The columnar and laminar organization of inhibitory connections to neocortical excitatory cells
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The cytoarchitectonic similarities of different neocortical regions have given rise to the idea of 'canonical' connectivity between excitatory neurons of different layers within a column. It is unclear whether similarly general organizational principles also exist for inhibitory neocortical circuits. Here we delineate and compare local inhibitory-to-excitatory wiring patterns in all principal layers of primary motor (M1), somatosensory (S1) and visual (V1) cortex, using genetically targeted photostimulation in a mouse knock-in line that conditionally expresses channelrhodopsin-2 in GABAergic neurons. Inhibitory inputs to excitatory neurons derived largely from the same cortical layer within a three-column diameter. However, subsets of pyramidal cells in layers 2/3 and 5B received extensive translaminar inhibition. These neurons were prominent in V1, where they might correspond to complex cells, less numerous in barrel cortex and absent in M1. Although inhibitory connection patterns were stereotypical, the abundance of individual motifs varied between regions and cells, potentially reflecting functional specializations.
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Inhibitory circuits share general organization principles across cortical areas, but the abundance of specific inhibitory connectivity motifs varies between regions, probably reflecting different computational requirements.
“Inhibitory circuits share general organization principles across cortical areas, but increasing evidence suggests that the abundance of specific inhibitory connectivity motifs varies between regions (Katzel et al., 2011), probably reflecting different computational requirements.”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Katzel et al., 2011
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- Authors
- Kätzel, D., Zemelman, B. V., Buetfering, C., Wölfel, M., & Miesenböck, G.
- Affiliations
- University of Oxford (GB)
- Yale University (US)
- Corresponding author
- Miesenböck, Gero
- Venue
- Nature Neuroscience
- Published
- 2010-11-14
- Volume
- 14
- Issue
- 1
- Pages
- 100-107
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3011044
- OpenAlex
- W2024174536
- Cited by
- 241
- References
- 49
- Citations by year
- 2025: 10 · 2024: 9 · 2023: 9 · 2022: 17 · 2021: 6 · 2020: 13 · 2019: 15 · 2018: 11 · 2017: 17 · 2016: 21 · 2015: 20 · 2014: 22 · 2013: 19 · 2012: 23
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- Wellcome Trust (84767, 090309/Z/09/Z, 090309)
- National Institute on Drug Abuse (R01DA017297)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- inhibitory connectivity, cortical columns, laminar organization, GABAergic interneurons, excitatory neurons, primary motor cortex, primary visual cortex, primary somatosensory cortex, complex cells, barrel cortex, pyramidal neurons
- MeSH terms
- Channelrhodopsins, Action Potentials, Animals, gamma-Aminobutyric Acid, Interneurons, Motor Cortex, Neural Inhibition, Neural Pathways, Neurons, Photic Stimulation, Somatosensory Cortex, Visual Cortex, Neocortex, Mice, Gene Knock-In Techniques, Neuroanatomical Tract-Tracing Techniques
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