Aggrecan: Beyond cartilage and into the brain

Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex

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Structure and function of aggrecan

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Perineuronal Nets Protect Fear Memories from Erasure

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Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity

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Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

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Extracellular matrix of the central nervous system: from neglect to challenge

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Perineuronal nets provide a polyanionic, glia‐associated form of microenvironment around certain neurons in many parts of the rat brain

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Aggrecan Glycoforms Contribute to the Molecular Heterogeneity of Perineuronal Nets

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Cortical neurons immunoreactive for the potassium channel Kv3.1b subunit are predominantly surrounded by perineuronal nets presumed as a buffering system for cations

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The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein– protein interactions independent of carbohydrate moiety

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Sensory Deprivation Alters Aggrecan and Perineuronal Net Expression in the Mouse Barrel Cortex

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Expression of neural proteoglycans correlates with the acquisition of mature neuronal properties in the mammalian brain

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Perineuronal nets potentially protect against oxidative stress

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Proteoglycans of articular cartilage: Changes in aging and in joint disease

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Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican.

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Perineuronal net formation and structure in aggrecan knockout mice

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Cortical areas abundant in extracellular matrix chondroitin sulphate proteoglycans are less affected by cytoskeletal changes in Alzheimer's disease

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A family of activity-dependent neuronal cell-surface chondroitin sulfate proteoglycans in cat visual cortex

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Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology

Morawski, M., Brückner, G., Jäger, C., Seeger, G., Matthews, R. T., & Arendt, T. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00557.x · Cited by 157 · see citing works

Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease

Morawski, M., Brückner, G., Jäger, C., Seeger, G., & Arendt, T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.022 · Cited by 156 · see citing works

Extracellular matrix molecules, their receptors, and secreted proteases in synaptic plasticity

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Axon initial segment ensheathed by extracellular matrix in perineuronal nets

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From barriers to bridges: chondroitin sulfate proteoglycans in neuropathology

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A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis

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Mouse aggrecan, a large cartilage proteoglycan: protein sequence, gene structure and promoter sequence

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Rat and human cartilage proteoglycan (aggrecan) gene structure

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Advances in the development of novel aggrecanase inhibitors

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Aggrecan-based extracellular matrix shows unique cortical features and conserved subcortical principles of mammalian brain organization in the Madagascan lesser hedgehog tenrec (Echinops telfairi Martin, 1838)

Morawski, M., Brückner, G., Jäger, C., Seeger, G., Künzle, H., & Arendt, T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.018 · Cited by 28 · see citing works

The Binding of Iron to Perineuronal Nets: A Combined Nuclear Microscopy and Mössbauer Study

Morawski, M., Reinert, T., Brückner, G., Wagner, F. E., Arendt, T. H., & Tröger, W. (2005) · Hyperfine Interactions · doi:10.1007/s10751-005-9116-1 · Cited by 12 · see citing works

Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R

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Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

Iozzo, R. V., & Schaefer, L. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.02.003 · Cited by 1,264 · see citing works

Fluid transport in the brain

Rasmussen, M. K., Mestre, H., & Nedergaard, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00031.2020 · Cited by 622 · see citing works

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

Fawcett, J. W., Oohashi, T., & Pizzorusso, T. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0196-3 · Cited by 589 · see citing works

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics

Karamanos, N. K., Piperigkou, Z., Theocharis, A. D., Watanabe, H., Franchi, M., Baud, S., Brézillon, S., Götte, M., Passi, A. G., Vigetti, D., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00354 · Cited by 372 · see citing works

Very long-term memories may be stored in the pattern of holes in the perineuronal net

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Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity

Rowlands, D., Lensjø, K. K., Dinh, T., Yang, S., Andrews, M. R., Hafting, T., Fyhn, M., Fawcett, J. W., & Dick, G. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1122-18.2018 · Cited by 204 · see citing works

Neural stem cell differentiation into mature neurons: Mechanisms of regulation and biotechnological applications

Vieira, M. S., Santos, A. K., Vasconcellos, R., Goulart, V. A. M., Parreira, R. C., Kihara, A. H., Ulrich, H., & Resende, R. R. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.08.002 · Cited by 191 · see citing works

Circulating myeloid-derived MMP8 in stress susceptibility and depression

Cathomas, F., Lin, H.-Y., Chan, K. L., Li, L., Parise, L. F., Alvarez, J., Durand-de Cuttoli, R., Aubry, A. V., Muhareb, S., Desland, F., et al. (2024) · Nature · doi:10.1038/s41586-023-07015-2 · Cited by 189 · see citing works

Chondroitin sulfate proteoglycans: Key modulators in the developing and pathologic central nervous system

Dyck, S. M., & Karimi‐Abdolrezaee, S. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.006 · Cited by 189 · see citing works

Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress

Suttkus, A., Rohn, S., Weigel, S., Glöckner, P., Arendt, T., & Morawski, M. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.25 · Cited by 168 · see citing works

Formation and remodeling of the brain extracellular matrix in neural plasticity: Roles of chondroitin sulfate and hyaluronan

Miyata, S., & Kitagawa, H. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.010 · Cited by 171 · see citing works

Primary Hippocampal Neurons, Which Lack Four Crucial Extracellular Matrix Molecules, Display Abnormalities of Synaptic Structure and Function and Severe Deficits in Perineuronal Net Formation

Geissler, M., Gottschling, C., Aguado, A., Rauch, U., Wetzel, C. H., Hatt, H., & Faissner, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3275-12.2013 · Cited by 140 · see citing works

The perineuronal net component of the extracellular matrix in plasticity and epilepsy

McRae, P. A., & Porter, B. E. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.08.007 · Cited by 143 · see citing works

Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory

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The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain

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Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets

Dzyubenko, E., Gottschling, C., & Faissner, A. (2016) · Neural Plasticity · doi:10.1155/2016/5214961 · Cited by 134 · see citing works

Extracellular matrix protein expression is brain region dependent

Dauth, S., Grevesse, T., Pantazopoulos, H., Campbell, P. H., Maoz, B. M., Berretta, S., & Parker, K. K. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.23965 · Cited by 134 · see citing works

Seasonal and Regional Differences in Gene Expression in the Brain of a Hibernating Mammal

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Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix

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“GAG-ing with the neuron”: The role of glycosaminoglycan patterning in the central nervous system

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Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan

Morawski, M., Dityatev, A., Hartlage-Rübsamen, M., Blosa, M., Holzer, M., Flach, K., Pavlica, S., Dityateva, G., Grosche, J., Brückner, G., et al. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0046 · Cited by 100 · see citing works

Chondroitin Sulfate Proteoglycans: Structure-Function Relationship with Implication in Neural Development and Brain Disorders

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Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries

Suna, G., Wojakowski, W., Lynch, M., Barallobre‐Barreiro, J., Yin, X., Mayr, U., Baig, F., Lu, R., Fava, M., Hayward, R., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.023381 · Cited by 103 · see citing works

Perineuronal net degradation in epilepsy

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Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer’s disease.

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Neuroprotection against iron-induced cell death by perineuronal nets - an in vivo analysis of oxidative stress.

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Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis

Stephenson, E. L., Mishra, M. K., Moussienko, D., Laflamme, N., Rivest, S., Ling, C., & Yong, V. W. (2018) · Brain · doi:10.1093/brain/awy033 · Cited by 85 · see citing works

Enriched housing enhances recovery of limb placement ability and reduces aggrecan-containing perineuronal nets in the rat somatosensory cortex after experimental stroke.

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Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome

Lovelace, J. W., Rais, M., Palacios, A. R., Shuai, X. S., Bishay, S., Popa, O., Pirbhoy, P. S., Binder, D. K., Nelson, D. L., Ethell, I. M., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz141 · Cited by 81 · see citing works

Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity

Hayes, A. J., & Melrose, J. (2020) · Biomolecules · doi:10.3390/biom10091244 · Cited by 77 · see citing works

Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan

Miyata, S., & Kitagawa, H. (2016) · Neural Plasticity · doi:10.1155/2016/1305801 · Cited by 70 · see citing works

Keratan sulfate ( KS )‐proteoglycans and neuronal regulation in health and disease: the importance of KS ‐glycodynamics and interactive capability with neuroregulatory ligands

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Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease

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Aggrecan Nanoscale Solid–Fluid Interactions Are a Primary Determinant of Cartilage Dynamic Mechanical Properties

Nia, H. T., Lin Han, B., Soltani, I., Roughley, P. J., Youcef‐Toumi, K., Grodzinsky, A. J., & Ortiz, C. (2015) · ACS Nano · doi:10.1021/nn5062707 · Cited by 67 · see citing works

The Role of Extracellular Matrix in Human Neurodegenerative Diseases

Pintér, P., & Alpár, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911085 · Cited by 66 · see citing works

Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration

Yang, S., Hilton, S., Alves, J. N., Saksida, L. M., Bussey, T., Matthews, R. T., Kitagawa, H., Spillantini, M. G., Kwok, J. C. F., & Fawcett, J. W. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.002 · Cited by 61 · see citing works

Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats

Alonge, K. M., Mirzadeh, Z., Scarlett, J. M., Logsdon, A. F., Brown, J. M., Cabrales, E., Chan, C. K., Kaiyala, K. J., Bentsen, M. A., Banks, W. A., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00275-6 · Cited by 63 · see citing works

Molecular heterogeneity of aggrecan-based perineuronal nets around five subclasses of parvalbumin-expressing neurons in the mouse hippocampus.

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Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate

Hayes, A. J., & Melrose, J. (2018) · Biochemical Journal · doi:10.1042/bcj20180283 · Cited by 58 · see citing works

Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep

Härtig, W., Mages, B., Aleithe, S., Nitzsche, B., Altmann, S., Barthel, H., Krueger, M., & Michalski, D. (2017) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2017.00015 · Cited by 53 · see citing works

Glycan susceptibility factors in autism spectrum disorders

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L yme disease spirochaetes possess an aggrecan‐binding protease with aggrecanase activity

Russell, T. M., & Johnson, B. J. B. (2013) · Molecular Microbiology · doi:10.1111/mmi.12276 · Cited by 50 · see citing works

Perineuronal Nets in Spinal Motoneurones: Chondroitin Sulphate Proteoglycan around Alpha Motoneurones

Irvine, S., & Kwok, J. C. F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041172 · Cited by 49 · see citing works

Perineuronal and perisynaptic extracellular matrix in the human spinal cord

Jäger, C., Lendvai, D., Seeger, G., Brückner, G., Matthews, R. T., Arendt, T., Alpár, A., & Morawski, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.014 · Cited by 48 · see citing works

Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex

Ueno, H., Fujii, K., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Aoki, S., Okamoto, M., Ishihara, T., & Takao, K. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.01.002 · Cited by 47 · see citing works

Sensory experience-dependent formation of perineuronal nets and expression of Cat-315 immunoreactive components in the mouse somatosensory cortex

Ueno, H., Suemitsu, S., Okamoto, M., Matsumoto, Y., & Ishihara, T. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.041 · Cited by 45 · see citing works

A Fully 3D Interconnected Graphene–Carbon Nanotube Web Allows the Study of Glioma Infiltration in Bioengineered 3D Cortex‐Like Networks

Xiao, M., Li, X., Song, Q., Zhang, Q., Lazzarino, M., Cheng, G., Severino, F. P. U., & Torre, V. (2018) · Advanced Materials · doi:10.1002/adma.201806132 · Cited by 45 · see citing works

Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function

Mariga, A., Zavadil, J., Ginsberg, S. D., & Chao, M. V. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22216 · Cited by 43 · see citing works

Extracellular matrix modulation is driven by experience-dependent plasticity during stroke recovery.

Quattromani, M. J., Pruvost, M., Guerreiro, C., Backlund, F., Englund, E., Aspberg, A., Jaworski, T., Hakon, J., Ruscher, K., Kaczmarek, L., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0461-2 · Cited by 39 · see citing works

Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology

Luca, C. D., & Papa, M. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.04.002 · Cited by 39 · see citing works

Quantitative analysis of chondroitin sulfate disaccharides from human and rodent fixed brain tissue by electrospray ionization-tandem mass spectrometry

Alonge, K. M., Logsdon, A. F., Murphree, T. A., Banks, W. A., Keene, C. D., Edgar, J. S., Whittington, D., Schwartz, M. W., & Guttman, M. (2019) · Glycobiology · doi:10.1093/glycob/cwz060 · Cited by 38 · see citing works

Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets

Sonntag, M., Blosa, M., Schmidt, S., Reimann, K., Blum, K., Eckrich, T., Seeger, G., Hecker, D., Schick, B., Arendt, T., et al. (2018) · BMC Biology · doi:10.1186/s12915-018-0566-8 · Cited by 38 · see citing works

Neurocan Contributes to Perineuronal Net Development

Schmidt, S., Arendt, T., Morawski, M., & Sonntag, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.06.040 · Cited by 36 · see citing works

The Role of Extracellular Matrix Components in the Spreading of Pathological Protein Aggregates

Moretto, E., Stuart, S., Surana, S., Vargas, J. N. S., & Schiavo, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.844211 · Cited by 32 · see citing works

Loss of Interneuron-Derived Collagen XIX Leads to a Reduction in Perineuronal Nets in the Mammalian Telencephalon

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Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity

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Hyalectanase Activities by the ADAMTS Metalloproteases

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Aggrecan modulates the expression and phosphorylation of tau in a novel bigenic TauP301L ‐ Acan mouse model

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Characterization of the Striatal Extracellular Matrix in a Mouse Model of Parkinson’s Disease

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Comparative Genomic Analysis Identifies Great–Ape–Specific Structural Variants and Their Evolutionary Relevance

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Biological variation of human aggrecan ARGS neoepitope in synovial fluid and serum in early-stage knee osteoarthritis and after knee injury

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Early ablation of Ccr2 in aggrecan-expressing cells following knee injury ameliorates joint damage and pain during post-traumatic osteoarthritis

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Label-free fluorescence lifetime spectroscopy detects radiation-induced necrotic changes in live brain in real-time

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Under the ECM Dome: The Physiological Role of the Perinodal Extracellular Matrix as an Ion Diffusion Barrier

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Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity

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Perineuronal net formation and structure in aggrecan knockout mice

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