The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

AKT/PKB signaling: navigating downstream

Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115

Signal transduction by receptors with tyrosine kinase activity

Ullrich, A., & Schlessinger, J. (1990) · Cell · doi:10.1016/0092-8674(90)90801-k · Cited by 5,435

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., Haqq, A. M., Shah, S. H., Arlotto, M., Slentz, C. A., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.002 · Cited by 3,165

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773

Critical nodes in signalling pathways: insights into insulin action

Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

O'Reilly, K. E., Rojo, F., She, Q.-B., Solit, D., Mills, G. B., Smith, D., Lane, H., Hofmann, F., Hicklin, D. J., Ludwig, D. L., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2925 · Cited by 2,561

Reactive oxygen species have a causal role in multiple forms of insulin resistance

Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · cited 1×

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464 · cited 1×

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365

Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene

Elchebly, M., Payette, P., Michaliszyn, E., Cromlish, W., Collins, S., Loy, A. L., Normandin, D., Cheng, A., Himms-Hagen, J., Chan, C.-C., et al. (1999) · Science · doi:10.1126/science.283.5407.1544 · Cited by 2,210

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.03.035 · Cited by 2,112

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020

Autophagy and Metabolism

Rabinowitz, J. D., & White, E. (2010) · Science · doi:10.1126/science.1193497 · Cited by 1,982

A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Settembre, C., Zoncu, R., Medina, D. L., Vetrini, F., Erdin, S., Erdin, S., Huynh, T., Ferron, M., Karsenty, G., Vellard, M. C., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.32 · Cited by 1,920

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

Russell, R. C., Tian, Y., Yuan, H., Park, H. W., Chang, Y.-Y., Kim, J., Kim, H., Neufeld, T. P., Dillin, A., & Guan, K.-L. (2013) · Nature Cell Biology · doi:10.1038/ncb2757 · Cited by 1,529

mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

Cunningham, J. T., Rodgers, J. T., Arlow, D. H., Vazquez, F., Mootha, V. K., & Puigserver, P. (2007) · Nature · doi:10.1038/nature06322 · Cited by 1,488

Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction

Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

Roczniak-Ferguson, A., Petit, C. S. V., Froehlich, F., Qian, S., Ky, J., Angarola, B. L., Walther, T. C., & Ferguson, S. M. (2012) · Science Signaling · doi:10.1126/scisignal.2002790 · Cited by 1,393

Untitled work

(2004) · doi:10.1016/s0092-8674(04)00452-0 · Cited by 1,356

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

Martina, J. A., Chen, Y., Gucek, M., & Puertollano, R. (2012) · Autophagy · doi:10.4161/auto.19653 · Cited by 1,333

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Peterson, T. R., Sengupta, S., Harris, T. E., Carmack, A. E., Kang, S. A., Balderas, E., Guertin, D. A., Madden, K. L., Carpenter, A. E., Finck, B. N., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.034 · Cited by 1,293

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

Kohn, A. D., Summers, S. A., Birnbaum, M. J., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31372 · Cited by 1,284

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Sancak, Y., Thoreen, C. C., Peterson, T. R., Lindquist, R. A., Kang, S. A., Spooner, E., Carr, S. A., & Sabatini, D. M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.003 · Cited by 1,236

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

Haar, E. V., Lee, S.-I., Bandhakavi, S., Griffin, T. J., & Kim, D. (2007) · Nature Cell Biology · doi:10.1038/ncb1547 · Cited by 1,227

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205

Nutrient-sensing mechanisms and pathways

Efeyan, A., Comb, W. C., & Sabatini, D. M. (2015) · Nature · doi:10.1038/nature14190 · Cited by 1,110

The mTOR‐regulated phosphoproteome reveals a mechanism of mTORC1‐mediated inhibition of growth factor signaling

Hsu, P. P., Kang, S. A., Rameseder, J., Zhang, Y., Ottina, K. A., Lim, D., Peterson, T. R., Choi, Y., Gray, N. S., Yaffe, M. B., et al. (2011) · Science · doi:10.1126/science.1199498 · Cited by 1,084

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

Bar-Peled, L., Chantranupong, L., Cherniack, A. D., Chen, W. W., Ottina, K. A., Grabiner, B. C., Spear, E. D., Carter, S. L., Meyerson, M., & Sabatini, D. M. (2013) · Science · doi:10.1126/science.1232044 · Cited by 1,080

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., & Chen, J. (2001) · Science · doi:10.1126/science.1066015 · Cited by 1,055

Making new contacts: the mTOR network in metabolism and signalling crosstalk

Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.

Copps, K. D., & White, M. F. (2012) · Diabetologia · doi:10.1007/s00125-012-2644-8 · Cited by 1,017 · cited 4×

Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation

Sano, H., Kane, S., Sano, E., Mı̂inea, C. P., Asara, J. M., Lane, W. S., Garner, C. W., & Lienhard, G. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300063200 · Cited by 964

Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes

Fu, Z., Gilbert, E. R., & Liu, D. (2012) · Current Diabetes Reviews · doi:10.2174/157339913804143225 · Cited by 925

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

Bar-Peled, L., Schweitzer, L. D., Zoncu, R., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.07.032 · Cited by 918 · cited 1×

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

Gual, P., Le Marchand-Brustel, Y., & Tanti, J.-F. (2005) · Biochimie · doi:10.1016/j.biochi.2004.10.019 · Cited by 912 · cited 2×

Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

Shah, O. J., Wang, Z., & Hunter, T. R. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.026 · Cited by 800

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

Nobukuni, T., Joaquin, M., Roccio, M., Dann, S. G., Kim, S. Y., Gulati, P., Byfield, M. P., Backer, J., Natt, F., Bos, J. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506925102 · Cited by 775

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

Ebato, C., Uchida, T., Arakawa, M., Komatsu, M., Ueno, T., Komiya, K., Azuma, K., Hirose, T., Tanaka, K., Kominami, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.009 · Cited by 774

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

Menon, S., Dibble, C. C., Talbott, G., Hoxhaj, G., Valvezan, A. J., Takahashi, H., Cantley, L. C., & Manning, B. D. (2014) · Cell · doi:10.1016/j.cell.2013.11.049 · Cited by 766

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

Dibble, C. C., & Manning, B. D. (2013) · Nature Cell Biology · doi:10.1038/ncb2763 · Cited by 743

The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

Nakae, J., Kitamura, T., Kitamura, Y., Biggs, W., Arden, K. C., & Accili, D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00401-x · Cited by 729

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

Yecies, J. L., Zhang, H., Menon, S., Liu, S., Yecies, D. W., Lipovsky, A. I., Görgün, C. Z., Kwiatkowski, D. J., Hotamışlıgil, G. S., Lee, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.002 · Cited by 685

Activation of mTORC2 by Association with the Ribosome

Zinzalla, V., Stracka, D., Oppliger, W., & Hall, M. N. (2011) · Cell · doi:10.1016/j.cell.2011.02.014 · Cited by 648

Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

Guo, S. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0327 · Cited by 648

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

Jung, H. S., Chung, K. W., Won Kim, J., Kim, J., Komatsu, M., Tanaka, K., Nguyen, Y. H., Kang, T. M., Yoon, K.-H., Kim, J.-W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.013 · Cited by 647

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

Sengupta, S., Peterson, T. R., Laplante, M., Oh, S., & Sabatini, D. M. (2010) · Nature · doi:10.1038/nature09584 · Cited by 646

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

Dibble, C. C., Elis, W., Menon, S., Qin, W., Klekota, J., Asara, J. M., Finan, P. M., Kwiatkowski, D. J., Murphy, L. O., & Manning, B. D. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.009 · Cited by 612

Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.

Fu, Z., Gilbert, E. R., & Liu, D. (2013) · PubMed · Cited by 600

mTOR complex 2 signaling and functions

Oh, W. J., & Jacinto, E. (2011) · Cell Cycle · doi:10.4161/cc.10.14.16586 · Cited by 597

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

Hagiwara, A., Cornu, M., Cybulski, N., Polak, P., Betz, C., Trapani, F., Terracciano, L., Heim, M. H., Rüegg, M. A., & Hall, M. N. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.015 · Cited by 585

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

Tsun, Z.-Y., Bar-Peled, L., Chantranupong, L., Zoncu, R., Wang, T., Kim, C., Spooner, E., & Sabatini, D. M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.09.016 · Cited by 565

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

Morita, M., Gravel, S.-P., Hulea, L., Larsson, O., Pollak, M., St-Pierre, J., & Topisirovic, I. (2015) · Cell Cycle · doi:10.4161/15384101.2014.991572 · Cited by 552

hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase

Byfield, M. P., Murray, J. T., & Backer, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507201200 · Cited by 540

Insulin Signaling and the Regulation of Glucose Transport

Chang, L. C., Chiang, S.-H., & Saltiel, A. R. (2004) · Molecular Medicine · doi:10.2119/2005-00029.saltiel · Cited by 535

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

Huang, J., Dibble, C. C., Matsuzaki, M., & Manning, B. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00289-08 · Cited by 520

Autophagy in the liver: functions in health and disease

Ueno, T., & Komatsu, M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.185 · Cited by 500

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

Chantranupong, L., Wolfson, R. L., Orozco, J. M., Saxton, R. A., Scaria, S. M., Bar-Peled, L., Spooner, E., Isasa, M., Gygi, S. P., & Sabatini, D. M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.014 · Cited by 466

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

Tremblay, F., Brûlé, S., Hee Um, S., Li, Y., Masuda, K., Roden, M., Sun, X. J., Krebs, M., Polakiewicz, R. D., Thomas, G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706517104 · Cited by 465

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

Houde, V. P., Brûlé, S., Festuccia, W. T., Blanchard, P.-G., Bellmann, K., Deshaies, Y., & Marette, A. (2010) · Diabetes · doi:10.2337/db09-1324 · Cited by 456

The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism

Yoon, M. (2016) · Nutrients · doi:10.3390/nu8070405 · Cited by 455

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

Tumaneng, K., Schlegelmilch, K., Russell, R. C., Yimlamai, D., Basnet, H., Mahadevan, N., Fitamant, J., Bardeesy, N., Camargo, F. D., & Guan, K.-L. (2012) · Nature Cell Biology · doi:10.1038/ncb2615 · Cited by 453

ER-Phagy: Selective Autophagy of the Endoplasmic Reticulum

Bernales, S., Schuck, S., & Walter, P. (2007) · Autophagy · doi:10.4161/auto.3930 · Cited by 375

Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention

Guo, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0584 · Cited by 375

Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner

Kovacina, K. S., Park, G. Y., Bae, S. S., Guzzetta, A. W., Schaefer, E., Birnbaum, M. J., & Roth, R. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210837200 · Cited by 374

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

Yip, C. K., Murata, K., Walz, T., Sabatini, D. M., & Kang, S. A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.017 · Cited by 372

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

Gulati, P., Gaspers, L. D., Dann, S. G., Joaquin, M., Nobukuni, T., Natt, F., Kozma, S. C., Thomas, A. P., & Thomas, G. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.002 · Cited by 371

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

Petit, C. S., Roczniak-Ferguson, A., & Ferguson, S. M. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201307084 · Cited by 355

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

Bacquer, O. L., Petroulakis, E., Paglialunga, S., Poulin, F., Richard, D., Cianflone, K., & Sonenberg, N. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29528 · Cited by 348

Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin

Toschi, A., Lee, E., Xu, L., Garcia, A., Gadir, N., & Foster, D. A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00782-08 · Cited by 341

The emerging role of autophagy in the pathophysiology of diabetes mellitus

González, C. D., Lee, M., Marchetti, P., Pietropaolo, M., Towns, R., Vaccaro, M. I., Watada, H., & Wiley, J. W. (2010) · Autophagy · doi:10.4161/auto.7.1.13044 · Cited by 326

The insulin signalling pathway

Lizcano, J. M., & Alessi, D. R. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00777-7 · Cited by 325

mTOR and the control of whole body metabolism

Polak, P., & Hall, M. N. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.024 · Cited by 310

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

Owen, J. L., Zhang, Y., Bae, S., Farooqi, M. S., Liang, G., Hammer, R. E., Goldstein, J. L., & Brown, M. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213343109 · Cited by 305

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

Zhang, J., Gao, Z., Yin, J., Quon, M. J., & Ye, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806480200 · Cited by 304

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

Yuan, H., Russell, R. C., & Guan, K. (2013) · Autophagy · doi:10.4161/auto.26058 · Cited by 303

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

Yang, G., Murashige, D., Humphrey, S. J., & James, D. E. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.016 · Cited by 297

The multifaceted role of mTORC1 in the control of lipid metabolism

Ricoult, S. J. H., & Manning, B. D. (2013) · EMBO Reports · doi:10.1038/embor.2013.5 · Cited by 291

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

Panchaud, N., Péli-Gulli, M.-P., & De Virgilio, C. (2013) · Science Signaling · doi:10.1126/scisignal.2004112 · Cited by 286

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

Saci, A., Cantley, L. C., & Carpenter, C. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.017 · Cited by 275

Attenuated mTOR Signaling and Enhanced Autophagy in Adipocytes from Obese Patients with Type 2 Diabetes

Öst, A., Svensson, K., Ruishalme, I., Brännmark, C., Franck, N., Krook, H., Sandström, P., Kjølhede, P., & Strålfors, P. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00023 · Cited by 274

TOR complex 2: a signaling pathway of its own

Cybulski, N., & Hall, M. N. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.09.004 · Cited by 264

Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

Kumar, A. T., Lawrence, J. C., Jung, D. Y., Ko, H. J., Keller, S. R., Kim, J. K., Magnuson, M. A., & Harris, T. E. (2010) · Diabetes · doi:10.2337/db09-1061 · Cited by 259

Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage

Chakrabarti, P., English, T., Shi, J., Smas, C. M., & Kandror, K. V. (2010) · Diabetes · doi:10.2337/db09-1602 · Cited by 242

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

Peng, M., Yin, N., & Li, M. O. (2014) · Cell · doi:10.1016/j.cell.2014.08.038 · Cited by 220

Metabolic Regulation by Leucine of Translation Initiation Through the mTOR-Signaling Pathway by Pancreatic β-Cells

Xu, G. H., Kwon, G., Cruz, W. S., Marshall, C. A., & McDaniel, M. L. (2001) · Diabetes · doi:10.2337/diabetes.50.2.353 · Cited by 207

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

Copps, K. D., Hançer, N. J., Opare-Ado, L., Qiu, W., Walsh, C., & White, M. F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.003 · Cited by 197

Turnover of the Active Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine Phosphorylation in Cell Culture Models of Tuberous Sclerosis

Shah, O. J., & Hunter, T. R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01254-05 · Cited by 183

PLD1 Regulates mTOR Signaling and Mediates Cdc42 Activation of S6K1

Fang, Y., Park, I., Wu, A.-L., Du, G., Huang, P. C., Frohman, M. A., Walker, S. J., Brown, H. A., & Chen, J. (2003) · Current Biology · doi:10.1016/j.cub.2003.11.021 · Cited by 180

Improved Glucose Homeostasis in Mice with Muscle-Specific Deletion of Protein-Tyrosine Phosphatase 1B

Delibegović, M., Bence, K. K., Mody, N., Hong, E., Ko, H. J., Kim, J. K., Kahn, B. B., & Neel, B. G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00959-07 · Cited by 173

Insulin signalling

Bevan, A. P. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.8.1429 · Cited by 167

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

Yoon, M., Du, G., Backer, J., Frohman, M. A., & Chen, J. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201107033 · Cited by 166

Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR

Veverka, V., Crabbe, T., Bird, I., Lennie, G., Muskett, F. W., Taylor, R. J., & Carr, M. D. (2007) · Oncogene · doi:10.1038/sj.onc.1210693 · Cited by 163

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Hernández-Negrete, I., Carretero-Ortega, J., Rosenfeldt, H. M., Hernández-García, R., Calderón-Salinas, J. V., Reyes‐Cruz, G., Gutkind, J. S., & Vázquez‐Prado, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703771200 · Cited by 161

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Gu, Y., Lindner, J., Kumar, A., Yuan, W., & Magnuson, M. A. (2011) · Diabetes · doi:10.2337/db10-1194 · Cited by 157

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Chaveroux, C., Eichner, L. J., Dufour, C. R., Shatnawi, A. A., Khoutorsky, A., Bourque, G., Sonenberg, N., & Giguère, V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.003 · Cited by 156

A Phosphorylation Cascade Controls the Degradation of Active SREBP1

Bengoechea-Alonso, M. T., & Ericsson, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807906200 · Cited by 149

A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation

Pezze, P. D., Sonntag, A., Thien, A., Prentzell, M. T., Gödel, M., Fischer, S., Neumann‐Haefelin, E., Huber, T. B., Baumeister, R., Shanley, D. P., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2002469 · Cited by 148

mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR

Yin, Y., Hua, H. M., Li, M., Liu, S., Kong, Q., Shao, T., Wang, J., Luo, Y., Wang, Q., Luo, T. L., et al. (2015) · Cell Research · doi:10.1038/cr.2015.133 · Cited by 147

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

Yoon, M., Sun, Y., Arauz, E. J., Jiang, Y., & Chen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.262816 · Cited by 138

Mitophagy mechanisms and role in human diseases

Redmann, M., Dodson, M. B., Boyer‐Guittaut, M., Darley-Usmar, V. M., & Zhang, J. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.05.010 · Cited by 138

Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion

Blanchard, P.-G., Festuccia, W. T., Houde, V. P., St‐Pierre, P., Brûlé, S., Turcotte, V., Côté, M., Bellmann, K., Marette, A., & Deshaies, Y. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m021485 · Cited by 134

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile

Wang, B. T., Ducker, G. S., Barczak, A. J., Barbeau, R., Erle, D. J., & Shokat, K. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103746108 · Cited by 127

mTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8

Kim, S. J., DeStefano, M. A., Oh, W. J., Wu, C., Vega-Cotto, N. M., Finlan, M., Liu, D., Su, B., & Jacinto, E. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.029 · Cited by 113

Activation of Mammalian Target of Rapamycin (mTOR) by Insulin Is Associated with Stimulation of 4EBP1 Binding to Dimeric mTOR Complex 1

Wang, L., Rhodes, C. J., & Lawrence, J. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603566200 · Cited by 112

Surfing the insulin signaling web

OBBERGHEN, E. V., Baron, V. T., Delahaye, L., Emanuelli, B., Filippa, N., Giorgetti‐Peraldi, S., Lebrun, P., Mothe‐Satney, I., Peraldi, P., Rocchi, S., et al. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00896.x · Cited by 111

Rapid Mitogenic Regulation of the mTORC1 Inhibitor, DEPTOR, by Phosphatidic Acid

Yoon, M., Rosenberger, C. L., Wu, C., Truong, N., Sweedler, J. V., & Chen, J. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.028 · Cited by 103

Nutrient-dependent and Insulin-stimulated Phosphorylation of Insulin Receptor Substrate-1 on Serine 302 Correlates with Increased Insulin Signaling

Giraud, J., Leshan, R. L., Lee, Y.-H., & White, M. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308631200 · Cited by 100

mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblastsPreprint

Dai, N., Christiansen, J., Nielsen, F. C., & Avruch, J. (2013) · Genes & Development · doi:10.1101/gad.209130.112 · Cited by 99

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

Wu, J., Tseng, Y. D., Xu, C., Neubert, T. A., White, M. F., & Hubbard, S. R. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1388 · Cited by 98

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

Yoon, M., Son, K., Arauz, E. J., Han, J. M., Kim, S., & Chen, J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.008 · Cited by 98

Attenuation of Insulin-stimulated Insulin Receptor Substrate-1 Serine 307 Phosphorylation in Insulin Resistance of Type 2 Diabetes

Danielsson, A., Öst, A., Nyström, F. H., & Strålfors, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500230200 · Cited by 89

l-Arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge

Krause, M. D. S., McClenaghan, N. H., Flatt, P. R., de Bittencourt, P. I. H., Murphy, C., & Newsholme, P. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0236 · Cited by 89

Role of S6K1 in regulation of SREBP1c expression in the liver

Li, S., Ogawa, W., Emi, A., Hayashi, K., Senga, Y., Nomura, K., Hara, K., Yu, D., & Kasuga, M. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.07.038 · Cited by 84

mTOR signaling: PLD takes center stage

Sun, Y., & Chen, J. (2008) · Cell Cycle · doi:10.4161/cc.7.20.6881 · Cited by 84

Phospholipase D1b and D2a generate structurally identical phosphatidic acid species in mammalian cells

Pettitt, T. R., McDermott, M. I., Saqib, K. M., Shimwell, N. J., & Wakelam, M. J. O. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600707 · Cited by 76

Raptor Binds the SAIN (Shc and IRS-1 NPXY Binding) Domain of Insulin Receptor Substrate-1 (IRS-1) and Regulates the Phosphorylation of IRS-1 at Ser-636/639 by mTOR

Tzatsos, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.027748 · Cited by 74

mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3‐L1 Adipocytes

Soliman, G. A., Acosta-Jaquez, H. A., & Fingar, D. C. (2010) · Lipids · doi:10.1007/s11745-010-3488-y · Cited by 72

Hierarchical Network between the Components of the Multi-tRNA Synthetase Complex

Han, J. M., Lee, M., Park, S. G., Lee, S. H., Razin, E., Choi, E., & Kim, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605211200 · Cited by 72

Interplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle Cells

Weigert, C., Kron, M., Kalbacher, H., Pohl, A. K., Runge, H., Häring, H., Schleicher, E. D., & Lehmann, R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0102 · Cited by 68

mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress

Chau, G. C., Im, D. U., Kang, T. M., Bae, J. M., Kim, W., Pyo, S., Moon, E.-Y., & Um, S. H. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201701085 · Cited by 67

Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

Yi, Z., Langlais, P. R., Filippis, E. A. D., Luo, M., Flynn, C. R., Schroeder, S., Weintraub, S. T., Mapes, R., & Mandarino, L. J. (2007) · Diabetes · doi:10.2337/db06-1355 · Cited by 65

Phosphorylation of Human Insulin Receptor Substrate-1 at Serine 629 Plays a Positive Role in Insulin Signaling

Luo, M., Langlais, P. R., Yi, Z., Lefort, N., Filippis, E. A. D., Hwang, H., Christ-Roberts, C. Y., & Mandarino, L. J. (2007) · Endocrinology · doi:10.1210/en.2007-0049 · Cited by 63

Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress

Lombardi, A., & Tomer, Y. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.02.002 · Cited by 63

Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown

Jain, A., Arauz, E. J., Aggarwal, V., Ikon, N., Chen, J., & Ha, T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419425111 · Cited by 59

Identification of Insulin Receptor Substrate 1 Serine/Threonine Phosphorylation Sites Using Mass Spectrometry Analysis: Regulatory Role of Serine 1223

Luo, M., Reyna, S. M., Wang, L., Yi, Z.-P., Carroll, C. A., Dong, L., Langlais, P. R., Weintraub, S. T., & Mandarino, L. J. (2005) · Endocrinology · doi:10.1210/en.2005-0260 · Cited by 59

Role of autophagy in β ‐cell function and mass

Hur, K. Y., Jung, H. S., & Lee, M. ‐. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01278.x · Cited by 58

The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance

Yoon, M., & Choi, C. S. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.93 · Cited by 55

Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass

Alejandro, E. U., Bozadjieva-Kramer, N., Blandino-Rosano, M., Wasan, M., Elghazi, L., Vadrevu, S., Satin, L. S., & Bernal‐Mizrachi, E. (2017) · Diabetes · doi:10.2337/db16-1349 · Cited by 49

4-PBA reverses autophagic dysfunction and improves insulin sensitivity in adipose tissue of obese mice via Akt/mTOR signaling

Guo, Q., Xu, L., Li, H., Sun, H., Wu, S., & Zhou, B. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.106 · Cited by 33

mTORC2 Puts Its Shoulder to Krebs’ Wheel

Apelo, S. I. A., & Lamming, D. W. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.016 · Cited by 11

Amino acid-sensing mTOR signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes

Zhang, C., Yoon, M., & Chen, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90651.2008 · Cited by 10

The landscape of aging

Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 450

Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes

Alejandro, E. U., Mamerto, T. P., Chung, G., Villavieja, A., Gaus, N. L., Morgan, E., & Pineda-Cortel, M. R. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145003 · Cited by 353

Alzheimer's disease and type 2 diabetes: a critical assessment of the shared pathological traits

Chatterjee, S., & Mudher, A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00383 · Cited by 270

Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism

Mann, G., Mora, S., Madu, G., & Adegoke, O. A. J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.702826 · Cited by 283

Causal roles of mitochondrial dynamics in longevity and healthy aging

Sharma, A., Smith, H. J., Yao, P., & Mair, W. B. (2019) · EMBO Reports · doi:10.15252/embr.201948395 · Cited by 222

Raptor Swoops in on Metabolism

Shaw, R. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.007 · Cited by 4

mTOR and the control of whole body metabolism

Polak, P., & Hall, M. N. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.024 · Cited by 310

The Endocrine Society Meeting: Topics in Insulin Sensitivity and Hypertension

Bloomgarden, Z. T. (2003) · Diabetes Care · doi:10.2337/diacare.26.9.2679 · Cited by 6

mTOR: dissecting regulation and mechanism of action to understand human disease

Goberdhan, D. C. I., & Boyd, C. A. R. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370213 · Cited by 27

mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR

Yin, Y., Hua, H. M., Li, M., Liu, S., Kong, Q., Shao, T., Wang, J., Luo, Y., Wang, Q., Luo, T. L., et al. (2015) · Cell Research · doi:10.1038/cr.2015.133 · Cited by 147