Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies
Open accessAbstract
Optical waveguides and integrated optical devices are promising solutions for many applications, such as medical diagnosis, health monitoring and light therapies. Despite the many existing reviews focusing on the materials that these devices are made from, a systematic review that relates these devices to the various materials, fabrication processes, sensing methods and medical applications is still seldom seen. This work is intended to link these multidisciplinary fields, and to provide a comprehensive review of the recent advances of these devices. Firstly, the optical and mechanical properties of optical waveguides based on glass, polymers and heterogeneous materials and fabricated via various processes are thoroughly discussed, together with their applications for medical purposes. Then, the fabrication processes and medical implementations of integrated passive and active optical devices with sensing modules are introduced, which can be used in many medical fields such as drug delivery and cardiovascular healthcare. Thirdly, wearable optical sensing devices based on light sensing methods such as colorimetry, fluorescence and luminescence are discussed. Additionally, the wearable optical devices for light therapies are introduced. The review concludes with a comprehensive summary of these optical devices, in terms of their forms, materials, light sources and applications.
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Microfluidics technology has become prominent in wearable intelligent sensor platforms for reducing samples and solvents.
“For reducing samples and solvents, microfluidics technology has become prominent in wearable intelligent sensor platforms [279,280,281].”
From The Current State of Optical Sensors in Medical Wearables (2022) · cites this paper as [279]
For accurate sensing and self-calibration in different lighting conditions, wearable colorimetric devices often have integrated reference graphic markers.
“For accurate sensing and self-calibration in different lighting conditions, wearable colorimetric devices often have integrated reference graphic markers [279].”
From The Current State of Optical Sensors in Medical Wearables (2022) · cites this paper as [279]
At present, there are already several wearable optical devices using the fluorescence method for health assessment or detection of biomarker concentration.
“At present, there are already several wearable optical devices using the fluorescence method for health assessment or detection of biomarker concentration [279].”
From The Current State of Optical Sensors in Medical Wearables (2022) · cites this paper as [279]
Luminescence-based optical devices are particularly attractive due to their good sensitivity and very high selectivity.
“Luminescence-based optical devices are particularly attractive due to their good sensitivity and very high selectivity [279].”
From The Current State of Optical Sensors in Medical Wearables (2022) · cites this paper as [279]
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Wearable biosensors for healthcare monitoring
Kim, J., Campbell, A. S., de Ávila, B. E.-F., & Wang, J. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0045-y · Cited by 3,373 · cited 2× · see citing works
“Significantly, non-invasive physiological signal detections including but not limited to blood glucose, blood oxygen and analysis of chemicals in the body fluid have been successfully achieved [7,8].”
BackgroundSelf-citationFully integrated silicon probes for high-density recording of neural activity
Jun, J. J., Steinmetz, N. A., Siegle, J. H., Denman, D. J., Bauza, M., Barbarits, B., Lee, A. K., Anastassiou, C. A., Andrei, A., Aydın, Ç., et al. (2017) · Nature · doi:10.1038/nature24636 · Cited by 2,190 · see citing works
Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy
de Freitas, L. F., & Hamblin, M. R. (2016) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2016.2561201 · Cited by 1,652 · see citing works
Bariya, M., Nyein, H. Y. Y., & Javey, A. (2018) · Nature Electronics · doi:10.1038/s41928-018-0043-y · Cited by 1,486 · see citing works
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350 · see citing works
Wearable and flexible electronics for continuous molecular monitoring
Yang, Y., & Gao, W. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00730b · Cited by 1,315 · cited 3× · see citing works
“Optical methods including, but not limited to, colorimetry, fluorescence and luminescence are integrated with other microfluidic or electrical modules to form multifunctional systems [7,97].”
BackgroundMethodMechanisms and applications of the anti-inflammatory effects of photobiomodulation
Hamblin, M. R., & 3 Harvard-MIT Division of Health Sciences and Technology, C. (2017) · AIMS Biophysics · doi:10.3934/biophy.2017.3.337 · Cited by 1,298 · see citing works
Robertson, C. A., Evans, D. H., & Abrahamse, H. (2009) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2009.04.001 · Cited by 1,201 · see citing works
Ultraflexible organic photonic skin
Yokota, T., Zalar, P., Kaltenbrunner, M., Jinno, H., Matsuhisa, N., Kitanosako, H., Tachibana, Y., Yukita, W., Koizumi, M., & Someya, T. (2016) · Science Advances · doi:10.1126/sciadv.1501856 · Cited by 1,024 · see citing works
Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy
Gao, M., Yu, F., Lv, C., Choo, J., & Chen, L. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00908e · Cited by 827 · see citing works
The Biomedical Use of Silk: Past, Present, Future
Holland, C., Numata, K., Rnjak‐Kovacina, J., & Seib, F. P. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800465 · Cited by 819 · see citing works
Light in diagnosis, therapy and surgery
Yun, S. H., & Kwok, S. J. J. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0008 · Cited by 806 · see citing works
Bandodkar, A. J., Gutruf, P., Choi, J., Lee, K., Sekine, Y., Reeder, J. T., Jeang, W. J., Aranyosi, A. J., Lee, S. P., Model, J. B., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav3294 · Cited by 761 · see citing works
Materials and technologies for soft implantable neuroprostheses
Lacour, S. P., Courtine, G., & Guck, J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.63 · Cited by 738 · see citing works
Choi, M. K., Yang, J., Kang, K., Kim, D. C., Choi, C., Park, C., Kim, S. J., Chae, S. I., Kim, J. H., Kim, J. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8149 · Cited by 706 · see citing works
Canales, A., Jia, X., Froriep, U. P., Koppes, R. A., Tringides, C. M., Selvidge, J., Lu, C., Hou, C., Wei, L., Fink, Y., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3093 · Cited by 668 · see citing works
Neural recording and modulation technologies
Chen, R., Canales, A., & Anikeeva, P. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.93 · Cited by 655 · see citing works
Yetisen, A. K., Martinez‐Hurtado, J. L., Ünal, B., Khademhosseini, A., & Butt, H. (2018) · Advanced Materials · doi:10.1002/adma.201706910 · Cited by 569 · cited 1× · see citing works
“Considering the properties, such as biocompatibility and flexibility to match human tissues, of optical devices, a large number of implantable and wearable biosensors has been investigated in analysis of biomarkers concentration related to various diseases noninvasively or minimally invasively [7,8,16,68,97].”
BackgroundHong, Y. J., Jeong, H., Cho, K. W., Lu, N., & Kim, D. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201808247 · Cited by 559 · cited 2× · see citing works
“Optical methods including, but not limited to, colorimetry, fluorescence and luminescence are integrated with other microfluidic or electrical modules to form multifunctional systems [7,97].”
BackgroundMethodWireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics
Jeong, J., McCall, J. G., Shin, G., Zhang, Y., Al‐Hasani, R., Kim, M. K., Li, S., Sim, J. Y., Jang, K., Shi, Y., et al. (2015) · Cell · doi:10.1016/j.cell.2015.06.058 · Cited by 493 · see citing works
Skin-like biosensor system via electrochemical channels for noninvasive blood glucose monitoring
Chen, Y., Lu, S., Zhang, S., Li, Y., Qu, Z., Chen, Y., Lu, B., Wang, X., & Feng, X. (2017) · Science Advances · doi:10.1126/sciadv.1701629 · Cited by 470 · see citing works
Plasmonic photo-thermal therapy (PPTT)
Huang, X., & El‐Sayed, M. A. (2011) · Alexandria Journal of Medicine · doi:10.1016/j.ajme.2011.01.001 · Cited by 439 · see citing works
Saliva as a diagnostic tool for oral and systemic diseases
Javaid, M. A., Ahmed, A. S., Durand, R., & Tran, S. D. (2016) · Journal of Oral Biology and Craniofacial Research · doi:10.1016/j.jobcr.2015.08.006 · Cited by 431 · see citing works
Optical Imaging: Current Applications and Future Directions
Luker, G. D., & Luker, K. E. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.045799 · Cited by 404 · see citing works
Shin, G., Gomez, A. M., Al-Hasani, R., Jeong, Y. R., Kim, J., Xie, Z., Banks, A., Lee, S. M., Han, S. Y., Yoo, C. J., et al. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.031 · Cited by 396 · see citing works
Light-guiding hydrogels for cell-based sensing and optogenetic synthesis in vivo
Choi, M., Choi, J. W., Kim, S., Nizamoğlu, S., Hahn, S. K., & Yun, S. H. (2013) · Nature Photonics · doi:10.1038/nphoton.2013.278 · Cited by 379 · see citing works
One-step optogenetics with multifunctional flexible polymer fibers
Park, S., Guo, Y., Jia, X., Choe, H. K., Grena, B. J.-B., Kang, J., Park, J., Lu, C., Canales, A., Chen, R., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4510 · Cited by 376 · see citing works
Activating positive memory engrams suppresses depression-like behaviour
Ramirez, S., Liu, X., MacDonald, C. J., Moffa, A., Zhou, J. Y., Redondo, R. L., & Tonegawa, S. (2015) · Nature · doi:10.1038/nature14514 · Cited by 373 · see citing works
Weaving Sensing Fibers into Electrochemical Fabric for Real‐Time Health Monitoring
Wang, L., Wang, L., Zhang, Y., Pan, J., Li, S., Sun, X., Zhang, B., & Peng, H. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201804456 · Cited by 353 · see citing works
Silk fabric-based wearable thermoelectric generator for energy harvesting from the human body
Lu, Z., Zhang, H., Mao, C., & Li, C. M. (2016) · Applied Energy · doi:10.1016/j.apenergy.2015.11.038 · Cited by 326 · see citing works
Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid
Yetisen, A. K., Jiang, N., Fallahi, A., Montelongo, Y., Ruiz‐Esparza, G. U., Tamayol, A., Zhang, Y. S., Mahmood, I., Yang, S., Kim, K. S., et al. (2017) · Advanced Materials · doi:10.1002/adma.201606380 · Cited by 310 · see citing works
Lee, C. M., Engelbrecht, C. J., Soper, T. D., et al. (2010) · Journal of Biophotonics · doi:10.1002/jbio.200900087 · Cited by 282 · see citing works
Biomechanical analysis of silicon microelectrode-induced strain in the brain
Lee, H., Bellamkonda, R. V., Sun, W., & Levenston, M. E. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/4/003 · Cited by 281 · see citing works
A flexible organic reflectance oximeter array
Khan, Y., Han, D., Pierre, A., Ting, J., Wang, X., Lochner, C. M., Bovo, G., Yaacobi-Gross, N., Newsome, C., Wilson, R., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813053115 · Cited by 278 · see citing works
Advanced Multimaterial Electronic and Optoelectronic Fibers and Textiles
Yan, W., Page, A., Nguyen-Dang, T., Qu, Y., Sordo, F., Wei, L., & Sorin, F. (2018) · Advanced Materials · doi:10.1002/adma.201802348 · Cited by 274 · see citing works
Step‐Index Optical Fiber Made of Biocompatible Hydrogels
Choi, M., Humar, M., Kim, S., & Yun, S. H. (2015) · Advanced Materials · doi:10.1002/adma.201501603 · Cited by 250 · see citing works
Sekine, Y., Kim, S. B., Zhang, Y., Bandodkar, A. J., Xu, S., Choi, J., Irie, M., Ray, T. R., Kohli, P., Kozai, N., et al. (2018) · Lab on a Chip · doi:10.1039/c8lc00530c · Cited by 242 · see citing works
Next-generation interfaces for studying neural function
Frank, J. A., Antonini, M.-J., & Anikeeva, P. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0198-8 · Cited by 241 · see citing works
Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases
Son, D., Lee, J., Lee, D. J., Ghaffari, R., Yun, S., Kim, S. J., Lee, J. E., Cho, H. R., Yoon, S., Yang, S., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b00651 · Cited by 240 · see citing works
Bioabsorbable polymer optical waveguides for deep-tissue photomedicine
Nizamoğlu, S., Gather, M. C., Humar, M., Choi, M., Kim, S., Kim, K. S., Hahn, S. K., Scarcelli, G., Randolph, M. A., Redmond, R. W., et al. (2016) · Nature Communications · doi:10.1038/ncomms10374 · Cited by 238 · see citing works
Flexible and stretchable nanowire-coated fibers for optoelectronic probing of spinal cord circuits
Lu, C., Park, S., Richner, T. J., Derry, A., Brown, I., Hou, C., Rao, S., Kang, J., Moritz, C. T., Fink, Y., et al. (2017) · Science Advances · doi:10.1126/sciadv.1600955 · Cited by 222 · see citing works
Textile Display for Electronic and Brain‐Interfaced Communications
Zhang, Z., Cui, L., Shi, X., Tian, X., Wang, D., Gu, C., Chen, E., Cheng, X., Xu, Y., Hu, Y., et al. (2018) · Advanced Materials · doi:10.1002/adma.201800323 · Cited by 220 · see citing works
Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice
Iyer, S. M., Montgomery, K. L., Towne, C. L., Lee, S. Y., Ramakrishnan, C., Deisseroth, K. A., & Delp, S. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2834 · Cited by 219 · see citing works
Optogenetics for in vivo cardiac pacing and resynchronization therapies
Nussinovitch, U., & Gepstein, L. (2015) · Nature Biotechnology · doi:10.1038/nbt.3268 · Cited by 216 · see citing works
Curto, V. F., Fay, C., Coyle, S. M., Byrne, R. J., O’Toole, C., Barry, C., Hughes, S. M., Moyna, N. M., Diamond, D., & Benito‐Lopez, F. (2012) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2012.06.048 · Cited by 211 · see citing works
In vivo wireless photonic photodynamic therapy
Bansal, A., Yang, F., Tian, X., Zhang, Y., & Ho, J. S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717552115 · Cited by 211 · see citing works
The Mitochondrial Pathway of Anesthetic Isoflurane-induced Apoptosis
Zhang, Y., Dong, Y., Wu, X., Lu, Y., Xu, Z., Knapp, A., Yue, Y., Xu, T., & Xie, Z. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.065664 · Cited by 204 · see citing works
Wu, F., Stark, E., Im, M., Cho, I., Yoon, E.-S., Buzsáki, G., Wise, K. D., & Yoon, E. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/5/056012 · Cited by 203 · see citing works
Zhang, Y., Mickle, A. D., Gutruf, P., McIlvried, L. A., Guo, H., Wu, Y., Golden, J. P., Xue, Y., Grajales-Reyes, J. G., Wang, X., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw5296 · Cited by 195 · see citing works
Multifunctional Photonic Nanomaterials for Diagnostic, Therapeutic, and Theranostic Applications
Kim, H., Beack, S., Han, S., Shin, M., Lee, T., Park, Y., Kim, K. S., Yetisen, A. K., Yun, S. H., Kwon, W., et al. (2018) · Advanced Materials · doi:10.1002/adma.201701460 · Cited by 191 · see citing works
Superelastic Multimaterial Electronic and Photonic Fibers and Devices via Thermal Drawing
Qu, Y., Nguyen-Dang, T., Page, A. G., Yan, W., Gupta, T. D., Rotaru, G. M., Rossi, R. M., Favrod, V. D., Bartolomei, N., & Sorin, F. (2018) · Advanced Materials · doi:10.1002/adma.201707251 · Cited by 191 · see citing works
Zhang, J., Laiwalla, F., Kim, J. A., Urabe, H., Wagenen, R. V., Song, Y., Connors, B. W., Zhang, F., Deisseroth, K. A., & Nurmikko, A. V. (2009) · Journal of Neural Engineering · doi:10.1088/1741-2560/6/5/055007 · Cited by 190 · see citing works
Overview of Poly(lactic acid) (PLA) Fibre
Avinç, O., & Khoddamı, A. (2009) · Fibre Chemistry · doi:10.1007/s10692-010-9213-z · Cited by 180 · see citing works
Shin, H., Son, Y., Chae, U., Kim, J., Choi, N., Lee, H. J., Woo, J., Cho, Y., Yang, S. H., Lee, C. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11628-5 · Cited by 169 · see citing works
Jeon, Y., Choi, H., Lim, M., Choi, S., Kim, H., Kwon, J. H., Park, K., & Choi, K. C. (2018) · Advanced Materials Technologies · doi:10.1002/admt.201700391 · Cited by 155 · see citing works
Silica-Based Highly Nonlinear Fibers and Their Application
Hirano, M., Nakanishi, T., Okuno, T., et al. (2009) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2008.2010241 · Cited by 154 · see citing works
Sensitive and Wearable Optical Microfiber Sensor for Human Health Monitoring
Li, J., Chen, J., & Xu, F. (2018) · Advanced Materials Technologies · doi:10.1002/admt.201800296 · Cited by 151 · see citing works
Overview of Poly(lactic acid) (PLA) fibre
Avinç, O., & Khoddamı, A. (2010) · Fibre Chemistry · doi:10.1007/s10692-010-9226-7 · Cited by 150 · see citing works
Kwon, S., Hwang, Y. H., Nam, M., Chae, H., Lee, H. S., Jeon, Y., Lee, S., Kim, C. Y., Choi, S., Jeong, E. G., et al. (2019) · Advanced Materials · doi:10.1002/adma.201903488 · Cited by 144 · see citing works
Nanomaterial mediated optogenetics: opportunities and challenges
Huang, K., Dou, Q., & Loh, X. J. (2016) · RSC Advances · doi:10.1039/c6ra11289g · Cited by 139 · see citing works
Flexible fiber-based optoelectronics for neural interfaces
Park, S., Loke, G. Z. J., Fink, Y., & Anikeeva, P. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00710a · Cited by 134 · see citing works
Biocompatible and Implantable Optical Fibers and Waveguides for Biomedicine
Nazempour, R., Zhang, Q., Fu, R., & Sheng, X. (2018) · Materials · doi:10.3390/ma11081283 · Cited by 133 · see citing works
Optogenetic control of contractile function in skeletal muscle
Bruegmann, T., Bremen, T. V., Vogt, C. C., Send, T., Fleischmann, B. K., & Sasse, P. (2015) · Nature Communications · doi:10.1038/ncomms8153 · Cited by 132 · see citing works
Guo, J., Yang, C., Dai, Q., & Kong, L. (2019) · Sensors · doi:10.3390/s19173771 · Cited by 129 · see citing works
An Optical Fibre-Based Sensor for Respiratory Monitoring
Krehel, M., Schmid, M., Rossi, R. M., Boesel, L. F., Bona, G. L., & Scherer, L. J. (2014) · Sensors · doi:10.3390/s140713088 · Cited by 127 · see citing works
Wu, Q., & Hu, J. (2016) · Composites Part B Engineering · doi:10.1016/j.compositesb.2016.09.068 · Cited by 127 · see citing works
Biocompatible silk step-index optical waveguides
Applegate, M. B., Perotto, G., Kaplan, D. L., & Omenetto, F. G. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.004221 · Cited by 118 · see citing works
Ultrasoft and Highly Stretchable Hydrogel Optical Fibers for In Vivo Optogenetic Modulations
Wang, L., Zhong, C., Ke, D., Ye, F., Tu, J., Wang, L., & Lu, Y. (2018) · Advanced Optical Materials · doi:10.1002/adom.201800427 · Cited by 116 · see citing works
Multifunctional Fibers to Shape Future Biomedical Devices
Zhang, Y., Ding, J., Qi, B., Tao, W., Wang, J., Zhao, C., Peng, H., & Shi, J. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201902834 · Cited by 114 · see citing works
Self-citationGlass optical waveguides: a review of fabrication techniques
Righini, G. C., & Chiappini, A. (2014) · Optical Engineering · doi:10.1117/1.oe.53.7.071819 · Cited by 112 · see citing works
Flexible biodegradable citrate-based polymeric step-index optical fiber
Shan, D., Zhang, C., Kalaba, S., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.08.003 · Cited by 110 · see citing works
Yang, X., Pan, X., Blyth, J., & Lowe, C. R. (2008) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2007.09.016 · Cited by 103 · see citing works
A polymer-based neural microimplant for optogenetic applications: design and first in vivo study
Rubehn, B., Wolff, S. B. E., Tovote, P., Lüthi, A., & Stieglitz, T. (2013) · Lab on a Chip · doi:10.1039/c2lc40874k · Cited by 100 · see citing works
Guo, Y., Jiang, S., Grena, B. J.-B., Kimbrough, I. F., Thompson, E. G., Fink, Y., Sontheimer, H. W., Yoshinobu, T., & Jia, X. (2017) · ACS Nano · doi:10.1021/acsnano.6b07550 · Cited by 100 · see citing works
Prospective for biodegradable microstructured optical fibers
Dupuis, A., Guo, N., Gao, Y., et al. (2006) · Optics Letters · doi:10.1364/ol.32.000109 · Cited by 98 · see citing works
An Integrated μLED Optrode for Optogenetic Stimulation and Electrical Recording
Cao, H., Gu, L., Mohanty, S. K., et al. (2012) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2012.2217395 · Cited by 97 · see citing works
A coaxial optrode as multifunction write-read probe for optogenetic studies in non-human primates
Ozden, I., Wang, J., Lu, Y., May, T., Lee, J., Goo, W., O'Shea, D. J., Kalanithi, P., Diester, I., Diagne, M., et al. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.06.011 · Cited by 97 · see citing works
Self-citationA flexible hydrophilic-modified graphene microprobe for neural and cardiac recording
Chen, C., Lin, C., Hsu, W.-L., Chang, Y., Yeh, S., Li, L., & Yao, D. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.12.004 · Cited by 96 · see citing works
Zhang, H., Zhao, H., Zeng, C., Dort, C. J. V., Faingold, C. L., Taylor, N. E., Solt, K., & Feng, H.-J. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.11.003 · Cited by 96 · see citing works
The photoactivity of natural products – An overlooked potential of phytomedicines?
Siewert, B., & Stuppner, H. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152985 · Cited by 96 · see citing works
Highly stretchable optical sensors for pressure, strain, and curvature measurement
To, C., Hellebrekers, T., & Park, Y. (2015) · IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) · doi:10.1109/iros.2015.7354215 · Cited by 94 · see citing works
Optogenetic approaches to restoring visual function in retinitis pigmentosa
Busskamp, V., & Roska, B. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.06.001 · Cited by 93 · see citing works
Polymeric biomaterials for biophotonic applications
Shan, D., Gerhard, E. M., Zhang, C., et al. (2018) · Bioactive Materials · doi:10.1016/j.bioactmat.2018.07.001 · Cited by 93 · see citing works
Flexible organic light-emitting diodes for antimicrobial photodynamic therapy
Lian, C., Piksa, M., Yoshida, K., Persheyev, S., Pawlik, K., Matczyszyn, K., & Samuel, I. D. W. (2019) · npj Flexible Electronics · doi:10.1038/s41528-019-0058-0 · Cited by 93 · see citing works
Toward biomaterial‐based implantable photonic devices
Humar, M., Kwok, S. J. J., Choi, M., Yetisen, A. K., Cho, S., & Yun, S. H. (2016) · Nanophotonics · doi:10.1515/nanoph-2016-0003 · Cited by 87 · see citing works
Optrodes for combined optogenetics and electrophysiology in live animals
Dufour, S., & Koninck, Y. D. (2015) · Neurophotonics · doi:10.1117/1.nph.2.3.031205 · Cited by 84 · see citing works
Qiao, X., Qian, Z., Li, J., Sun, H., Han, Y. F., Xia, X., Zhou, J., Wang, C., Wang, Y., & Wang, C. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b01752 · Cited by 84 · see citing works
A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose
Ruan, J.-L., Chen, C., Shen, J., Zhao, X., Qian, S., & Zhu, Z. (2017) · Polymers · doi:10.3390/polym9040125 · Cited by 83 · see citing works
Critical-depth Raman spectroscopy enables home-use non-invasive glucose monitoring
Lundsgaard-Nielsen, S. M., Pors, A., Banke, S. O., Henriksen, J. E., Hepp, D. K., & Weber, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197134 · Cited by 83 · see citing works
Biomaterial microlasers implantable in the cornea, skin, and blood
Humar, M., Dobravec, A., Zhao, X., et al. (2017) · Optica · doi:10.1364/optica.4.001080 · Cited by 82 · see citing works
Kofler, B., Romani, A., Pritz, C. O., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041107 · Cited by 82 · see citing works
Optogenetic approaches to retinal prosthesis
Barrett, J. M., Palmini, R. B., & Degenaar, P. A. (2014) · Visual Neuroscience · doi:10.1017/s0952523814000212 · Cited by 81 · see citing works
Optical techniques in optogenetics
Mohanty, S. K., & Lakshminarayanan, V. (2015) · Journal of Modern Optics · doi:10.1080/09500340.2015.1010620 · Cited by 75 · see citing works
Jiang, N., Montelongo, Y., Butt, H., & Yetisen, A. K. (2018) · Small · doi:10.1002/smll.201704363 · Cited by 73 · see citing works
Highly-sensitive optical fiber temperature sensors based on PDMS/silica hybrid fiber structures
Gao, H. C., Hu, H., Zhao, Y., et al. (2018) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2018.10.011 · Cited by 71 · see citing works
Novel biocompatible and resorbable UV-transparent phosphate glass based optical fiber
Ceci‐Ginistrelli, E., Pugliese, D., Boetti, N. G., et al. (2016) · Optical Materials Express · doi:10.1364/ome.6.002040 · Cited by 70 · see citing works
Optical lens-microneedle array for percutaneous light delivery
Kim, M., An, J., Kim, K. S., et al. (2016) · Biomedical Optics Express · doi:10.1364/boe.7.004220 · Cited by 70 · see citing works
Luminous fabric devices for wearable low-level light therapy
Shen, J., Chui, C.-H., & Tao, X. (2013) · Biomedical Optics Express · doi:10.1364/boe.4.002925 · Cited by 67 · see citing works
Micropatterned conductive polymer biosensors on flexible PDMS films
Pal, R. K., Pradhan, S., Narayanan, L., & Yadavalli, V. K. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.12.082 · Cited by 67 · see citing works
The optical properties of regenerated silk fibroin films obtained from different sources
Perotto, G., Zhang, Y., Naskar, D., Patel, N., Kaplan, D. L., Kundu, S. C., & Omenetto, F. G. (2017) · Applied Physics Letters · doi:10.1063/1.4998950 · Cited by 65 · see citing works
Wearable Biosensors for Monitoring Wound Healing
Pasche, S., Angeloni, S., Ischer, R., Liley, M., Luprano, J., & Voirin, G. (2008) · Advances in science and technology · doi:10.4028/www.scientific.net/ast.57.80 · Cited by 63 · see citing works
Bioactive silk hydrogels with tunable mechanical properties
Wang, X., Ding, Z., Wang, C., Chen, X., Xu, H., Lü, Q., & Kaplan, D. L. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00607e · Cited by 61 · see citing works
Upconversion System with Quantum Dots as Sensitizer: Improved Photoluminescence and PDT Efficiency
Song, D., Chi, S., Li, X., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b16237 · Cited by 57 · see citing works
Technology for the Preparation of PDMS Optical Fibers and Some Fiber Structures
Martinček, I., Pudiš, D., & Chalupová, M. (2014) · IEEE Photonics Technology Letters · doi:10.1109/lpt.2014.2326695 · Cited by 54 · see citing works
Liu, H., Daly, L., Rudd, G., et al. (2018) · Lasers in Surgery and Medicine · doi:10.1002/lsm.23019 · Cited by 54 · see citing works
Poly(D,L-Lactic Acid) (PDLLA) Biodegradable and Biocompatible Polymer Optical Fiber
Gierej, A., Berghmans, F., Vagenende, M., et al. (2019) · Journal of Lightwave Technology · doi:10.1109/jlt.2019.2895220 · Cited by 51 · see citing works
Implantable optoelectronic probes for in vivo optogenetics
Iseri, E., & Kuzum, D. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa60b3 · Cited by 49 · see citing works
Applications of Light Emitting Diodes in Health Care
Dong, J., & Xiong, D. (2017) · Annals of Biomedical Engineering · doi:10.1007/s10439-017-1930-5 · Cited by 49 · see citing works
Self-citationFlexible quantum dot light‐emitting devices for targeted photomedical applications
Chen, H., Yeh, T., He, J., et al. (2018) · Journal of the Society for Information Display · doi:10.1002/jsid.650 · Cited by 46 · see citing works
Moradi, V., Akbari, M., & Wild, P. (2019) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2019.07.031 · Cited by 42 · see citing works
Fabrication and Characterization of Recombinant Silk‐Elastin‐Like‐Protein (SELP) Fiber
Roberts, E. G., Rim, N., Huang, W., et al. (2018) · Macromolecular Bioscience · doi:10.1002/mabi.201800265 · Cited by 37 · see citing works
Development and application of LED arrays for use in phototherapy research
Hadis, M. A., Cooper, P. R., Milward, M. R., et al. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201600273 · Cited by 33 · see citing works
Au nanorod–coupled microfiber optical humidity sensors
Zhou, N., Wang, P., Shi, Z., et al. (2019) · Optics Express · doi:10.1364/oe.27.008180 · Cited by 32 · see citing works
Tian, Z., Cheng, J., Liu, J., et al. (2018) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2019.15884 · Cited by 31 · see citing works
Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy?
Ji, Z.-G., & Wang, H. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.10.013 · Cited by 29 · see citing works
An implantable, miniaturized SU-8 optical probe for optogenetics-based deep brain stimulation
Fan, B., Kwon, K. Y., Weber, A. J., et al. (2014) · doi:10.1109/embc.2014.6943625 · Cited by 29 · see citing works
Cheng, Q., Varga, S. J., Oh, S., Lee, C. J., & Lee, D. (2017) · Experimental Neurobiology · doi:10.5607/en.2017.26.2.97 · Cited by 29 · see citing works
Chang, W., Chang, W. P., & Shyu, B. (2017) · Molecular Brain · doi:10.1186/s13041-017-0320-0 · Cited by 29 · see citing works
Low level laser (light) therapy and photobiomodulation: the path forward
Hamblin, M. R., de Sousa, M. V. P., Arany, P. R., et al. (2015) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2084049 · Cited by 28 · see citing works
Flexible Optical Waveguides for Uniform Periscleral Cross-Linking
Kwok, S. J. J., Kim, M., Lin, H. H., et al. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-21559 · Cited by 28 · see citing works
Femtosecond direct laser writing of silk fibroin optical waveguides
dos Santos, M. V., dos Santos, S. N. C., Martins, R., Almeida, J. M. P., Paula, K. T., Almeida, G. F. B., Ribeiro, S. J. L., & Mendonça, C. R. (2019) · Journal of Materials Science Materials in Electronics · doi:10.1007/s10854-019-01406-w · Cited by 22 · see citing works
Optogenetic entrainment of neural oscillations with hybrid fiber probes
Kilias, A., Canales, A., Froriep, U. P., Park, S., Egert, U., & Anikeeva, P. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aacdb9 · Cited by 21 · see citing works
Zhang, S., Tsang, W. M., Merugu, S., Sun, T., Singh, N., Kwong, D., & Lee, C. (2014) · Applied Physics Letters · doi:10.1063/1.4875961 · Cited by 18 · see citing works
Xue, J., Ye, L., Li, C., Zhang, M., & Li, P. (2018) · Optik · doi:10.1016/j.ijleo.2018.05.050 · Cited by 18 · see citing works
Li, Z., Marks, H. L., Evans, C. L., et al. (2018) · Journal of Biomedical Optics · doi:10.1117/1.jbo.24.2.021201 · Cited by 18 · see citing works
Polydimethylsiloxane-based optical waveguides for tetherless powering of floating microstimulators
Erşen, A., & Şahin, M. (2017) · Journal of Biomedical Optics · doi:10.1117/1.jbo.22.5.055005 · Cited by 17 · see citing works
Miniature probe for the delivery and monitoring of a photopolymerizable material
Schmocker, A. M., Khoushabi, A., Schizas, C., Bourban, P. ‐., Pioletti, D. P., & Moser, C. (2015) · Journal of Biomedical Optics · doi:10.1117/1.jbo.20.12.127001 · Cited by 15 · see citing works
In vivo photothermal treatment with real-time monitoring by optical fiber-needle array
Yang, T.-S., Park, K., Kim, H., et al. (2017) · Biomedical Optics Express · doi:10.1364/boe.8.003482 · Cited by 15 · see citing works
Soft-glass imaging microstructured optical fibers
Warren-Smith, S. C., Dowler, A., & Ebendorff‐Heidepriem, H. (2018) · Optics Express · doi:10.1364/oe.26.033604 · Cited by 15 · see citing works
Disposable MEMS optrode array integrated with single LED for neurostimulation
Yoo, S., Lee, H., Jun, S. B., Kim, Y.-K., & Ji, C. (2018) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2018.02.039 · Cited by 12 · see citing works
Fabrication strategies and potential applications of the “green” microstructured optical fibers
Dupuis, A., Guo, N., Gao, Y., et al. (2008) · Journal of Biomedical Optics · doi:10.1117/1.2978062 · Cited by 11 · see citing works
Liu, S., Tang, Y., Xing, Y., Kramer, P. R., Bellinger, L. L., & Tao, F. (2019) · Brain Sciences · doi:10.3390/brainsci9020026 · Cited by 11 · see citing works
Optical waveguiding properties of colloidal quantum dots doped polymer microfibers
Yu, J., Wang, X., & Chen, R. (2018) · Optics Express · doi:10.1364/oe.26.013408 · Cited by 9 · see citing works
Konishi, S., Kobayashi, T. R., & Muramatsu, Y. (2016) · Advanced Robotics · doi:10.1080/01691864.2016.1181007 · Cited by 8 · see citing works
Micro-lens-coupled LED neural stimulator for optogenetics
Bi, X., Fan, B., & Li, W. (2015) · IEEE Biomedical Circuits and Systems Conference (BioCAS) · doi:10.1109/biocas.2015.7348344 · Cited by 6 · see citing works
Fabrication of large area flexible PDMS waveguide sheets
Green, R., Knopf, G. K., & Bordatchev, E. V. (2016) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2208789 · Cited by 6 · see citing works
Muramatsu, Y., Kobayashi, T. R., & Konishi, S. (2015) · Proceedings, IEEE micro electro mechanical systems · doi:10.1109/memsys.2015.7050912 · Cited by 4 · see citing works
Super-elastic multi-material optical fibers for healthcare applications
Sorin, F., Qu, Y., Nguyen-Dang, T., Yan, W., Page, A. G., Gupta, T. D., Bartolomei, N., & Leber, A. (2019) · Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications · doi:10.1117/12.2510697 · Cited by 4 · see citing works
A PDMS-based optical waveguide for transcutaneous powering of microelectrode arrays
Erşen, A., & Şahin, M. (2016) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2016.7591721 · Cited by 3 · see citing works
Integration of High-performance Optoelectronic Nanowire-based Devices at Optical Fiber Tips
Yan, W. Q., Gupta, T. D., Richard, I., et al. (2018) · Conference on Lasers and Electro-Optics · doi:10.1364/cleo_si.2018.sf2k.4 · Cited by 3 · see citing works
Implantable light delivery interfaces for optical neural stimulation
Abaya, T. V. F. (2015) · J. Willard Marriott Library · doi:10.26053/0h-3cac-cf00 · Cited by 2 · see citing works
Novel technology platform for PBM delivery using printed LEDs
Castel, J. C., Castel, D., & Wei, T. Y. (2019) · Mechanisms of Photobiomodulation Therapy · doi:10.1117/12.2508729 · Cited by 2 · see citing works
Wearable POF-based heart-rate monitor
Barba, Á. R., López, I. S., Cardona, J. D. L., et al. (2019) · Seventh European Workshop on Optical Fibre Sensors · doi:10.1117/12.2541302 · Cited by 2 · see citing works
Sieno, L. D., Boetti, N. G., Mora, A. D. D., et al. (2019) · doi:10.1117/12.2509501 · Cited by 1 · see citing works
Multimaterial bioresorbable optical fibers for theranostics
Milanese, D., Pugliese, D., Boetti, N. G., et al. (2019) · doi:10.1117/12.2527679 · Cited by 1 · see citing works
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The Current State of Optical Sensors in Medical Wearables
Vavrinsky, E., Esfahani, N. E., Hausner, M., Kuzma, A., Rezo, V., Donoval, M., & Kosnacova, H. (2022) · Biosensors · doi:10.3390/bios12040217 · Cited by 103 · see citing works
- Authors
- Wang, J., & Dong, J.
- Affiliations
- University of Science and Technology of China (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Dong, Jianfei
- Venue
- Sensors
- Publisher
- MDPI AG
- Published
- 2020-07-17
- Volume
- 20
- Issue
- 14
- Pages
- 3981
- ISSN
- 1424-8220 (ISSN-L)
- PMC
- PMC7411870
- OpenAlex
- W3043079208
- Cited by
- 77
- References
- 145
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 13 · 2023: 6 · 2022: 6 · 2021: 20 · 2020: 2
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Sensors (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Suzhou Institute of Biomedical Engineering and Technology (No. Y85212A705)
- Nanjing Institute of Intelligent Health and Innovation (No. Y85K023705)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Photonic and Optical Devices
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Fiber Optic Sensors
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Keywords
- optical waveguides, integrated optical devices, diagnosis, health monitoring, phototherapy, glass waveguides, polymer waveguides, heterogeneous materials, fabrication techniques, optical sensors, drug delivery, colorimetry, fluorescence sensing, luminescence sensing
- MeSH terms
- Wearable Electronic Devices, Glass, Phototherapy, Polymers, Optical Devices
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