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Glucocorticoid Effects on Memory Retrieval Require Concurrent Noradrenergic Activity in the Hippocampus and Basolateral Amygdala
Open accessAbstract
Previous findings indicate that administration of aβ-adrenoceptor antagonist systemically blocks glucocorticoid impairment of memory retrieval. Here, we report that β-adrenoceptor activation in the hippocampus and the basolateral complex of the amygdala (BLA) is implicated in the impairing effects of glucocorticoids on memory retrieval. The specific glucocorticoid receptor (GR) agonist 11β,17β-dihydroxy-6,21-dimethyl-17α-pregna-4,6-trien-20yn-3-one (RU 28362) (15 ng) infused into the hippocampus of male Sprague Dawley rats 60 min before water maze retention testing, 24 hr after training, impaired probe trial retention performance, as assessed by quadrant search time and initial latency to cross the platform location. Because we found previously that RU 28362 infused into the hippocampus does not affect water maze acquisition or immediate recall, the findings suggest that the GR agonist-induced retention impairment was attributable to a selective influence on long-term memory retrieval. Likewise, systemic injections of the β 1-adrenoceptor partial agonist xamoterol (3.0 or 10.0 mg/kg, s.c.) 60 min before the probe trial dose-dependently impaired retention performance. The β-adrenoceptor antagonist propranolol (2.0 mg/kg) administered subcutaneously before retention testing did not affect retention performance alone, but blocked the memory retrieval impairment induced by concurrent intrahippocampal infusions of RU 28362. Pretest infusions of the β 1-adrenoceptor antagonist atenolol into either the hippocampus (1.25 μg in 0.5 μl) or the BLA (0.5 μg in 0.2 μl) also prevented the GR agonist-induced memory retrieval impairment. These findings suggest that glucocorticoids impair retrieval of long-term spatial memory by facilitating noradrenergic mechanisms in the hippocampus, and additionally, that norepinephrine-mediated BLA activity is critical in enabling hippocampal glucocorticoid effects on memory retrieval.
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“and can impair hippocampus-specific memory processing in rats (de Quervain et al. [157]; Conrad et al. [158]; Roozendaal et al. [159]) and people (Kirschbaum et al. [160]; de Quervain et al. [161]; Wolf et al. [162]; Payne et al. [163]; Buss et al. [164]; Wolf et al. [165]; Elzinga et al. [76]; Kuhlmann et al. [166]; Kuhlmann et al. [167]; Payne et al. [168]; Buchanan”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Roozendaal et al. [159]
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“…and can impair hippocampus-specific memory processing in rats (de Quervain et al. [157]; Conrad et al. [158]; Roozendaal et al. [159]) and people (Kirschbaum et al. [160]; de Quervain et al. [161]; Wolf et al. [162]; Payne et al. [163]; Buss et al. [164]; Wolf et al. [165]; Elzinga et al. [76];…”
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Metadata
- Authors
- Roozendaal, B., Hahn, E. L., Nathan, S. V., de Quervain, D. J.-F., & McGaugh, J. L.
- Affiliations
- University of California, Irvine (US)
- University of Zurich (CH)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-09-15
- Volume
- 24
- Issue
- 37
- Pages
- 8161-8169
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6729799
- OpenAlex
- W2050582843
- Cited by
- 301
- References
- 87
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 9 · 2019: 10 · 2018: 16 · 2017: 13 · 2016: 21 · 2015: 19 · 2014: 20 · 2013: 17 · 2012: 20
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (58420)
- U.S. Public Health Service
- National Institute of Mental Health (R01MH012526, MH12526, R56MH012526)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- glucocorticoids, memory retrieval, noradrenergic activity, hippocampus, basolateral amygdala, beta-adrenergic receptors, glucocorticoid receptor, RU 28362, xamoterol, propranolol, atenolol, spatial memory, water maze, long-term memory, norepinephrine
- MeSH terms
- Adrenergic beta-Antagonists, Amygdala, Androstanols, Animals, Atenolol, Corticosterone, Emotions, Escape Reaction, Hippocampus, Hormone Antagonists, Male, Propranolol, Reaction Time, Mental Recall, Receptors, Glucocorticoid, Stress, Psychological, Rats, Sprague-Dawley, Xamoterol, Receptors, Adrenergic, beta-1, Receptors, Adrenergic, beta-2, Maze Learning, Rats
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