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The Kaleidoscope of Microglial Phenotypes

Dubbelaar, Marissa L., Kracht, Laura, Eggen, Bart J. L., Boddeke, Erik W. G. M.·2018·Frontiers in Immunology
DOI 10.3389/fimmu.2018.01753PMC PMC6079257
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Figure 1 Overlapping gene signatures of microglial core profiles associated with multiple diseases identified in three independent studies. Using the “primed” module by Holtman and coworkers (95), the gene profile of disease-associated microglia identified by Keren-Shaul and coworkers (35) and the gene profile of the microglial neurodegenerative phenotype identified by Krasemann and coworkers (34), three genes were identified to be shared among the three microglia datasets associated with multiple diseases.
Figure 1 Overlapping gene signatures of microglial core profiles associated with multiple diseases identified in three independent studies. Using the “primed” module by Holtman and coworkers (95), the gene profile of disease-associated microglia identified by Keren-Shaul and coworkers (35) and the gene profile of the microglial neurodegenerative phenotype identified by Krasemann and coworkers (34), three genes were identified to be shared among the three microglia datasets associated with multiple diseases.CC BY · PubMed Central
Figure 2 The kaleidoscope of microglial phenotypes: complexity of determining a microglial core profile associated with multiple diseases. This figure depicts examples of factors that impinge on the microglia epigenome and transcriptome. Seven factors are depicted that have been shown to influence the microglial transcriptome: brain region, ontogeny, disease, age, sex, experimental procedures, and species. The influence of these factors on the transcriptome converges in the center of the gray rim. This rim represents the imprint of these factors on the epigenome, which yet remains to be revealed.
Figure 2 The kaleidoscope of microglial phenotypes: complexity of determining a microglial core profile associated with multiple diseases. This figure depicts examples of factors that impinge on the microglia epigenome and transcriptome. Seven factors are depicted that have been shown to influence the microglial transcriptome: brain region, ontogeny, disease, age, sex, experimental procedures, and species. The influence of these factors on the transcriptome converges in the center of the gray rim. This rim represents the imprint of these factors on the epigenome, which yet remains to be revealed.CC BY · PubMed Central

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Metadata

Authors
Dubbelaar, M. L., Kracht, L., Eggen, B. J. L., & Boddeke, E. W. G. M.
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2018-07-31
Volume
9
ISSN
1664-3224
DOI
10.3389/fimmu.2018.01753
PMC
PMC6079257
Cited by
260
References
47
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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