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The Importance of Vitamin D and Magnesium in Athletes

Dominguez, Ligia J., Veronese, Nicola, Ragusa, Francesco Saverio, Baio, Salvatore Maria, Sgrò, Francesco, Russo, Arcangelo, Battaglia, Giuseppe, Bianco, Antonino, Barbagallo, Mario·2025·Nutrients
DOI 10.3390/nu17101655
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Abstract

Vitamin D and magnesium are essential nutrients that play key roles in an athlete’s performance, recovery, and overall health. Vitamin D is crucial for bone health (aiding calcium absorption and preventing stress fractures), muscle function (preventing weakness and injury), and reducing respiratory infections. Magnesium is fundamental in muscle function, adenosine triphosphate production for muscle contraction, electrolyte balance, bone strength, and cardiovascular health. The magnesium requirement of healthy adults is estimated at 300–400 mg/day, but there is evidence that athletes may have higher magnesium needs compared to sedentary persons. Magnesium and vitamin D are closely linked—vitamin D aids magnesium absorption, while magnesium is vital for vitamin D synthesis, transport, and activation. Given their importance in athletes, this article explores their functions, interactions, and the effects of deficiencies and supplementation in athletic populations.

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Research works printed but not linked: 230

  1. Bytomski, 2018, Fueling for Performance, Sports Health, 10, 47, 10.1177/1941738117743913 · DOI · Paper page
  2. Thomas, 2016, American College of Sports Medicine Joint Position Statement. Nutrition and Athletic Performance, Med. Sci. Sports Exerc., 48, 543
  3. Charoenngam, N., and Holick, M.F. (2020). Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients, 12. · DOI · Paper page
  4. Pike, 2017, Biology and Mechanisms of Action of the Vitamin D Hormone, Endocrinol. Metab. Clin. N. Am., 46, 815, 10.1016/j.ecl.2017.07.001 · DOI · Paper page
  5. Dominguez, L.J., Farruggia, M., Veronese, N., and Barbagallo, M. (2021). Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment. Metabolites, 11. · DOI · Paper page
  6. Bauer, 2019, High prevalence of vitamin D insufficiency in professional handball athletes, Phys. Sportsmed., 47, 71, 10.1080/00913847.2018.1520055 · DOI · Paper page
  7. Carswell, 2018, Influence of Vitamin D Supplementation by Sunlight or Oral D3 on Exercise Performance, Med. Sci. Sports Exerc., 50, 2555, 10.1249/MSS.0000000000001721 · DOI · Paper page
  8. Rebolledo, 2018, The Association of Vitamin D Status in Lower Extremity Muscle Strains and Core Muscle Injuries at the National Football League Combine, J. Arthrosc. Relat. Surg., 34, 1280, 10.1016/j.arthro.2017.10.005 · DOI · Paper page
  9. de la Puente Yague, M., Collado Yurrita, L., Ciudad Cabanas, M.J., and Cuadrado Cenzual, M.A. (2020). Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends. Nutrients, 12. · DOI · Paper page
  10. Dominguez, L.J., Veronese, N., and Barbagallo, M. (2024). Magnesium and the Hallmarks of Aging. Nutrients, 16. · DOI
  11. Barbagallo, 2009, Magnesium homeostasis and aging, Magnes. Res., 22, 235, 10.1684/mrh.2009.0187 · DOI
  12. Kleczkowski, 2025, Adenylate-driven equilibration of both ribo- and deoxyribonucleotides is under magnesium control: Quantification of the Mg2+-signal, J. Plant Physiol., 304, 154380, 10.1016/j.jplph.2024.154380 · DOI
  13. Romani, 2011, Cellular magnesium homeostasis, Arch. Biochem. Biophys., 512, 1, 10.1016/j.abb.2011.05.010 · DOI · Paper page
  14. Littlefield, 1991, Effect of magnesium on the growth and cell cycle of transformed and non-transformed epithelial rat liver cells in vitro, Cell Biol. Toxicol., 7, 203, 10.1007/BF00250975 · DOI
  15. Barbagallo, 2003, Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X, Mol. Aspects Med., 24, 39, 10.1016/S0098-2997(02)00090-0 · DOI · Paper page
  16. Barbagallo, 2015, Magnesium and type 2 diabetes, World J. Diabetes, 6, 1152, 10.4239/wjd.v6.i10.1152 · DOI · Paper page
  17. Caspi, 2012, The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases, Nucleic Acids Res., 40, D742, 10.1093/nar/gkr1014 · DOI · Paper page
  18. Dorup, 1991, Effects of magnesium and zinc deficiencies on growth and protein synthesis in skeletal muscle and the heart, Br. J. Nutr., 66, 493, 10.1079/BJN19910050 · DOI
  19. Gupta, 1978, The determination of the free magnesium level in the human red blood cell by 31P NMR, J. Biol. Chem., 253, 6172, 10.1016/S0021-9258(17)34595-7 · DOI · Paper page
  20. Cameron, D., Welch, A.A., Adelnia, F., Bergeron, C.M., Reiter, D.A., Dominguez, L.J., Brennan, N.A., Fishbein, K.W., Spencer, R.G., and Ferrucci, L. (2019). Age and Muscle Function Are More Closely Associated With Intracellular Magnesium, as Assessed by (31)P Magnetic Resonance Spectroscopy, Than With Serum Magnesium. Front. Physiol., 10. · DOI
  21. Dominguez, 2006, Magnesium and muscle performance in older persons: The InCHIANTI study, Am. J. Clin. Nutr., 84, 419, 10.1093/ajcn/84.2.419 · DOI · Paper page
  22. Potter, 1981, Magnesium and the regulation of muscle contraction, Fed. Proc., 40, 2653
  23. Dominguez, L., Veronese, N., and Barbagallo, M. (2020). Magnesium and Hypertension in Old Age. Nutrients, 13. · DOI
  24. Barbagallo, 2000, Cellular ionic alterations with age: Relation to hypertension and diabetes, J. Am. Geriatr. Soc., 48, 1111, 10.1111/j.1532-5415.2000.tb04788.x · DOI
  25. Dominguez, L.J., Veronese, N., Sabico, S., Al-Daghri, N.M., and Barbagallo, M. (2025). Magnesium and Migraine. Nutrients, 17. · DOI
  26. Lukaski, 2001, Magnesium, zinc, and chromium nutrition and athletic performance, Can. J. Appl. Physiol., 26, S13, 10.1139/h2001-038 · DOI
  27. Nielsen, 2006, Update on the relationship between magnesium and exercise, Magnes. Res., 19, 180
  28. Rayssiguier, 1990, New experimental and clinical data on the relationship between magnesium and sport, Magnes. Res., 3, 93
  29. Santos, 2011, Magnesium intake is associated with strength performance in elite basketball, handball and volleyball players, Magnes. Res., 24, 215, 10.1684/mrh.2011.0290 · DOI · Paper page
  30. Matias, 2010, Magnesium and strength in elite judo athletes according to intracellular water changes, Magnes. Res., 23, 138
  31. Wang, 2011, Magnesium sulfate enhances non-depolarizing muscle relaxant vecuronium action at adult muscle-type nicotinic acetylcholine receptor in vitro, Acta Pharmacol. Sin., 32, 1454, 10.1038/aps.2011.117 · DOI
  32. Serita, 2007, Effects of magnesium sulfate on neuromuscular function and spontaneous breathing during sevoflurane and spinal anesthesia, J. Anesth., 21, 86, 10.1007/s00540-006-0452-3 · DOI
  33. Garrison, 2012, Magnesium for skeletal muscle cramps, Cochrane Database Syst. Rev., 2012, CD009402
  34. Dominguez, L.J., Veronese, N., Guerrero-Romero, F., and Barbagallo, M. (2021). Magnesium in Infectious Diseases in Older People. Nutrients, 13. · DOI
  35. Dai, 2018, Magnesium status and supplementation influence vitamin D status and metabolism: Results from a randomized trial, Am. J. Clin. Nutr., 108, 1249, 10.1093/ajcn/nqy274 · DOI
  36. Wolf, 2004, The discovery of vitamin D: The contribution of Adolf Windaus, J. Nutr., 134, 1299, 10.1093/jn/134.6.1299 · DOI
  37. Blunt, 1968, Biological activity of 25-hydroxycholecalciferol, a metabolite of vitamin D3, Proc. Natl. Acad. Sci. USA, 61, 1503, 10.1073/pnas.61.4.1503 · DOI
  38. Ponchon, 1969, “Activation” of vitamin D by the liver, J. Clin. Investig., 48, 2032, 10.1172/JCI106168 · DOI · Paper page
  39. Norman, 1971, 1,25-dihydroxycholecalciferol: Identification of the proposed active form of vitamin D3 in the intestine, Science, 173, 51, 10.1126/science.173.3991.51 · DOI
  40. Holick, 1971, Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine, Proc. Natl. Acad. Sci. USA, 68, 803, 10.1073/pnas.68.4.803 · DOI · Paper page
  41. DeLuca, 2004, Overview of general physiologic features and functions of vitamin D, Am. J. Clin. Nutr., 80, 1689S, 10.1093/ajcn/80.6.1689S · DOI · Paper page
  42. Holick, 2007, Vitamin D deficiency, N. Engl. J. Med., 357, 266, 10.1056/NEJMra070553 · DOI · Paper page
  43. Dattola, 2020, Role of Vitamins in Skin Health: A Systematic Review, Curr. Nutr. Rep., 9, 226, 10.1007/s13668-020-00322-4 · DOI
  44. Webb, 2006, Calculated ultraviolet exposure levels for a healthy vitamin D status, Photochem. Photobiol., 82, 1697, 10.1111/j.1751-1097.2006.tb09833.x · DOI · Paper page
  45. Holick, 2004, Vitamin D: Importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis, Am. J. Clin. Nutr., 79, 362, 10.1093/ajcn/79.3.362 · DOI · Paper page
  46. Vieth, 1999, Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety, Am. J. Clin. Nutr., 69, 842, 10.1093/ajcn/69.5.842 · DOI · Paper page
  47. Binkley, 2007, Low vitamin D status despite abundant sun exposure, J. Clin. Endocrinol. Metab., 92, 2130, 10.1210/jc.2006-2250 · DOI · Paper page
  48. Haddad, 1992, Vitamin D--solar rays, the Milky Way, or both?, N. Engl. J. Med., 326, 1213, 10.1056/NEJM199204303261808 · DOI
  49. Neville, 2021, Physical Determinants of Vitamin D Photosynthesis: A Review, JBMR Plus, 5, e10460, 10.1002/jbm4.10460 · DOI
  50. Christakos, 2016, Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects, Physiol. Rev., 96, 365, 10.1152/physrev.00014.2015 · DOI · Paper page
  51. Smith, 1971, The turnover and transport of vitamin D and of a polar metabolite with the properties of 25-hydroxycholecalciferol in human plasma, J. Clin. Investig., 50, 2159, 10.1172/JCI106710 · DOI
  52. Takeyama, 1997, 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis, Science, 277, 1827, 10.1126/science.277.5333.1827 · DOI · Paper page
  53. Haussler, 1969, Chromosomal receptor for a vitamin D metabolite, Proc. Natl. Acad. Sci. USA, 62, 155, 10.1073/pnas.62.1.155 · DOI
  54. Baker, 1988, Cloning and expression of full-length cDNA encoding human vitamin D receptor, Proc. Natl. Acad. Sci. USA, 85, 3294, 10.1073/pnas.85.10.3294 · DOI · Paper page
  55. McDonnell, 1987, Molecular cloning of complementary DNA encoding the avian receptor for vitamin D, Science, 235, 1214, 10.1126/science.3029866 · DOI · Paper page
  56. Yoshizawa, 1997, Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning, Nat. Genet., 16, 391, 10.1038/ng0897-391 · DOI · Paper page
  57. Bikle, 2011, Vitamin D: An ancient hormone, Exp. Dermatol., 20, 7, 10.1111/j.1600-0625.2010.01202.x · DOI
  58. Walters, 1992, Newly identified actions of the vitamin D endocrine system, Endocr. Rev., 13, 719
  59. Larson-Meyer, D.E., Douglas, C.S., Thomas, J.J., Johnson, E.C., Barcal, J.N., Heller, J.E., Hollis, B.W., and Halliday, T.M. (2019). Validation of a Vitamin D Specific Questionnaire to Determine Vitamin D Status in Athletes. Nutrients, 11. · DOI · Paper page
  60. Sempos, 2018, Vitamin D assays and the definition of hypovitaminosis D: Results from the First International Conference on Controversies in Vitamin D, Br. J. Clin. Pharmacol., 84, 2194, 10.1111/bcp.13652 · DOI · Paper page
  61. Giustina, 2019, Controversies in Vitamin D: Summary Statement From an International Conference, J. Clin. Endocrinol. Metab., 104, 234, 10.1210/jc.2018-01414 · DOI · Paper page
  62. Mehran, 2016, Prevalence of Vitamin D Insufficiency in Professional Hockey Players, Orthop. J. Sports Med., 4, 2325967116677512, 10.1177/2325967116677512 · DOI
  63. Engelsen, 2010, The relationship between ultraviolet radiation exposure and vitamin D status, Nutrients, 2, 482, 10.3390/nu2050482 · DOI · Paper page
  64. Mottonen, 1999, Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-year-old Finnish girls, Eur. J. Clin. Nutr., 53, 746, 10.1038/sj.ejcn.1600844 · DOI
  65. Bezuglov, E., Tikhonova, A., Zueva, A., Khaitin, V., Waskiewicz, Z., Gerasimuk, D., Zebrowska, A., Rosemann, T., Nikolaidis, P., and Knechtle, B. (2019). Prevalence and Treatment of Vitamin D Deficiency in Young Male Russian Soccer Players in Winter. Nutrients, 11. · DOI
  66. Barsan, M., Chelaru, V.F., Rajnoveanu, A.G., Popa, S.L., Socaciu, A.I., and Badulescu, A.V. (2023). Difference in Levels of Vitamin D between Indoor and Outdoor Athletes: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci., 24. · DOI
  67. Ksiazek, A., Zagrodna, A., and Slowinska-Lisowska, M. (2019). Vitamin D, Skeletal Muscle Function and Athletic Performance in Athletes-A Narrative Review. Nutrients, 11. · DOI · Paper page
  68. Farrokhyar, 2017, Effects of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentrations and Physical Performance in Athletes: A Systematic Review and Meta-analysis of Randomized Controlled Trials, Sports Med., 47, 2323, 10.1007/s40279-017-0749-4 · DOI · Paper page
  69. Langley, 2024, The Prevalence of Low Vitamin D in Elite Para-Athletes: A Systematic Review, Sports Med. Open, 10, 96, 10.1186/s40798-024-00756-y · DOI
  70. Scragg, 1992, Plasma 25-hydroxyvitamin D3 and its relation to physical activity and other heart disease risk factors in the general population, Ann. Epidemiol., 2, 697, 10.1016/1047-2797(92)90014-H · DOI
  71. Kluczynski, 2011, Duration of physical activity and serum 25-hydroxyvitamin D status of postmenopausal women, Ann. Epidemiol., 21, 440, 10.1016/j.annepidem.2010.11.011 · DOI
  72. Brock, 2007, Effects of diet and exercise on plasma vitamin D (25(OH)D) levels in Vietnamese immigrant elderly in Sydney, Australia, J. Steroid Biochem. Mol. Biol., 103, 786, 10.1016/j.jsbmb.2006.12.048 · DOI
  73. Scragg, 2008, Frequency of leisure-time physical activity and serum 25-hydroxyvitamin D levels in the US population: Results from the Third National Health and Nutrition Examination Survey, Am. J. Epidemiol., 168, 577, 10.1093/aje/kwn163 · DOI
  74. Sun, 2017, Effect of an Acute Bout of Endurance Exercise on Serum 25(OH)D Concentrations in Young Adults, J. Clin. Endocrinol. Metab., 102, 3937, 10.1210/jc.2017-00146 · DOI
  75. Barker, 2013, Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury, Nutrients, 5, 1253, 10.3390/nu5041253 · DOI
  76. Maimoun, 2006, The intensity level of physical exercise and the bone metabolism response, Int. J. Sports Med., 27, 105, 10.1055/s-2005-837621 · DOI
  77. Maimoun, 2009, Response of calciotropic hormones and bone turnover to brisk walking according to age and fitness level, J. Sci. Med. Sport, 12, 463, 10.1016/j.jsams.2008.05.004 · DOI
  78. Rosen, 2012, The nonskeletal effects of vitamin D: An Endocrine Society scientific statement, Endocr. Rev., 33, 456, 10.1210/er.2012-1000 · DOI · Paper page
  79. Knechtle, B., and Nikolaidis, P.T. (2020). Vitamin D and Sport Performance. Nutrients, 12. · DOI
  80. Wicinski, M., Adamkiewicz, D., Adamkiewicz, M., Sniegocki, M., Podhorecka, M., Szychta, P., and Malinowski, B. (2019). Impact of Vitamin D on Physical Efficiency and Exercise Performance—A Review. Nutrients, 11. · DOI · Paper page
  81. Bischoff, 2001, In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue, Histochem. J., 33, 19, 10.1023/A:1017535728844 · DOI · Paper page
  82. Wang, 2011, Is the vitamin d receptor found in muscle?, Endocrinology, 152, 354, 10.1210/en.2010-1109 · DOI
  83. Srikuea, 2012, VDR and CYP27B1 are expressed in C2C12 cells and regenerating skeletal muscle: Potential role in suppression of myoblast proliferation, Am. J. Physiol. Cell Physiol., 303, C396, 10.1152/ajpcell.00014.2012 · DOI
  84. Ceglia, 2008, Vitamin D and skeletal muscle tissue and function, Mol. Asp. Med., 29, 407, 10.1016/j.mam.2008.07.002 · DOI · Paper page
  85. Alliband, K.H., Parr, T., Jethwa, P.H., and Brameld, J.M. (2023). Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter. Front. Physiol., 14. · DOI
  86. Stratos, I., Schleese, S., Rinas, I., Vollmar, B., and Mittlmeier, T. (2023). Effect of Calcitriol and Vitamin D Receptor Modulator 2 on Recovery of Injured Skeletal Muscle in Wistar Rats. Biomedicines, 11. · DOI
  87. Sist, M., Zou, L., Galloway, S.D.R., and Rodriguez-Sanchez, N. (2023). Effects of vitamin D supplementation on maximal strength and power in athletes: A systematic review and meta-analysis of randomized controlled trials. Front. Nutr., 10. · DOI
  88. Maroon, 2015, Vitamin D profile in National Football League players, Am. J. Sports Med., 43, 1241, 10.1177/0363546514567297 · DOI · Paper page
  89. Silk, 2017, The effect of calcium and vitamin D supplementation on bone health of male Jockeys, J. Sci. Med. Sport, 20, 225, 10.1016/j.jsams.2016.08.004 · DOI
  90. Fredericson, 2006, Stress fractures in athletes, Top. Magn. Reson. Imaging, 17, 309, 10.1097/RMR.0b013e3180421c8c · DOI · Paper page
  91. Schnackenburg, 2011, Bone quality and muscle strength in female athletes with lower limb stress fractures, Med. Sci. Sports Exerc., 43, 2110, 10.1249/MSS.0b013e31821f8634 · DOI
  92. Kelsey, 2007, Risk factors for stress fracture among young female cross-country runners, Med. Sci. Sports Exerc., 39, 1457, 10.1249/mss.0b013e318074e54b · DOI
  93. Bennell, 1996, The incidence and distribution of stress fractures in competitive track and field athletes. A twelve-month prospective study, Am. J. Sports Med., 24, 211, 10.1177/036354659602400217 · DOI · Paper page
  94. Davey, 2016, Low serum 25-hydroxyvitamin D is associated with increased risk of stress fracture during Royal Marine recruit training, Osteoporos. Int., 27, 171, 10.1007/s00198-015-3228-5 · DOI
  95. Richards, 2020, British Army recruits with low serum vitamin D take longer to recover from stress fractures, BMJ Mil. Health, 166, 240, 10.1136/jramc-2018-000983 · DOI
  96. Lappe, 2008, Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits, J. Bone Miner. Res., 23, 741, 10.1359/jbmr.080102 · DOI · Paper page
  97. Dao, 2015, Serum 25-Hydroxyvitamin D Levels and Stress Fractures in Military Personnel: A Systematic Review and Meta-analysis, Am. J. Sports Med., 43, 2064, 10.1177/0363546514555971 · DOI
  98. Shimasaki, 2016, Evaluating the Risk of a Fifth Metatarsal Stress Fracture by Measuring the Serum 25-Hydroxyvitamin D Levels, Foot Ankle Int., 37, 307, 10.1177/1071100715617042 · DOI
  99. Nieves, 2010, Nutritional factors that influence change in bone density and stress fracture risk among young female cross-country runners, Randomized Control. Trial, 2, 740
  100. Sejersen, 2024, The athlete’s heart: Allometric considerations on published papers and relation to cardiovascular variables, Eur. J. Appl. Physiol., 124, 1337, 10.1007/s00421-024-05449-8 · DOI
  101. Thompson, 2023, Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial, BMJ, 381, e075230, 10.1136/bmj-2023-075230 · DOI
  102. Vallecillo, 2021, Vitamin D and cardiovascular health, Clin. Nutr., 40, 2946, 10.1016/j.clnu.2020.12.025 · DOI · Paper page
  103. Allison, 2015, Severely vitamin D-deficient athletes present smaller hearts than sufficient athletes, Eur. J. Prev. Cardiol., 22, 535, 10.1177/2047487313518473 · DOI
  104. Owens, 2018, Vitamin D and the Athlete: Current Perspectives and New Challenges, Sports Med., 48, 3, 10.1007/s40279-017-0841-9 · DOI · Paper page
  105. Halliday, 2011, Vitamin D status relative to diet, lifestyle, injury, and illness in college athletes, Med. Sci. Sports Exerc., 43, 335, 10.1249/MSS.0b013e3181eb9d4d · DOI
  106. Sabetta, J.R., DePetrillo, P., Cipriani, R.J., Smardin, J., Burns, L.A., and Landry, M.L. (2010). Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults. PLoS ONE, 5. · DOI · Paper page
  107. He, 2016, Is there an optimal vitamin D status for immunity in athletes and military personnel?, Exerc. Immunol. Rev., 22, 42
  108. Urashima, 2010, Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren, Am. J. Clin. Nutr., 91, 1255, 10.3945/ajcn.2009.29094 · DOI · Paper page
  109. Rhodes, 2020, Editorial: Low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity, Aliment. Pharmacol. Ther., 51, 1434, 10.1111/apt.15777 · DOI
  110. Barbagallo, M., Veronese, N., and Dominguez, L.J. (2021). Magnesium in Aging, Health and Diseases. Nutrients, 13. · DOI · Paper page
  111. Kleczkowski, 2023, Magnesium and cell energetics: At the junction of metabolism of adenylate and non-adenylate nucleotides, J. Plant Physiol., 280, 153901, 10.1016/j.jplph.2022.153901 · DOI
  112. Veronese, 2020, Magnesium and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational and intervention studies, Eur. J. Nutr., 59, 263, 10.1007/s00394-019-01905-w · DOI
  113. Barbagallo, M., Veronese, N., and Dominguez, L.J. (2022). Magnesium in Type 2 Diabetes Mellitus, Obesity, and Metabolic Syndrome. Nutrients, 14. · DOI
  114. Feeney, 2016, Daily magnesium fluxes regulate cellular timekeeping and energy balance, Nature, 532, 375, 10.1038/nature17407 · DOI · Paper page
  115. Veronese, N., Dominguez, L.J., Pizzol, D., Demurtas, J., Smith, L., and Barbagallo, M. (2021). Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients, 13. · DOI
  116. Hou, 2020, Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons, Mol. Neurobiol., 57, 2539, 10.1007/s12035-020-01871-z · DOI · Paper page
  117. Pochwat, 2014, Antidepressant-like activity of magnesium in the chronic mild stress model in rats: Alterations in the NMDA receptor subunits, Int. J. Neuropsychopharmacol., 17, 393, 10.1017/S1461145713001089 · DOI
  118. Sun, J., Lin, H., He, G., Lin, W., and Yang, J. (2017). Magnesium sulphate attenuate remifentanil-induced postoperative hyperalgesia via regulating tyrosine phosphorylation of the NR(2)B subunit of the NMDA receptor in the spinal cord. BMC Anesthesiol., 17. · DOI
  119. Li, 2011, Second messenger role for Mg2+ revealed by human T-cell immunodeficiency, Nature, 475, 471, 10.1038/nature10246 · DOI · Paper page
  120. Li, 2014, XMEN disease: A new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus, Blood, 123, 2148, 10.1182/blood-2013-11-538686 · DOI
  121. Li, 2013, Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D, Science, 341, 186, 10.1126/science.1240094 · DOI · Paper page
  122. Tur, J., Chapalamadagu, K.C., Manickam, R., Cheng, F., and Tipparaju, S.M. (2021). Deletion of Kvbeta2 (AKR6) Attenuates Isoproterenol Induced Cardiac Injury with Links to Solute Carrier Transporter SLC41a3 and Circadian Clock Genes. Metabolites, 11. · DOI
  123. Resnick, 2001, Relation of cellular potassium to other mineral ions in hypertension and diabetes, Hypertension, 38, 709, 10.1161/01.HYP.38.3.709 · DOI
  124. Saris, 2000, Magnesium. An update on physiological, clinical and analytical aspects, Clin. Chim. Acta, 294, 1, 10.1016/S0009-8981(99)00258-2 · DOI · Paper page
  125. Ford, 2003, Dietary magnesium intake in a national sample of US adults, J. Nutr., 133, 2879, 10.1093/jn/133.9.2879 · DOI · Paper page
  126. Mensink, 2013, Mapping low intake of micronutrients across Europe, Br. J. Nutr., 110, 755, 10.1017/S000711451200565X · DOI · Paper page
  127. King, 2005, Dietary magnesium and C-reactive protein levels, J. Am. Coll. Nutr., 24, 166, 10.1080/07315724.2005.10719461 · DOI · Paper page
  128. Rosanoff, 2012, Suboptimal magnesium status in the United States: Are the health consequences underestimated?, Nutr. Rev., 70, 153, 10.1111/j.1753-4887.2011.00465.x · DOI · Paper page
  129. Marriott, 2010, Intake of added sugars and selected nutrients in the United States, National Health and Nutrition Examination Survey (NHANES) 2003-2006, Crit. Rev. Food Sci. Nutr., 50, 228, 10.1080/10408391003626223 · DOI · Paper page
  130. Ye, 2023, Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease, J. Am. Heart Assoc., 12, e030077, 10.1161/JAHA.123.030077 · DOI
  131. Oost, 2021, Serum Magnesium Is Inversely Associated With Heart Failure, Atrial Fibrillation, and Microvascular Complications in Type 2 Diabetes, Diabetes Care, 44, 1757, 10.2337/dc21-0236 · DOI
  132. Mooren, 2003, Effect of magnesium on granulocyte function and on the exercise induced inflammatory response, Magnes. Res., 16, 49
  133. Beller, 1975, Changes in serum and sweat magnesium levels during work in the heat, Aviat. Space Environ. Med., 46, 709
  134. Soria, 2011, Submaximal exercise intensities do not provoke variations in plasma magnesium concentration in well-trained euhydrated endurance athletes with no magnesium deficiency, Magnes. Res., 24, 36, 10.1684/mrh.2011.0279 · DOI
  135. Bartolome, 2019, Effect of heat exposure and physical exercise until exhaustion in normothermic and hyperthermic conditions on serum, sweat and urinary concentrations of magnesium and phosphorus, J. Therm. Biol., 84, 176, 10.1016/j.jtherbio.2019.07.010 · DOI
  136. Chen, W., Hammond-Bennett, A., Hypnar, A., and Mason, S. (2018). Health-related physical fitness and physical activity in elementary school students. BMC Public. Health, 18. · DOI
  137. Veronese, 2024, Physical activity and persistence of supra-threshold depressive symptoms in older adults: A ten-year cohort study, Psychiatry Res., 342, 116259, 10.1016/j.psychres.2024.116259 · DOI
  138. Mikkelsen, 2017, Exercise and mental health, Maturitas, 106, 48, 10.1016/j.maturitas.2017.09.003 · DOI · Paper page
  139. Chow, 2022, Exerkines in health, resilience and disease, Nat. Rev. Endocrinol., 18, 273, 10.1038/s41574-022-00641-2 · DOI · Paper page
  140. Margolis, 2013, Optimizing intramuscular adaptations to aerobic exercise: Effects of carbohydrate restriction and protein supplementation on mitochondrial biogenesis, Adv. Nutr., 4, 657, 10.3945/an.113.004572 · DOI
  141. Paulsen, 2014, Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training, J. Physiol., 592, 5391, 10.1113/jphysiol.2014.279950 · DOI · Paper page
  142. Wardenaar, 2025, Summary of the 2024 Professionals in Nutrition for Exercise and Sport “10 Questions/10 Experts” Session-Hot Topics for the Paris Olympic Games, Int. J. Sport Nutr. Exerc. Metab., 35, 76, 10.1123/ijsnem.2024-0167 · DOI
  143. Souza, A.C.R., Vasconcelos, A.R., Dias, D.D., Komoni, G., and Name, J.J. (2023). The Integral Role of Magnesium in Muscle Integrity and Aging: A Comprehensive Review. Nutrients, 15. · DOI
  144. Mert, 2003, Effects of calcium and magnesium on peripheral nerve conduction, Pol. J. Pharmacol., 55, 25
  145. Petrovic, 2016, Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man, Oxid. Med. Cell Longev., 2016, 2019643, 10.1155/2016/2019643 · DOI · Paper page
  146. Nocella, C., Cammisotto, V., Pigozzi, F., Borrione, P., Fossati, C., D’Amico, A., Cangemi, R., Peruzzi, M., Gobbi, G., and Ettorre, E. (2019). Impairment between Oxidant and Antioxidant Systems: Short- and Long-term Implications for Athletes’ Health. Nutrients, 11. · DOI
  147. Powers, 2020, Exercise-induced oxidative stress: Friend or foe?, J. Sport Health Sci., 9, 415, 10.1016/j.jshs.2020.04.001 · DOI · Paper page
  148. Negru, A.G., Pastorcici, A., Crisan, S., Cismaru, G., Popescu, F.G., and Luca, C.T. (2022). The Role of Hypomagnesemia in Cardiac Arrhythmias: A Clinical Perspective. Biomedicines, 10. · DOI
  149. Scherr, 2012, Repolarization perturbation and hypomagnesemia after extreme exercise, Med. Sci. Sports Exerc., 44, 1637, 10.1249/MSS.0b013e318258aaf4 · DOI
  150. Bohl, 2002, Magnesium and exercise, Crit. Rev. Food Sci. Nutr., 42, 533, 10.1080/20024091054247 · DOI
  151. Zalcman, 2007, Nutritional status of adventure racers, Nutrition, 23, 404, 10.1016/j.nut.2007.01.001 · DOI
  152. Noda, 2009, Nutrient intake and blood iron status of male collegiate soccer players, Asia Pac. J. Clin. Nutr., 18, 344
  153. Imamura, 2013, Nutrient intake, serum lipids and iron status of colligiate rugby players, J. Int. Soc. Sports Nutr., 10, 9, 10.1186/1550-2783-10-9 · DOI
  154. Silva, 2015, Low energy availability and low body fat of female gymnasts before an international competition, Eur. J. Sport Sci., 15, 591, 10.1080/17461391.2014.969323 · DOI · Paper page
  155. Heaney, 2010, Comparison of strategies for assessing nutritional adequacy in elite female athletes’ dietary intake, Int. J. Sport Nutr. Exerc. Metab., 20, 245, 10.1123/ijsnem.20.3.245 · DOI · Paper page
  156. Lukaski, 2000, Magnesium, zinc, and chromium nutriture and physical activity, Am. J. Clin. Nutr., 72, 585S, 10.1093/ajcn/72.2.585S · DOI · Paper page
  157. Zhang, 2023, Lower serum magnesium concentration and higher 24-h urinary magnesium excretion despite higher dietary magnesium intake in athletes: A systematic review and meta-analysis, Food Sci. Hum. Wellness, 12, 10, 10.1016/j.fshw.2023.02.015 · DOI
  158. Maeda, 2022, Determination of Optimal Daily Magnesium Intake among Physically Active People: A Scoping Review, J. Nutr. Sci. Vitaminol., 68, 189, 10.3177/jnsv.68.189 · DOI
  159. Pollock, 2020, An 8-year Analysis of Magnesium Status in Elite International Track & Field Athletes, J. Am. Coll. Nutr., 39, 443, 10.1080/07315724.2019.1691953 · DOI
  160. Fiorentini, D., Cappadone, C., Farruggia, G., and Prata, C. (2021). Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency. Nutrients, 13. · DOI · Paper page
  161. Reinhart, 1988, Magnesium metabolism. A review with special reference to the relationship between intracellular content and serum levels, Arch. Intern. Med., 148, 2415, 10.1001/archinte.1988.00380110065013 · DOI
  162. Ketteler, 2012, Magnesium basics, Clin. Kidney J., 5, i3, 10.1093/ndtplus/sfr163 · DOI · Paper page
  163. Reddy, 2018, Magnesium Balance and Measurement, Adv. Chronic Kidney Dis., 25, 224, 10.1053/j.ackd.2018.03.002 · DOI
  164. Preedy, 2014, Chapter 16-Magnesium, Oxidative Stress, and Aging Muscle, Aging-Oxidative Stress and Dietary Antioxidants, Volume 1, 157
  165. Short, 2005, Decline in skeletal muscle mitochondrial function with aging in humans, Proc. Natl. Acad. Sci. USA, 102, 5618, 10.1073/pnas.0501559102 · DOI · Paper page
  166. Barbagallo, 2010, Magnesium and aging, Curr. Pharm. Des., 16, 832, 10.2174/138161210790883679 · DOI
  167. Zajac, A., Golas, A., Chycki, J., Halz, M., and Michalczyk, M.M. (2020). The Effects of Long-Term Magnesium Creatine Chelate Supplementation on Repeated Sprint Ability (RAST) in Elite Soccer Players. Nutrients, 12. · DOI · Paper page
  168. Golf, 1998, On the significance of magnesium in extreme physical stress, Cardiovasc. Drugs Ther., 12, 197, 10.1023/A:1007708918683 · DOI
  169. Peveler, 2012, Effect of magnesium lactate dihydrate and calcium lactate monohydrate on 20-km cycling time trial performance, J. Strength. Cond. Res., 26, 1149, 10.1519/JSC.0b013e31822dcd7f · DOI
  170. Kass, 2013, A pilot study on the effects of magnesium supplementation with high and low habitual dietary magnesium intake on resting and recovery from aerobic and resistance exercise and systolic blood pressure, J. Sports Sci. Med., 12, 144
  171. Steward, 2019, One week of magnesium supplementation lowers IL-6, muscle soreness and increases post-exercise blood glucose in response to downhill running, Eur. J. Appl. Physiol., 119, 2617, 10.1007/s00421-019-04238-y · DOI
  172. Terblanche, 1992, Failure of magnesium supplementation to influence marathon running performance or recovery in magnesium-replete subjects, Int. J. Sport Nutr., 2, 154, 10.1123/ijsn.2.2.154 · DOI · Paper page
  173. Kanis, 2021, SCOPE 2021: A new scorecard for osteoporosis in Europe, Arch. Osteoporos., 16, 82, 10.1007/s11657-020-00871-9 · DOI · Paper page
  174. Lorentzon, 2022, Osteoporosis epidemiology using international cohorts, Curr. Opin. Rheumatol., 34, 280
  175. Rondanelli, M., Faliva, M.A., Barrile, G.C., Cavioni, A., Mansueto, F., Mazzola, G., Oberto, L., Patelli, Z., Pirola, M., and Tartara, A. (2021). Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid. Nutrients, 14. · DOI
  176. Rude, 2006, Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism, Osteoporos. Int., 17, 1022, 10.1007/s00198-006-0104-3 · DOI
  177. Rude, 2004, Bone loss induced by dietary magnesium reduction to 10% of the nutrient requirement in rats is associated with increased release of substance P and tumor necrosis factor-alpha, J. Nutr., 134, 79, 10.1093/jn/134.1.79 · DOI
  178. Rude, 2009, Skeletal and hormonal effects of magnesium deficiency, J. Am. Coll. Nutr., 28, 131, 10.1080/07315724.2009.10719764 · DOI · Paper page
  179. Wu, 2014, Effects of extracellular magnesium on the differentiation and function of human osteoclasts, Acta Biomater., 10, 2843, 10.1016/j.actbio.2014.02.010 · DOI
  180. Belluci, 2013, Magnesium deficiency results in an increased formation of osteoclasts, J. Nutr. Biochem., 24, 1488, 10.1016/j.jnutbio.2012.12.008 · DOI
  181. Choi, 2020, Biochemical activity of magnesium ions on human osteoblast migration, Biochem. Biophys. Res. Commun., 531, 588, 10.1016/j.bbrc.2020.07.057 · DOI
  182. Wu, 2015, Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture, Acta Biomater., 27, 294, 10.1016/j.actbio.2015.08.042 · DOI
  183. Orchard, 2014, Magnesium intake, bone mineral density, and fractures: Results from the Women’s Health Initiative Observational Study, Am. J. Clin. Nutr., 99, 926, 10.3945/ajcn.113.067488 · DOI
  184. Tucker, 1999, Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women, Am. J. Clin. Nutr., 69, 727, 10.1093/ajcn/69.4.727 · DOI · Paper page
  185. Groenendijk, 2022, Impact of magnesium on bone health in older adults: A systematic review and meta-analysis, Bone, 154, 116233, 10.1016/j.bone.2021.116233 · DOI
  186. Ryder, 2005, Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects, J. Am. Geriatr. Soc., 53, 1875, 10.1111/j.1532-5415.2005.53561.x · DOI
  187. Veronese, 2017, Dietary magnesium intake and fracture risk: Data from a large prospective study, Br. J. Nutr., 117, 1570, 10.1017/S0007114517001350 · DOI
  188. Dominguez, L.J., Veronese, N., Ciriminna, S., Perez-Albela, J.L., Vasquez-Lopez, V.F., Rodas-Regalado, S., Di Bella, G., Parisi, A., Tagliaferri, F., and Barbagallo, M. (2023). Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients, 15. · DOI
  189. Matias, 2012, Magnesium intake mediates the association between bone mineral density and lean soft tissue in elite swimmers, Magnes. Res., 25, 120, 10.1684/mrh.2012.0317 · DOI
  190. Resnick, 1997, Magnesium in the pathophysiology and treatment of hypertension and diabetes mellitus: Where are we in 1997?, Am. J. Hypertens., 10, 368
  191. Chiarello, 2018, Mechanisms of the effect of magnesium salts in preeclampsia, Placenta, 69, 134, 10.1016/j.placenta.2018.04.011 · DOI
  192. Dalton, 2016, Magnesium in pregnancy, Nutr. Rev., 74, 549, 10.1093/nutrit/nuw018 · DOI
  193. Tangvoraphonkchai, 2018, Magnesium and Cardiovascular Disease, Adv. Chronic Kidney Dis., 25, 251, 10.1053/j.ackd.2018.02.010 · DOI
  194. Mannuss, 2020, Inhibition of agonist-induced platelet aggregation by magnesium sulfate warrants its use as an alternative in vitro anticoagulant in pseudothrombocytopenia, Platelets, 31, 680, 10.1080/09537104.2019.1663804 · DOI
  195. Zaslow, S.J., Oliveira-Paula, G.H., and Chen, W. (2024). Magnesium and Vascular Calcification in Chronic Kidney Disease: Current Insights. Int. J. Mol. Sci., 25. · DOI
  196. Levine, 1984, Magnesium, the mimic/antagonist of calcium, N. Engl. J. Med., 310, 1253, 10.1056/NEJM198405103101910 · DOI
  197. Nielsen, F.H. (2024). The Role of Dietary Magnesium in Cardiovascular Disease. Nutrients, 16. · DOI
  198. Celeski, M., Di Gioia, G., Nusca, A., Segreti, A., Squeo, M.R., Lemme, E., Mango, F., Ferrera, A., Ussia, G.P., and Grigioni, F. (2024). The Spectrum of Coronary Artery Disease in Elite Endurance Athletes-A Long-Standing Debate: State-of-the-Art Review. J. Clin. Med., 13. · DOI
  199. Eisenberg, 1992, Magnesium deficiency and sudden death, Am. Heart J., 124, 544, 10.1016/0002-8703(92)90633-7 · DOI
  200. 1992, Sudden death of athletes: Is it due to long-term changes in serum magnesium, lipids and blood sugar?, J. Basic. Clin. Physiol. Pharmacol., 3, 153, 10.1515/JBCPP.1992.3.2.153 · DOI

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Metadata

Authors
Dominguez, L. J., Veronese, N., Ragusa, F. S., Baio, S. M., Sgrò, F., Russo, A., Battaglia, G., Bianco, A., & Barbagallo, M.
Affiliations
  • Department of Medicine and Surgery, “Kore” University of Enna, 94100 Enna, Italy
  • Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90100 Palermo, Italy
  • Department of Human and Society Sciences, “Kore” University of Enna, 94100 Enna, Italy
  • Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Science and Human Movement, University of Palermo, 90133 Palermo, Italy
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2025-05-13
Volume
17
Issue
10
Pages
1655
ISSN
2072-6643
DOI
10.3390/nu17101655
Cited by
19
References
20
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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CoChat. (2026). Citation check: The Importance of Vitamin D and Magnesium in Athletes. https://app.cochat.ai/papers/10.3390/nu17101655
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Dominguez, L. J., Veronese, N., Ragusa, F. S., Baio, S. M., Sgrò, F., Russo, A., Battaglia, G., Bianco, A., & Barbagallo, M. (2025). The Importance of Vitamin D and Magnesium in Athletes. Nutrients. https://doi.org/10.3390/nu17101655

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