Exercise increases serum fibroblast growth factor 21 (FGF21) levels
Open accessAbstract
BACKGROUND: Fibroblast growth factor 21 (FGF21) increases glucose uptake. It is unknown if FGF21 serum levels are affected by exercise. METHODOLOGY/PRINCIPAL FINDINGS: This was a comparative longitudinal study. Anthropometric and biochemical evaluation were carried out before and after a bout of exercise and repeated after two weeks of daily supervised exercise. The study sample was composed of 60 sedentary young healthy women. The mean age was 24±3.7 years old, and the mean BMI was 21.4±7.0 kg/m². The anthropometric characteristics did not change after two weeks of exercise. FGF21 levels significantly increased after two weeks of exercise (276.8 ng/l (142.8-568.6) vs. (460.8 (298.2-742.1), p<0.0001)). The delta (final-basal) log of serum FGF21, adjusted for BMI, showed a significant positive correlation with basal glucose (r = 0.23, p = 0.04), mean maximal heart rate (MHR) (r = 0.54, p<0.0001), mean METs (r = 0.40, p = 0.002), delta plasma epinephrine (r = 0.53, p<0.0001) and delta plasma FFAs (r = 0.35, p = 0.006). A stepwise linear regression model showed that glucose, MHR, METs, FFAs, and epinephrine, were factors independently associated with the increment in FGF21 after the exercise program (F = 4.32; r² = 0.64, p<0.0001). CONCLUSIONS: Serum FGF21 levels significantly increased after two weeks of physical activity. This increment correlated positively with clinical parameters related to the adrenergic and lipolytic response to exercise. TRIAL REGISTRATION: ClinicalTrials.gov NCT01512368.
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In runners after 2 weeks of training, serum FGF21 levels increased, but there was no change in FGF21 gene expression in skeletal muscle.
“A study by Cuevas-Ramos et al. found an increase in serum FGF21 levels in runners after 2 weeks of training, but found no change in their gene expression in SkM (Cuevas-Ramos et al., 2012).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Cuevas-Ramos et al., 2012
The Results section (‘Change in FGF21 levels after two weeks of exercising’; page unavailable) reports a significant rise in serum FGF21 after two weeks. The Methods and Abstract identify the participants as sedentary young healthy women, not runners. The retrieved passages do not report a skeletal-muscle FGF21 gene-expression measurement, so the claimed absence of a change is unsupported. (LLM, conf=0.90)
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- Authors
- Cuevas-Ramos, D., Almeda-Valdés, P., Meza-Arana, C. E., Brito-Córdova, G., Gómez-Pérez, F. J., Mehta, R., Oseguera-Moguel, J., & Aguilar-Salinas, C. A.
- Affiliations
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Corresponding author
- Aguilar-Salinas, Carlos A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-05-31
- Volume
- 7
- Issue
- 5
- Pages
- e38022
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3365112
- OpenAlex
- W1967485751
- Cited by
- 178
- References
- 31
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 10 · 2023: 9 · 2022: 15 · 2021: 13 · 2020: 13 · 2019: 19 · 2018: 15 · 2017: 11 · 2016: 16 · 2015: 11 · 2014: 14 · 2013: 8 · 2012: 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Consejo Nacional de Ciencia y Tecnología
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- FGF21, physical activity, glucose uptake, maximal heart rate, exercise intensity, epinephrine, free fatty acids, lipolysis, adrenergic response, sedentary young women, supervised exercise
- MeSH terms
- Fibroblast Growth Factors, Humans, Exercise
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