Cited by 81Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsGut microbiota and health

Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer’s disease progression based on the “brain-gut” axis through multiple integrated omics

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Gu, Xinru, Zhou, Junyi, Zhou, Yanyan, Wang, Hongjie, Si, Nan, Ren, Wei, Zhao, Wei, Fan, Xiaorui +5 more·2021·Alzheimer's Research & Therapy

Abstract

Background: In recent years, excellent results have suggested an association between the “brain-gut” axis and Alzheimer’s disease (AD) progression, yet the role of the “brain-gut” axis in AD pathogenesis still remains obscure. Herein, we provided a potential link between the central and peripheral neuroinflammatory disorders in AD progression. Methods: The Morris water maze (MWM) test, immunohistochemistry, ELISA, ProcartaPlex Multiplex immunoassay, multiple LC-MS/MS methods, and the V3-V4 regions of 16S rRNA genes were applied to explore potential biomarkers. Results: In Tg-APP/PS1 mice, gut dysbiosis and lipid metabolism were highly associated with AD-like neuroinflammation. The combination of inflammatory factors (IL-6 and INF-γ), phosphatidylcholines (PCs) and SCFA-producing bacteria were expected to be early diagnostic biomarkers for AD. Huanglian Jiedu decoction (HLJDD) suppressed gut dysbiosis and the associated Aβ accumulation, harnessed neuroinflammation and reversed cognitive impairment. Conclusion: Together, our findings highlighted the roles of neuroinflammation induced by gut dysbiosis and lipid metabolism disorder in AD progression. This integrated metabolomics approach showed its potential to understand the complex mechanisms of HLJDD in the treatment of AD.

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  • Administration of a traditional Chinese medicine decoction ameliorates Aβ plaque pathology, neuroinflammation, and cognitive impairment in APP/PS1 mice, attributed to suppression of gut dysbiosis and reduction in serum levels of secondary bile acids DCA and taurohyodeoxycholic acid.

    “In another study, the administration of a traditional Chinese medicine decoction effectively ameliorated Aβ plaque pathology, neuroinflammation, and cognitive impairment in APP/PS1 mice. These beneficial effects were attributed to the suppression of gut dysbiosis and a reduction in the serum levels of secondary BAs, namely DCA and taurohyodeoxycholic acid.359”

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Research works printed but not linked: 2

  1. [94]Dinan TG Cryan JF Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration J Physiol 2016 595 489 503 10.1113/JP273106 27641441 PMC5233671 · DOI · Paper page
  2. [108]Jia W Xie G Jia W Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis Nat Rev Gastro Hepat 2017 15 111 128 10.1038/nrgastro.2017.119 PMC5899973 29018272 · DOI · Paper page

Cited by

Sorted by citations

Authors
Gu, X., Zhou, J., Zhou, Y., Wang, H., Si, N., Ren, W., Zhao, W., Fan, X., Gao, W., Wei, X., Yang, J., Bian, B., & Zhao, H.
Affiliations
  • China Academy of Chinese Medical Sciences (CN)
  • Southwest Medical University (CN)
  • National Medical Products Administration (CN)
Corresponding author
  • Bian, Baolin
  • Zhao, Haiyu
Venue
Alzheimer's Research & Therapy
Published
2021-02-12
Volume
13
Issue
1
Pages
44-44
ISSN
1758-9193 (ISSN-L)
OpenAlex
W3126337434
Cited by
81
References
110
Citations by year
2026: 13 · 2025: 14 · 2024: 21 · 2023: 16 · 2022: 14 · 2021: 3
FWCI
8.47
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s Research & Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Fund Project (NO. 81573967, NO.81974523)
  • National Science and Technology Major Projects “Major New Drugs Innovation and Development” (No. 2019ZX09201005-006-002, No. 2019ZX09201005-002-005)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Huanglian Jiedu Decoction, Alzheimer's disease, gut-brain axis, gut dysbiosis, neuroinflammation, lipid metabolism, gut microbiota, short-chain fatty acids, phosphatidylcholine, amyloid-beta deposition, cognitive impairment, biomarkers, traditional Chinese medicine
MeSH terms
Alzheimer Disease, Animals, Brain, Chromatography, Liquid, Drugs, Chinese Herbal, RNA, Ribosomal, 16S, Disease Progression, Mice, Tandem Mass Spectrometry

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