Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation?

Role of Insulin Resistance in Human Disease

Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154

Inflammation and insulin resistance

Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769

Lipid rafts as a membrane-organizing principle

Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417

Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains

Ritter, M., Schmidt, S., Jakab, M., Paulmichl, M., & Henderson, R. M. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350122 · Cited by 3,923

Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease

Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism

Desvergne, B., & Wahli, W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0380 · Cited by 3,115

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428

Mechanisms for Insulin Resistance: Common Threads and Missing Links

Samuel, V. T., & Shulman, G. I. (2012) · Cell · doi:10.1016/j.cell.2012.02.017 · Cited by 2,294

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism

Desvergne, B. (1999) · Endocrine Reviews · doi:10.1210/er.20.5.649 · Cited by 1,251

Resolution Phase of Inflammation: Novel Endogenous Anti-Inflammatory and Proresolving Lipid Mediators and Pathways

Serhan, C. N. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141647 · Cited by 1,020

Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid

Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967

Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms

Larsson, S. C., Kumlin, M., Ingelman-Sundberg, M., & Wolk, A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.935 · Cited by 950

High-Density Lipoprotein Subfractions - What the Clinicians Need to Know

Pirillo, A., Norata, G. D., & Catapano, A. L. (2013) · Cardiology · doi:10.1159/000346463 · Cited by 754

Protein carbamylation links inflammation, smoking, uremia and atherogenesis

Wang, Z., Nicholls, S. J., Rodríguez, E. R., Kummu, O., Hörkkö, S., Barnard, J., Reynolds, W. F., Topol, E. J., DiDonato, J. A., & Hazen, S. L. (2007) · Nature Medicine · doi:10.1038/nm1637 · Cited by 722

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., Flower, R. J., Perretti, M., & Serhan, C. N. (2009) · Nature · doi:10.1038/nature08541 · Cited by 695

Increased dietary intake of ω-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis

Connor, K. M., SanGiovanni, J. P., Löfqvist, C., Aderman, C. M., Chen, J., Higuchi, A., Hong, S., Pravda, E. A., Majchrzak, S. F., Carper, D. A., et al. (2007) · Nature Medicine · doi:10.1038/nm1591 · Cited by 687

Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 677

Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats

Storlien, L. H., Kraegen, E. W., Chisholm, D. J., Ford, G. L., Bruce, D. G., & Pascoe, W. S. (1987) · Science · doi:10.1126/science.3303333 · Cited by 648

Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin

DeFronzo, R. A. (1979) · Diabetes · doi:10.2337/diab.28.12.1095 · Cited by 595

Endurance Exercise as a Countermeasure for Aging

Lanza, I. R., Short, D. K., Short, K. R., Raghavakaimal, S., Basu, R., Joyner, M. J., McConnell, J. P., & Nair, K. S. (2008) · Diabetes · doi:10.2337/db08-0349 · Cited by 582

n–3 Fatty Acids in Cardiovascular Disease

Caterina, R. D. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1008153 · Cited by 572

Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance

Kelley, D. E., Thaete, F. L., Troost, F., Huwe, T., & Goodpaster, B. H. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.5.e941 · Cited by 538

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

Spite, M., Clària, J., & Serhan, C. N. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.006 · Cited by 464

Racial Differences in the Relation between Blood Pressure and Insulin Resistance

Saad, M. F., Lillioja, S., Nyomba, B. L., Castillo, C., Ferraro, R., De Gregorio, M., Ravussin, E., Knowler, W. C., Bennett, P. H., Howard, B. V., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103143241105 · Cited by 421

Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review

Lombardo, Y. B., & Chicco, A. G. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.08.002 · Cited by 364

M USCLE T RIGLYCERIDE AND I NSULIN R ESISTANCE

Kelley, D. E., Goodpaster, B. H., & Storlien, L. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102912 · Cited by 364

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

Farzaneh‐Far, R. (2010) · JAMA · doi:10.1001/jama.2009.2008 · Cited by 362

Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults

Couet, C., Delarue, J., Ritz, P., Antoine, J.-M., & Lamisse, F. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800451 · Cited by 344

Resolution phase lipid mediators of inflammation: agonists of resolution

Serhan, C. N., & Chiang, N. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.05.012 · Cited by 343

Omega-3 fatty acids and incident type 2 diabetes: A systematic review and meta-analysis

Wu, J. H. Y., Micha, R., Imamura, F., Pan, A., Biggs, M. L., Ajaz, O., Djousse, L., B. Hu, F., & Mozaffarian, D. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001602 · Cited by 340

Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids.

Kidd, P. M. (2007) · PubMed · Cited by 336

Omega‐3 Dietary Supplements and the Risk of Cardiovascular Events: A Systematic Review

Marik, P. E., & Varon, J. (2009) · Clinical Cardiology · doi:10.1002/clc.20604 · Cited by 328

Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: A randomized controlled study

Kabir, M., Skurnik, G., Naour, N., Pechtner, V., Meugnier, E., Rome, S., Quignard-Boulangé, A., Vidal, H., Slama, G., Clément, K., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1670 · Cited by 316

(n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights

Kalupahana, N. S., Claycombe, K. J., & Moustaid-Moussa, N. (2011) · Advances in Nutrition · doi:10.3945/an.111.000505 · Cited by 305

Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial

Rajkumar, H., Mahmood, N., Kumar, M., Varikuti, S. R., Challa, H. R., & Myakala, S. P. (2014) · Mediators of Inflammation · doi:10.1155/2014/348959 · Cited by 301

Eicosapentaenoic Acid Prevents and Reverses Insulin Resistance in High-Fat Diet-Induced Obese Mice via Modulation of Adipose Tissue Inflammation1–3

Kalupahana, N. S., Claycombe, K., Newman, S. J., Stewart, T. P., Siriwardhana, N., Matthan, N. R., Lichtenstein, A. H., & Moustaïd‐Moussa, N. (2010) · Journal of Nutrition · doi:10.3945/jn.110.125732 · Cited by 301

Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function

Karakelides, H., Irving, B. A., Short, K. R., O'Brien, P., & Nair, K. S. (2010) · Diabetes · doi:10.2337/db09-0591 · Cited by 293

Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus

Hartweg, J., Perera, R., Montori, V. M., Dinneen, S. F., Neil, A. H., & Farmer, A. J. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003205.pub2 · Cited by 282

Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia

Skulas-Ray, A. C., Kris-Etherton, P. M., Harris, W. S., Vanden Heuvel, J. P., Wagner, P. R., & West, S. G. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.003871 · Cited by 280

Effect of Oral Eicosapentaenoic Acid on Weight Loss in Patients With Pancreatic Cancer

Wigmore, S. J., Barber, M. D., Ross, J. A., Tisdale, M. J., & Fearon, K. C. H. (2000) · Nutrition and Cancer · doi:10.1207/s15327914nc3602_6 · Cited by 275

Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle

Ellis, B. A., Poynten, A., Lowy, A. J., Furler, S. M., Chisholm, D. J., Kraegen, E. W., & Cooney, G. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e554 · Cited by 273

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

Turinsky, J., O'Sullivan, D. M., & Bayly, B. P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44844-7 · Cited by 269

Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content

Þórsdóttir, I., Tómasson, H., Gunnarsdóttir, I., Gisladottir, E. U., Kiely, M. E., Parra, M. D., Bandarra, N. M., Schaafsma, G., & Martínez, J. A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803643 · Cited by 265

Combining fish-oil supplements with regular aerobic exercise improves body composition and cardiovascular disease risk factors

Hill, A. M., Buckley, J. D., Murphy, K. J., & Howe, P. R. C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1267 · Cited by 244

Fish oil supplementation in type 2 diabetes: a quantitative systematic review.

Montori, V. M., Farmer, A. A., Wollan, P. C., & Dinneen, S. F. (2000) · Diabetes Care · doi:10.2337/diacare.23.9.1407 · Cited by 241

n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner

Neschen, S., Morino, K., Dong, J., Wang-Fischer, Y., Cline, G. W., Romanelli, A. J., Rossbacher, J. C., Moore, I. K., Regittnig, W., Muñoz, D. S., et al. (2007) · Diabetes · doi:10.2337/db06-1206 · Cited by 236

Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women

Krebs, J. D., Browning, L. M., McLean, N., Rothwell, J. L., Mishra, G. D., Moore, C. S., & Jebb, S. A. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803309 · Cited by 228

Glucose tolerance in young and older athletes and sedentary men

Seals, D. R., Hagberg, J. M., Allen, W. K., Hurley, B. F., Dalsky, G. P., Ehsani, A. A., & Holloszy, J. O. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.6.1521 · Cited by 228

Fish Consumption, Dietary Long-Chain n-3 Fatty Acids, and Risk of Type 2 Diabetes

Wallin, A., Giuseppe, D. D., Orsini, N., Patel, P. S., Forouhi, N. G., & Wolk, A. (2012) · Diabetes Care · doi:10.2337/dc11-1631 · Cited by 226

Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes

Strączkowski, M., Kowalska, I., Baranowski, M., Nikołajuk, A., Otziomek, E., Zabielski, P., Adamska, A., Blachnio, A., Górski, J., & Górska, M. (2007) · Diabetologia · doi:10.1007/s00125-007-0781-2 · Cited by 222

Effects of altering the ratio of dietary n−6 to n−3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45–70 y: the OPTILIP Study

Griffin, M., Sanders, T. A. B., Davies, I. G., Morgan, L., Millward, D. J., Lewis, F., Slaughter, S. L., Cooper, J. A., Miller, G. J., & Griffin, B. A. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.6.1290 · Cited by 190

The Effect of n-3 Fatty Acids on Glucose Homeostasis and Insulin Sensitivity

Flachs, P., Rossmeisl, M., & Kopecký, J. (2014) · Physiological Research · doi:10.33549/physiolres.932715 · Cited by 190

Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects With Insulin Resistance

Spencer, M. L., Finlin, B. S., Ünal, R., Zhu, B., Morris, A. J., Shipp, L. R., Lee, J. D., Walton, R. G., Adu, A. K., Erfani, R. A., et al. (2013) · Diabetes · doi:10.2337/db12-1042 · Cited by 186

Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice

White, P. J., Arita, M., Taguchi, R., Kang, J. X., & Marette, A. (2010) · Diabetes · doi:10.2337/db10-0054 · Cited by 185

n -3 Polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle

Taouis, M., Dagou, C., Ster, C., Durand, G., Pinault, M., & Delarue, J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00320.2001 · Cited by 184

Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle

Herbst, E. A. F., Paglialunga, S., Gerling, C., Whitfield, J., Mukai, K., Chabowski, A., Heigenhauser, G. J. F., Spriet, L. L., & Holloway, G. P. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.267336 · Cited by 179

Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

Poudyal, H., Panchal, S. K., Ward, L. C., & Brown, L. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.07.014 · Cited by 173

Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains

Williams, J. A., Batten, S. E., Harris, M., Rockett, B. D., Shaikh, S. R., Stillwell, W., & Wassall, S. R. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.06.016 · Cited by 168

Omega-3 polyunsaturated fatty acid and insulin sensitivity: A meta-analysis of randomized controlled trials

Akinkuolie, A. O., Ngwa, J. S., Meigs, J. B., & Djoussé, L. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.08.013 · Cited by 167

Long-Term Effects of Fish Oil on Insulin Resistance and Plasma Lipoproteins in NIDDM Patients With Hypertriglyceridemia

Rivellese, A. A., Maffettone, A., Iovine, C., Marino, L. D., Annuzzi, G., Mancini, M., & Riccardi, G. (1996) · Diabetes Care · doi:10.2337/diacare.19.11.1207 · Cited by 166

A high ratio of dietary n-3/n-6 polyunsaturated fatty acids improves obesity-linked inflammation and insulin resistance through suppressing activation of TLR4 in SD rats

Liu, H.-Q., Qiu, Y. F., Mu, Y., Zhang, X.-J., Liu, L., Hou, X.-H., Zhang, L., Xu, X., Ji, A.-L., Cao, R., et al. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.07.004 · Cited by 165

The impact of long chain n ‐3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype

Browning, L. M., Krebs, J. D., Moore, C. S., Mishra, G. D., O’Connell, M. A., & Jebb, S. A. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00576.x · Cited by 162

Mediterranean Diet for Primary Prevention of Cardiovascular Disease

(2014) · New England Journal of Medicine · doi:10.1056/nejmx140016 · Cited by 158

Effects of n−3 fatty acids in subjects with type 2 diabetes: reduction of insulin sensitivity and time-dependent alteration from carbohydrate to fat oxidation

Mostad, I. L., Bjerve, K. S., Bjorgaas, M. R., Lydersen, S., & Grill, V. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.540 · Cited by 152 · cited 2×

n-3 Fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet

Kuda, O., Jelenik, T., Jilkova, Z., Flachs, P., Rossmeisl, M., Hensler, M., Kazdova, L., Ogston, N., Baranowski, M., Gorski, J., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1305-z · Cited by 142

Mediterranean Diet for Primary Prevention of Cardiovascular Disease

Estruch, R., Ros, E., & Martínez‐González, M. Á. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1306659 · Cited by 141

Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis

White, P. J., St‐Pierre, P., Charbonneau, A., Mitchell, P. L., St-Amand, E., Marcotte, B., & Marette, A. (2014) · Nature Medicine · doi:10.1038/nm.3549 · Cited by 136

Trends in Hyperinsulinemia Among Nondiabetic Adults in the U.S.

Li, C., Ford, E. S., McGuire, L. C., Mokdad, A. H., Little, R. R., & Reaven, G. M. (2006) · Diabetes Care · doi:10.2337/dc06-0289 · Cited by 136

Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet

Lanza, I. R., Blachnio-Zabielska, A., Johnson, M. L., Schimke, J. M., Jakaitis, D. R., Lebrasseur, N. K., Jensen, M. D., Sreekumaran Nair, K., & Zabielski, P. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00584.2012 · Cited by 135

High Omega-3 Fat Intake Improves Insulin Sensitivity and Reduces CRP and IL6, but does not Affect Other Endocrine Axes in Healthy Older Adults

Tsitouras, P. D., Gucciardo, F., Salbe, A. D., Heward, C. B., & Harman, S. M. (2008) · Hormone and Metabolic Research · doi:10.1055/s-2008-1046759 · Cited by 135

Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults

Ramel, A., Martínez, J. A., Kiely, M. E., Morais, G., Bandarra, N. M., & Þórsdóttir, I. (2008) · Diabetologia · doi:10.1007/s00125-008-1035-7 · Cited by 133

Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults

Johnson, M. L., Distelmaier, K., Lanza, I. R., Irving, B. A., Robinson, M. M., Konopka, A. R., Shulman, G. I., & Nair, K. S. (2016) · Diabetes · doi:10.2337/db15-0675 · Cited by 129

Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice

Liu, X., Xue, Y., Liu, C., Lou, Q., Wang, J., Yanagita, T., Xue, C., & Wang, Y. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-109 · Cited by 128

Marine N-3 Polyunsaturated Fatty Acids Are Inversely Associated with Risk of Type 2 Diabetes in Asians: A Systematic Review and Meta-Analysis

Zheng, J.-S., Huang, T., Yang, J., Fu, Y.-Q., & Li, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044525 · Cited by 126

n-6:n-3 PUFA ratio is involved in regulating lipid metabolism and inflammation in pigs

Duan, Y., Li, F., Li, L., Fan, J., Sun, X., & Yin, Y. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002584 · Cited by 120

Differential effects of safflower oil versus fish oil feeding on insulin-stimulated glycogen synthesis, glycolysis, and pyruvate dehydrogenase flux in skeletal muscle: a 13C nuclear magnetic resonance study.

Jucker, B. M., Cline, G. W., Barucci, N., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.1.134 · Cited by 119

Omega-3 fatty acids improve glucose tolerance and components of the metabolic syndrome in Alaskan Eskimos: the Alaska Siberia project

Ebbesson, S. O. E., Risica, P. M., Ebbesson, L. O. E., Kennish, J. M., & Tejero, M. E. (2005) · International Journal of Circumpolar Health · doi:10.3402/ijch.v64i4.18016 · Cited by 117

Fish Consumption and Incidence of Diabetes

Xun, P., & He, K. (2012) · Diabetes Care · doi:10.2337/dc11-1869 · Cited by 114

Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training

Konopka, A. R., Asante, A., Lanza, I. R., Robinson, M. M., Johnson, M. L., Dalla Man, C., Cobelli, C., Amols, M. H., Irving, B. A., & Nair, K. S. (2015) · Diabetes · doi:10.2337/db14-1701 · Cited by 112

Regulation of adipokine secretion by n -3 fatty acids

Moreno-Aliaga, M. J., Lorente‐Cebrián, S., & Martínez, J. A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110001801 · Cited by 112

The structure of DHA in phospholipid membranes

Gawrisch, K., Eldho, N. V., & Holte, L. L. (2003) · Lipids · doi:10.1007/s11745-003-1082-0 · Cited by 110

Endogenously Decreasing Tissue n-6/n-3 Fatty Acid Ratio Reduces Atherosclerotic Lesions in Apolipoprotein E –Deficient Mice by Inhibiting Systemic and Vascular Inflammation

Wan, J., Huang, L., Rong, R., Tan, R., Wang, J., & Kang, J. X. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.210054 · Cited by 107

Fish oil, insulin sensitivity, insulin secretion and glucose tolerance in healthy people: Is there any effect of fish oil supplementation in relation to the type of background diet and habitual dietary intake of n-6 and n-3 fatty acids?

Giacco, R., Cuomo, V., Vessby, B. O., Uusitupa, M. I. J., Hermansen, K., Meyer, B. J., Riccardi, G., & Rivellese, A. A. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.06.006 · Cited by 105

Intake of Fish and n-3 Fatty Acids and Future Risk of Metabolic Syndrome

Baik, I., Abbott, R. D., Curb, J. D., & Shin, C. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.04.013 · Cited by 103

A Comparison of the Effects of n-3 Fatty Acids From Linseed Oil and Fish Oil in Well-Controlled Type II Diabetes

McManus, R. M., Jumpson, J., Finegood, D. T., Clandinin, M. T., & Ryan, E. A. (1996) · Diabetes Care · doi:10.2337/diacare.19.5.463 · Cited by 103

Effects of N-3 PUFAs Supplementation on Insulin Resistance and Inflammatory Biomarkers in Hemodialysis Patients

Rašić-Milutinović, Z., Peruničić, G., Plješa, S., Gluvic, Z. M., Sobajic, S. S., Djuricic, I. D., & Ristić, D. (2007) · Renal Failure · doi:10.1080/08860220601184092 · Cited by 99

The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials

López‐Huertas, E. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001572 · Cited by 97

A controlled study on the effects of n − 3 fatty acids on lipid and glucose metabolism in non-insulin-dependent diabetic patients

Annuzzi, G., Rivellese, A. A., Capaldo, B., Marino, L., Iovine, C., Marotta, G., & Riccardi, G. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90233-s · Cited by 96

AMP-activated protein kinase α2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids

Jelenik, T., Rossmeisl, M., Kuda, O., Jilkova, Z. M., Medrikova, D., Kus, V., Hensler, M., Janovska, P., Miksik, I., Baranowski, M., et al. (2010) · Diabetes · doi:10.2337/db09-1716 · Cited by 88

Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some metabolic risk factors in women with polycystic ovary syndrome.

Mohammadi, E., Rafraf, M., Farzadi, L., Jafarabadi, M. A., & Sabour, S. (2012) · PubMed · Cited by 84

Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with Omega‐3 polyunsaturated fatty acids

Fontani, G., Corradeschi, F., Felici, A., Alfatti, F., Bugarini, R., Fiaschi, A. I., Cerretani, D., Montorfano, G., Rizzo, A. M., & Berra, B. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01540.x · Cited by 83

Effects of fish oil on metabolic responses to oral fructose and glucose loads in healthy humans

Delarue, J., Couet, C., Cohen, R., Bréchot, J.-F., Antoine, J. M., & Lamisse, F. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.2.e353 · Cited by 80

Unsaturated Fatty Acids

The British Nutrition Foundation (1992) · Springer eBooks · doi:10.1007/978-1-4899-4429-0 · Cited by 80

The nutritional and clinical significance of lipid rafts

Yaqoob, P., & Shaikh, S. R. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328335725b · Cited by 79

Omega-3 index, obesity and insulin resistance in children

Burrows, T. L., Collins, C. E., & Garg, M. L. (2011) · International Journal of Pediatric Obesity · doi:10.3109/17477166.2010.549489 · Cited by 78

Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans

Lalia, A. Z., Dasari, S., Johnson, M. L., Robinson, M. M., Konopka, A. R., Distelmaier, K., Port, J. D., Glavin, M., Esponda, R. R., Nair, K. S., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2892 · Cited by 78

Effects of dietary n-3 fatty acids on hepatic and peripheral insulin sensitivity in insulin resistant humans

Lalia, A. Z., Johnson, M. L., Jensen, M. D., Hames, K. C., Port, J. D., & Lanza, I. R. (2015) · Diabetes Care · doi:10.2337/dc14-3101 · Cited by 73

Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: Evaluation with euglycemic clamp and oral fat load

Derosa, G., Cicero, A. F. G., Fogari, E., D’Angelo, A., Bonaventura, A., Romano, D., & Maffioli, P. (2012) · Journal of clinical lipidology · doi:10.1016/j.jacl.2012.02.010 · Cited by 68

Omega-3 polyunsaturated fatty acids reduce insulin resistance and triglycerides in obese children and adolescents

Juárez-López, C., Klünder‐Klünder, M., Madrigal-Azcárate, A., & Flores‐Huerta, S. (2013) · Pediatric Diabetes · doi:10.1111/pedi.12024 · Cited by 67

Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice

Johnson, M. L., Lalia, A. Z., Dasari, S., Pallauf, M., Fitch, M., Hellerstein, M. K., & Lanza, I. R. (2015) · Aging Cell · doi:10.1111/acel.12352 · Cited by 66

ω‐3 Polyunsaturated Fatty Acid Supplementation Does Not Influence Body Composition, Insulin Resistance, and Lipemia in Women With Type 2 Diabetes and Obesity

Crochemore, I. C. C., Souza, A. F. P., de Souza, A. C. F., & Rosado, E. L. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612444535 · Cited by 66

Fatty Acid Consumption and Metabolic Syndrome Components: The GOCADAN Study

Ebbesson, S. O. E., Tejero, M. E., Nobmann, E. D., López-Alvarenga, J. C., Ebbesson, L. O. E., Romenesko, T., Carter, E. A., Resnick, H. E., Devereux, R. B., MacCluer, J. W., et al. (2007) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4564.2007.07393.x · Cited by 64

Effects of Fish Oil Supplementation on Markers of the Metabolic Syndrome

Pedersen, M. H., Mølgaard, C., Hellgren, L. I., & Lauritzen, L. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.04.001 · Cited by 58

Supplementation of n3 Long-chain Polyunsaturated Fatty Acid Synergistically Decreases Insulin Resistance with Weight Loss of Obese Prepubertal and Pubertal Children

López‐Alarcón, M., Martínez-Coronado, A., Velarde-Castro, O., Rendón-Macías, E., & Fernández, J. R. (2011) · Archives of Medical Research · doi:10.1016/j.arcmed.2011.06.010 · Cited by 56

Effects of marine n-3 fatty acid supplementation on lipoprotein subclasses measured by nuclear magnetic resonance in subjects with type II diabetes

Mostad, I. L., Bjerve, K. S., Lydersen, S., & Grill, V. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602703 · Cited by 55

Effects of Olanzapine and Risperidone on Glucose Metabolism and Insulin Sensitivity in Chronic Schizophrenic Patients With Long-Term Antipsychotic Treatment

Smith, R. C., Lindenmayer, J., Davis, J. M., Kelly, E., Viviano, T. F., Cornwell, J., Hu, Q., Khan, A., & Vaidhyanathaswamy, S. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04446yel · Cited by 55

Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia

Oh, P. C., Koh, K. K., Sakuma, I., Lim, S., Lee, Y., Lee, S., Lee, K., Han, S. H., & Shin, E. K. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.07.075 · Cited by 54

Fish Oil Supplementation Ameliorates Fructose-Induced Hypertriglyceridemia and Insulin Resistance in Adult Male Rhesus Macaques

Bremer, A. A., Stanhope, K. L., Graham, J. L., Cummings, B. P., Ampah, S. B., Saville, B. R., & Havel, P. J. (2013) · Journal of Nutrition · doi:10.3945/jn.113.178061 · Cited by 53

Effect of n -3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome

Molinar‐Toribio, E., Pérez‐Jiménez, J., Ramos‐Romero, S., Romeu, M., Giralt, M., Taltavull, N., Muñoz-Cortés, M., Jáuregui, O., Méndez, L., Medina, I., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514004437 · Cited by 51

Effect of fish oil supplementation and exercise on serum lipids and aerobic fitness.

BRILLA, L. R., & Landerholm, T. E. (1990) · PubMed · Cited by 50

n−3 polyunsaturated fatty acids modulate metabolism of insulin-sensitive tissues: implication for the prevention of type 2 diabetes

Pinel, A., Morio, B., & Capel, F. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0303-2 · Cited by 50

Dietary Docosahexaenoic Acid and Eicosapentaenoic Acid Influence Liver Triacylglycerol and Insulin Resistance in Rats Fed a High-Fructose Diet

de Castro, G. S., Deminice, R., Simões-Ambrósio, L. M. C., Calder, P. C., Jordão, A. A., & Vannucchi, H. (2015) · Marine Drugs · doi:10.3390/md13041864 · Cited by 49

Differential Effects of High-Fish Oil and High-Lard Diets on Cells and Cytokines Involved in the Inflammatory Process in Rat Insulin-Sensitive Tissues

Lionetti, L., Mollica, M. P., Sica, R., Donizzetti, I., Gifuni, G., Pignalosa, A., Cavaliere, G., & Putti, R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15023040 · Cited by 49

A randomized trial of fish oil omega-3 fatty acids on arterial health, inflammation, and metabolic syndrome in a young healthy population

Root, M. M., Collier, S. R., Zwetsloot, K. A., West, K. L., & McGinn, M. C. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-40 · Cited by 49

Body and Liver Fat Mass Rather Than Muscle Mitochondrial Function Determine Glucose Metabolism in Women With a History of Gestational Diabetes Mellitus

Prikoszovich, T., Winzer, C., Schmid, A. I., Szendroedi, J., Chmelík, M., Pacini, G., Krššák, M., Moser, E., Funahashi, T., Waldhäusl, W. K., et al. (2010) · Diabetes Care · doi:10.2337/dc10-1002 · Cited by 49

Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects

Delarue, J., Li, C.-H., Cohen, R., Corporeau, C., & Simon, B. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051631 · Cited by 48

Long-chain n-3 polyunsaturated fatty acids dissociate phosphorylation of Akt from phosphatidylinositol 3’-kinase activity in rats

Le Foll, C., Corporeau, C., Le Guen, V., Gouygou, J.-P., Bergé, J.-P., & Delarue, J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2006 · Cited by 45

Fish oil supplementation does not lower C‐reactive protein or interleukin‐6 levels in healthy adults

Muldoon, M. F., Laderian, B., Kuan, D. C.-H., Sereika, S. M., Marsland, A. L., & Manuck, S. B. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12442 · Cited by 45

n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys

Damsgaard, C. T., Stark, K. D., Hjorth, M. F., Biltoft-Jensen, A. P., Astrup, A. V., Michaelsen, K. F., & Lauritzen, L. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513000585 · Cited by 43

The association between n-3 fatty acids in erythrocyte membranes and insulin resistance: The inuit health in transition study

Thorseng, T., Witte, D. R., Vistisen, D., Borch‐Johnsen, K., Bjerregaard, P., & Jørgensen, M. E. (2009) · International Journal of Circumpolar Health · doi:10.3402/ijch.v68i4.17373 · Cited by 43

Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: The National Heart, Lung, and Blood Institute Family Heart Study

Lai, Y., Petrone, A. B., Pankow, J. S., Arnett, D. K., North, K. E., Ellison, R. C., Hunt, S. C., & Djoussé, L. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.05.002 · Cited by 43

Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome

Nigam, A., Frasure‐Smith, N., Lespérance, F., & Julien, P. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.07.008 · Cited by 42

Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients

Farsi, P. F., Djazayery, A., Eshraghian, M. R., Koohdani, F., Saboor-Yaraghi, A. A., Derakhshanian, H., Zarei, M., Javanbakht, M. H., & Djalali, M. (2014) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/0004-2730000002861 · Cited by 40

Nonalcoholic fatty liver disease: Roles of the gut and the liver and metabolic modulation by some dietary factors and especially long‐chain n‐3 PUFA

Delarue, J., & Lallès, J. P. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500346 · Cited by 37

The Effects of Low Dose n-3 Fatty Acids on Serum Lipid Profiles and Insulin Resistance of the Elderly: a Randomized Controlled Clinical Trial

Fakhrzadeh, H., Ghaderpanahi, M., Sharifi, F., Mirarefin, M., Badamchizade, Z., Kamrani, A. A., & Larijani, B. A. (2010) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000011 · Cited by 37

A decreased n-6/n-3 ratio in the fat-1 mouse is associated with improved glucose tolerance

Smith, B. K., Holloway, G. P., Reza-Lopez, S., Jeram, S. M., Kang, J. X., & Ma, D. W. L. (2010) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h10-066 · Cited by 35

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation

Stephens, F. B., Mendis, B., Shannon, C. E., Cooper, S., Ortori, C. A., Barrett, D. A., Mansell, P., & Tsintzas, K. (2014) · Clinical Science · doi:10.1042/cs20140031 · Cited by 35

Decreased activity of desaturase 5 in association with obesity and insulin resistance aggravates declining long-chainn-3 fatty acid status in Cree undergoing dietary transition

Zhou, Y., Kubow, S. J., Dewailly, É., Julien, P., & Egeland, G. M. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509301609 · Cited by 33

Docosahexaenoic Acid Content in Plasma Phospholipids and Desaturase Indices in Obese Children

Saito, E., Okada, T., Abe, Y., Kuromori, Y., Miyashita, M., Iwata, F., Hara, M., Ayusawa, M., Mugishima, H., & Kitamura, Y. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.6270 · Cited by 33

Docosahexaenoic Acid Supplementation Improved Lipocentric but Not Glucocentric Markers of Insulin Sensitivity in Hypertriglyceridemic Men

Kelley, D. S., Adkins, Y. C., Woodhouse, L. R., Swislocki, A., Mackey, B. E., & Siegel, D. (2011) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2011.0081 · Cited by 32

Fish intake, erythrocyten-3 fatty acid status and metabolic health in Danish adolescent girls and boys

Lauritzen, L., Harsløf, L. B. S., Hellgren, L. I., Pedersen, M. H., Mølgaard, C., & Michaelsen, K. F. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002418 · Cited by 32

Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet‐fed middle‐aged mice via a sirt1‐dependent mechanism

Luo, X., Jia, R., Yao, Q., Xu, Y., Luo, Z., Luo, X., & Wang, N. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500714 · Cited by 30

Addition of n-3 fatty acids to a 4-hour lipid infusion does not affect insulin sensitivity, insulin secretion, or markers of oxidative stress in subjects with type 2 diabetes mellitus

Mostad, I. L., Bjerve, K. S., Basu, S., Sutton, P., Frayn, K. N., & Grill, V. (2009) · Metabolism · doi:10.1016/j.metabol.2009.06.003 · Cited by 28

n-3 Polyunsaturated fatty acids and trans fatty acids in patients with the metabolic syndrome: a case–control study in Korea

Lee, E., Lee, S. Y., & Park, Y. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508925435 · Cited by 27

Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men

Åhrén, B., Mari, A., Fyfe, C., Tsofliou, F., Sneddon, A. A., Wahle, K. W. J., Winzell, M. S., Pacini, G., & Williams, L. M. (2008) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2008.45 · Cited by 26

Functional modulation of mitochondria by eicosapentaenoic acid provides protection against ceramide toxicity to C6 glioma cells

Jeng, J.-Y., Lee, W.-H., Tsai, Y.-H., Chen, C.-Y., Chao, S.-Y., & Hsieh, R.-H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902021h · Cited by 24

Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease

Lou, D.-J., Zhu, Q.-Q., Si, X.-W., Guan, L.-L., You, Q.-Y., Yu, Z., Zhang, A., & Li, D. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.04.008 · Cited by 24

Ratio of Dietary n-6/n-3 Polyunsaturated Fatty Acids Independently Related to Muscle Mass Decline in Hemodialysis Patients

Wong, T.-C., Chen, Y.-T., Wu, P.-Y., Chen, T., Chen, H.-H., Chen, T.-H., & Yang, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140402 · Cited by 24

Protective effect of eicosapentaenoic acid on insulin resistance in hyperlipidemic patients and on the postoperative course of cardiac surgery patients: the possible involvement of adiponectin.

(2014) · PubMed · doi:10.18926/amo/53024 · Cited by 19

Prevention of liver steatosis through fish oil supplementation: correlation of oxidative stress with insulin resistance and liver fatty acid content

Espinosa, A., Rodrigo Valenzuela, B., Gonzalez‐Mañán, D., D’Espessailles, A., Gormaz, J. G., Barrera, C. R., & Gladys Tapia, O. (2005) · Archivos Latinoamericanos de Nutrición · doi:10.37527/2013.63.1.004 · Cited by 12

Hypocaloric diet associated with the consumption of jam enriched with microencapsulated fish oil decreases insulin resistance.

Carvalho, A. P. S. D. O., Uehara, S. K., Netto, J. F. N., & Rosa, G. (2014) · PubMed · doi:10.3305/nh.2014.29.5.6654 · Cited by 9

Levels of eicosapentaenoic acid in obese schoolchildren with and without insulin resistance.

Sánchez‐Meza, K., Pérez, C. E. T., Sánchez-Ramírez, C. A., Muñiz‐Valencia, R., & Toro-Equihua, M. D. (2014) · PubMed · doi:10.3305/nh.2015.31.3.8047 · Cited by 5

Effect of Early Intervention with Omega-3 on Insulin Resistance in Patients Initiated on Olanzapine with either Sodium Valproate or Lithium: A randomized, Double-blind, Placebo-Controlled Trial.

Faghihi, T., Ghaeli, P., Adel, J., Mahmoudi‐Gharaei, J., Sharifi‎, V., & Akhondzadeh, S. (2010) · Europe PMC (PubMed Central) · Cited by 4

Effects of Mediterranean diet on the primary prevention of cardiovascular disease

Estruch, R. (2012) · http://isrctn.org/> · doi:10.1186/isrctn35739639

Omega-3 polyunsaturated fatty acids and their health benefits

Shahidi, F., & Ambigaipalan, P. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-111317-095850 · Cited by 1,390

Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments

Ruze, R., Liu, T., Zou, X., Song, J., Chen, Y., Xu, R., Yin, X., & Xu, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1161521 · Cited by 799

Metabolites as regulators of insulin sensitivity and metabolism

Yang, Q., Vijayakumar, A., & Kahn, B. B. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0044-8 · Cited by 698

Significance of long chain polyunsaturated fatty acids in human health

Zárate, R., el Jaber-Vazdekis, N., Tejera, N., Pérez, J. A., & Rodríguez, C. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0153-6 · Cited by 573

An Integrated View of Immunometabolism

Lee, Y. S., Wollam, J., & Olefsky, J. M. (2018) · Cell · doi:10.1016/j.cell.2017.12.025 · Cited by 452

Prevention of insulin resistance by n-3 polyunsaturated fatty acids

Fedor, D. M., & Kelley, D. S. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283218299 · Cited by 229

Effects of n-3 Polyunsaturated Fatty Acids (PUFAs) on Circulating Adiponectin and Leptin in Subjects with Type 2 Diabetes Mellitus

Stirban, A. O., Nandrean, S., Götting, C., Stratmann, B., & Tschoepe, D. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1363225 · Cited by 22

Benefits of omega-3 polyunsaturated fatty acids to patients with oral and metabolic diseases

Da-Ming, L., & Chieh, C. (2023) · Global Journal of Obesity Diabetes and Metabolic Syndrome · doi:10.17352/2455-8583.000061 · Cited by 1

Effects of n-3 Fatty Acids Supplementation on Insulin Resistance

Villarreal-Molina, M. T., & Canizales‐Quinteros, S. (2011) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/978160805177911101010046

n-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity?

Delarue, J., Foll, C. L., Corporeau, C., & Lucas, D. (2004) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2004033 · Cited by 205