The Role of the Microbiota-Gut-Brain Axis in the Development of Alzheimer’s Disease
Open accessAbstract
Along with the increase in life expectancy in the populations of developed and developing countries resulting from better access and improved health care, the number of patients with dementia, including Alzheimer’s disease (AD), is growing. The disease was first diagnosed and described at the beginning of the 20th century. However, to this day, there is no effective causal therapy, and symptomatic treatment often improves patients’ quality of life only for a short time. The current pharmacological therapies are based mainly on the oldest hypotheses of the disease—cholinergic (drugs affecting the cholinergic system are available), the hypothesis of amyloid-β aggregation (an anti-amyloid drug was conditionally approved by the FDA in 2020), and one drug is an N-methyl-D-aspartate receptor (NMDAR) antagonist (memantine). Hypotheses about AD pathogenesis focus on the nervous system and the brain. As research progresses, it has become known that AD can be caused by diseases that have been experienced over the course of a lifetime, which could also affect other organs. In this review, we focus on the potential association of AD with the digestive system, primarily the gut microbiota. The role of diet quality in preventing and alleviating Alzheimer’s disease is also discussed. The problem of neuroinflammation, which may be the result of microbiota disorders, is also described. An important aspect of the work is the chapter on the treatment strategies for changing the microbiota, potentially protecting against the disease and alleviating its course in the initial stages.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The microbiota-gut-brain axis hypothesis suggests a bidirectional communication system between the gut and the brain, involving metabolic, endocrine, neural, and immune pathways.
“The microbiota–gut–brain axis hypothesis suggests a bidirectional communication system between the gut and the brain, involving metabolic, endocrine, neural, and immune pathways.”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [17]
Dysbiosis can lead to a compromised intestinal epithelial barrier, allowing harmful substances and microorganisms to enter the bloodstream and trigger systemic inflammation, which may affect microglia and exacerbate neuroinflammation.
“Dysbiosis, or disruption of the microbiota’s composition and functionality, can occur due to factors such as dietary changes, antibiotic use, psychosocial stress, or immune irregularities, leading to a compromised intestinal epithelial barrier.”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
Zhou, B., Li, L., Qiu, X., Wu, J., Xu, L., & Shao, W. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11203 · Cited by 58 · see citing works
RetractedSayed, N. S. E., Kandil, E. A., & Ghoneum, M. H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5525306 · Cited by 28 · see citing works
RetractedHost-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · cited 1× · see citing works
“Studies in an animal model have shown that the level of noradrenaline in the cecal in mice lacking the gut microbiota is reduced [46,47].”
BackgroundGut microbiome alterations in Alzheimer’s disease
Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137 · see citing works
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
Dominy, S. S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau3333 · Cited by 1,966 · see citing works
Neuroinflammation in Alzheimer's disease: current evidence and future directions
Calsolaro, V., & Edison, P. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726 · see citing works
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 8× · see citing works
“For example, SCFAs are produced by fermentation from dietary fiber.”
BackgroundInfluentialNeurotransmitter modulation by the gut microbiota
Strandwitz, P. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.015 · Cited by 1,527 · see citing works
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
O’Toole, P. W., & Jeffery, I. B. (2015) · Science · doi:10.1126/science.aac8469 · Cited by 1,202 · see citing works
Stress & the gut-brain axis: Regulation by the microbiome
Foster, J. A., Rinaman, L., & Cryan, J. F. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.03.001 · Cited by 1,150 · see citing works
Control of brain development, function, and behavior by the microbiome
Sampson, T. R., & Mazmanian, S. K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.011 · Cited by 1,093 · see citing works
The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009505 · Cited by 1,060 · see citing works
Kumar, D. K. V., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf1059 · Cited by 971 · see citing works
Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946 · see citing works
Chen, Y., Xu, J., & Chen, Y. (2021) · Nutrients · doi:10.3390/nu13062099 · Cited by 917 · see citing works
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
Harach, T., Marungruang, N., Duthilleul, N., Cheatham, V., Mc Coy, K. D., Frisoni, G., Neher, J. J., Fåk, F., Jucker, M., Lasser, T., et al. (2017) · Scientific Reports · doi:10.1038/srep41802 · Cited by 901 · see citing works
Brain-Gut-Microbiota Axis in Alzheimer’s Disease
Kowalski, K., & Mulak, A. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18087 · Cited by 826 · see citing works
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804 · see citing works
Human Intestinal Barrier Function in Health and Disease
König, J., Wells, J. M., Cani, P. D., García‐Ródenas, C. L., MacDonald, T. T., Mercenier, A., Whyte, J., Troost, F. J., & Brummer, R. J. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.54 · Cited by 787 · see citing works
Acute and Impaired Wound Healing
Demidova‐Rice, T. N., Hamblin, M. R., & Herman, I. M. (2012) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000416006.55218.d0 · Cited by 726 · see citing works
Asano, Y., Hiramoto, T., Nishino, R., Aiba, Y., Kimura, T., Yoshihara, K., Koga, Y., & Sudo, N. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00341.2012 · Cited by 659 · see citing works
Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., et al. (2016) · Scientific Reports · doi:10.1038/srep30028 · Cited by 655 · see citing works
Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?
Bourassa, M. W., Alim, I., Bultman, S. J., & Ratan, R. R. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.009 · Cited by 636 · see citing works
Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier
Hoyles, L., Snelling, T., Umlai, U.-K., Nicholson, J. K., Carding, S. R., Glen, R. C., & McArthur, S. (2018) · Microbiome · doi:10.1186/s40168-018-0439-y · Cited by 591 · see citing works
Sochocka, M., Donskow-Łysoniewska, K., Diniz, B. S., Kurpas, D., Brzozowska, E., & Leszek, J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1188-4 · Cited by 584 · see citing works
Garcia-Mantrana, I., Selma-Royo, M., Alcantara, C., & Collado, M. C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00890 · Cited by 574 · see citing works
Kim, C.-S., Cha, J., Sim, M., Jung, S., Chun, W. Y., Baik, H. W., & Shin, D.-M. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa090 · Cited by 551 · see citing works
Lee, W., Loo, C., Bebawy, M., Luk, F., Mason, R. S., & Rohanizadeh, R. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040002 · Cited by 539 · see citing works
Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry
Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491 · see citing works
Part 1: The Human Gut Microbiome in Health and Disease.
Bull, M. J., & Plummer, N. T. (2014) · PubMed Central · Cited by 459 · see citing works
Gut Microbiota and Inflammation
Håkansson, Å., & Molin, G. (2011) · Nutrients · doi:10.3390/nu3060637 · Cited by 454 · see citing works
Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02587-2 · Cited by 453 · see citing works
The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease
Minter, M. R., Taylor, J. M., & Crack, P. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13411 · Cited by 451 · see citing works
Tamtaji, O. R., Heidari‐Soureshjani, R., Mirhosseini, N. Z., Kouchaki, E., Bahmani, F., Aghadavod, E., Ebrahimi, M. T., & Asemi, Z. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.11.034 · Cited by 409 · see citing works
Zhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379 · see citing works
Zhan, X.-H., Stamova, B., & Sharp, F. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00042 · Cited by 335 · see citing works
Mitsou, E. K., Kakali, A., Antonopoulou, S., Mountzouris, K. C., Yannakoulia, M., Panagiotakos, D. B., & Kyriacou, A. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517001593 · Cited by 325 · see citing works
Diversity, biogenesis and function of microbial amyloids
Blanco, L. P., Evans, M. L., Smith, D. R., Badtke, M. P., & Chapman, M. R. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2011.11.005 · Cited by 320 · see citing works
Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model
Brandscheid, C., Schuck, F., Reinhardt, S., Schäfer, K.-H., Pietrzik, C. U., Grimm, M., Hartmann, T., Schwiertz, A., & Endres, K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160926 · Cited by 318 · see citing works
Gastrointestinal Tract Disorders in Older Age
Dumic, I., Nordin, T., Jecmenica, M., Lalošević, M. S., Milosavljević, T., & Milovanovic, T. (2019) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2019/6757524 · Cited by 315 · see citing works
The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease
Brothers, H. M., Gosztyla, M. L., & Robinson, S. R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00118 · Cited by 314 · see citing works
The LPS receptor (CD14) links innate immunity with Alzheimer's disease
Fassbender, K., Walter, S., Kühl, S., Landmann, R., Ishii, K., Bertsch, T., Stalder, A. K., Muehlhauser, F., Liu, Y., Ulmer, A. J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0364fje · Cited by 307 · see citing works
Tooth Loss and Periodontal Disease Predict Poor Cognitive Function in Older Men
Krall, E. A., Valencia, A., Baba, N. Z., Spiro, A., Dietrich, T., & García, R. I. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02788.x · Cited by 292 · see citing works
Bacteroides fragilis Lipopolysaccharide and Inflammatory Signaling in Alzheimer’s Disease
Lukiw, W. J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01544 · Cited by 290 · see citing works
Human gut microbiota: the links with dementia development
Alkasir, R., Li, J., Li, X., Jin, M., & Zhu, B. (2016) · Protein & Cell · doi:10.1007/s13238-016-0338-6 · Cited by 283 · see citing works
Song, M., Jin, J., Lim, J.-E., Kou, J., Pattanayak, A., Rehman, J. A., Kim, H.-D., Tahara, K., Lalonde, R., & Fukuchi, K.-I. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-92 · Cited by 273 · see citing works
Communication between gastrointestinal bacteria and the nervous system
Bravo, J. A., Julio-Pieper, M., Forsythe, P., Kunze, W., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.09.010 · Cited by 261 · see citing works
Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer’s Disease
Chang, C.-H., Lin, C.-H., & Lane, H.-Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052761 · Cited by 257 · see citing works
Alzheimer's disease and the microbiome
Bhattacharjee, S., & Lukiw, W. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00153 · Cited by 248 · see citing works
Role of neuroinflammation in neurodegeneration: new insights
McManus, R. M., & Heneka, M. T. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0241-2 · Cited by 247 · see citing works
Liu, Q., Xi, Y., Wang, Q., Liu, J., Li, P., Meng, X., Liu, K., Chen, W., Liu, X., & Liu, Z. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.04.005 · Cited by 241 · see citing works
On Your Own: Older Adults’ Food Choice and Dietary Habits
Whitelock, E., & Ensaff, H. (2018) · Nutrients · doi:10.3390/nu10040413 · Cited by 240 · see citing works
The Link Between Periodontal Disease and Rheumatoid Arthritis: An Updated Review
Kozieł, J., Mydel, P. M., & Potempa, J. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-014-0408-9 · Cited by 235 · see citing works
Kim, N., Jeon, S. H., Ju, I. G., Gee, M. S., Do, J., Oh, M. S., & Lee, J. K. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.09.002 · Cited by 231 · see citing works
Den, H., Dong, X., Chen, M., & Zou, Z. (2020) · Aging · doi:10.18632/aging.102810 · Cited by 230 · see citing works
Saji, N., Niida, S., Murotani, K., Hisada, T., Tsuduki, T., Sugimoto, T., Kimura, A., Toba, K., & Sakurai, T. (2019) · Scientific Reports · doi:10.1038/s41598-018-38218-7 · Cited by 224 · see citing works
The ageing gastrointestinal tract
Soenen, S., Rayner, C., Jones, K., & Horowitz, M. (2016) · Current opinion in clinical nutrition and metabolic care · doi:10.1097/mco.0000000000000238 · Cited by 211 · see citing works
Effects of curcumin on mitochondria in neurodegenerative diseases
Bagheri, H., Ghasemi, F., Barreto, G. E., Rafiee, R., Sathyapalan, T., & Sahebkar, A. (2019) · BioFactors · doi:10.1002/biof.1566 · Cited by 211 · see citing works
A gut (microbiome) feeling about the brain
Sherwin, E., Rea, K., Dinan, T. G., & Cryan, J. F. (2016) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000244 · Cited by 206 · see citing works
Heijtz, R. D. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2016.04.012 · Cited by 193 · see citing works
d-glutamate and Gut Microbiota in Alzheimer’s Disease
Chang, C.-H., Lin, C.-H., & Lane, H.-Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082676 · Cited by 191 · see citing works
Probiotics and prebiotics and health in ageing populations
Duncan, S. H., & Flint, H. J. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.02.004 · Cited by 187 · see citing works
Jang, H.-M., Lee, H.-J., Jang, S.-E., Han, M. J., & Kim, D.-H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0042-3 · Cited by 181 · see citing works
Microbial amyloids – functions and interactions within the host
Schwartz, K., & Boles, B. R. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.12.001 · Cited by 174 · see citing works
Microbial-generated amyloids and Alzheimer's disease (AD)
Hill, J. M., & Lukiw, W. J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00009 · Cited by 173 · see citing works
Zhao, Y., Cong, L., Jaber, V. R., & Lukiw, W. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01064 · Cited by 170 · see citing works
Pathogenic microbes, the microbiome, and Alzheimer’s disease (AD)
Hill, J. M., Clément, C., Pogue, A. I., Bhattacharjee, S., Zhao, Y., & Lukiw, W. J. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00127 · Cited by 169 · see citing works
Madeira, C., Vargas-Lopes, C., Brandão, C. O., Reis, T., Laks, J., Panizzutti, R., & Ferreira, S. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00561 · Cited by 163 · see citing works
Fungal Infection in Patients with Alzheimer's Disease
Alonso, R., Pisa, D., Marina, A., Morato, E., Rábano, A., & Carrasco, L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132681 · Cited by 156 · see citing works
Chen, Y., Fang, L., Chen, S., Zhou, H., Fan, Y., Li, L., Li, J., Xu, J., Chen, Y., Ma, Y., et al. (2020) · BioMed Research International · doi:10.1155/2020/8456596 · Cited by 150 · see citing works
Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD).
Zhao, Y., & Lukiw, W. J. (2015) · PubMed · Cited by 149 · see citing works
Erickson, M. A., Hartvigson, P. E., Morofuji, Y., Owen, J. B., Butterfield, D. A., & Banks, W. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-150 · Cited by 145 · see citing works
On communication between gut microbes and the brain
Forsythe, P., Kunze, W. A., & Bienenstock, J. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283572ffa · Cited by 137 · see citing works
Chen, C.-H., Lin, C.-L., & Kao, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144589 · Cited by 115 · see citing works
Zhao, Y., Cong, L., & Lukiw, W. J. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00407 · Cited by 112 · see citing works
Precision pharmacology for Alzheimer’s disease
Hampel, H. J., Vergallo, A., Aguilar, L. F., Benda, N., Broich, K., Cuello, A. C., Cummings, J. L., Dubois, B., Federoff, H. J., Fiandaca, M. S., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.02.014 · Cited by 112 · see citing works
Arora, K., Green, M., & Prakash, S. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.537847 · Cited by 110 · see citing works
Microbiota and Aging. A Review and Commentary
García‐Peña, C., Álvarez‐Cisneros, T., Quiroz‐Baez, R., & Friedland, R. P. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.11.005 · Cited by 105 · see citing works
Neuroinflammation in Alzheimer’s Disease: from Pathogenesis to a Therapeutic Target
Pimplikar, S. W. (2014) · Journal of Clinical Immunology · doi:10.1007/s10875-014-0032-5 · Cited by 103 · see citing works
The Formation of Escherichia coli Curli Amyloid Fibrils is Mediated by Prion-like Peptide Repeats
Cherny, I., Rockah-Shmuel, L., Levy‐Nissenbaum, O., Gophna, U., Ron, E. Z., & Gazit, E. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.07.028 · Cited by 100 · see citing works
Huang, S., Chen, L., Wang, M.-F., Hsu, C.-C., Chan, C.-H., Li, J.-X., & Huang, H.-Y. (2018) · Nutrients · doi:10.3390/nu10070894 · Cited by 99 · see citing works
Ball, M. J., Lukiw, W. J., Kammerman, E. M., & Hill, J. M. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.07.005 · Cited by 89 · see citing works
Study of neuroprotection of donepezil, a therapy for Alzheimer's disease
Akasofu, S., Kimura, M., Kosasa, T., et al. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.04.045 · Cited by 86 · see citing works
Sanborn, V. E., Azcárate-Peril, M. A., Updegraff, J. A., Manderino, L. M., & Gunstad, J. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s270035 · Cited by 86 · see citing works
Clark, I. A., & Vissel, B. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13181 · Cited by 84 · see citing works
Zhu, G., Zhao, J., Zhang, H., Chen, W., & Wang, G. (2021) · Nutrients · doi:10.3390/nu13051602 · Cited by 82 · see citing works
Potential role of antimicrobial peptides in the early onset of Alzheimer's disease
Welling, M. M., Nabuurs, R. J. A., & van der Weerd, L. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.020 · Cited by 80 · see citing works
Allen, H. B. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160388 · Cited by 80 · see citing works
Lin, C., Yang, H.-T., & Lane, H. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172760 · Cited by 79 · see citing works
The role of regulatory T cells in neurodegenerative diseases
HeFeng, F. Q., & Balling, R. (2012) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1187 · Cited by 78 · see citing works
The innate immune system in Alzheimer's disease
Boutajangout, A., & Wisniewski, T. (2013) · International Journal of Cell Biology · doi:10.1155/2013/576383 · Cited by 69 · see citing works
Alzheimer’s disease and disseminated mycoses
Alonso, R., Pisa, D., Rábano, A., & Carrasco, L. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-013-2045-z · Cited by 68 · see citing works
Pourbadie, H. G., Sayyah, M., Khoshkholgh-Sima, B., Choopani, S., Nategh, M., Motamedi, F., & Shokrgozar, M. A. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.06.020 · Cited by 68 · see citing works
Anti-inflammatory and Immune Therapy for Alzheimers Disease: Current Status and Future Directions
Walker, D., & Lue, L.-F. (2007) · Current Neuropharmacology · doi:10.2174/157015907782793667 · Cited by 66 · see citing works
Cuervo-Zanatta, D., Garcı́a-Mena, J., & Perez‐Cruz, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201367 · Cited by 57 · see citing works
Ma, X., Shin, Y.-J., Jang, H., Joo, M.-K., Yoo, J.-W., & Kim, D. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-00096-x · Cited by 55 · see citing works
Relationship of Wine Consumption with Alzheimer’s Disease
Reale, M., Costantini, E., Jagarlapoodi, S., Khan, H. Z., Belwal, T., & Cichelli, A. (2020) · Nutrients · doi:10.3390/nu12010206 · Cited by 53 · see citing works
Chang, C.-H., Lin, C., Liu, C., Huang, C., Chen, S.-J., Lin, W.-C., Yang, H.-T., & Lane, H. (2021) · Journal of Psychopharmacology · doi:10.1177/0269881120972331 · Cited by 51 · see citing works
Are Certain Lifestyle Habits Associated with Lower Alzheimer's Disease Risk?
Arab, L. R., & Sabbagh, M. N. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091573 · Cited by 48 · see citing works
Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer’s Disease
Zhao, Y., & Lukiw, W. J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00145 · Cited by 47 · see citing works
Cen, J., Guo, H., Chen, H., Lv, J., Yang, Y., Wang, T., Fang, D., Luo, W., & Wang, C. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.12.005 · Cited by 44 · see citing works
Téglás, T., Ábrahám, D., Jókai, M., Kondo, S., Mohammadi, R., Fehér, J., Szabó, D., Wilhelm, M., & Radak, Z. O. (2020) · Biogerontology · doi:10.1007/s10522-020-09895-7 · Cited by 43 · see citing works
Inflammation: A Major Target for Compounds to Control Alzheimer’s Disease
Maccioni, R. B., Navarrete, L. P., González, A., González-Canacer, A., Guzmán‐Martínez, L., & Cortés, N. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191014 · Cited by 42 · see citing works
Reilly, A. M., Tsai, A. P., Lin, P. B., Ericsson, A. C., Oblak, A. L., & Ren, H. (2020) · Nutrients · doi:10.3390/nu12102977 · Cited by 41 · see citing works
Lin, C.-H., & Lane, H.-Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00540 · Cited by 37 · see citing works
Sayed, N. S. E., Kandil, E. A., & Ghoneum, M. H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.666502 · Cited by 36 · see citing works
Szymański, P., Karpiński, A., & Mikiciuk‐Olasik, E. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.04.038 · Cited by 35 · see citing works
Sex-Dependent Effects of Intestinal Microbiome Manipulation in a Mouse Model of Alzheimer’s Disease
Kaur, H., Nookala, S., Singh, S., Mukundan, S., Nagamoto‐Combs, K., & Combs, C. K. (2021) · Cells · doi:10.3390/cells10092370 · Cited by 34 · see citing works
Wiatrak, B., & Balon, K. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02204-w · Cited by 27 · see citing works
Self-citationTargeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease
Fülöp, T., Tripathi, S., Rodrigues, S., Desroches, M., Bunt, T., Eiser, A. R., Bernier, F., Beauregard, P. B., Barron, A. E., Khalil, A., et al. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s264910 · Cited by 27 · see citing works
Probiotics, prebiotics and their role in Alzheimer’s disease
D’Argenio, V., & Sarnataro, D. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.306072 · Cited by 26 · see citing works
Probiotics for Preventing Cognitive Impairment in Alzheimer’s Disease
Wong, C. B., Kobayashi, Y., & Xiao, J. (2018) · IntechOpen eBooks · doi:10.5772/intechopen.79088 · Cited by 18 · see citing works
Wiatrak, B., Jawień, P., Matuszewska, A., Szeląg, A., & Kubis-Kubiak, A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112880 · Cited by 18 · see citing works
Self-citationAuthor response: Gram-negative bacterial molecules associate with Alzheimer disease pathology
Zhan, X. (2017) · Neurology · doi:10.1212/wnl.0000000000004048 · Cited by 12 · see citing works
Role of Microbiota in Neurodegenerative Diseases
Sobol, C. V. (2018) · Russian Journal of Developmental Biology · doi:10.1134/s1062360418060061 · Cited by 7 · see citing works
Kaur, H., Nagamoto‐Combs, K., & Combs, C. K. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.042122 · Cited by 5 · see citing works
Neurochemical Aspects of Alzheimer’s Type of Dementia
Farooqui, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816347-4.00003-9 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease
Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2024) · Molecules · doi:10.3390/molecules29215131 · Cited by 56 · see citing works
“Such inflammation may enable inflammatory mediators to cross the blood–brain barrier (BBB) and affect microglia, exacerbating neuroinflammation, which ultimately contributes to neuronal degeneration and damage [17,18].”
Background
- Authors
- Wiatrak, B., Balon, K., Jawień, P., Bednarz, D., Jęśkowiak, I., & Szeląg, A.
- Affiliations
- Wroclaw Medical University (PL)
- Ludwik Hirszfeld Institute of Immunology and Experimental Therapy (PL)
- Wrocław University of Environmental and Life Sciences (PL)
- Corresponding author
- Wiatrak, Benita
- Jawień, Paulina
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-04-27
- Volume
- 23
- Issue
- 9
- Pages
- 4862
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9104401
- OpenAlex
- W4225006092
- Cited by
- 58
- References
- 122
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 11 · 2023: 23 · 2022: 5
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, gut microbiota, microbiota-gut-brain axis, neuroinflammation, diet quality, Alzheimer's disease pathogenesis, cholinergic hypothesis, amyloid-beta aggregation, NMDA receptor antagonists, dementia
- MeSH terms
- Brain-Gut Axis, Alzheimer Disease, Humans, Memantine, Quality of Life, Receptors, N-Methyl-D-Aspartate, Cholinergic Agents, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
