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Novel subcellular localization for α-synuclein: possible functional consequences
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Disruption or dysfunction of MAMs is associated with a variety of pathophysiological conditions, including neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
“Disruption of contact between the mitochondria and ER is associated with a variety of pathophysiological conditions including neurodegenerative diseases.”
From The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs (2020) · cites this paper as [16]
Impairment or perturbation of MAM function has been implicated in several neurodegenerative disease conditions.
“While impairment or perturbation of MAM function has been implicated in several neurodegenerative disease conditions [13–20, 76], the contributing underlying mechanism(s) remain unknown.”
From The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs (2020) · cites this paper as [16]
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Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
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Endoplasmic reticulum-mitochondria contacts: Function of the junction
Rowland, A. A., & Voeltz, G. K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3440 · Cited by 1,018 · cited 2×
“It is also well known that ER-mitochondria connections regulate mitochondrial dynamic processes (Csordás et al., 2006; Hayashi et al., 2009; Friedman et al., 2011; Rowland and Voeltz, 2012).”
BackgroundImmunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.
Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E. R., & Mizuno, Y. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2696 · Cited by 981
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Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease
Area‐Gomez, E., del Carmen Lara Castillo, M., Tambini, M. D., Guardia‐Laguarta, C., de Groof, A. J. C., Madra, M., Ikenouchi, J., Umeda, M., Bird, T. D., Sturley, S. L., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.202 · Cited by 638
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Self-citationEvidence of Oxidative Stress in the Neocortex in Incidental Lewy Body Disease
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Metadata
- Authors
- Guardia-Laguarta, C., Area-Gomez, E., Schon, E. A., & Przedborski, S.
- Venue
- Frontiers in Neuroanatomy
- Publisher
- Frontiers Media SA
- Published
- 2015-02-23
- Volume
- 9
- ISSN
- 1662-5129
- PMC
- PMC4337379
- Cited by
- 44
- References
- 9
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