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Cited by 1,401

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

Schreck, Ralf, Albermann, Kaj, Baeuerle, Patrick A.·1992·Free Radical Research Communications
DOI 10.3109/10715769209079515
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Abstract

NF-kappa B is a multiprotein complex that can activate a great variety of genes involved in early defence reactions of higher organisms. In nonstimulated cells, NF-kappa B resides in the cytoplasm in an inactive complex with the inhibitor I kappa B. Pathogenic stimuli cause release of I kappa B and allow NF-kappa B to enter the nucleus, bind to DNA control elements and, thereby, induce the synthesis of mRNA. A puzzling feature of NF-kappa B is that its activation is triggered by a great variety of agents. These include the cytokines interleukin-1 and tumor necrosis factor, viruses, double-stranded RNA, endotoxins, phorbol esters, UV light and ionizing radiation. We recently found that also low concentrations of H2O2 activate NF-kappa B and that various antioxidants prevent the induction by H2O2. Subsequent analysis revealed that antioxidants not only suppress the activation of NF-kappa B by H2O2 but by all other inducers tested so far. In this review, we will discuss the evidences that NF-kappa B is an oxidative stress-responsive transcription factor of higher eukaryotic cells.

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Metadata

Authors
Schreck, R., Albermann, K., & Baeuerle, P. A.
Venue
Free Radical Research Communications
Publisher
Informa UK Limited
Published
1992-01
Volume
17
Issue
4
Pages
221-237
ISSN
8755-0199 (ISSN-L)
DOI
10.3109/10715769209079515
OpenAlex
W2204123985
Cited by
1,401
References
4
FWCI
23.84
Type
journal article
Language
en
Open access
closed

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