Oxytocin Modulates Neural Reactivity to Children's Faces as a Function of Social Salience
Open accessAbstract
Oxytocin (OT) enhances social behaviors such as attachment and parental caretaking. Neural correlates of maternal attachment are found in reward-related brain regions, for example, in the globus pallidus (GP). The present work investigates the effects of OT on the neural correlates of parental attachment. Fathers viewed pictures of their own child (oC), a familiar child (fC), and an unfamiliar child (uC) after intranasal application of OT vs placebo. OT reduced activation and functional connectivity of the left GP with reward- and attachment-related regions responsive to pictures of the oC and the uC. The present results emphasize the key role of OT in human parental attachment and suggest that OT reduces neural reactivity to social cues as a function of social salience. Our results together with previous findings speak to a selective reduction of neural reactivity to social stimuli, irrespective of their valence. We argue that one major pathway by which OT exerts its positive effects on affiliative and social behaviors is the attenuation of automatic neural responses, which in turn leads to increased approach behaviors and decreased social avoidance.
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When fathers view their children's faces, fMRI scanning shows activation of the ventral striatum and the oxytocin-associated hypothalamus/pituitary region, areas that correspond with reward and attachment.
“When fathers view their children’s faces, fMRI scanning shows activation of the ventral striatum and the oxytocin-associated hypothalamus/pituitary region, areas that correspond with reward and attachment.”
From The evolved nest, oxytocin functioning, and prosocial development (2023) · cites this paper as Wittfoth-Schardt et al. (2012)
The Discussion (page unavailable) says fathers activated reward- and attachment-related regions, specifically the left globus pallidus, when viewing pictures of their own children. The Familiarity Effects in Fathers Under PL section also reports increased activation in the medial orbitofrontal cortex and ventral tegmental area, but our copy does not report the claimed activation of the ventral striatum or hypothalamus/pituitary region. (LLM, conf=0.88)
Experimental — accuracy not yet measuredParental recognition of their child's signals is related to brain circuits that belong to a reward system saturated with oxytocin receptors.
“This may be due to the fact that parental recognition of their child’s signals is related to brain circuits that belong to a reward system saturated with oxytocin receptors (Wittfoth-Schardt et al., 2012).”
From The evolved nest, oxytocin functioning, and prosocial development (2023) · cites this paper as Wittfoth-Schardt et al. (2012)
Previous studies examining functional connectivity during tasks show enhanced connectivity in women but decreased connectivity in men.
“For example, previous studies examining functional connectivity during tasks show enhanced connectivity in women but decreased connectivity in men.47, 50”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [50]
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“This may be due to the fact that parental recognition of their child’s signals is related to brain circuits that belong to a reward system saturated with oxytocin receptors (Wittfoth-Schardt et al., 2012).”
Backgroundvan ‘t Veer, A. E., Thijssen, S., Witteman, J., van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz018 · Cited by 25 · see citing works
Oxytocin effects on self-referential processing: behavioral and neuroimaging evidence
Liu, Y., Wu, B., Wang, X., Li, W., Zhang, T., Wu, X., & Han, S. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx116 · Cited by 15 · see citing works
- Authors
- Wittfoth-Schardt, D., Gründing, J., Wittfoth, M., Lanfermann, H., Heinrichs, M., Domes, G., Buchheim, A., Gündel, H., & Waller, C.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- University of Freiburg (DE)
- Universität Innsbruck (AT)
- Universität Ulm (DE)
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2012-04-18
- Volume
- 37
- Issue
- 8
- Pages
- 1799-1807
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3376330
- OpenAlex
- W2136034271
- Cited by
- 139
- References
- 62
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 15 · 2020: 12 · 2019: 7 · 2018: 15 · 2017: 12 · 2016: 16 · 2015: 14 · 2014: 12 · 2013: 10 · 2012: 2
- FWCI
- 18.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, parental attachment, children's faces, social salience, globus pallidus, neural reactivity, functional connectivity, reward processing, fathers, social behavior, social avoidance
- MeSH terms
- Administration, Intranasal, Adult, Child, Preschool, Double-Blind Method, Face, Fathers, Globus Pallidus, Humans, Magnetic Resonance Imaging, Male, Object Attachment, Oxytocin, Photic Stimulation, Placebos, Visual Perception, Recognition, Psychology, Functional Neuroimaging
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