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Immediate Reward Bias in Humans: Fronto-Parietal Networks and a Role for the Catechol-O-Methyltransferase 158Val/ValGenotype
Open accessAbstract
The tendency to choose lesser immediate benefits over greater long-term benefits characterizes alcoholism and other addictive disorders. However, despite its medical and socioeconomic importance, little is known about its neurobiological mechanisms. Brain regions that are activated when deciding between immediate or delayed rewards have been identified (McClure et al., 2004, 2007), as have areas in which responses to reward stimuli predict a paper-and-pencil measure of temporal discounting (Hariri et al., 2006). These studies assume "hot" and "cool" response selection systems, with the hot system proposed to generate impulsive choices in the presence of a proximate reward. However, to date, brain regions in which the magnitude of activity during decision making reliably predicts intertemporal choice behavior have not been identified. Here we address this question in sober alcoholics and non-substance-abusing control subjects and show that immediate reward bias directly scales with the magnitude of functional magnetic resonance imaging bold oxygen level-dependent (BOLD) signal during decision making at sites within the posterior parietal cortex (PPC), dorsal prefrontal cortex (dPFC), and rostral parahippocampal gyrus regions. Conversely, the tendency of an individual to wait for a larger, delayed reward correlates directly with BOLD signal in the lateral orbitofrontal cortex. In addition, genotype at the Val158Met polymorphism of the catechol-O-methyltransferase gene predicts both impulsive choice behavior and activity levels in the dPFC and PPC during decision making. These genotype effects remained significant after controlling for alcohol abuse history. These results shed new light on the neurobiological underpinnings of temporal discounting behavior and identify novel behavioral and neural consequences of genetic variation in dopamine metabolism.
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In the citing paper
“genetic variation at the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene influences decision-making behavior and underlying activity in brain activity associated with impulsive choice (Boettiger et al., 2007).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Boettiger et al., 2007
In the citing paper
“numerous neuroimaging studies have found abnormal OFC function associated with substance abuse (Boettiger et al., 2007; Dom et al., 2005; Ersche et al., 2005; London et al., 2000; Volkow and Fowler, 2000).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Boettiger et al., 2007
In the citing paper
“we have found that reduced OFC activity during decision-making among abstinent alcoholics is correlated with their tendency to choose immediate over delayed rewards (Boettiger et al., 2007)”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Boettiger et al., 2007
In the citing paper
“while a single study has examined the effects of COMTVal158Met in an adult sample of abstinent alcoholics and healthy participants (Boettiger et al, 2007)”
From DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls (2010) · cites this paper as Boettiger et al, 2007
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Metadata
- Authors
- Boettiger, C. A., Mitchell, J. M., Tavares, V. C., Robertson, M., Joslyn, G., D'Esposito, M., & Fields, H. L.
- Affiliations
- Ernest Gallo Clinic and Research Center (US)
- University of California, San Francisco (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-12-26
- Volume
- 27
- Issue
- 52
- Pages
- 14383-14391
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673461
- OpenAlex
- W2032471892
- Cited by
- 300
- References
- 80
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 12 · 2022: 6 · 2021: 8 · 2020: 16 · 2019: 13 · 2018: 15 · 2017: 17 · 2016: 18 · 2015: 24 · 2014: 24 · 2013: 22 · 2012: 34
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- delay discounting, intertemporal choice, impulsive decision-making, alcoholism, catechol-O-methyltransferase, COMT Val158Met polymorphism, dopamine metabolism, posterior parietal cortex, dorsal prefrontal cortex, lateral orbitofrontal cortex
- MeSH terms
- Adult, Alcoholism, Brain Mapping, Catechol O-Methyltransferase, Decision Making, Female, Humans, Image Processing, Computer-Assisted, Luria-Nebraska Neuropsychological Battery, Magnetic Resonance Imaging, Male, Nerve Net, Oxygen, Parietal Lobe, Polymorphism, Genetic, Reward, Valine, Bias, Prefrontal Cortex
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