Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections

Hetta, Helal F.; Ramadan, Yasmin N.; Al-Kadmy, Israa M. S.; Ellah, Noura H. Abd; Shbibe, Lama; Battah, Basem

doi:10.3390/pathogens12081033

Cited by 24Antifungal resistance and susceptibilityNanoparticles: synthesis and applicationsNanoparticle-Based Drug Delivery

Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections

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Hetta, Helal F., Ramadan, Yasmin N., Al-Kadmy, Israa M. S., Ellah, Noura H. Abd, Shbibe, Lama, Battah, Basem·2023·Pathogens

DOI 10.3390/pathogens12081033PMC PMC10458664

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Abstract

An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Additionally, the fungus has become resistant to decontamination techniques and can survive for weeks in a hospital environment. Nanoparticles might be a good substitute to treat illnesses brought on by this newly discovered pathogen. Nanoparticles have become a trend and hot topic in recent years to combat this fatal fungus. This review gives a general insight into the epidemiology of C. auris and infection. It discusses the current conventional therapy and mechanism of resistance development. Furthermore, it focuses on nanoparticles, their different types, and up-to-date trials to evaluate the promising efficacy of nanoparticles with respect to C. auris.

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Nanostructuring of antifungal drugs can significantly enhance their efficacy, particularly against resistant strains of Candida.
“Within this framework, recent studies indicate that the nanostructuring of antifungal drugs can significantly enhance their efficacy, particularly against resistant strains of Candida [133].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [133]

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Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies
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“Within this framework, recent studies indicate that the nano-structuring of antifungal drugs can significantly enhance their efficacy, particularly against resistant strains of Candida [133].”

First Detection of Emergent Fungal Pathogen Candida auris in Khartoum State, Sudan
Badri, A. M. (2019) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2019.06.000982 · Cited by 13 · see citing works
A synthetic construct for genetic engineering of the emerging pathogenic yeast Candida auris
Defosse, T. A., Govic, Y. L., Vandeputte, P., Courdavault, V., Clastre, M., Bouchara, J., Chowdhary, A., Giglioli‐Guivarc’h, N., & Papon, N. (2017) · Plasmid · doi:10.1016/j.plasmid.2017.11.001 · Cited by 11 · see citing works
Global emergence of a multi-drug resistant fungal pathogen, Candida auris
Britz, E., & Govender, N. P. (2016) · Southern African Journal of Infectious Diseases · doi:10.4102/sajid.v31i3.78 · Cited by 11 · see citing works
Candida auris as a significant emerging human fungal pathogen
Pruc, M., Krajsman, M. J., Feduniw, S., Szczepanski, P., Holzer, J., Jaroszewska, A., & Szarpak, Ł. (2023) · Disaster and Emergency Medicine Journal · doi:10.5603/demj.a2023.0014
Global emergence of a multi-drug resistant fungal pathogen,Candida auris
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Authors: Hetta, H. F., Ramadan, Y. N., Al-Kadmy, I. M. S., Ellah, N. H. A., Shbibe, L., & Battah, B.
Affiliations: Assiut University (EG)
Mustansiriyah University (IQ)
Badr University in Assiut (EG)
Damascus University (SY)
Syrian Private University (SY)
Corresponding author: Battah, Basem
ORCID: Hetta, Helal F.
Ramadan, Yasmin N.
Al-Kadmy, Israa M. S.
Ellah, Noura H. Abd
Battah, Basem
Venue: Pathogens
Publisher: MDPI AG
Published: 2023-08-13
Volume: 12
Issue: 8
Pages: 1033
ISSN: 2076-0817 (ISSN-L)
DOI: 10.3390/pathogens12081033
PMC: PMC10458664
OpenAlex: W4385812481
Cited by: 24
References: 157
Citations by year: 2026: 7 · 2025: 10 · 2024: 5 · 2023: 2
FWCI: 1.14
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Pathogens (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: Candida auris, multidrug resistance, nanoparticles, antifungal therapy, nosocomial infections, hospital outbreak, resistance mechanisms, immunocompromised patients

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Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections

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