Low-Volume Interval Training Improves Muscle Oxidative Capacity in Sedentary Adults

HOOD, MELANIE S.; LITTLE, JONATHAN P.; TARNOPOLSKY, MARK A.; MYSLIK, FRANK; GIBALA, MARTIN J.

doi:10.1249/mss.0b013e3182199834

Cited by 375Cardiovascular and exercise physiologyExercise and Physiological ResponsesMuscle metabolism and nutrition

Low-Volume Interval Training Improves Muscle Oxidative Capacity in Sedentary Adults

HOOD, MELANIE S., LITTLE, JONATHAN P., TARNOPOLSKY, MARK A., MYSLIK, FRANK, GIBALA, MARTIN J.·2011·Medicine & Science in Sports & Exercise

DOI 10.1249/mss.0b013e3182199834

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Abstract

INTRODUCTION: High-intensity interval training (HIT) increases skeletal muscle oxidative capacity similar to traditional endurance training, despite a low total exercise volume. Much of this work has focused on young active individuals, and it is unclear whether the results are applicable to older less active populations. In addition, many studies have used "all-out" variable-load exercise interventions (e.g., repeated Wingate tests) that may not be practical for all individuals. We therefore examined the effect of a more practical low-volume submaximal constant-load HIT protocol on skeletal muscle oxidative capacity and insulin sensitivity in middle-aged adults, who may be at a higher risk for inactivity-related disorders. METHODS: Seven sedentary but otherwise healthy individuals (three women) with a mean ± SD age, body mass index, and peak oxygen uptake (VO(2peak)) of 45 ± 5 yr, 27 ± 5 kg·m(-2), and 30 ± 3 mL·kg(-1)·min(-1) performed six training sessions during 2 wk. Each session involved 10 × 1-min cycling at ∼60% of peak power achieved during a ramp VO(2peak) test (eliciting ∼80%-95% of HR reserve) with 1 min of recovery between intervals. Needle biopsy samples (vastus lateralis) were obtained before training and ∼72 h after the final training session. RESULTS: Muscle oxidative capacity, as reflected by the protein content of citrate synthase and cytochrome c oxidase subunit IV, increased by ∼35% after training. The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1α was increased by ∼56% after training, but the transcriptional corepressor receptor-interacting protein 140 remained unchanged. Glucose transporter protein content increased ∼260%, and insulin sensitivity, on the basis of the insulin sensitivity index homeostasis model assessment, improved by ∼35% after training. CONCLUSIONS: Constant-load low-volume HIT may be a practical time-efficient strategy to induce metabolic adaptations that reduce the risk for inactivity-related disorders in previously sedentary middle-aged adults.

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HOMA-IR was improved in both men and women after training, owing to significant reductions in fasting plasma insulin.
“HOMA-IR was improved in both men and women after training, owing to significant reductions in fasting plasma insulin, and consistent with previous studies [3], [33].”
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Background

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Authors: HOOD, M. S., LITTLE, J. P., TARNOPOLSKY, M. A., MYSLIK, F., & GIBALA, M. J.
Affiliations: McMaster University (CA)
ORCID: LITTLE, JONATHAN P.
TARNOPOLSKY, MARK A.
MYSLIK, FRANK
GIBALA, MARTIN J.
Venue: Medicine & Science in Sports & Exercise
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-10
Volume: 43
Issue: 10
Pages: 1849-1856
ISSN: 0195-9131 (ISSN-L)
DOI: 10.1249/mss.0b013e3182199834
OpenAlex: W2048634064
Cited by: 375
References: 42
Citations by year: 2026: 7 · 2025: 10 · 2024: 10 · 2023: 13 · 2022: 31 · 2021: 26 · 2020: 21 · 2019: 22 · 2018: 31 · 2017: 29 · 2016: 30 · 2015: 42 · 2014: 33 · 2013: 40 · 2012: 26
FWCI: 88.00
Type: journal article
Language: en
Open access: closed
Locations: Medicine & Science in Sports & Exercise (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: high-intensity interval training, low-volume training, skeletal muscle oxidative capacity, sedentary adults, middle-aged adults, insulin sensitivity, citrate synthase, cytochrome c oxidase, PGC-1α, RIP140, glucose transporters, vastus lateralis, cycling, metabolic adaptation
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adaptation, Physiological, Adult, Bicycling, Citrate (si)-Synthase, Electron Transport Complex IV, Female, Heat-Shock Proteins, Humans, Insulin Resistance, Male, Middle Aged, Mitochondria, Muscle, Oxidation-Reduction, Oxygen Consumption, Physical Endurance, Transcription Factors, Body Mass Index, Muscle, Skeletal, Glucose Transport Proteins, Facilitative, Quadriceps Muscle, Sedentary Behavior

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Low-Volume Interval Training Improves Muscle Oxidative Capacity in Sedentary Adults

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