Cited by 516Infant Nutrition and HealthGut microbiota and healthBreastfeeding Practices and Influences

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Development and Differences of Intestinal Flora in the Neonatal Period in Breast-Fed and Bottle-Fed Infants

Yoshioka, Hajime, Iseki, Ken-ichi, Fujita, Kozo·1983·PEDIATRICS

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Abstract

The development of stool bacterial flora was studied in breast-fed and bottle-fed infants. In both groups of infants, the intestine was first colonized with enterobacteria and their number attained 10(9) per gram of feces. On day 6, bifidobacteria were the predominant organisms in the stool of breast-fed infants, exceeding enterobacteria by a ratio of 1,000:1, whereas enterobacteria were the predominant organisms in formula-fed infants, exceeding bifidobacteria by approximately 10:1. At 1 month of age, bifidobacteria were the most prevalent organisms in both groups but the number of these organisms in the stool of bottle-fed infants was approximately one tenth that of breast-fed infants. The properties of breast milk that promote the growth of bifidobacteria and suppress the growth of coliform and other potentially pathogenic organisms, theoretically, would help to minimize the incidence of neonatal diseases caused by these organisms. The results would support the advantages of breast-feeding for optimal care of newborn infants.

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Authors: Yoshioka, H., Iseki, K.-I., & Fujita, K.
Affiliations: Asahikawa Medical University (JP)
From the Department of Pediatrics, Asahikawa Medical College, Asahikawa, Japan
Venue: PEDIATRICS
Publisher: American Academy of Pediatrics (AAP)
Published: 1983-09-01
Volume: 72
Issue: 3
Pages: 317-321
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.72.3.317
OpenAlex: W1600123260
Cited by: 516
References: 0
Citations by year: 2026: 5 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 12 · 2021: 19 · 2020: 19 · 2019: 12 · 2018: 15 · 2017: 10 · 2016: 15 · 2015: 22 · 2014: 22 · 2013: 24 · 2012: 27
FWCI: 5.92
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Epidemiology › Breastfeeding Practices and Influences
Keywords: gut microbiota, neonatal period, breastfeeding, bottle feeding, Bifidobacterium, Enterobacteriaceae, coliform bacteria, infant stool, breast milk
MeSH terms: Bottle Feeding, Breast Feeding, Enterobacteriaceae, Feces, Gram-Negative Anaerobic Bacteria, Humans, Infant, Newborn, Intestines, Lactobacillus acidophilus

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Development and Differences of Intestinal Flora in the Neonatal Period in Breast-Fed and Bottle-Fed Infants

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