Cited by 213Clinical Nutrition and GastroenterologyNutrition and Health in AgingDialysis and Renal Disease Management

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Inflammation and Nutrition: Friend or Foe?

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Stumpf, Franziska, Keller, Bettina, Gressies, Carla, Schuetz, Philipp·2023·Nutrients

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Abstract

The importance of the interplay between inflammation and nutrition has generated much interest in recent times. Inflammation has been identified as a key driver for disease-related malnutrition, leading to anorexia, reduced food intake, muscle catabolism, and insulin resistance, which are stimulating a catabolic state. Interesting recent data suggest that inflammation also modulates the response to nutritional treatment. Studies have demonstrated that patients with high inflammation show no response to nutritional interventions, while patients with lower levels of inflammation do. This may explain the contradictory results of nutritional trials to date. Several studies of heterogeneous patient populations, or in the critically ill or advanced cancer patients, have not found significant benefits on clinical outcome. Vice versa, several dietary patterns and nutrients with pro- or anti-inflammatory properties have been identified, demonstrating that nutrition influences inflammation. Within this review, we summarize and discuss recent advances in both the role of inflammation in malnutrition and the effect of nutrition on inflammation.

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Figure 1 Classification of Malnutrition by (a) European Society of Clinical Nutrition and Metabolism (ESPEN) [8] and (b) American Society for Parenteral and Enteral Nutrition (ASPEN) [16].CC BY · PubMed Central

Figure 2 Selected Pathways in the Interplay of Inflammation and the Pathophysiology of Disease-related Malnutrition. IL-6, interleukin 6; IL-1β, interleukin 1β; TNF-α, tumor necrosis factor α; GLP-1, glucagon-like Peptide-1.CC BY · PubMed Central

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See all 213

Authors: Stumpf, F., Keller, B., Gressies, C., & Schuetz, P.
Affiliations: University of Hohenheim (DE)
University of Basel (CH)
Kantonsspital Aarau (CH)
Medical University Department of Medicine, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, 5001 Aarau, Switzerland
ORCID: Stumpf, Franziska
Keller, Bettina
Gressies, Carla
Schuetz, Philipp
Venue: Nutrients
Publisher: MDPI AG
Published: 2023-02-25
Volume: 15
Issue: 5
Pages: 1159
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu15051159
PMC: PMC10005147
OpenAlex: W4322502894
Cited by: 213
References: 125
Citations by year: 2026: 64 · 2025: 91 · 2024: 48 · 2023: 10
FWCI: 7.70
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Swiss National Science Foundation (PP00P3_150531)
Kantonsspital Aarau (1410.000.058, 1410.000.044)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords: inflammation, nutrition, disease-related malnutrition, anorexia, insulin resistance, muscle catabolism, dietary intervention, anti-inflammatory nutrients, critically ill patients, cancer patients
MeSH terms: Anorexia, Humans, Inflammation, Neoplasms, Nutritional Status, Malnutrition

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Inflammation and Nutrition: Friend or Foe?

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