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Cited by 253Biochemical Analysis and Sensing TechniquesDiet, Metabolism, and DiseasePancreatic function and diabetes

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load

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Pepino, M. Yanina, Tiemann, Courtney D., Patterson, Bruce W., Wice, Burton M., Klein, Samuel·2013·Diabetes Care
DOI 10.2337/dc12-2221PMC PMC3747933
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Abstract

OBJECTIVE: Nonnutritive sweeteners (NNS), such as sucralose, have been reported to have metabolic effects in animal models. However, the relevance of these findings to human subjects is not clear. We evaluated the acute effects of sucralose ingestion on the metabolic response to an oral glucose load in obese subjects. RESEARCH DESIGN AND METHODS: Seventeen obese subjects (BMI 42.3 ± 1.6 kg/m(2)) who did not use NNS and were insulin sensitive (based on a homeostasis model assessment of insulin resistance score ≤ 2.6) underwent a 5-h modified oral glucose tolerance test on two separate occasions preceded by consuming either sucralose (experimental condition) or water (control condition) 10 min before the glucose load in a randomized crossover design. Indices of β-cell function, insulin sensitivity (SI), and insulin clearance rates were estimated by using minimal models of glucose, insulin, and C-peptide kinetics. RESULTS: Compared with the control condition, sucralose ingestion caused 1) a greater incremental increase in peak plasma glucose concentrations (4.2 ± 0.2 vs. 4.8 ± 0.3 mmol/L; P = 0.03), 2) a 20 ± 8% greater incremental increase in insulin area under the curve (AUC) (P < 0.03), 3) a 22 ± 7% greater peak insulin secretion rate (P < 0.02), 4) a 7 ± 4% decrease in insulin clearance (P = 0.04), and 5) a 23 ± 20% decrease in SI (P = 0.01). There were no significant differences between conditions in active glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide, glucagon incremental AUC, or indices of the sensitivity of the β-cell response to glucose. CONCLUSIONS: These data demonstrate that sucralose affects the glycemic and insulin responses to an oral glucose load in obese people who do not normally consume NNS.

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Figure 1 Mean plasma glucose (A), insulin (B), C-peptide (C), and glucagon (D) concentrations in obese subjects after drinking either sucralose or water 10 min before ingestion of a 75-g glucose load (given at time = 0 min). *Value significantly different from corresponding water condition value, P < 0.004.
Figure 1 Mean plasma glucose (A), insulin (B), C-peptide (C), and glucagon (D) concentrations in obese subjects after drinking either sucralose or water 10 min before ingestion of a 75-g glucose load (given at time = 0 min). *Value significantly different from corresponding water condition value, P < 0.004.CC BY-NC-ND · PubMed Central
Figure 2 Mean plasma GIP (A) and active GLP-1 (B) concentrations in obese subjects after drinking either sucralose or water 10 min before ingestion of a 75-g glucose load (given at time = 0 min).
Figure 2 Mean plasma GIP (A) and active GLP-1 (B) concentrations in obese subjects after drinking either sucralose or water 10 min before ingestion of a 75-g glucose load (given at time = 0 min).CC BY-NC-ND · PubMed Central
Figure 3 ISR in response to a glucose load after subjects drank either sucralose 10 min before ingestion of 75 g glucose (given at time = 0 min). Total ISR (A) and ISRdynamic and ISRstatic components (B). *Value significantly different from corresponding water condition value, P < 0.002.
Figure 3 ISR in response to a glucose load after subjects drank either sucralose 10 min before ingestion of 75 g glucose (given at time = 0 min). Total ISR (A) and ISRdynamic and ISRstatic components (B). *Value significantly different from corresponding water condition value, P < 0.002.CC BY-NC-ND · PubMed Central

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Metadata

Authors
Pepino, M. Y., Tiemann, C. D., Patterson, B. W., Wice, B. M., & Klein, S.
Affiliations
  • Washington University in St. Louis (US)
  • Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri
Corresponding author
Klein, Samuel
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2013-08-13
Volume
36
Issue
9
Pages
2530-2535
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc12-2221
PMC
PMC3747933
OpenAlex
W2111548886
Cited by
253
References
34
Citations by year
2026: 19 · 2025: 17 · 2024: 23 · 2023: 17 · 2022: 16 · 2021: 15 · 2020: 36 · 2019: 17 · 2018: 26 · 2017: 25 · 2016: 17 · 2015: 12 · 2014: 6 · 2013: 6
FWCI
12.63
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetes Care (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (KL2TR000450, UL1TR000448, DK56341, TR000448)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK37948, DK56341, DK088126, R01DK088126, R01DK037948, P30DK056341, P30DK020579)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
sucralose, artificial sweeteners, oral glucose tolerance, glycemic response, insulin secretion, insulin sensitivity, insulin clearance, beta-cell function, obesity, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, glucagon, insulin resistance
MeSH terms
Adult, Blood Glucose, Female, Glucose Tolerance Test, Humans, Insulin, Male, Obesity, Sucrose, Cross-Over Studies

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