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Cited by 170Attention Deficit Hyperactivity DisorderBehavioral and Psychological StudiesDevelopmental and Educational Neuropsychology

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Sustained Release and Standard Methylphenidate Effects on Cognitive and Social Behavior in Children With Attention Deficit Disorder

Pelham, William E., Sturges, James, Hoza, JoAnn, Schmidt, Casey, Bijlsma, Jan Jaap, Milich, Richard, Moorer, Sam·1987·PEDIATRICS
DOI 10.1542/peds.80.4.491
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Abstract

Two studies were conducted to investigate the relative effects of sustained release methylphenidate (Ritalin [SR-20]) and standard methylphenidate (Ritalin, 10 mg, administered twice daily). In the first study, 13 boys with attention deficit disorder participating in a summer treatment program went through a double-blind, within-subject trial of each form of methylphenidate and placebo. Measures of social and cognitive behavior were gathered in classroom and play settings. Although group analyses of the data showed that both drugs were effective and there were few differences between them, standard methylphenidate was superior to SR-20 on several important measures of disruptive behavior. Furthermore, analyses of individual responsivity showed clearly that most boys responded more positively to standard methylphenidate than to SR-20. The second study involved a partially overlapping group of nine boys with attention deficit disorder participating in the same summer treatment program. Also double-blind, within-subject, and placebo controlled, this study tracked the time courses of the two forms of methylphenidate. Both were shown to have similar time courses on the Abbreviated Conners Rating Scale and other measures, but SR-20 had a slower onset than did the standard drug form on a continuous performance task. Effects of SR-20 were still evident eight hours after ingestion.

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Metadata

Authors
Pelham, W. E., Sturges, J., Hoza, J., Schmidt, C., Bijlsma, J. J., Milich, R., & Moorer, S.
Affiliations
Florida State University (US)
ORCID
Venue
PEDIATRICS
Publisher
American Academy of Pediatrics (AAP)
Published
1987-10-01
Volume
80
Issue
4
Pages
491-501
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.80.4.491
OpenAlex
W2158421224
Cited by
167
References
0
Citations by year
2025: 2 · 2023: 2 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 5 · 2013: 5 · 2012: 5
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
  • UKnowledge (University of Kentucky) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
Keywords
methylphenidate, attention deficit disorder, children, cognitive behavior, social behavior, disruptive behavior, drug formulation comparison, time course of drug effects, continuous performance test, Conners rating scales, summer treatment program
MeSH terms
Attention Deficit Disorder with Hyperactivity, Child, Cognition, Delayed-Action Preparations, Double-Blind Method, Humans, Male, Methylphenidate, Random Allocation, Social Behavior, Task Performance and Analysis, Time Factors

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