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Synaptic Scaling Requires the GluR2 Subunit of the AMPA Receptor
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Two functionally distinct forms of synaptic plasticity, Hebbian long-term potentiation (LTP) and homeostatic synaptic scaling, are thought to cooperate to promote information storage and circuit refinement. Both arise through changes in the synaptic accumulation of AMPA receptors (AMPARs), but whether they use similar or distinct receptor-trafficking pathways is unknown. Here, we show that TTX-induced synaptic scaling in cultured visual cortical neurons leads to the insertion of GluR2-containing AMPARs at synapses. Similarly, visual deprivation with monocular TTX injections results in synaptic accumulation of GluR2-containing AMPARs. Unlike chemical LTP, synaptic scaling is blocked by a GluR2 C-tail peptide but not by a GluR1 C-tail peptide. Knockdown of endogenous GluR2 with an short hairpin RNA (shRNA) also blocks synaptic scaling but not chemical LTP. Scaling can be rescued with expression of exogenous GluR2 resistant to the shRNA, but a chimeric GluR2 subunit with the C-terminal domain swapped with the GluR1 C-terminal domain (GluR2/CT1) does not rescue synaptic scaling, indicating that regulatory sequences on the GluR2 C-tail are required for the accumulation of synaptic AMPARs during scaling. Together, our results suggest that synaptic scaling and LTP use different trafficking pathways, making these two forms of plasticity both functionally and molecularly distinct.
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“One such mechanism is synaptic scaling, which allows neurons to detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites.”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Gainey et al. 2009
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“by measuring minis arising from many synapses onto the same neuron, it was observed that modulating network activity induced uniform increases or decreases in the entire mini amplitude distribution, in effect scaling postsynaptic strength up or down (Turrigiano et al. 1998;Desai et al. 2002;Gainey et al. 2009).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Gainey et al. 2009
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“This global enhancement of AMPAR abundance in response to activity blockade requires sequences on the carboxyl terminus of the GluA2 subunit of the AMPAR (Gainey et al. 2009)”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Gainey et al. 2009
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“It is worth noting, however, that postsynaptic knockdown of GluA2 is able to completely block synaptic scaling (Gainey et al. 2009), suggesting that if there is a presynaptic change in transmitter packaging it is not sufficient to enhance mini amplitude on its own.”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Gainey et al. 2009
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“Visual deprivation induced by optic nerve block scale ups mEPSC amplitude in vivo as in vitro, and results in insertion of GluA2-containing AMPAR (Desai et al. 2002;Maffei and Turrigiano 2008;Gainey et al. 2009).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Gainey et al. 2009
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“Scaling-up can be blocked by the expression of the soluble cytosolic C-terminal tail of GluA2 or by shRNA-mediated knock-down of GluA2 (Gainey et al., 2009, Ancona Esselmann et al., 2017).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Gainey et al., 2009
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“Scaling-up can be rescued by expression of shRNA-resistant WT GluA2, but not by a GluA2 chimera with the C-tail swapped for GluA1, suggesting that elements of the GluA2 C-terminus are required for scaling-up (Gainey et al., 2009).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Gainey et al., 2009
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Citations
Cites
Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,056
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Self-citationStructural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Synaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263 · cited 2×
“Synaptic scaling and long-term potentiation (LTP) coexist at excitatory central synapses where they cooperate to maintain stability in neuronal output while selectively adjusting synaptic weights (Abbott and Nelson, 2000; Malenka and Bear, 2004; Turrigiano and Nelson, 2004).”
BackgroundActivity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226
Self-citationHayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524
Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276
AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
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Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139
Self-citationThe AMPA Receptor Code of Synaptic Plasticity
Diering, G. H., & Huganir, R. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.018 · Cited by 844
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Lee, H., & Kirkwood, A. (2011) · Cited by 692
Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement
Turrigiano, G. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153238 · Cited by 671
Self-citationUnraveling mechanisms of homeostatic synaptic plasticity
Pozo, K., & Goda, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.028 · Cited by 565
Synaptic AMPA receptor composition in development, plasticity and disease
Henley, J. M., & Wilkinson, K. A. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.37 · Cited by 526
Firing Rate Homeostasis in Visual Cortex of Freely Behaving Rodents
Hengen, K. B., Lambo, M. E., Hooser, S. D. V., Katz, D. B., & Turrigiano, G. G. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.038 · Cited by 362
Self-citationThe role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity
Chater, T. E., & Goda, Y. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00401 · Cited by 377
Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake
Hengen, K. B., Pacheco, A. T., McGregor, J. N., Hooser, S. D. V., & Turrigiano, G. G. (2016) · Cell · doi:10.1016/j.cell.2016.01.046 · Cited by 302
Self-citationHomeostatic Signaling and the Stabilization of Neural Function
Davis, G. W. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.044 · Cited by 276
The dialectic of Hebb and homeostasis
Turrigiano, G. G. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0258 · Cited by 251
Self-citationSingle-Cell Optogenetic Excitation Drives Homeostatic Synaptic Depression
Goold, C. P., & Nicoll, R. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.020 · Cited by 244
AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging
Henley, J. M., & Wilkinson, K. A. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/jhenley · Cited by 242
Compartmentalized versus Global Synaptic Plasticity on Dendrites Controlled by Experience
Makino, H., & Malinow, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.036 · Cited by 228
Lleó, A., Núñez-Llaves, R., Alcolea, D., Chiva, C., Balateu-Paños, D., Colom-Cadena, M., Gomez-Giro, G., Muñoz, L., Querol-Vilaseca, M., Pegueroles, J., et al. (2019) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.001290 · Cited by 219
Garay, P. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00136 · Cited by 217
Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation
Rizzo, F. R., Musella, A., Vito, F. D., Fresegna, D., Bullitta, S., Vanni, V., Guadalupi, L., Bassi, M. S., Buttari, F., Mandolesi, G., et al. (2018) · Neural Plasticity · doi:10.1155/2018/8430123 · Cited by 221
Keck, T., Toyoizumi, T., Chen, L., Doiron, B., Feldman, D. E., Fox, K. D., Wulfram Gerstner, B., Haydon, P. G., Hübener, M., Lee, H., et al. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0158 · Cited by 217
Self-citationThe developmental stages of synaptic plasticity
Löhmann, C., & Kessels, H. W. H. G. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235119 · Cited by 195
Mechanisms of homeostatic plasticity in the excitatory synapse
Fernandes, D., & Carvalho, A. L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13687 · Cited by 179
MAGUKs: multifaceted synaptic organizers
Won, S., Levy, J. M., Nicoll, R. A., & Roche, K. W. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.01.006 · Cited by 157
The interplay between Hebbian and homeostatic synaptic plasticity
Vitureira, N., & Goda, Y. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201306030 · Cited by 152
Lambo, M. E., & Turrigiano, G. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4502-12.2013 · Cited by 140
Self-citationSteinmetz, C. C., & Turrigiano, G. G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2210-10.2010 · Cited by 146
Self-citationGao, M., Sossa, K. G., Song, L., Errington, L., Cummings, L. W., Hwang, H., Kuhl, D., Worley, P. F., & Lee, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1067-10.2010 · Cited by 143
Nascent Proteome Remodeling following Homeostatic Scaling at Hippocampal Synapses
Schanzenbächer, C. T., Sambandan, S., Langer, J. D., & Schuman, E. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.058 · Cited by 138
GluA2-lacking, calcium-permeable AMPA receptors--inducers of plasticity?
Man, H.-Y. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.01.001 · Cited by 142
A Critical and Cell-Autonomous Role for MeCP2 in Synaptic Scaling Up
Blackman, M. P., Djukic, B., Nelson, S. B., & Turrigiano, G. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3077-12.2012 · Cited by 140
Self-citationThe Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling
Qiu, Z., Sylwestrak, E., Lieberman, D. N., Zhang, Y., Liu, X., & Ghosh, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0175-11.2012 · Cited by 136
PSD-95 and PSD-93 Play Critical But Distinct Roles in Synaptic Scaling Up and Down
Sun, Q., & Turrigiano, G. G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5616-10.2011 · Cited by 135
Self-citationRanson, A., Cheetham, C. E. J., Fox, K. D., & Sengpiel, F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112204109 · Cited by 138
MEF2 negatively regulates learning-induced structural plasticity and memory formation
Cole, C. J., Mercaldo, V., Restivo, L., Yiu, A. P., Sekeres, M. J., Han, J., Vetere, G., Pekar, T., Ross, P. J., Neve, R. L., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3189 · Cited by 137
The development of human visual cortex and clinical implications
Siu, C. R., & Murphy, K. M. (2018) · Eye and Brain · doi:10.2147/eb.s130893 · Cited by 139
Unconventional secretory processing diversifies neuronal ion channel properties
Hanus, C., Geptin, H., Tushev, G., Garg, S., Alvarez‐Castelao, B., Sambandan, S., Kochen, L., Hafner, A., Langer, J. D., & Schuman, E. M. (2016) · eLife · doi:10.7554/elife.20609 · Cited by 129
Haselmann, H., Mannara, F., Werner, C. D., Planagumà, J., Míguez‐Cabello, F., Schmidl, L., Grünewald, B., Petit‐Pedrol, M., Kirmse, K., Claßen, J., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.048 · Cited by 126
Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1
Tatavarty, V., Pacheco, A. T., Kuhnle, C. G., Lin, H. K., Koundinya, P., Miska, N. J., Hengen, K. B., Wagner, F. F., Hooser, S. D. V., & Turrigiano, G. G. (2020) · Neuron · doi:10.1016/j.neuron.2020.02.033 · Cited by 127
Self-citationBarnes, S. J., Franzoni, E., Jacobsen, R. I., Erdélyi, F., Szabó, G., Clopath, C., Keller, G. B., & Keck, T. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.052 · Cited by 125
Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors
Kim, S., & Ziff, E. B. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001900 · Cited by 114
Neuroimmune regulation of homeostatic synaptic plasticity
Pribiag, H., & Stellwagen, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.008 · Cited by 106
PICK1 loss of function occludes homeostatic synaptic scaling
Anggono, V., Clem, R. L., & Huganir, R. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5633-10.2011 · Cited by 111
The aging mouse brain: cognition, connectivity and calcium
Radulescu, C. I., Cerar, V., Haslehurst, P., Kopanitsa, M. V., & Barnes, S. J. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102358 · Cited by 109
MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity
Hou, Q., Ruan, H., Gilbert, J. P., Wang, G., Ma, Q., Yao, W., & Man, H. (2015) · Nature Communications · doi:10.1038/ncomms10045 · Cited by 106
Keeping your brain in balance: homeostatic regulation of network function
Wen, W., & Turrigiano, G. G. (2024) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-092523-110001 · Cited by 137
Self-citationTNF-Mediated Homeostatic Synaptic Plasticity: From in vitro to in vivo Models
Heir, R., & Stellwagen, D. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.565841 · Cited by 109
REST/NRSF‐mediated intrinsic homeostasis protects neuronal networks from hyperexcitability
Pozzi, D., Lignani, G., Ferrea, E., Contestabile, A., Paonessa, F., D’Alessandro, R., Lippiello, P., Boido, D., Fassio, A., Meldolesi, J., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.231 · Cited by 103
Goel, A., Xu, L. W., Snyder, K. P., Song, L., Goenaga-Vazquez, Y., Megill, A., Takamiya, K., Huganir, R. L., & Lee, H.-K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018264 · Cited by 103
Synaptopodin regulates denervation-induced homeostatic synaptic plasticity
Vlachos, A., Ikenberg, B. D., Lenz, M., Becker, D., Reifenberg, K., Orth, C. B., & Deller, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213677110 · Cited by 105
Target-Specific Properties of Thalamocortical Synapses onto Layer 4 of Mouse Primary Visual Cortex
Kloc, M., & Maffei, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2595-14.2014 · Cited by 99
Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?
Nahmani, M., & Turrigiano, G. G. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.029 · Cited by 97
Self-citationHistone Methylation by the Kleefstra Syndrome Protein EHMT1 Mediates Homeostatic Synaptic Scaling
Benevento, M., Iacono, G., Selten, M. M., Ba, W., Oudakker, A. R., Frega, M., Keller, J., Mancini, R., Lewerissa, E., Kleefstra, T., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.003 · Cited by 95
Keck, T., Hübener, M., & Bonhoeffer, T. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.02.003 · Cited by 93
“Another example is the observation that synaptic upscaling involves the insertion of the GluR2 subunit, while LTP is mediated by GluR1 insertion (44).”
Wang, G., Gilbert, J. P., & Man, H. (2012) · Neural Plasticity · doi:10.1155/2012/825364 · Cited by 91
Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity
Jang, S.-S., & Chung, H. J. (2016) · Neural Plasticity · doi:10.1155/2016/7969272 · Cited by 93
AMPA‐receptor trafficking and injury‐induced cell death
Beattie, M. S., Ferguson, A. R., & Bresnahan, J. C. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07343.x · Cited by 87
Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes
Guo, S.-M., Veneziano, R., Gordonov, S., Li, L., Danielson, E., de Arce, K. P., Park, D., Kulesa, A. B., Wamhoff, E., Blainey, P. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12372-6 · Cited by 83
Yamasaki, M., Miyazaki, T., Azechi, H., Abe, M., Natsume, R., Hagiwara, T., Aiba, A., Mishina, M., Sakimura, K., & Watanabe, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5601-10.2011 · Cited by 80
Synaptic Consolidation Normalizes AMPAR Quantal Size following MAGUK Loss
Levy, J. M., Chen, X., Reese, T. S., & Nicoll, R. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.015 · Cited by 83
AMPAR trafficking in synapse maturation and plasticity
Bassani, S., Folci, A., Zapata, J., & Passafaro, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1309-1 · Cited by 86
Soares, C., Lee, K. F. H., Nassrallah, W., & Béïque, J.-C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1873-13.2013 · Cited by 80
Emerging roles for MEF2 transcription factors in memory
Rashid, A. J., Cole, C. J., & Josselyn, S. A. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12058 · Cited by 79
AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex
Lee, H., & Kirkwood, A. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.06.007 · Cited by 772
Differential control of presynaptic efficacy by postsynaptic N-cadherin and β-catenin
Vitureira, N., Letellier, M., White, I. J., & Goda, Y. (2011) · Nature Neuroscience · doi:10.1038/nn.2995 · Cited by 78
Christian, D., Alexander, N. J., Diaz, M. R., Robinson, S. L., & McCool, B. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.02.017 · Cited by 76
Sanderson, J. L., Scott, J. D., & Dell’Acqua, M. L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2362-17.2018 · Cited by 77
Nakayama, K., Ohashi, R., Shinoda, Y., Yamazaki, M., Abe, M., Fujikawa, A., Shigenobu, S., Futatsugi, A., Noda, M., Mikoshiba, K., et al. (2017) · eLife · doi:10.7554/elife.29677 · Cited by 73
AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases
de León-López, C. A. M., Carretero-Rey, M., & Khan, Z. U. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01529-7 · Cited by 73
Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation
Evers, D. M., Matta, J. A., Hoe, H., Zarkowsky, D. S., Lee, S. H., Isaac, J. T. R., & Pak, D. T. S. (2010) · Nature Neuroscience · doi:10.1038/nn.2624 · Cited by 73
Uzunova, G., Hollander, E., & Shepherd, J. D. (2014) · Current Neuropharmacology · doi:10.2174/1570159x113116660046 · Cited by 73
Patriarchi, T., Buonarati, O. R., & Hell, J. W. (2018) · The EMBO Journal · doi:10.15252/embj.201899771 · Cited by 68
GRIP1 is required for homeostatic regulation of AMPAR trafficking
Tan, H. L., Queenan, B. N., & Huganir, R. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512786112 · Cited by 69
Ca2+-permeable AMPA receptors in homeostatic synaptic plasticity
Lee, H. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00017 · Cited by 69
Experience-dependent homeostatic synaptic plasticity in neocortex
Whitt, J. L., Petrus, E., & Lee, H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.02.016 · Cited by 70
Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons
Ha, H., Leal‐Ortiz, S., Lalwani, K., Kiyonaka, S., Hamachi, I., Mysore, S. P., Montgomery, J. M., Garner, C. C., Huguenard, J. R., & Kim, S. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00405 · Cited by 69
Diniz, C. R. A. F., & Crestani, A. P. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01931-x · Cited by 77
Homeostatic synaptic scaling establishes the specificity of an associative memory
Wu, C.-H., Ramos, R., Katz, D. B., & Turrigiano, G. G. (2021) · Current Biology · doi:10.1016/j.cub.2021.03.024 · Cited by 63
Self-citationMcCartney, A. J., Zolov, S. N., Kauffman, E. J., Zhang, Y., Strunk, B. S., Weisman, L. S., & Sutton, M. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411117111 · Cited by 69
Schanzenbächer, C. T., Langer, J. D., & Schuman, E. M. (2018) · eLife · doi:10.7554/elife.33322 · Cited by 63
Vlachos, A., Becker, D., Jedlička, P., Winkels, R., Roeper, J., & Deller, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032883 · Cited by 61
Activity-regulated RNA editing in select neuronal subfields in hippocampus
Balík, A., Penn, A. C., Nemoda, Z., & Greger, I. H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1045 · Cited by 59
Synaptic clustering during development and learning: the why, when, and how
Winnubst, J., & Löhmann, C. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00070 · Cited by 60
Gainey, M. A., Tatavarty, V., Nahmani, M., Lin, H. K., & Turrigiano, G. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510754112 · Cited by 55
Self-citationDevelopmental Regulation of Homeostatic Plasticity in Mouse Primary Visual Cortex
Wen, W., & Turrigiano, G. G. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1200-21.2021 · Cited by 51
Self-citationRubio, F. J., Ampuero, E., Sandoval, R., Toledo, J., Pancetti, F., & Wyneken, U. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00066 · Cited by 54
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Metadata
- Authors
- Gainey, M. A., Hurvitz-Wolff, J. R., Lambo, M. E., & Turrigiano, G. G.
- Affiliations
- Brandeis University (US)
- Corresponding author
- Turrigiano, Gina G.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-05-20
- Volume
- 29
- Issue
- 20
- Pages
- 6479-6489
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2714274
- OpenAlex
- W2011046807
- Cited by
- 234
- References
- 52
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 11 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 13 · 2019: 10 · 2018: 19 · 2017: 11 · 2016: 14 · 2015: 7 · 2014: 12 · 2013: 30 · 2012: 22
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NS 36853)
- National Institute of Neurological Disorders and Stroke (NS 36853, R56NS036853, F31NS063532, R01NS036853)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- synaptic scaling, GluR2 subunit, AMPA receptors, long-term potentiation, homeostatic plasticity, receptor trafficking, GluR1, visual cortex, visual deprivation, tetrodotoxin, synaptic plasticity
- MeSH terms
- Disks Large Homolog 4 Protein, Adamantane, Analysis of Variance, Animals, Animals, Newborn, Biophysics, Cells, Cultured, Electric Stimulation, Membrane Proteins, Neurons, Synapses, Tetrodotoxin, Transfection, Visual Cortex, Long-Term Potentiation, Receptors, AMPA, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Rats, Long-Evans, Sodium Channel Blockers, RNA Interference, RNA, Small Interfering, Intracellular Signaling Peptides and Proteins, Rats, In Vitro Techniques
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