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Oxytocin Makes a Face in Memory Familiar
Open accessAbstract
Social recognition is the basis of all social interactions. Here, we show that, in humans, the evolutionarily highly conserved neuropeptide oxytocin, after intranasal administration, specifically improves recognition memory for faces, but not for nonsocial stimuli. With increased oxytocin levels, previously presented faces were more correctly assessed as “known,” whereas the ability of recollecting faces was unchanged. This pattern speaks for an immediate and selective effect of the peptide strengthening neuronal systems of social memory.
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“Administering oxytocin enhances recognition of face identities, but not nonsocial stimuli (Rimmele et al. 2009)”
From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Rimmele et al. 2009
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“Furthermore, oxytocin administration has been shown to enhance memory for social but not non-social stimuli (Rimmele et al., 2009).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Rimmele et al., 2009
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“Indeed, previous published OT studies have also compared images of landscapes to faces [16], [34].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [34]
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In the citing paper
“other scholars reported that OT increased generosity (5)”
From Is there a Publication Bias in Behavioural Intranasal Oxytocin Research on Humans? Opening the File Drawer of One Laboratory (2016) · cites this paper as [5]
Experimental — accuracy not yet measuredIn the citing paper
“improving social and emotion recognition (Domes et al, 2007b;Guastella et al, 2008;Rimmele et al, 2009)”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Rimmele et al, 2009
In the citing paper
“Researchers found that IN-OT increases cooperation and social trust in others (Kosfeld et al. 2005), increases envy and schadenfreude in situations of loss (Shamay-Tsoory et al. 2009), enhances mind-reading capacities (Domes et al. 2007b), increases memory for faces (Rimmele et al. 2009), and improves emotion recognition (Schulze et al. 2011).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Rimmele et al. 2009
In the citing paper
“OT administration has been shown to enhance recognition of faces but not non-social stimuli [34]”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [34]
In the citing paper
“However, it is worth noting that previous studies have shown that the enhancing effect of OT nasal spray on the processing of faces is independent of the sex of stimuli faces [10], [34], [12].”
From A direct examination of the effect of intranasal administration of oxytocin on approach-avoidance motor responses to emotional stimuli (2013) · cites this paper as [34]
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Metadata
- Authors
- Rimmele, U., Hediger, K., Heinrichs, M., & Klaver, P.
- Affiliations
- University of Zurich (CH)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-01-07
- Volume
- 29
- Issue
- 1
- Pages
- 38-42
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6664913
- OpenAlex
- W2118287087
- Cited by
- 402
- References
- 46
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 11 · 2023: 13 · 2022: 20 · 2021: 20 · 2020: 16 · 2019: 16 · 2018: 18 · 2017: 24 · 2016: 15 · 2015: 31 · 2014: 32 · 2013: 52 · 2012: 35
- FWCI
- 49.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Research Bank (Australian Catholic University) (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- edoc (University of Basel) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (114788, 118850)
- Universität Zürich (PP001-114788)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, face memory, social memory, intranasal administration, recollection, familiarity, neuropeptides, social cognition
- MeSH terms
- Affect, Analysis of Variance, Attention, Double-Blind Method, Face, Humans, Male, Oxytocin, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Sex Factors, Wakefulness, Recognition, Psychology, Young Adult
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