefits characterizes alcoholism and other addictive disorders. However, despite its medical and socioeconomic importance, little is known about its neurobiological mechanisms. Brain regions that are activated when deciding between immediate or delayed rewards have been identified (McClure et al., 2004, 2007), as have areas in which responses to reward stimuli predict a paper-and-pencil measure of temporal discounting (Hariri et al., 2006). These studies assume "hot" and "cool" response selection systems, with the hot system proposed to generate impulsive choices in the presence of a proximate reward. However, to date, brain regions in which the magnitude of activity during decision making reliably predicts intertemporal choice behavior have not been identified. Here we address this question in sober alcoholics and non-substance-abusing control subjects and show that immediate reward bias directly scales with the magnitude of functional magnetic resonance imaging bold oxygen level-dependent (BOLD) signal during decision making at sites within the posterior parietal cortex (PPC), dorsal prefrontal cortex (dPFC), and rostral parahippocampal gyrus regions. Conversely, the tendency of an individual to wait for a larger, delayed reward correlates directly with BOLD signal in the lateral orbitofrontal cortex. In addition, genotype at the Val158Met polymorphism of the catechol-O-methyltransferase gene predicts both impulsive choice behavior and activity levels in the dPFC and PPC during decision making. These genotype effects remained significant after controlling for alcohol abuse history. These results shed new light on the neurobiological underpinnings of temporal discounting behavior and identify novel behavioral and neural consequences of genetic variation in dopamine metabolism.

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Authors: Boettiger, C. A., Mitchell, J. M., Tavares, V. C., Robertson, M., Joslyn, G., D'Esposito, M., & Fields, H. L.
Affiliations: Ernest Gallo Clinic and Research Center (US)
University of California, San Francisco (US)
ORCID: Boettiger, Charlotte A.
Mitchell, Jennifer M.
Fields, Howard L.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2007-12-26
Volume: 27
Issue: 52
Pages: 14383-14391
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.2551-07.2007
PMC: PMC6673461
OpenAlex: W2032471892
Cited by: 300
References: 80
Citations by year: 2026: 2 · 2025: 7 · 2024: 3 · 2023: 12 · 2022: 6 · 2021: 8 · 2020: 16 · 2019: 13 · 2018: 15 · 2017: 17 · 2016: 18 · 2015: 24 · 2014: 24 · 2013: 22 · 2012: 34
FWCI: 8.68
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Defense
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Keywords: delay discounting, intertemporal choice, impulsive decision-making, alcoholism, catechol-O-methyltransferase, COMT Val158Met polymorphism, dopamine metabolism, posterior parietal cortex, dorsal prefrontal cortex, lateral orbitofrontal cortex
MeSH terms: Adult, Alcoholism, Brain Mapping, Catechol O-Methyltransferase, Decision Making, Female, Humans, Image Processing, Computer-Assisted, Luria-Nebraska Neuropsychological Battery, Magnetic Resonance Imaging, Male, Nerve Net, Oxygen, Parietal Lobe, Polymorphism, Genetic, Reward, Valine, Bias, Prefrontal Cortex

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Immediate Reward Bias in Humans: Fronto-Parietal Networks and a Role for the Catechol-O-Methyltransferase 158Val/ValGenotype

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