Chronic multichannel neural recordings from soft regenerative microchannel electrodes during gait
Open accessAbstract
Reliably interfacing a nerve with an electrode array is one of the approaches to restore motor and sensory functions after an injury to the peripheral nerve. Accomplishing this with current technologies is challenging as the electrode-neuron interface often degrades over time, and surrounding myoelectric signals contaminate the neuro-signals in awake, moving animals. The purpose of this study was to evaluate the potential of microchannel electrode implants to monitor over time and in freely moving animals, neural activity from regenerating nerves. We designed and fabricated implants with silicone rubber and elastic thin-film metallization. Each implant carries an eight-by-twelve matrix of parallel microchannels (of 120 × 110 μm(2) cross-section and 4 mm length) and gold thin-film electrodes embedded in the floor of ten of the microchannels. After sterilization, the soft, multi-lumen electrode implant is sutured between the stumps of the sciatic nerve. Over a period of three months and in four rats, the microchannel electrodes recorded spike activity from the regenerating sciatic nerve. Histology indicates mini-nerves formed of axons and supporting cells regenerate robustly in the implants. Analysis of the recorded spikes and gait kinematics over the ten-week period suggests firing patterns collected with the microchannel electrode implant can be associated with different phases of gait.
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In vivo experiments have shown fascicles regenerated through the regenerative electrode for every implant, after which stable long-term recording or stimulation up to 3 months was possible.
“However, in vivo experiments have been performed in which the fascicles regenerated through the electrode for every implant after which stable long term recording or stimulation (up to 3 months) was possible (Musick et al., 2015; MacEwan et al., 2016).”
From Update on Peripheral Nerve Electrodes for Closed-Loop Neuroprosthetics (2018) · cites this paper as Musick et al., 2015
Originally made from polyimide, more recent microchannel designs are built from stretchable and softer materials such as PDMS.
“While originally made from polyimide (FitzGerald et al., 2012), more recent microchannel designs are built from stretchable and softer materials such as PDMS (Musick et al., 2015; Lancashire et al., 2016).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Musick et al., 2015
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- Authors
- Musick, K. M., Rigosa, J., Narasimhan, S., Wurth, S., Capogrosso, M., Chew, D. J., Fawcett, J. W., Micera, S., & Lacour, S. P.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Scuola Superiore Sant'Anna (IT)
- University of Cambridge (GB)
- Corresponding author
- Lacour, Stéphanie P.
- ORCID
- Venue
- Scientific Reports
- Published
- 2015-09-24
- Volume
- 5
- Issue
- 1
- Pages
- 14363-14363
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4585830
- OpenAlex
- W2198380397
- Cited by
- 70
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 11 · 2020: 9 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 7
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- SDL (submittedVersion, cc-by)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Funders
- Fondation Bertarelli
- Engineering and Physical Sciences Research Council (EP/H00727X/1)
- FP7 Ideas: European Research Council (259419)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
- Keywords
- peripheral nerve regeneration, sciatic nerve, chronic neural recording, spiking activity, gait kinematics, gold thin film electrodes, silicone rubber implants, freely moving animals, rat model
- MeSH terms
- Animals, Electrodes, Implanted, Gait, Male, Microelectrodes, Neurons, Peripheral Nerves, Sciatic Nerve, Rats, Electrophysiological Phenomena
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