Increased xanthine oxidase in the thalamus and putamen in depression

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works

The Metabolic and Molecular Bases of Inherited Disease

Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101 · see citing works

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062 · see citing works

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399 · see citing works

Biological effects of the superoxide radical

Fridovich, I. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90526-6 · Cited by 1,422 · see citing works

Neuroimaging studies of mood disorders

Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,313 · see citing works

Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications

Berry, C. E., & Hare, J. M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.055913 · Cited by 925 · see citing works

Structure and function of xanthine oxidoreductase: where are we now?

Harrison, R. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00956-5 · Cited by 787 · see citing works

The anatomy of mood disorders—review of structural neuroimaging studies

Soares, J. C., & Mann, J. J. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00006-6 · Cited by 760 · see citing works

Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments

Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works

Neuroimaging studies of mood disorder effects on the brain

Sheline, Y. I. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00347-0 · Cited by 660 · see citing works

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

Petrone, W. F., English, D. K., Wong, K. L., & McCord, J. M. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.2.1159 · Cited by 616 · see citing works

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

Zweier, J. L., Kuppusamy, P., & Lutty, G. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4046 · Cited by 601 · see citing works

Elevated Monoamine Oxidase A Levels in the Brain: An Explanation for the Monoamine Imbalance of Major Depression

Meyer, J. H., Ginovart, N., Boovariwala, A., Sagrati, S., Hussey, D., Garcia, A., Young, T., Praschak-Rieder, N., Wilson, A. A., & Houle, S. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1209 · Cited by 585 · see citing works

Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients

Peet, M., Murphy, B., Shay, J., & Horrobin, D. F. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00206-0 · Cited by 578 · see citing works

Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems

Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., & Kirli, S. (2007) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.829 · Cited by 486 · see citing works

3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity

Sheline, Y. I. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00994-x · Cited by 485 · see citing works

Oxidative stress: Free radical production in neural degeneration

Götz, M. E., Künig, G., Riederer, P. F., & Youdim, M. B. H. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)90055-8 · Cited by 479 · see citing works

Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors

Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458 · see citing works

A Selective Increase in Particulate Superoxide Dismutase Activity in Parkinsonian Substantia Nigra

Saggu, H. K., Cooksey, J., Dexter, D. T., Wells, F. R., Lees, A. J., Jenner, P. G., & MARSDEN, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb11759.x · Cited by 454 · see citing works

Superoxide as an intracellular radical sink

Winterbourn, C. C. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90512-s · Cited by 365 · see citing works

Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes

Grünblatt, E., Mandel, S. A., Jacob‐Hirsch, J., Zeligson, S., Amariglo, N., Rechavi, G., Li, J., Ravid, R., Roggendorf, W., Riederer, P. F., et al. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0212-1 · Cited by 358 · see citing works

Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.

Akaike, T., Ando, M., Oda, T., Doi, T., Ijiri, S., Araki, S., & Maeda, H. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114499 · Cited by 333 · see citing works

Adenosine Deaminase, Nitric Oxide, Superoxide Dismutase, and Xanthine Oxidase in Patients with Major Depression: Impact of Antidepressant Treatment

Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.005 · Cited by 322 · see citing works

Molybdenum-containing hydroxylases

Hille, R. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.08.012 · Cited by 319 · see citing works

Dual Effects of Antioxidants in Neurodegeneration: Direct Neuroprotection against Oxidative Stress and Indirect Protection via Suppression of Gliamediated Inflammation

Wang, J.-Y., Wen, L. L., Huang, Y.-N., Chen, Y.-T., & Ku, M.-C. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206778343109 · Cited by 250 · see citing works

Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism

Zoroğlu, S. S., Armutçu, F., Özen, Ş., Gürel, A., Sivaslı, E., Yetkin, O., & Meram, İ. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0456-7 · Cited by 235 · see citing works

Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder—A postmortem study

Michel, T. M., Frangou, S., Thiemeyer, D., Camara, S., Jecel, J., Nara, K., Brunklaus, A., Zoechling, R., & Riederer, P. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.04.013 · Cited by 218 · see citing works

Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: A voxel-based morphometry study

Vasić, N., Walter, H., Höse, A., & Wolf, R. C. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.11.011 · Cited by 215 · see citing works

The Conversion of Xanthine Dehydrogenase to Xanthine Oxidase and the Role of the Enzyme in Reperfusion Injury1

Nishino, T. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124480 · Cited by 212 · see citing works

Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity.

Terada, L. S., Guidot, D. M., Leff, J. A., Willingham, I. R., Hanley, M. E., Piermattei, D., & Repine, J. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3362 · Cited by 207 · see citing works

Reduced Volume of Limbic System–Affiliated Basal Ganglia in Mood Disorders: Preliminary Data From a Postmortem Study

Baumann, B., Danos, P., Krell, D., Diekmann, S., Leschinger, A., Stauch, R., Wurthmann, C., Bernstein, H.-G., & Bogerts, B. (1999) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.11.1.71 · Cited by 198 · see citing works

Mood effects on limbic blood flow correlate with emotional self-rating: A PET study with oxygen-15 labeled water

Schneider, F., Gur, R. E., Mozley, L. H., Smith, R. J., Mozley, P. D., Censits, D. M., Alavi, A., & Gur, R. C. (1995) · Psychiatry Research: Neuroimaging · doi:10.1016/0925-4927(95)02678-q · Cited by 188 · see citing works

Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder

Milak, M. S., Parsey, R. V., Keilp, J. G., Oquendo, M. A., Malone, K. M., & Mann, J. J. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.397 · Cited by 177 · see citing works

Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria.

Ichida, K., Amaya, Y., Kamatani, N., Nishino, T., Hosoya, T., & Sakai, O. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119421 · Cited by 153 · see citing works

Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): Structural analysis of the protein and chromosomal location of the gene

Ichida, K., Amaya, Y., Nöda, K., Shinsei, M., Hosoya, T., Sakai, O., Shimizu, N., & Takeshi, N. (1993) · Gene · doi:10.1016/0378-1119(93)90652-j · Cited by 144 · see citing works

Xanthine oxidase produces hydrogen peroxide which contributes to reperfusion injury of ischemic, isolated, perfused rat hearts.

Brown, J. M., Terada, L. S., Grosso, M. A., Whitmann, G. J., Velasco, S. E., Patt, A., Harken, A. H., & Repine, J. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113448 · Cited by 137 · see citing works

Magnetic-resonance morphometry in patients with major depression

Parashos, I. A., Tupler, L. A., Blitchington, T. F., & Krishnan, K. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00042-0 · Cited by 130 · see citing works

Changes in brain metabolism associated with remission in unipolar major depression

Holthoff‐Detto, V., Beuthien‐Baumann, B., Zündorf, G., Triemer, A., Lüdecke, S., Winiecki, P., Koch, R., Füchtner, F., & Herholz, K. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2004.00351.x · Cited by 127 · see citing works

Oxidative Stress Kills Human Primary Oligodendrocytes Via Neutral Sphingomyelinase: Implications for Multiple Sclerosis

Jana, A., & Pahan, K. (2007) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-007-9066-2 · Cited by 125 · see citing works

Human liver xanthine oxidase: Nature and extent of individual variation

Guerciolini, R., Szumlanski, C. L., & Weinshilboum, R. M. (1991) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1991.205 · Cited by 116 · see citing works

Generation of superoxide anion by brain endothelial cell xanthine oxidase

Terada, L. S., Willingham, I. R., Rosandich, M. E., Leff, J. A., Kindt, G. W., & Repine, J. E. (1991) · Journal of Cellular Physiology · doi:10.1002/jcp.1041480202 · Cited by 99 · see citing works

Tell Me about Free Radicals, Doctor: A Review

Halliwell, B. B. (1989) · Journal of the Royal Society of Medicine · doi:10.1177/014107688908201216 · Cited by 96 · see citing works

MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals

Caetano, S. C., Sassi, R. B., Brambilla, P., Harenski, K. A., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00123-8 · Cited by 91 · see citing works

Cu, Zn- and Mn-superoxide dismutase levels in brains of patients with schizophrenic psychosis

Michel, T. M., Thome, J., Martin, D., Keinosuke, N. A. R. A., Zwerina, S., Tatschner, T., Weijers, H. ‐., & Koutsilieri, E. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0160-9 · Cited by 89 · see citing works

Investigations on oxidative stress and therapeutical implications in dementia

Durany, N., Münch, G. W., Michel, T. M., & Riederer, P. F. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/pl00014177 · Cited by 88 · see citing works

Degeneration of neuronal cells due to oxidative stress—microglial contribution

Koutsilieri, E., Scheller, C., Tribl, F., & Riederer, P. F. (2002) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(02)00021-4 · Cited by 81 · see citing works

Neurobiology of Non-REM Sleep in Depression: Further Evidence for Hypofrontality and Thalamic Dysregulation

Germain, A., Nofzinger, E. A., Kupfer, D. J., & Buysse, D. J. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1856 · Cited by 80 · see citing works

Changes in regional cerebral blood flow during acute electroconvulsive therapy in patients with depression

Takano, H., Motohashi, N., Uema, T., Ogawa, K., Ohnishi, T., Nishikawa, M., Kashima, H., & Matsuda, H. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.023036 · Cited by 80 · see citing works

Age-related increase in xanthine oxidase activity in human plasma and rat tissues

Aranda, R., Domènech, E. B., Rus, A. D., Real, J. T., Sastre, J., Viña, J., & Pallardó, F. V. (2007) · Free Radical Research · doi:10.1080/10715760701481461 · Cited by 72 · see citing works

Nitric oxide, adenosine deaminase, xanthine oxidase and superoxide dismutase in patients with panic disorder: alterations by antidepressant treatment

Herken, H., Akyol, Ö., Yılmaz, H. R., Tutkun, H., SAVAS, H. A., Özen, M. E., Kalenderoğlu, A., & Güleç, M. (2005) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.742 · Cited by 69 · see citing works

Regional cerebral blood flow in depressed patients with white matter magnetic resonance hyperintensity

Oda, K., Okubo, Y., Ishida, R., Murata, Y., Ohta, K., Matsuda, T., Matsushima, E., Ichimiya, T., Suhara, T., Shibuya, H., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01548-2 · Cited by 66 · see citing works

Molecular Cloning, Tissue Expression of Human Xanthine Dehydrogenase

Xu, P., Huecksteadt, T. P., Harrison, R., & Hoidal, J. R. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2482 · Cited by 60 · see citing works

Xanthine Oxidoreductase Gene Expression and Enzyme Activity in Developing Human Tissues

Saksela, M., Lapatto, R., & Raivio, K. O. (1998) · Neonatology · doi:10.1159/000014034 · Cited by 59 · see citing works

How to run a brain bank. A report from the Austro-German brain bank

Gsell, W., Lange, K. W., Pfeuffer, R., Heckers, S., Heinsen, H., Senitz, D., Jellinger, K. A., Ransmayr, G. N., Wichart, I., & Vock, R. (1993) · PubMed · doi:10.5283/epub.25424 · Cited by 58 · see citing works

XDH gene mutation is the underlying cause of classical xanthinuria: A second report

Levartovsky, D., Lagziel, A., Sperling, O., Liberman, U. A., Yaron, M., Hosoya, T., Ichida, K., & Peretz, H. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00082.x · Cited by 58 · see citing works

Maternal and fetal plasma adenosine deaminase, xanthine oxidase and malondialdehyde levels in pre‐eclampsia

Karabulut, A. B., Kafkaslı, A., Burak, F., & Gözükara, E. M. (2004) · Cell Biochemistry and Function · doi:10.1002/cbf.1152 · Cited by 56 · see citing works

Mutational analysis of the xanthine dehydrogenase gene in a Turkish family with autosomal recessive classical xanthinuria

Gök, F. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg385 · Cited by 51 · see citing works

Molecular Cloning, Tissue Expression of Human Xanthine Dehydrogenase

Xu, P., Huecksteadt, T. P., Harrison, R., & Hoidal, J. R. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1328 · Cited by 51 · see citing works

Oxidative-stress associated parameters (lactoferrin, superoxide dismutases) in serum of patients with Alzheimer's disease

Thome, J., Gsell, W., Rösier, M., Kornhuber, J., Frölich, L., Hashimoto, E., Zielke, B., Wiesbeck, G. A., & Riedcrer, P. (1996) · Life Sciences · doi:10.1016/s0024-3205(96)00583-8 · Cited by 50 · see citing works

A population phenotyping study of three drug‐metabolizing enzymes in Kyushu, Japan, with use of the caffeine test

Saruwatari, J., Nakagawa, K., Shindo, J., Tajiri, T., Fujieda, M., Yamazaki, H., Kamataki, T., & Ishizaki, T. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.126173 · Cited by 47 · see citing works

Identification of a new point mutation in the human xanthine dehydrogenase gene responsible for a case of classical type I xanthinuria

Sakamoto, N., Yamamoto, T., Moriwaki, Y., Teranishi, T., Toyoda, M., Onishi, Y., Kuroda, S., Sakaguchi, K., Fujisawa, T., Maeda, M., et al. (2001) · Human Genetics · doi:10.1007/s004390100477 · Cited by 42 · see citing works

Two Siblings with Classical Xanthinuria Type 1: Significance of Allopurinol Loading Test.

Ichida, K., Yoshida, M., Sakuma, R., & Hosoya, T. (1998) · Internal Medicine · doi:10.2169/internalmedicine.37.77 · Cited by 41 · see citing works

Phagomimetic Action of Antimicrobial Agents

Gutteridge, J. M. C., Quinlan, G. J., & Kovacic, P. (1998) · Free Radical Research · doi:10.3109/10715769809097871 · Cited by 40 · see citing works

Mapping of the gene for human xanthine dehydrogenase (oxidase) (XDH) to band p23 of chromosome 2

Minoshima, S., Wang, Y., Ichida, K., Nishino, T., & Shimizu, N. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000133887 · Cited by 38 · see citing works

Assignment of Human Xanthine Dehydrogenase Gene to Chromosome 2p22

Xu, P., Zhu, X. L., Huecksteadt, T. P., Brothman, A. R., & Hoidal, J. R. (1994) · Genomics · doi:10.1006/geno.1994.1498 · Cited by 35 · see citing works

Oxidative stress related markers in the “VITA” and the centenarian projects

Grünblatt, E., Schlosser, R. J., Fischer, P. A., Fischer, M. O., Li, J., Koutsilieri, E., Wichart, I., Sterba, N., Rujescu, D., Møller, H. J., et al. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.001 · Cited by 32 · see citing works

Pathogenesis of Parkinson's disease

Riederer, P., & Lange, K. W. (1992) · PubMed · doi:10.5283/epub.25428 · Cited by 28 · see citing works

Pregnancy in and incidence of xanthine oxidase deficiency

HARKNESS, R. A., McCreanor, G. M., Simpson, D., & MacFadyen, I. R. (1986) · Journal of Inherited Metabolic Disease · doi:10.1007/bf01800499 · Cited by 28 · see citing works

Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression

Ende, G., Demirakça, T., Walter, S., Wokrina, T., Sartorius, A., Wildgruber, D., & Henn, F. A. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-0680-4 · Cited by 18 · see citing works

[Free radical processes and antioxidant system in depression and treatment efficiency].

Lukash, A. I., Григорьевич, З. В., Kucherenko, A. O., & Np, M. (2002) · PubMed · Cited by 18 · see citing works

THE USE OF THE XANTHINE OXIDASE INHIBITOR, ALLOPURINOL, IN THE CONTROL OF HYPERURICÆMIA, GOUT AND URIC ACID CALCULI

Emmerson, B. T. (1967) · Australasian Annals of Medicine · doi:10.1111/imj.1967.16.3.205 · Cited by 11 · see citing works

Regional cerebral blood flow in the patients with depressive disorders.

Murata, T., Suzuki, R., Higuchi, T., & Oshima, A. (2000) · PubMed · Cited by 8 · see citing works

What's New in Neuropsychiatry

Yudofsky, S. C., & Hales, R. E. (1999) · Journal of Neuropsychiatry · doi:10.1176/jnp.11.1.1 · Cited by 5 · see citing works

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140 · see citing works

Role of oxidative stress in depression

Bhatt, S., Nagappa, A. N., & Patil, C. R. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.05.001 · Cited by 839 · see citing works

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805 · see citing works

Recent progress in the development of fluorescent probes for imaging pathological oxidative stress

Geng, Y., Wang, Z., Zhou, J., Zhu, M., Liu, J., & James, T. D. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00172a · Cited by 359 · see citing works

Markers of Oxidative Stress and Neuroprogression in Depression Disorder

Vaváková, M., Ďuračková, Z., & Trebatická, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/898393 · Cited by 324 · see citing works

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325 · see citing works

Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity: Supplementary Issue: Brain Plasticity and Repair

Beckhauser, T. F., Francis-Oliveira, J., & De Pasquale, R. (2016) · Journal of Experimental Neuroscience · doi:10.4137/jen.s39887 · Cited by 301 · see citing works

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga, I., Niedzielska, E., Gawlik, M., Moniczewski, A., Krzek, J., Przegaliński, E., Pera, J., & Filip, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.015 · Cited by 252 · see citing works

Depression uncouples brain hate circuit

Tao, H., Guo, S., Ge, T., Kendrick, K. M., Xue, Z., Liu, Z., & Feng, J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.127 · Cited by 254 · see citing works

Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression

Behl, T., Rana, T., Alotaibi, G., Shamsuzzaman, M., Naqvi, M., Sehgal, A., Singh, S., Sharma, N., Almoshari, Y., Abdellatif, A. A. H., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112545 · Cited by 230 · see citing works

Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder

Behr, G. A., Moreira, J. C. F., & Frey, B. N. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/609421 · Cited by 205 · see citing works

Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study

Guo, W., Liu, F., Xue, Z., Xu, X., Wu, R., Ma, C., Wooderson, S. C., Tan, C., Sun, X., Chen, J., et al. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.01.011 · Cited by 180 · see citing works

Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis / chronic fatigue syndrome.

Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2009) · PubMed · Cited by 157 · see citing works

Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease

Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.12.014 · Cited by 144 · see citing works

The volumetric and shape changes of the putamen and thalamus in first episode, untreated major depressive disorder

Lü, Y., Liang, H., Han, D., Mo, Y., Li, Z., Cheng, Y., Xu, X., Shen, Z., Tan, C., Zhao, W. D., et al. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.04.008 · Cited by 144 · see citing works

Oxidative stress markers in affective disorders

Siwek, M., Sowa-Kućma, M., Dudek, D., Styczeń, K., Szewczyk, B., Kotarska, K., Misztak, P., Pilc, A., Wolak, M., & Nowak, G. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71517-2 · Cited by 142 · see citing works

Neuroimmune, metabolic and oxidative stress pathways in major depressive disorder

Maes, M. H. J., Almulla, A. F., You, Z., & Zhang, Y. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-025-01116-4 · Cited by 134 · see citing works

Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets

Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works

An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways

Maes, M. H. J. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.023 · Cited by 93 · see citing works

Major Depressive Disorder and Oxidative Stress: A Review of Peripheral and Genetic Biomarkers According to Clinical Characteristics and Disease Stages

Tayeb, A. E. K. A., Poinsignon, V., Chappell, K., Bouligand, J., Becquemont, L., & Verstuyft, C. (2023) · Antioxidants · doi:10.3390/antiox12040942 · Cited by 100 · see citing works

Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments

Morris, G., Puri, B. K., OLIVE, L. S., Carvalho, A. F., Berk, M., Walder, K. R., Gustad, L. T., & Maes, M. H. J. (2020) · BMC Medicine · doi:10.1186/s12916-020-01749-w · Cited by 83 · see citing works

Epigenetics and cerebral organoids: promising directions in autism spectrum disorders

Forsberg, S. L., Ilieva, M. S., & Michel, T. M. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0062-x · Cited by 79 · see citing works

Emerging Role of Flavonoids as the Treatment of Depression

Pannu, A. S., Sharma, P. C., Thakur, V. K., & Goyal, R. K. (2021) · Biomolecules · doi:10.3390/biom11121825 · Cited by 80 · see citing works

Targeting inflammation: a potential approach for the treatment of depression

Bhatt, S., Devadoss, T., Jha, N. K., Baidya, M., Gupta, G., Chellappan, D. K., Singh, S. K., & Dua, K. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01095-1 · Cited by 81 · see citing works

Altered glial cell line-derived neurotrophic factor (GDNF) concentrations in the brain of patients with depressive disorder: A comparative post-mortem study

Michel, T. M., Frangou, S., Camara, S., Thiemeyer, D., Jecel, J., Tatschner, T., Zoechling, R., & Grünblatt, E. (2008) · European Psychiatry · doi:10.1016/j.eurpsy.2008.06.001 · Cited by 78 · see citing works

Role of endoplasmic reticulum stress in depression (Review)

Mao, J., Hu, Y., Ruan, L., Ji, Y., & Lou, Z. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10789 · Cited by 74 · see citing works

Difference in amplitude of low-frequency fluctuation between currently depressed and remitted females with major depressive disorder

Jing, B., Liu, C.-H., Ma, X., Yan, H., Zhuo, Z., Zhang, Y., Wang, S.-H., Li, J., & Wang, C. (2013) · Brain Research · doi:10.1016/j.brainres.2013.09.039 · Cited by 72 · see citing works

Inflammation as the Common Biological Link Between Depression and Cardiovascular Diseases: Can Carnosine Exert a Protective Role?

Caruso, G., Fresta, C. G., Grasso, M., Santangelo, R., Lazzarino, G., Lunte, S. M., & Caraci, F. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190712091515 · Cited by 74 · see citing works

The significance of routine biochemical markers in patients with major depressive disorder

Peng, Y.-F., Xiang, Y., & Wei, Y.-S. (2016) · Scientific Reports · doi:10.1038/srep34402 · Cited by 70 · see citing works

Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review

Cecerska-Heryć, E., Polikowska, A., Serwin, N., Roszak, M., Grygorcewicz, B., Heryć, R., Michalczyk, A., & Dołęgowska, B. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2021.105269 · Cited by 68 · see citing works

DNA Damage in Major Psychiatric Diseases

Raza, M. U., Tufan, T., Wang, Y., Hill, C. P., & Zhu, M. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9621-9 · Cited by 67 · see citing works

Lactobacillus paracasei CCFM1229 and Lactobacillus rhamnosus CCFM1228 Alleviated Depression- and Anxiety-Related Symptoms of Chronic Stress-Induced Depression in Mice by Regulating Xanthine Oxidase Activity in the Brain

Xu, M., Tian, P., Zhu, H., Zou, R., Zhao, J., Zhang, H., Wang, G., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14061294 · Cited by 65 · see citing works

Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis

Li, X., Wu, T., Yu, Z., Li, T., Zhang, J., Zhang, Z., Cai, M., Zhang, W., Xiang, J. Y., & Cai, D. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.137 · Cited by 64 · see citing works

The molecular aspects of oxidative & nitrosative stress and the tryptophan catabolites pathway (TRYCATs) as potential causes of depression

Wigner, P., Czarny, P. L., Gałecki, P., Su, K., & Śliwiński, T. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.09.045 · Cited by 64 · see citing works

Purinergic Signaling and Related Biomarkers in Depression

Bartoli, F., Burnstock, G., Crocamo, C., & Carrà, G. (2020) · Brain Sciences · doi:10.3390/brainsci10030160 · Cited by 64 · see citing works

Chronic clomipramine treatment restores hippocampal expression of glial cell line-derived neurotrophic factor in a rat model of depression

Liu, Q., Zhu, H., Li, B., Wang, Y.-Q., Yu, J. M., & Wu, G.-C. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.03.018 · Cited by 57 · see citing works

Altered neuronal spontaneous activity correlates with glutamate concentration in medial prefrontal cortex of major depressed females: An fMRI-MRS study

Zhang, X., Tang, Y., Maletić‐Savatić, M., Sheng, J., Zhang, X., Zhu, Y., Zhang, T., Wang, J., Tong, S., Wang, J., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.014 · Cited by 55 · see citing works

Flavonols in Action: Targeting Oxidative Stress and Neuroinflammation in Major Depressive Disorder

Jembrek, M. J., Oršolić, N., Karlović, D., & Peitl, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086888 · Cited by 54 · see citing works

The Reactive Species Interactome in the Brain

Malard, E., Valable, S., Bernaudin, M., Pérès, E. A., & Châtre, L. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8238 · Cited by 46 · see citing works

Variation of genes involved in oxidative and nitrosative stresses in depression

Wigner, P., Czarny, P. L., Synowiec, E., Bijak, M., Białek, K. I., Talarowska, M. E., Gałecki, P., Szemraj, J., & Śliwiński, T. (2018) · European Psychiatry · doi:10.1016/j.eurpsy.2017.10.012 · Cited by 48 · see citing works

Synergist effects of n-acetylcysteine and deferoxamine treatment on behavioral and oxidative parameters induced by chronic mild stress in rats

Arent, C. O., Réus, G. Z., Abelaira, H. M., Ribeiro, K. F., Steckert, A. V., Mina, F., Dal‐Pizzol, F., & Quevedo, J. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.07.024 · Cited by 45 · see citing works

Unraveling the Microbial Mechanisms Underlying the Psychobiotic Potential of a Bifidobacterium breve Strain

Tian, P., Bastiaanssen, T. F. S., Song, L., Jiang, B., Zhang, X., Zhao, J., Zhang, H., Chen, W., Cryan, J. F., & Wang, G. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000704 · Cited by 43 · see citing works

Expression of oxidative stress-response genes is not activated in the prefrontal cortex of patients with depressive disorder

Teyssier, J.-R., Ragot, S., Chauvet-Gélinier, J.-C., Trojak, B., & Bonin, B. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2010.07.030 · Cited by 39 · see citing works

Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways

Ditzen, C., Varadarajulu, J., Czibere, L., Gonik, M., Targosz, B., Hambsch, B., Bettecken, T., Kessler, M. S., Frank, E., Bunck, M., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.146 · Cited by 39 · see citing works

The effect of 12-wk ω-3 fatty acid supplementation on in vivo thalamus glutathione concentration in patients “at risk” for major depression

Duffy, S. L., Lagopoulos, J., Cockayne, N. L., Lewis, S. J. G., Hickie, I. B., Hermens, D. F., & Naismith, S. L. (2015) · Nutrition · doi:10.1016/j.nut.2015.04.019 · Cited by 37 · see citing works

A systematic review of noninflammatory cerebrospinal fluid biomarkers for clinical outcome in neonates with perinatal hypoxic brain injury that could be biologically significant

Shi, Z., Luo, K., Deol, S., & Tan, S. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24801 · Cited by 36 · see citing works

Abnormal coupling among spontaneous brain activity metrics and cognitive deficits in major depressive disorder

Zhu, J., Zhang, Y., Zhang, B., Yang, Y., Wang, Y., Zhang, C., Zhao, W., Zhu, D., & Yu, Y. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.030 · Cited by 35 · see citing works

Unveiling the Anti-Inflammatory Effects of Antidepressants: A Systematic Review of Human Studies over the Last Decade

Bleibel, L., Sokołowska, P., Henrykowska, G. A., Owczarek, J., & Wiktorowska‐Owczarek, A. (2025) · Pharmaceuticals · doi:10.3390/ph18060867 · Cited by 34 · see citing works

Targeting Xanthine Oxidase by Natural Products as a Therapeutic Approach for Mental Disorders

Martorell, M., Lucas, X., Alarcón, P., Capó, X., Quetglas‐Llabrés, M. M., Tejada, S., & Sureda, A. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200621165839 · Cited by 36 · see citing works

Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress

Wigner, P., Synowiec, E., Czarny, P. L., Bijak, M., Jóźwiak, P., Szemraj, J., Gruca, P., Papp, M., & Śliwiński, T. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15231 · Cited by 30 · see citing works

Prophylactic treatment of curcumin in a rat model of depression by attenuating hippocampal synaptic loss

Fan, C., Li, Y., Lan, T., Wang, W., Mao, X., & Yu, S. Y. (2021) · Food & Function · doi:10.1039/d1fo02676c · Cited by 29 · see citing works

Antioxidant-Like Effects and Protective Action of Transcranial Magnetic Stimulation in Depression Caused by Olfactory Bulbectomy

Tasset, I., Drucker-Colı́n, R., Peña, J., Jimena, I., Montilla, P., Medina-Fernández, F. J., & Túnez, I. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0172-9 · Cited by 28 · see citing works

Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice

Lima, E. B. C., de Sousa, C. N. S., Vasconcelos, G. S., Meneses, L. N., Pereira, Y. F. E. S., Ximenes, N. C., Júnior, M. A. S., Matos, N. C. B., Brito, R., Miron, D., et al. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-0970-8 · Cited by 27 · see citing works

Antioxidant Capacity and Behavioral Relevance of a Polyphenolic Extract of Chrysanthellum americanum in a Rat Model of Irritable Bowel Syndrome

Cojocariu, R. O., Ciobica, A. S., Balmuș, I.-M., Guenné, S., Trifan, A. V., Stanciu, C., Hrițcu, L. D., & Lefter, R. M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3492767 · Cited by 27 · see citing works

Xanthine oxidase mediates chronic stress-induced cerebrovascular dysfunction and cognitive impairment

Burrage, E. N., Coblentz, T., Prabhu, S. S., Childers, R., Bryner, R. W., Lewis, S. E., DeVallance, E., Kelley, E. E., & Chantler, P. D. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231152551 · Cited by 27 · see citing works

In vitro multimodal-effect of Trichilia catigua A. Juss. (Meliaceae) bark aqueous extract in CNS targets

Bernardo, J., Ferreres, F., Gil‐Izquierdo, Á., Videira, R. A., Valentão, P., Veiga, F., & Andrade, P. B. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.09.039 · Cited by 25 · see citing works

Xenobiotic transport and metabolism in the human brain

Silva‐Adaya, D., Garza-Lombó, C., & Gonsebatt, M. E. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.08.004 · Cited by 24 · see citing works

Biochemical and histological alterations of doxorubicin‐induced neurotoxicity in rats: Protective role of luteolin

Imosemi, I. O., Owumi, S. E., & Arunsi, U. O. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22962 · Cited by 24 · see citing works

Myelin deficits in patients with recurrent major depressive disorder: An inhomogeneous magnetization transfer study

Hou, G., Lai, W., Jiang, W., Liu, X., Qian, L., Zhang, Y., & Zhou, Z. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135768 · Cited by 22 · see citing works

The Changes of Expression and Methylation of Genes Involved in Oxidative Stress in Course of Chronic Mild Stress and Antidepressant Therapy with Agomelatine

Wigner, P., Synowiec, E., Jóźwiak, P., Czarny, P. L., Bijak, M., Barszczewska-Pietraszek, G., Białek, K. I., Szemraj, J., Gruca, P., Papp, M., et al. (2020) · Genes · doi:10.3390/genes11060644 · Cited by 20 · see citing works

Medicinal plants and plant-based traditional medicine: Alternative treatments for depression and their potential mechanisms of action

Remali, J., & Aizat, W. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38986 · Cited by 20 · see citing works

Serum ApoB levels in depressive patients: associated with cognitive deficits

Hui, L., Han, M., Du, X., Zhang, B. H., He, S. C., Shao, T. N., & Yin, G. (2017) · Scientific Reports · doi:10.1038/srep39992 · Cited by 19 · see citing works

Serum NOX1 and Raftlin as new potential biomarkers of Major Depressive Disorder: A study in treatment-naive first episode patients

Hursitoglu, O., Kurutas, E. B., Strawbridge, R., Oner, E., Gungor, M., Tuman, T. C., & Uygur, O. F. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110670 · Cited by 18 · see citing works

p53 promote oxidative stress, neuroinflammation and behavioral disorders via DDIT4-NF-κB signaling pathway

Zhang, K., Zhao, Y., Chen, X., Li, Y., Lan, T., Chang, M., Wang, W., Wang, C., Zhuang, X., Zhang, B., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103836 · Cited by 17 · see citing works

Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways

Motafeghi, F. S., Bagheri, A., Seyedabadi, M., Shaki, F., & Shokrzadeh, M. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00603-6 · Cited by 17 · see citing works

Trazodone generates m-CPP: In 2008 risks from m-CPP might outweigh benefits of trazodone

Kast, R. E. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970902836022 · Cited by 17 · see citing works

Distance-dependent alterations in local functional connectivity in drug-naive major depressive disorder

Zhu, J., Lin, X., Lin, C., & Zhuo, C. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.10.009 · Cited by 16 · see citing works

Association of dietary overall antioxidant intake with all-cause and cause-specific mortality among adults with depression: evidence from NHANES 2005–2018

Wang, W., Shi, Y., Zhang, J., Wang, Y., Wabo, T. M. C., Yang, Y., He, W., & Zhu, S. (2024) · Food & Function · doi:10.1039/d4fo00236a · Cited by 13 · see citing works

Sertoli cell therapy: A novel possible treatment strategy for treatment-resistant major depressive disorder

Loftis, J. M. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.03.017 · Cited by 11 · see citing works

Cognitive dysfunction and neurometabolic alternations in major depressive disorder with gastrointestinal symptoms

Huang, X., Lai, S., Lü, X., Wang, Y., Zhang, Y., Chen, G., Chen, P., Ye, K., Duan, M., Song, K., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.10.036 · Cited by 10 · see citing works

Neural substrates of rewarding and punishing self representations in depressed suicide-attempting adolescents

Quevedo, K. M., Teoh, J. Y., Liu, G., Santana‐Gonzalez, C., Forbes, E. E., & Engstrom, M. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.01.037 · Cited by 9 · see citing works

The role of inflammation and oxidative stress in depression and cardiovascular disease

Wood, S. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815015-3.00008-8 · Cited by 9 · see citing works

Dysfunction of the Purinergic System in Bipolar Disorder

Malewska-Kasprzak, M., Permoda‐Osip, A., & RYBAKOWSKI, J. K. (2022) · Neuropsychobiology · doi:10.1159/000520146 · Cited by 8 · see citing works

Advances of paeoniflorin in depression: the molecular mechanism and formula application

Hou, Y., Li, H., Zhu, L., Tian, Q., Feng, X., Li, Y., Bian, Y., & Wei, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1614429 · Cited by 8 · see citing works

Evaluation of thiol/disulfide homeostasis in patients with a first episode of major depressive disorder

Karaaslan, Ö., Hacımusalar, Y., Bal, C., & Ercan, M. (2019) · Medical Science and Discovery · doi:10.17546/msd.488247 · Cited by 8 · see citing works

Systematic review of optimizing brain-targeted vitamin D delivery: Novel approaches to enhance mental illness therapeutics

He, J., Gao, Z., Li, X., Zhao, L., Tian, X., & Gao, B. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149656 · Cited by 7 · see citing works

Polyphenols in food and food wastes: Extraction, isolation, and health applications

Fredsgaard, M., Fussy, A., Nybo, G. K., Papenbrock, J., Hulkko, L. S. S., Dadjoo, M., Chaturvedi, T., & Thomsen, M. H. (2026) · Food Chemistry Molecular Sciences · doi:10.1016/j.fochms.2025.100351 · Cited by 7 · see citing works

Temporal change of serum xanthine oxidase levels and its relation to clinical outcome of severe traumatic brain injury: a prospective cohort study

Yan, T., Shan, H., Wang, Z., Zou, S., Chen, Z., Yu, W., Du, Q., & Dong, X. (2023) · Neurosurgical Review · doi:10.1007/s10143-023-02233-8 · Cited by 7 · see citing works

Effect of electroconvulsive therapy on the oxidative metabolism in major depressive disorder

Şahin, Ş. K., Aybastı, Ö., Elboğa, G., & Altındağ, A. (2017) · Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi) · doi:10.17826/cutf.323838 · Cited by 7 · see citing works

An Insight through Various Models being used for Assessment of Depression and its Management at Primary Level in Current Scenario

Bee, R., Ahmad, M., & Verma, S. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220516105907 · Cited by 6 · see citing works

Balance of Antioxidants vs. Oxidants in Perinatal Asphyxia

Rallis, D., Dermitzaki, N., Baltogianni, M. S., Kapetaniou, K., & Giapros, V. I. (2024) · Applied Sciences · doi:10.3390/app14219651 · Cited by 6 · see citing works

Elevated serum xanthine oxidase activities in patients with Henoch–Schonlein purpura

Chen, T., Guo, Z., Zhang, Y., & Gao, Y. (2009) · Clinical Rheumatology · doi:10.1007/s10067-009-1253-5 · Cited by 6 · see citing works

Association between total antioxidant capacity and prevalence of depression: NHANES 2007–2018

Liu, Y., Han, Y., Gao, Y.-Q., Sun, M., Wang, F., Wu, Z., Wang, S., Dong, Y., Zhao, J., Xin, S., et al. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.11.004 · Cited by 5 · see citing works

N -Acetylcysteine-Capped TLQP21-Containing Au Nanocages Alleviate Depression in Mice

Shi, M., Li, X., Fan, Z., Wang, Y., Li, C., Ning, Y., Ma, Y., Sun, M., Xia, X., Du, J., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c11681 · Cited by 5 · see citing works

Associations between urinary level of bisphenol A, phthalates, 8-iso-prostaglandin-F2α, and emotional and behavioral problems among Chinese adolescents

Cui, Y., Hong, Y. C., Xu, Y., Jin, Z., Ji, Y., Liu, Y., Zhao, L., & Ren, L. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.07.040 · Cited by 5 · see citing works

Magnetic resonance spectroscopy biomarkers of anti-inflammatory interventions in mood disorders: A systematic review of clinical trials

Valizadeh, P., Jannatdoust, P., Bagherieh, S., Cattarinussi, G., Squarcina, L., Maleki, S., Sambataro, F., Barone, Y., & Delvecchio, G. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119661 · Cited by 4 · see citing works

The Role of Various Types of Diets in the Treatments of Depressive Disorders

Lis, A., Maj, P., Świętek, A., & Romuk, E. B. (2025) · Medicina · doi:10.3390/medicina61101737 · Cited by 5 · see citing works

Thiol/Disulfide Homeostasis: A Potential New Peripheral Biomarker in Adolescent Depression

Öztürk, M., Özkan, Y., Sapmaz, Ş. Y., Erdal, S., Taneli, F., & Kandemır, H. (2024) · Psychiatry and Clinical Psychopharmacology · doi:10.5152/pcp.2024.23744 · Cited by 4 · see citing works

The Gender‐Specific Interaction of DVL3 and GSK3β Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case‐Control Study

Ke, S., Li, J., Zhao, L., Yang, J., Zhao, X., Zhang, W., Qiu, X., Yang, X., Zhou, J., Tong, Y., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2633127 · Cited by 4 · see citing works

The abnormal choline to creatine ratio of the right anterior cingulate gyrus is linked to cognitive impairment in youth with major depressive disorder

Luo, S., Lai, S., Chu, L., Wang, Y., Chen, P., Ye, X., Zhuo, J., Abula, M., Liang, Y., Wei, D., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.161 · Cited by 2 · see citing works

Potential of an antioxidant combination Twendee X® to treat depressive disorders

You, F., Harakawa, Y., Toshikazu, Y., & Inufusa, H. (2023) · Archives of Depression and Anxiety · doi:10.17352/2455-5460.000083 · Cited by 2 · see citing works

An effort toward molecular neuroeconomics of food deprivation induced food hoarding in mice: focus on xanthine oxidoreductase gene expression and xanthine oxidase activity

Karimi, I., Motamedi, S., & Becker, L. A. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0166-2 · Cited by 2 · see citing works

Pathogenetic Mechanisms of Mental Disorders: Endogenous Intoxication

Uzbekov, M. G. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923040053 · Cited by 2 · see citing works

Evaluation of Antidepressant Activity of Dolichos Biflorus Methanolic Seed Extract in Animal Models of Depression

Petimani, M. S., Adake, P., & Aditya, A. (2019) · International Journal of Biochemistry and Biophysics · doi:10.13189/ijbb.2019.070101 · Cited by 2 · see citing works

Rola stresu oksydacyjnego i nitracyjnego oraz szlaku katabolitów tryptofanu w patogenezie depresji

Wigner, P., & Śliwiński, T. (2022) · Postępy Biochemii · doi:10.18388/pb.2021_436 · Cited by 1 · see citing works

Effects of Duloxetine on Oxidant-Antioxidant System in Rat Brain Tissues

KARAKUŞ, K., Demirci, K., Uz, E., YİĞİT, A., & Özçankaya, R. (2023) · Phoenix Medical Journal · doi:10.38175/phnx.1383064 · Cited by 1 · see citing works

Neuroimaging biomarkers distinguishing medication-naïve adolescents with major depressive disorder and bipolar disorder during depressive episodes

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