Cited by 328Neurogenesis and neuroplasticity mechanismsNeonatal and fetal brain pathologyMultiple Sclerosis Research Studies

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Oligodendrocyte development and the onset of myelination in the human fetal brain

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Jakovcevski, Igor·2009·Frontiers in Neuroanatomy

DOI 10.3389/neuro.05.005.2009PMC PMC2694674

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Abstract

Oligodendrocytes are cells that myelinate axons, providing saltatory conduction of action potentials and proper function of the central nervous system. Myelination begins prenatally in the human, and the sequence of oligodendrocyte development and the onset of myelination are not thoroughly investigated. This knowledge is important to better understand human diseases, such as periventricular leukomalacia, one of the leading causes of motor deficit in premature babies, and demyelinating disorders such as multiple sclerosis (MS). In this review we discuss the spatial and temporal progression of oligodendrocyte lineage characterized by the expression of specific markers and transcription factors in the human fetal brain from the early embryonic period (5 gestational weeks, gw) until midgestation (24 gw). Our in vitro evidence indicated that a subpopulation of human oligodendrocytes may have dorsal origin, from cortical radial glia cells, in addition to their ventral telencephalic origin. Furthermore, we demonstrated that the regulation of myelination in the human fetal brain includes positive and negative regulators. Chemokines, such as CXCL1, abundant in proliferative zones during brain development and in regions of remyelination in adult, are discussed in the view of their potential roles in stimulating oligodendrocyte development. Other signals are inhibitory and may include, but are not limited to, polysialic acid modification of the neural cell adhesion molecule on axons. Overall, important differences in temporal and spatial distribution and regulatory signals for oligodendrocyte differentiation exist between human and rodent brains. Those differences may underlie the unique susceptibility of humans to demyelinating diseases, such as MS.

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Authors: Jakovcevski, I.
Venue: Frontiers in Neuroanatomy
Publisher: Frontiers Media SA
Published: 2009
Volume: 3
Pages: 5-5
ISSN: 1662-5129 (ISSN-L)
DOI: 10.3389/neuro.05.005.2009
PMC: PMC2694674
OpenAlex: W2018440098
Cited by: 323
References: 144
Citations by year: 2026: 14 · 2025: 17 · 2024: 31 · 2023: 30 · 2022: 26 · 2021: 34 · 2020: 22 · 2019: 17 · 2018: 22 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 20 · 2013: 23 · 2012: 8
FWCI: 3.35
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Neuroanatomy (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (R01NS041489)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: oligodendrocyte development, myelination, human fetal brain, oligodendrocyte lineage, transcription factors, radial glia, polysialic acid, CD56, demyelinating disease, multiple sclerosis, periventricular leukomalacia, gestational development

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Oligodendrocyte development and the onset of myelination in the human fetal brain

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