Evidence that the laminar fate of LGE/CGE-derived neocortical interneurons is dependent on their progenitor domains
Open accessAbstract
Neocortical interneurons show tremendous diversity in terms of their neurochemical marker expressions, morphology, electrophysiological properties, and laminar fate. Allocation of interneurons to their appropriate regions and layers in the neocortex is thought to play important roles for the emergence of higher functions of the neocortex. Neocortical interneurons mainly originate from the medial ganglionic eminence (MGE) and the caudal ganglionic eminence (CGE). The diversity and the laminar fate of MGE-derived interneurons depend on the location of their birth and birthdate, respectively. However, this relationship does not hold for CGE-derived interneurons. Here, using the method of in utero electroporation, which causes arbitrary occurrence of labeled progenitor domains, we tracked all descendants of the lateral ganglionic eminence (LGE)/CGE progenitors in mice. We provide evidence that neocortical interneurons with distinct laminar fate originate from distinct progenitor domains within the LGE/CGE. We find layer I interneurons are predominantly labeled in a set of animals, whereas other upper layer neurons are predominantly labeled in another set. We also find distinct subcortical structures labeled between the two sets. Further, interneurons labeled in layer I show distinct neurochemical properties from those in other layers. Together, these results suggest that the laminar fate of LGE/CGE-derived interneurons depends on their spatial origin. SIGNIFICANCE STATEMENT: Diverse types of neocortical interneurons have distinct laminar fate, neurochemical marker expression, morphology, and electrophysiological properties. Although the specifications and laminar fate of medial ganglionic eminence-derived neocortical interneurons depend on their location of embryonic origin and birthdate, no similar causality of lateral/caudal ganglionic eminence (LGE/CGE)-derived neocortical interneurons is known. Here, we performed in utero electroporation on mouse LGE/CGE and found two groups of animals, one with preferential labeling of layer I and the other with preferential labeling of other layers. Interneurons labeled in these two groups show distinct neurochemical properties and morphologies and are associated with labeling of distinct subcortical structures. These findings suggest that the laminar fate of LGE/CGE-derived neocortical interneurons depends on their spatial origin.
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Most neurogliaform cells and multipolar NPY+ interneurons do not derive from Nkx2-1-expressing progenitors and most likely originate from the POH domain.
“Most of these cells do not derive from Nkx2-1-expressing progenitor cells”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Torigoe et al., 2016
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- Authors
- Torigoe, M., Yamauchi, K., Kimura, T., Uemura, Y., & Murakami, F.
- Affiliations
- The University of Osaka (JP)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2016-02-10
- Volume
- 36
- Issue
- 6
- Pages
- 2044-2056
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6602017
- OpenAlex
- W2288107702
- Cited by
- 21
- References
- 63
- Citations by year
- 2026: 2 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (22220004)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neocortical interneurons, lateral ganglionic eminence, caudal ganglionic eminence, interneuron morphology, subcortical structures, in utero electroporation, mouse neocortex, birth date
- MeSH terms
- Animals, Astrocytes, Female, Immunohistochemistry, Interneurons, Neurons, Pregnancy, Electroporation, Gene Expression Regulation, Developmental, Neocortex, Mice
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