Psychedelic harm reduction and integration: A transtheoretical model for clinical practice
Open accessAbstract
Psychedelic Harm Reduction and Integration (PHRI) is a transtheoretical and transdiagnostic clinical approach to working with patients who are using or considering using psychedelics in any context. The ongoing discussion of psychedelics in academic research and mainstream media, coupled with recent law enforcement deprioritization of psychedelics and compassionate use approvals for psychedelic-assisted therapy, make this model exceedingly timely. Given the prevalence of psychedelic use, the therapeutic potential of psychedelics, and the unique cultural and historical context in which psychedelics are placed, it is important that mental health providers have an understanding of the unique motivations, experiences, and needs of people who use them. PHRI incorporates elements of harm reduction psychotherapy and psychedelic-assisted psychotherapy, and can be applied in both brief and ongoing psychotherapy interactions. PHRI represents a shift away from assessment limited to untoward outcomes of psychedelic use and abstinence-based addiction treatment paradigms and toward a stance of compassionate, destigmatizing acceptance of patients' choices. Considerations for assessment, preparation, and working with difficult experiences are presented.
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This critical period is context-dependent and has been linked to the ability to induce social reward learning, psychological flexibility, cognitive reappraisal, and new patterns of behavior.
“This critical period is context-dependent and has been linked to the ability to induce social reward learning, psychological flexibility, cognitive reappraisal and new patterns of behavior (46, 48, 49).”
From Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol (2025) · cites this paper as [48]
In Integration > Working With Positive Experiences (Afterglow; page unavailable), the paper describes a possible post-psychedelic neuroplastic window associated with psychological flexibility and exploration of new behaviors and ways of thinking. It does not link that period to social reward learning or cognitive reappraisal, or explicitly describe the period as context-dependent. (LLM, conf=0.86)
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“74,84,85 Results of this review can therefore not be generalized to uncontrolled and recreational contexts of drug administration where unpleasant and challenging experiences might not be cushioned by a holding environment.”
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- Authors
- Gorman, I., Nielson, E. M., Molinar, A., Cassidy, K., & Sabbagh, J.
- Affiliations
- Fluent (United States) (US)
- The New School (US)
- Corresponding author
- Gorman, Ingmar
- Nielson, Elizabeth M.
- Venue
- Frontiers in Psychology
- Publisher
- Frontiers Media SA
- Published
- 2021-03-15
- Volume
- 12
- Pages
- 645246-645246
- ISSN
- 1664-1078 (ISSN-L)
- PMC
- PMC8008322
- OpenAlex
- W3139397908
- Cited by
- 147
- References
- 147
- Citations by year
- 2026: 28 · 2025: 46 · 2024: 21 · 2023: 22 · 2022: 24 · 2021: 5
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Vlaamse regering
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Keywords
- psychedelic integration, transtheoretical model, transdiagnostic approach, psychedelic-assisted psychotherapy, psychedelic use, compassionate use, psychedelic therapy, stigma reduction, patient assessment, mental health professionals
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