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Dense, Unspecific Connectivity of Neocortical Parvalbumin-Positive Interneurons: A Canonical Microcircuit for Inhibition?
Open accessAbstract
GABAergic interneurons play a major role in the function of the mammalian neocortex, but their circuit connectivity is still poorly understood. We used two-photon RuBi-Glutamate uncaging to optically map how the largest population of cortical interneurons, the parvalbumin-positive cells (PV+), are connected to pyramidal cells (PCs) in mouse neocortex. We found locally dense connectivity from PV+ interneurons onto PCs across cortical areas and layers. In many experiments, all nearby PV+ cells were connected to every local PC sampled. In agreement with this, we found no evidence for connection specificity, as PV+ interneurons contacted PC pairs similarly regardless of whether they were synaptically connected or not. We conclude that the microcircuit architecture for PV+ interneurons, and probably neocortical inhibition in general, is an unspecific, densely homogenous matrix covering all nearby pyramidal cells.
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In the citing paper
“Individual PV-INs contact nearly every local pyramidal neuron which enables them to synchronize networks [74].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [74]
In the citing paper
“In addition, PV-INs connect to many principal neurons [74,75,87,88].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [74]
In the citing paper
“Some subtypes, such as PVBCs and NGFCs, demonstrate very high rates of connectivity to PCs: connection probabilities in paired recordings are in the range of ~50–90% (204, 331, 876, 880).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [876]
In the citing paper
“However, recent evidence suggests that certain forms of inhibition are promiscuous and less selective in downstream targeting than initially thought (331, 552, 876, 918).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [876]
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Metadata
- Authors
- Packer, A. M., & Yuste, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-09-14
- Volume
- 31
- Issue
- 37
- Pages
- 13260-13271
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3178964
- OpenAlex
- W2014350866
- Cited by
- 506
- References
- 45
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 53 · 2023: 31 · 2022: 36 · 2021: 43 · 2020: 40 · 2019: 34 · 2018: 30 · 2017: 35 · 2016: 35 · 2015: 35 · 2014: 26 · 2013: 42 · 2012: 16
- FWCI
- 11.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- parvalbumin interneurons, GABAergic interneurons, neocortex, pyramidal neurons, cortical connectivity, inhibitory microcircuits, dense connections, glutamate uncaging, two-photon calcium imaging, mouse cortex
- MeSH terms
- Animals, Brain Mapping, Female, Interneurons, Male, Mice, Transgenic, Neural Inhibition, Neural Pathways, Parvalbumins, Pyramidal Cells, Patch-Clamp Techniques, Microscopy, Confocal, Neocortex, Mice, In Vitro Techniques
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