Cited by 118Transcranial Magnetic Stimulation StudiesElectroconvulsive Therapy StudiesTreatment of Major Depression

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A randomized double-blind sham-controlled comparison of unilateral and bilateral repetitive transcranial magnetic stimulation for treatment-resistant major depression

Blumberger, Daniel M., Mulsant, Benoit H., Fitzgerald, Paul B., Rajji, Tarek K., Ravindran, Arun V., Young, L. Trevor, Levinson, Andrea J., Daskalakis, Zafiris J.·2012·The World Journal of Biological Psychiatry

DOI 10.3109/15622975.2011.579163

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Abstract

Objectives High frequency left-sided (HFL) and low frequency right-sided (LFR) unilateral repetitive transcranial magnetic stimulation (rTMS) are efficacious in treatment-resistant major depression (TRD). Similar benefit has been suggested for sequential bilateral rTMS (LFR then HFL). There are few published reports on the efficacy of sequential bilateral rTMS compared to HFL and sham rTMS. Therefore, this study evaluated the efficacy of HFL and sequential bilateral rTMS compared to sham in TRD. Methods Subjects between the ages of 18 and 85 were recruited from a tertiary care university hospital. Seventy-four subjects with TRD and a 17-item Hamilton Depression Rating Scale (HDRS) greater than 21 were randomized to receive unilateral, bilateral, or sham rTMS. The rates of remission were compared among the three treatment groups. Results The remission rates differed significantly among the three treatment groups using a modified intention to treat analysis that excluded subjects who did not respond to electroconvulsive therapy (ECT) during the current episode. The remission rate was significantly higher in the bilateral group than the sham group. The remission rate in the unilateral group did not differ from either group. Conclusion These findings warrant larger controlled studies that compare the efficacy of sequential bilateral rTMS and HFL rTMS in TRD.

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See all 118

Authors: Blumberger, D. M., Mulsant, B. H., Fitzgerald, P. B., Rajji, T. K., Ravindran, A. V., Young, L. T., Levinson, A. J., & Daskalakis, Z. J.
Affiliations: Centre for Addiction and Mental Health (CA)
The Alfred Hospital (AU)
Corresponding author: Daskalakis, Zafiris J.
ORCID: Blumberger, Daniel M.
Mulsant, Benoit H.
Fitzgerald, Paul B.
Rajji, Tarek K.
Ravindran, Arun V.
Young, L. Trevor
Levinson, Andrea J.
Daskalakis, Zafiris J.
Venue: The World Journal of Biological Psychiatry
Publisher: Informa UK Limited
Published: 2011-07-08
Volume: 13
Issue: 6
Pages: 423-435
ISSN: 1562-2975 (ISSN-L)
1814-1412
DOI: 10.3109/15622975.2011.579163
OpenAlex: W1969447202
Cited by: 118
References: 195
Citations by year: 2026: 4 · 2025: 7 · 2024: 12 · 2023: 4 · 2022: 13 · 2021: 13 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 11 · 2015: 8 · 2014: 6 · 2013: 8 · 2012: 10
FWCI: 4.42
Type: journal article
Language: en
Open access: closed
Locations: The World Journal of Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
Ulster University
Canadian Institutes of Health Research
National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: repetitive transcranial magnetic stimulation, high-frequency rTMS, low-frequency rTMS, remission rate
MeSH terms: Adult, Aged, Major Depressive Disorder, Double-Blind Method, Female, Humans, Male, Middle Aged, Treatment Outcome, Transcranial Magnetic Stimulation, Depressive Disorder, Treatment-Resistant

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A randomized double-blind sham-controlled comparison of unilateral and bilateral repetitive transcranial magnetic stimulation for treatment-resistant major depression

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