Contextual novelty changes reward representations in the striatum
Open accessAbstract
Reward representation in ventral striatum is boosted by perceptual novelty, although the mechanism of this effect remains elusive. Animal studies indicate a functional loop (Lisman and Grace, 2005) that includes hippocampus, ventral striatum, and midbrain as being important in regulating salience attribution within the context of novel stimuli. According to this model, reward responses in ventral striatum or midbrain should be enhanced in the context of novelty even if reward and novelty constitute unrelated, independent events. Using fMRI, we show that trials with reward-predictive cues and subsequent outcomes elicit higher responses in the striatum if preceded by an unrelated novel picture, indicating that reward representation is enhanced in the context of novelty. Notably, this effect was observed solely when reward occurrence, and hence reward-related salience, was low. These findings support a view that contextual novelty enhances neural responses underlying reward representation in the striatum and concur with the effects of novelty processing as predicted by the model of Lisman and Grace (2005).
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The human SN/VTA is activated by rewards.
“Such studies (e.g. [48, 51]) have demonstrated that the human SN/VTA is activated by rewards, a finding confirmed by a recent study using electrophysiological recordings [52].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [51]
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- Authors
- Guitart-Masip, M., Bunzeck, N., Stephan, K. E., Dolan, R. J., & Düzel, E.
- Affiliations
- University College London (GB)
- Wellcome Centre for Human Neuroimaging (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-02-03
- Volume
- 30
- Issue
- 5
- Pages
- 1721-1726
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2838369
- OpenAlex
- W2082907353
- Cited by
- 104
- References
- 41
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 10 · 2014: 12 · 2013: 13 · 2012: 9
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Wellcome Trust (81259, 078865)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- reward representation, ventral striatum, salience attribution, reward-predictive cues, novelty processing, hippocampus, midbrain
- MeSH terms
- Adult, Basal Ganglia, Exploratory Behavior, Female, Humans, Magnetic Resonance Imaging, Male, Reference Values, Reward, Young Adult
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